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0 RCE Corporate Presentation Annual General Meeting 2025 ASX:RCE | FSE:R9Q November 2025 For personal use only
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Disclaimer DISCLAIMER This presentation has been prepared by Recce Pharmaceuticals Ltd (the “Company”). It does not purport to contain all the information that a prospective investor may require in connection with any potential investment in the Company. You should not treat the contents of this presentation, or any information provided in connection with it, as financial advice, financial product advice or advice relating to legal, taxation or investment matters. No representation or warranty (whether express or implied) is made by the Company or any of its officers, advisers, agents or employees as to the accuracy, completeness or reasonableness of the information, statements, opinions or matters (express or implied) arising out of, contained in or derived from this presentation or provided in connection with it, or any omission from this presentation, nor as to the attainability of any estimates, forecasts or projections set out in this presentation. This presentation is provided expressly on the basis that you will carry out your own independent inquiries into the matters contained in the presentation and make your own independent decisions about the affairs, financial position or prospects of the Company. The Company reserves the right to update, amend or supplement the information at any time in its absolute discretion (without incurring any obligation to do so). Neither the Company, nor its related bodies corporate, officers, their advisers, agents and employees accept any responsibility or liability to you or to any other person or entity arising out of this presentation including pursuant to the general law (whether for negligence, under statute or otherwise), or under the Australian Securities and Investments Commission Act 2001, Corporations Act 2001, Competition and Consumer Act 2010 or any corresponding provision of any Australian state or territory legislation (or the law of any similar legislation in any other jurisdiction), or similar provision under any applicable law. Any such responsibility or liability is, to the maximum extent permitted by law, expressly disclaimed and excluded. Nothing in this material should be construed as either an offer to sell or a solicitation of an offer to buy or sell securities. It does not include all available information and should not be used in isolation as a basis to invest in the Company. 1 FUTURE MATTERS This presentation contains reference to certain intentions, expectations, future plans, strategy and prospects of the Company. Those intentions, expectations, future plans, strategy and prospects may or may not be achieved. They are based on certain assumptions, which may not be met or on which views may differ and may be affected by known and unknown risks. The performance and operations of the Company may be influenced by a number of factors, many of which are outside the control of the Company. No representation or warranty, express or implied, is made by the Company, or any of its directors, officers, employees, advisers or agents that any intentions, expectations or plans will be achieved either totally or partially or that any particular rate of return will be achieved. Given the risks and uncertainties that may cause the Company’s actual future results, performance or achievements to be materially different from those expected, planned or intended, recipients should not place undue reliance on these intentions, expectations, future plans, strategy and prospects. The Company does not warrant or represent that the actual results, performance or achievements will be as expected, planned or intended. US DISCLOSURE This document does not constitute any part of any offer to sell, or the solicitation of an offer to buy, any securities in the United States or to, or for the account or benefit of any “US person” as defined in Regulation S under the US Securities Act of 1993 (“Securities Act”). The Company’s shares have not been , and will not be, registered under the Securities Act or the securities laws of any state or other jurisdiction of the United States, and may not be offered or sold in the United States or to any US person without being so registered or pursuant to an exemption from registration including an exemption for qualified institutional buyers. For personal use only
