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Vitrafy Life SciencesPioneering Technology, Preserving Life.Building the foundational infrastructure for the global biologicseconomy.Q1 FY2027 Quarterly Update ASX: VFY | October 2026 | vitrafy.com | Strictly Private & Confidential
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Important Notice and DisclaimerThis presentation is provided by Vitrafy Life Sciences Limited (ACN 622 720 254) (the Company). Statements in this presentation are made only as at the date of this presentation and the information in this presentation remains subject to change without notice. The information in this presentation is of a general nature and does not purport to be complete, is provided solely for information purposes of giving you summary information and background about the Company and its activities, current as at 28 October 2026 and should not be relied upon by the recipient.This presentation is not, and does not constitute, or form any part of, an offer to sell or issue, or the solicitation, invitation or recommendation to purchase any securities.No representation or warranty, express or implied, is made as to the fairness, accuracy, completeness or correctness of the information, opinions and conclusions contained in this presentation. This presentation does not purport to summariseall information that a recipient should consider when making an investment decision, and should not form the basis of any decision by a recipient.Recipients should carry out their own investigations and analysis of the Company and verify the accuracy, reliability and completeness of the information contained in this presentation or any other form of communication to which the recipient is permitted access in the course of evaluating an investment in the Company.No liabilityTo the maximum extent permitted by law, the Company, or their respective affiliates or related bodies corporate or any of their respective officers, directors, employees, agents and advisers (Related Parties), nor any other person, accepts any responsibility or liability for, and makes no recommendation, representation or warranty concerning, the content of this presentation, the Company, or the Company’s securities including, without limitation, any liability arising from fault or negligence, for any loss arising from the use of or reliance on any of the information contained in this presentation or otherwise arising in connection with it.Eligible recipientsThis presentation is provided to you as an investor to whom an offer document is not required to be given, and no registration, lodgementor other formality is required, in connection with an offer of securities. 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3 Q1 FY27 HIGHLIGHTS A Clear Step Up in U.S. MomentumBlood partnerships executed, CGT entry secured, leading Scientific Advisory Board set-up and FDA listing on track. 3rdMajor U.S. civilian blood partnersecured – Versiti ~17%Exposure to U.S.civilian blood collectionsites across partnersup from zero at the start of the year 1stU.S. cell & gene therapy agreementsecured – Charter Medical SABEstablished a Scientific Advisory Board comprising leading global human health experts 9Guardion devices manufactured with Medical Device Listing on track for 1H FY2027 $38.3mCash and term deposits at 30 September2026
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4 BLOOD U.S. Blood NetworkThree civilian partnerships plus the U.S. Army, giving exposure to civilian and sovereign blood networks. 3U.S. civilian blood partners+ U.S. military~179fixed collection sites~2.4munits collected annuallyby Vitrafy partners Blood Partners Partnership Focus: Red blood cells Partner exposure based on ~2.4m of ~14.2m annual U.S. blood collections. Fixed sites exclude mobile collections. Industry logos are examples only and do not represent agreements. ~17%of U.S. blood collection sites across partners Partnership Focus: Platelets and Plasma Partnership Focus: Platelets and Plasma Partnership Focus: Red blood cells
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5 MARKET DEVELOPMENT Growing Recognition Across the IndustryAABB 2026 put Vitrafy in front of the blood and biotherapies industry leaders, with panel presentations and the introduction of our new Scientific Advisory Board. Mean post-thaw platelet recovery – USAISR Phase II results presented independently to the field Scientific Advisory BoardLaunched at AABB 2026 to advise on scientific, regulatory and commercial development. Transfusion medicinePampeeYoungMD, PhDAmerican Red Cross Cell therapyJoseCancelasMD, PhDDana-Farber Cancer Institute Cell & gene therapyFolashadeOtegbeyeMD, MPHFred Hutch Cancer Center Trauma careDonJenkinsMDUT Health San Antonio BiostatisticsRichardCookPhDUniversity of Waterloo
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6 MARKET DEVELOPMENT Growing Recognition Across the IndustryVitrafy also presented its cryopreservation ecosystemand the results of its cryopreserved platelets study were presented by Kristin Reddoch-Cardenas of USAISR.
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7 EXPANDING APPLICATIONS Cell & Gene Therapy and Animal HealthOne cryopreservation platform, multiple markets. Cell & Gene TherapyCharter Medical Entry into the U.S. cell and gene therapy market Guardion + LifeChain at its North Carolina Innovation Hub Freeze-curve optimisation studies for its customers Animal HealthIMV Technologies Testing and validation continued in Q1FY2027 Focus: proving commercial viability Program continues through Q2 FY27 300CDMOs operating in the U.S. 1,800CGT Manufacturers in North America2,200Animal collection sites
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8 PRODUCT & OPERATIONS Guardion DeviceManufacturingDevice fleet scalingacross research use, into Medical Device manufacturing Q3 FY2027 following FDA regulatory milestone 44 2 9 6 Q2 FY26Q3 FY26Q4 FY26Q1 FY27Q2 FY27F Guardion devices built per quarterGuardion Manufacturing9 Guardion devices were built during quarter for partner use and medical device testing First medical device fleet production commencing early 2H FY27 Verification and validationwork well progressed ahead of Medical Device listing in 1H FY2027 U.S. manufacturing on stream in the second half of 2027
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9 FINANCIAL POSITION Strong FundingPosition Supporting Scale UpSpend shifting from product development to manufacturing, validation and market development. $38.3mCash and term deposits at30 September 2026 $4.9mNet operating cash outflow in Q1 FY27 ~$1.9mAverage monthly cash burn ~7.9Quarters of funding available¹0. 0 2. 0 4. 0 6. 0 Q1 FY26Q2 FY26Q3 FY26Q4 FY26Q1 FY27 Operating cash costs per quarter (A$m) Pro duc t develo pmentStaffAdmin / corporateMan ufactu ring & marketin g ¹ Based on Q1 FY27 net operating cash outflow; refer Appendix 4C section8.5. Q1 receipts: customers $0.1m, government grants $0.3m, interest $0.4m.
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10 OUTLOOK Building Towards FDA ListingDevice fleet scaling, regulatory milestone approaching and U.S. team strengthened. H1 FY27•Guardion U.S. FDA medical device listing•U.S Headquarters securedwithCEO relocation•Converting pipeline opportunities across the U.S Blood and CGT networkH2FY27•First medical device fleetmanufactured •Aus based CFO start Feb 2027 –Jan Gielen