Ladies and gentlemen, welcome to the Lonza Half Year Results 2023 Investor and Analyst Conference Call and Live Webcast. I am Sandra, the chorus call operator. I would like to remind you that all participants will be in listen-only mode, and the conference is being recorded. The presentation will be followed by a Q&A session. You can register for questions over the conference call by pressing star and one on your telephone, and follow up the presentation over the webcast. Please limit yourself to one question, and then re-enter the queue in case you have a follow-up. For participants over the webcast, kindly note that you have the possibility to increase and decrease the size of the media player by placing the mouse between the slideshow and video. For operator assistance, please press star and zero. The conference must not be recorded for publication or broadcast. At this time, it's my pleasure to hand over to Mr. Pierre-Alain Ruffieux, CEO. Please go ahead, sir. Good morning, good afternoon to all of you, and thank you for joining us for our half year results presentation. I'm here today with Philippe Deecke, our CFO. He will be joining me in presenting the update and answering your questions. Looking at our agenda, I will start with an overview of our performance in H1 2023, before handing over to Philippe to talk through our financial. I will take you through a tour of our division and say a few words about our priorities for the second half. As usual, we will make sure that there is plenty of time at the end for us to answer your questions. Let's start by taking a look at our group results. In H1, we delivered sales of CHF 3.1 billion. These represent a 5.6% sales growth as constant exchange rate against an elevated H1 2022 base, mainly set by high COVID sales. Looking at our underlying performance, we grew about 10% at constant exchange rate, which reflect the continuing momentum in commercial CDMO business. Turning to our CORE EBITDA, CHF 922 million resulted in a margin of 30%. Looking at our performance and the current market dynamics, we have updated our outlook to mid to high single-digit constant exchange rate sales growth and 28%-29% CORE EBITDA margin. This reflects lower growth than expected in early stage services, coming from a lower level of biotech fundings. It also reflects continued weakness in the nutraceutical capsule business. Both of these factors led to lower utilization of assets. Regarding our midterm guidance, we confirm our three-year sales growth trajectory, but our margin range has been updated at 31%-33%. More on this in a moment. Looking at some of our key events in the first half, we are pleased to report solid underlying growth in Biologics. This has been driven by our bioconjugate, mammalian, and microbial businesses. In Biologics, we saw a healthy increase in value of contract signing in H1 2023, compared to the first half of the prior year. In small molecule, strong performance was driven by higher asset utilization, a favorable mix from production phasing, and an ongoing focus on more complex and high-value offerings. As we noted in our Q1 qualitative update, our Cell & Gene division continued to experience low demand. In our Biologics division, we saw the same trend increasing in Q2 due to low funding of biotech. In our capsule business, we have seen softer demand for nutraceutical, mainly in the U.S. as the U.S. customer are deserting the inventory they built in the pandemic, there is a lower demand from the end consumer in the current economic environment. Looking at new investment, in June, we were happy to announce our agreement with Vertex to build a dedicated manufacturing facility for type 1 diabetes cell therapies. Construction at our U.S. site in Portsmouth is scheduled to begin later this year. Turning to our growth investment, we are making good progress across our larger assets, with a series of milestones reached in H1. At our biopark in Visp, two new bioconjugates manufacturing suite come online, as well as a new line for commercial drug product. Our U.S. presence in biologics has also been extended with an early development service lab in Cambridge, Massachusetts. We have already mentioned our collaboration with Vertex. This is a great opportunity for us to leverage our strong track record in manufacturing Cell & Gene therapies and our experience in bringing new facilities and technologies online. In June, we announced the acquisition of Synaffix, a biotech with the leading platform to develop ADCs. The acquisition has brought an impressive team of scientists to Lonza, as well as new and innovative technologies. Synaffix already has multiple contracts with small and large biotech, bringing a potential future source of royalties revenue. The transaction is revenue and margin accretive from the date of the acquisition. By combining our existing capability with the Synaffix technology and IP, we can deliver a best-in-class offering to streamline our customer path from ADC discovery to commercialization. The acquisition leaves us uniquely placed in the industry with the complete ADC offering. We see ADCs as an exciting modality, which bring effective treatment for patients and is driving growth for Lonza. Moving to ESG, Lonza has made significant progress in its emission reduction program. We submitted a letter of commitment to the Science Based Targets initiative, a leading carbon footprint reduction initiative. The letter confirms our commitment to reduce Scope 1 and 2 of greenhouse gas emission by more than 40% by the end of 2030. We also signed a 10-year virtual power purchase agreement for solar electricity with IGNIS, the Spanish renewable energy group. Under this agreement, IGNIS will produce more than 300 gigawatt hours of solar electricity, which is equal to our electricity need across Switzerland and the European Union. Together, these programs support our carbon reduction program and underline our long-term commitment to doing business in a responsible way that protects the environment. As we come to the end of this section, I wanted to share our priorities for the second half. Ramping up our new commercial asset will support growth in biologics in the second half and beyond. We will also focus on converting more early-stage opportunity, which help us to optimize our increased capacity in this area. Our continuous improvement initiative