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Recce Pharmaceuticals – Company Overview • Publicly-traded on the Australian and Frankfurt exchanges – (ASX: RCE, FSE: R9Q). • Therapeutics to address the global healthcare crisis of antibiotic resistance: works faster than traditional antibiotics and against multidrug-resistant bacteria. • Phase 3 Clinical trial (Indonesia) – patient dosing commenced. • Multiple successful Phase I and Phase II clinical trials across Australia. • US Defense Burn Research Program grant; US Army Medical Research Institute of Infectious Diseases – in progress. • >40 granted patents across major pharmaceutical markets out to 2041. • Our goal is for our product to be made available in Indonesia in 2026. An Australian clinical-stage biotech with a United States presence, developing a New Class of Synthetic Anti-infectives with a unique mechanism of action for a broad spectrum of infections including serious/life-threatening indications. RECCE® 327 granted Qualified Infectious Disease Product (QIDP) Designation by U.S. Food and Drug Administration giving 10 years market exclusivity plus fast-track approval. RECCE®327 added to World Health Organization’s List of Antibacterial Products in Clinical Development. 2 For personal use only
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Board and Management Structure 3 Dr John Prendergast – Chairman BSc (Hons), MSc (UNSW), PhD (UNSW), CSS (HU) US-based biotechnology executive and investor with extensive experience in the commercialisation, financing, and sale of pharmaceutical assets. He has overseen three New Drug Approvals and led multiple licensing and M&A transactions, including the successful sale of Vyleesi® to Cosette Pharmaceuticals for USD $159 million in contingent, sales-based milestones. Over his career, he has been instrumental in capital raises exceeding USD $1 billion and has directed numerous transactions involving the sale of assets, technologies, and companies across the biotechnology and healthcare sectors. James Graham – Managing Director & Chief Executive Officer BCom (Entrepreneurship), GAICD Mr Graham is the Chief Executive Officer of Recce Pharmaceuticals. He brings extensive experience in marketing, business development, and the commercialisation of early-stage technologies with global potential. With a proven track record of growing globally focused companies, Mr Graham has applied his expertise to Recce, including serving on its Board of Directors. He has participated in nearly every capital raise to date, demonstrating a strong commitment to expanding Recce’s commercial opportunities and clinical programs. Dr Alan Dunton – Chief Medical Advisor & Non-Executive Director BSc (BioChem) Hons, M.D. (NYU) US-based pharmaceutical executive with more than 30 years of experience in drug development and commercial leadership. Former President and Managing Director of Janssen Research Foundation (Johnson & Johnson), he directed the approval and launch of around 20 New Drug Applications, including Levaquin®, Regranex®, Aleve®, Procrit®, Sporanox®, Reminyl® and Risperdal®. He has held senior roles at Roche, CIBA-GEIGY, Syntex and Purdue Pharma, and served as CEO of Panacos, Metaphore and EpiCept Pharmaceuticals, overseeing multiple corporate transactions and the successful sale of Vyleesi® to Cosette Pharmaceuticals for USD $159 million in contingent, sales-based milestones. Michele Dilizia – Executive Director & Chief Scientific Officer BSc (Med Sci), Grad Dip Bus (Mkting), BA (Journ), GAICD, MASM Co-inventor and qualified medical scientist with a specialisation in medical microbiology and regulatory affairs. Ms Dilizia successfully co-led the research and development of Recce’s suite of anti- infective compounds, resulting in a portfolio of granted patents across the globe, including a Qualified Infectious Disease Product designation with the U.S. FDA. Dr Justin Ward – Executive Director & Principal Quality Chemist BSc (Chem), PhD (Chem), M Pharm, MRACI, CChem A quality control expert who has worked with leading pharmaceutical companies. He previously held a technical role with Pfizer, involving providing data for the regulatory submissions to the FDA and TGA. Dr Ward is bringing Recce’s research and development and manufacturing up to US FDA requirements. Alistair McKeough – Non-Executive Director Mr McKeough is an experienced executive and solicitor. Before being appointed as a non-executive director in 2022, Alistair served as Recce’s company secretary and he has been involved with the company since 2017. Alistair has extensive experience in a variety of private and listed corporations across many sectors, including professional services, technology, financial services, charities, health, biotech, childcare and education. Recent roles include Managing Director of a legal practice specialising in equity capital markets and advice to listed companies and as part of the senior leadership team at share registry, Automic Group. For personal use only
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recce.com.au World Health Organization added RECCE® compounds to its list of antibacterial products in clinical development for priority pathogens US FDA Qualified Infectious Disease Product designation provides 10 years of market exclusivity plus fast-track approval* Multiple clinical indications and formulations in Phase I and II addressing unmet medical needs Leading, Australian Anti-Infective Company Near-term commercialisation pathway expected to launch in 2026 Products address the global healthcare crisis of antibiotic resistance Phase 3 in Indonesia of lead asset RECCE® 327 Gel for the treatment of Diabetic Foot Infections – Expected launch in 2026 and opens gateway to ASEAN and other markets *Awarded by the US FDA in 2017 for R327 bacteraemia (broad-spectrum bacterial sepsis). Time starts only from potential market approval 4 For personal use only
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recce.com.au Company Overview Capital Structure – October 2025 ASX & FSE Code RCE, R9Q Share Price AUD $0.405 3-Month Daily Average Daily Volume 114.94k Shares on Issue 289.18 million Unlisted Options (Avg $1.087) 24.17 million Market Capitalisation AUD $121.46 million Top 20 Shareholders 53.64% RCE Share Price and Volume Chart – 12 Months (price shown in AUD) Australian Government awarded AUD $54,947,284 (USD $37,043,433) Advanced Overseas Finding across RCE infectious disease portfolio* Multiple clinical indications and formulations in Phase I and Phase II addressing unmet medical needs: Sepsis, UTI/Urosepsis, Burn Wounds and ABSSSI, including Diabetic Foot Infections Recce Pharmaceuticals Ltd is a clinical-stage biotech company with a new class of novel synthetic anti-infectives Volume Close $ *The Advanced Finding is a binding, underwritten guarantee provided by the Australian Government, which affirms the Company’s R&D activities are of national interest and extends the 43.5% R&D rebate from locally, to cover those undertaken by the Company anywhere in the world for a period of three years. This finding does not constitute a grant, or an upfront payment of the amount awarded Proprietary first-in-class, broad- spectrum anti-infectives against bacteria I.V. and topical treatments advancing for UTI/Urosepsis and Acute Bacterial Skin and Skin Structure Infections (ABSSSI) including DFI; as well as US Department of Defense Burn Wound Program and Indonesian clinical trials for topical treatments. *Non-Dilutive Financing via debt facility of up to ~A$30 million with Avenue Capital Group. 5 $- $0.10 $0.20 $0.30 $0.40 $0.50 $0.60 - 500,000 1,000,000 1,500,000 2,000,000 2,500,000 3,000,000 For personal use only
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ExecutiveOverview Currently only 6 companies on the ASX are conducting Phase III therapeutic trials 6 5.44B 3.22B 2.75B 821M 306M 180M 123M 98M 72M ** Not started or failed ** A medical device • Telix Pharmaceuticals (ASX: TLX) • Mesoblast (ASX: MSB) • Neuren Pharmaceuticals (ASX: NEU) • Opthea (ASX: OPT) ** • Dimerix (ASX: DXB) • Paradigm Biopharmaceuticals (ASX: PAR) • Recce Pharmaceuticals (ASX: RCE) • Avita Medical (ASX: AVH) ** • Amplia Therapeutics (ASX: ATX) ** Significant potential for value creation in next 12-18mos For personal use only
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recce.com.au Synthetic Anti-Infectives The need for a new class of antibiotics On-track to be the only global clinical stage company whose drug is shown to be efficacious against the full suite of ESKAPE pathogens NO pre-formed natural superbugs Very broad-spectrum coverage of bacteria with no signs of resistance Universal Mechanism of Action - does not succumb to resistance Unprecedented, broad- spectrum activity against Gram +ve and Gram -ve bacteria and maintains its activity even with repeated use Extremely rapid onset of effect – measured in minutes as compared to hours for typical antibiotics Multiple formulations available – intravenous, topical liquid, topical gel and aerosol for inhalation or intranasal 7 For personal use only
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Since Last AGM – Clinical Trial Progress 8 ALL Objectives Achieved from last AGM New Objectives for 2025/2026 ✓ Phase II Clinical Trial data successfully demonstrated R327G achieving a 93% primary efficacy endpoint over 14-days, meeting all study endpoints. ✓ Phase II Clinical Trial receives approval for additional diabetic patients to be treated with R327G. Phase II ABSSSI Clinical Trial Topical Phase III Registrational Clinical Trial in Indonesia Topical Gel ✓ Patient dosing is now underway with five (5) clinical study sites activated across Indonesia. Trial designed to enrol up to 310 patients, assessing clinical response according to the Lipsky Scale. Launch Registrational Phase III trial for ABSSSI in Australia Phase III ABSSSI Clinical Trial Topical Gel Phase III Indonesia Interim data readout Q1 2026 potential market approval mid 2026 Phase III DFI Clinical Trial Topical Gel Dept. of Defense Burn Wound Programs Topical Gel Advance across three US Defense Programs Trial Data Released Trial CommencedFor personal use only
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2025/2026 Corporate Goals 9 Global Expansion into High-Growth Healthcare Markets Regulatory approvals in ASEAN, Middle East (MENA region) Military Partnerships and Grant Funding Funding, R&D partnerships, licensing, grant submissions Delivery of Phase 3 Clinical Data Expected Interim data readout Q1 2026; potential market approval mid 2026 Commercial Partnerships Advancing clinical evaluation, registration, and potential commercialisation of Recce’s proprietary anti-infective portfolio For personal use only
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• Patient dosing is now underway with five (5) clinical study sites activated across Indonesia. Trial designed to enrol up to 310 patients, assessing clinical response according to the Lipsky Scale. • Opportunity to access 10 ASEAN member states – 680 million inhabitant, including 280 million in Indonesia. • Memorandum of Understanding (MoU) with leading Indonesian biomedical company PT Etana Biotechnologies. 10 Phase 3 Registrational Clinical Trial in Indonesia Topical Gel Recce & Badan POM Team’s - Recce CEO James Graham (centre left) and Head of Drug and Food Authority Badan POM, Professor Taruna Ikrar (centre) Awarded expedited regulatory review status in Indonesia to fast-track progression of Phase 3 trial Strategic Opportunity in South-East Asia Opportunity Presents an Innovative Path to Global Access • Significant bilateral initiative supported by Australian and Indonesian Governments. • Expected launch in 2026 in ASEAN region. • Multiple therapeutics for unmet medical needs expected to follow such as: tuberculosis, post-op infections, burn wounds etc. For personal use only
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Registrational Phase III Clinical Trial - Indonesia 11 Title: Phase III, Double-blind, Placebo-Controlled Study of R327 Topical Gel for the Treatment of Diabetic Foot Ulcer Infections Multi-centre, 5 activated sites across Indonesia. Over 20.9 million adults in Indonesia are living with diabetes – more than 1 in every 10 adults. Up to 310 participants, participants will be enrolled who present with a mild diabetic foot ulcer infection. Interim data analysis to be conducted after 155 participants. Primary Endpoint: Assess the clinical response of the DFI according to the Lipsky Scale. Secondary Endpoints: DFI total wound score and safety of R327G. Population Locations Endpoints Intervention Participants to receive either R327 topical gel or placebo topical gel. Expected Interim data readout Q1 2026; potential market approval mid 2026 For personal use only
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Diabetic Foot Infections - Large Addressable Market 12 • Significant near-term opportunity for Recce with registrational Phase 3 trials anticipated to be completed in FY26 paving the way for future revenues • Opportunity to access 10 ASEAN member states covering a population of 670 million inhabitants • Initially targeting Indonesian market valued at ~US$189 million where DFI impacts 11% of the population2 US$5.2B Est. global DFI treatment market1 • Indonesian approvals provide access to the broader Asia Pacific market worth ~US$1.0 billion per year3 • In Indonesia, DFIs are severe resulting in amputation in 46.9% of hospitalised patients4. • In-hospital treatment costs averaging USD ~$4,100 per patient and significantly higher costs for amputees, highlighting the substantial clinical and economic burden of DFI on the national health system5 US$189M Est. Indonesian DFI Market2 Source: (1) Grand View Research, Diabetic Foot Ulcer Treatment Market Size, 2023 (2) Diabetes Atlas, International Diabetic Federation and Prof EM Yunir, Faculty of Medicines, University of Indonesia. (3) Business Market Insights, Asia Pacific Diabetic Foot Ulcer Market, 2021 (4) Grand View Research, Anti-Infective Agents Market Size, 2023 5. https://doi.org/10.1016/j.heliyon.2024.e41263 ~US$135.4B Estimated value of the significant additional market opportunities in the broader anti-infectives market Recce already exploring opportunities in burn wound infections, skin and soft tissue infections post operation4 For personal use only
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Military Partnerships and Additional Funding Non-Dilutive Financing via Debt Facility with Avenue Capital Group • Debt facility of up to ~A$30m (US$20m) established with Avenue Capital Group • Funding to support two Registrational Phase 3 clinical trials in Indonesia and Australia, including manufacturing, regulatory submissions, and market launch preparation for R327G. Canadian Scientific Research & Experimental Development Rebate • US$175,122 (A$271,987) from the Canadian Government received. 13 US Military Engagement U.S. Department of Defense Burn Wound Program • U.S. Department of Defense Grants Recce Pharmaceuticals US$2 million to accelerate development of R327G for acute treatment of burn wound infections Defense Threat Reduction Agency (DTRA) Backed Cooperative Research & Development Agreement with United States Army Medical Research Institute of Infectious Diseases (USAMRIID) • Testing R327 against highly hazardous pathogens of biodefense concern in USAMRIID under high biocontainment conditions. Non-dilutive Funding For personal use only
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recce.com.au • This Phase II study achieved all primary and secondary endpoints as an open-label clinical trial evaluating the safety and tolerability, efficacy, and plasma pharmacokinetics of R327G when applied directly to the infected area • The study enrolled 30 patients, with 29 included in the final data analysis. One patient was withdrawn due to pre-existing pain at the wound site that was deemed unrelated to R327G • After 7 days of treatment, 86% of patients (25 out of 29) treated with R327G had a successful clinical response • At 14 days of treatment, 93% of patients (27 out of 29) achieved a primary efficacy endpoint • R327G demonstrated to be safe and well tolerated, achieving all endpoints - no Serious Adverse Events reported Phase II ABSSSI Clinical Trial Achieved all Endpoints Study Outcome* To evaluate the efficacy of RECCE®327 topical gel on ABSSSI Assessment method Lipsky Scale/Bates Jensen Wound Assessment Tool Endpoint met Yes *https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=387997&isReview=true Successful clinical response 86% 93% After 7 days of treatment After 14 days of treatment 14 For personal use only
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Robust Worldwide Intellectual Property Portfolio 15 Family 1 group relates to the Company’s Unique and Highly Economical Manufacturing Process and use of the Polymer in Treatment of Diseases. Family 2 relates to the Method of Manufacture, Administration and Application to Treat a Broad Range of Common Human Infections. Family 3 relates to a Method of Treatment of a Broad Range of Viral Infections, particularly Parenteral Viral Infection. Family 4 relates to Process for Preparation of Biologically Active Copolymer, other Patent Cooperation Treaty countries pending/granted) Recce’s patent portfolio contains over 40 patents and patent applications in the world’s major markets. Filed Patent Family 1 Expiry Patent Family 2 Expiry Patent Family 3 Expiry Patent Family 4 Expiry Australia ✓ 2028 ✓ 2037 ✓ 2037 ✓ 2041 USA ✓ 2029 ✓ 2037 ✓ 2037 Pending - Europe ✓ 2028 ✓ 2037 ✓ 2037 Pending - Germany ✓ 2028 ✓ 2037 ✓ 2037 - - Spain ✓ 2028 ✓ 2037 ✓ 2037 - - France ✓ 2029 ✓ 2037 ✓ 2037 - - UK ✓ 2028 ✓ 2037 ✓ 2037 - - Italy ✓ 2028 ✓ 2037 ✓ 2037 - - Sweden ✓ 2028 ✓ 2037 ✓ 2037 - - Japan ✓ 2028 ✓ 2037 ✓ 2037 ✓ 2041 China ✓ 2028 ✓ 2037 ✓ 2037 ✓ 2041 HK Pending 2028 Pending 2037 ✓ 2037 Pending - Israel - - - - - - ✓ 2041 Canada - - - - - - ✓ 2041 For personal use only
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Summary 16 Significant value creating opportunities Novel, Synthetic, Broad-Spectrum, Rapid-Acting, Anti-Infectives: demonstrated against >500 clinical isolates including all resistant species; no signs of resistance to R327 Indonesian Phase 3 registrational clinical trial data read-out and regulatory submission expected in late 2025, potential market approval and commercial launch in H1 2026 Upon completion of Phase 3 registrational clinical trial, enables Recce to replicate regulatory approval for R327G across the broader ASEAN region Development of a first new class of antibiotic in over 40 years, recognised by the World Health organisation, with accelerated de-risking via registrational Phase 3 trials in Indonesia and Australia Expansion of Recce’s Global Regulatory Strategy including US IND and Department of Defense partnership For personal use only
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recce.com.au Thank you James Graham Managing Director and Chief Executive Officer Recce Pharmaceuticals Ltd ASX:RCE; FSE:R9Q 17 For personal use only