will drive performance and cost efficiency across the network. With that, I will conclude our group update and hand over to Philippe for a more detailed look at our financials for the first half. Thank you, Pierre-Alain. Good morning, good afternoon to you all. Before we start our financial review, let me remind you that growth is reported at actual exchange rates, except sales growth, which is reported at constant exchange rates. Let's start by taking a look at our financial highlights. Overall, our H1 results are solid, despite market headwinds impacting our early stage and nutraceutical capsules offerings. The group delivered sales of CHF 3.1 billion, growing 5.6%. CHF 922 million CORE EBITDA resulted in a margin of 30%. We are pleased with the performance of biologics and small molecules, supported by sustained customer demand across our businesses, especially for commercial assets. Our Cell & Gene and capsules divisions were impacted by more adverse market conditions. We will look at the divisions more closely in a moment. On an underlying basis, Lonza sales grew around 10% in H1. Our underlying growth excludes the effects of the COVID sales loss and the Allakos cancellation fee, as well as other disclosed one-time effects in H1 2022 and H1 2023. Margins reached a solid 30% in line with expectations, but is three percentage points lower than the high base in 2022, which included the items just mentioned. Let's move to the next page to look at our margin in more detail. Looking at our margin evolution, we have reported a decrease of 3.1 percentage points in H1 2023 versus H1 2022. Breaking it down, the decline can be explained by three key factors with roughly the same contribution. First, the loss of COVID sales, which delivered good margins. Second, the overall negative impact of current and prior year one-off items. Third, the impact of lower utilization in early stage and CHI assets. Of course, we continue to deliver productivity gains and operating leverage. These are offset by our usual gross project dilution, divisional and business unit mix, and a small residual effect of inflation like we saw last year. Moving to our divisions, Biologics reported sales growth of 2%. This represents double-digit growth when adjusting for mRNA sales loss and the prior year Allakos cancellation fee. We are especially pleased with the growth of our divisional of our different modalities, particularly bioconjugates, mammalian, and microbial. The newly acquired Synaffix business is now also part of our Biologics division. It had a minimal effect in the first half, as the acquisition completed in June, meaning only one month of revenue and margin was consolidated. The decline in the Biologics margin was mainly driven by the effect on sales just mentioned and the dilutive impact of the assets in ramp-up. Turning to small molecules, the division reported a strong first half performance. Assets are highly utilized and delivered sales growth at 37.5%. Adjusting for last year's H1, H2 customer shipment phasing, growth would be high single digit. Margins were strong at 35% due to good product mix and phasing. The benefits will reverse in the second half. We can expect full year performance to be in line with the midterm divisional guidance. The Cell & Gene division had a softer H1 2023, with sales growth at 11%. Looking across the business units inside the division, we see two different dynamics. Bioscience performed well through a combination of volume growth and pricing. Cell & Gene Technologies was impacted by weak demand due to the current biotech funding environment and some clinical stage customer failures. The decline in the regular business was more than offset by the accounting treatment of the Codiak BioSciences bankruptcy resolution in Q2. The termination with Codiak, Lonza's former exosome partner, released Lonza from a multi-year manufacturing liability of around CHF 50 million, which positively impacted both sales and margin. We have provided more detail at the back of the presentation. It is important to note that Lonza remains fully committed to the exosome space, and we continue to operate our site in Lexington, purchased from Codiak in 2021. Our Capsules division reported flat sales in H1. This was driven by a weak nutraceutical market as we see customers destocking post-COVID, alongside a slowdown in end consumer demand. Other areas of the business showed a more positive performance, with sales growth in pharmaceutical hard capsules and good dynamics in the APAC region. Margins were below the first half of the prior year, mainly from underutilized production lines and increased global prices for gelatin, the most important raw material for the capsules business. As Pierre-Alain already mentioned, in H1 2023, Lonza spent CHF 765 million, or 25% of sales, on CapEx. Around 80% of this spend was focused on growth projects, mainly in our Biologics division. The remainder was invested in maintenance, as well as infrastructure and systems projects to support the growth of our different divisions. We remain on track to spend the guided amount of around 30% of sales in CapEx projects in 2023. I will finish my part of the presentation with a look at our free cash flow. Our free cash flow was negative CHF 62 million, mainly driven by our capital allocation strategy of continued organic growth investments. Our pre-growth investment cash generation remains solid at around 20% of sales. Inventory has not declined as expected, with our days inventory outstanding still at around 7 months, which is in line with year-end 2022. The absence of a reduction is mainly due to higher-than-expected finished goods and work-in-progress inventories. It's also important to note that we make to order, there is little risk around the inventory. We remain committed to reducing inventory by about 1 month over the next year. With that, I thank you for your time, and I will hand back to Pierre-Alain. Thank you, Philippe. Let me now take a moment to provide a business update on each of our four divisions. Let's start with Biologics. Philippe already commented on sales and margin. Looking at the business unit, we saw strong sales growth in bioconjugate, mammalian and microbial. The performance in bioconjugate was driven by the two new manufacturing suite coming online in the first half in our biopark in Visp. We saw a healthy increase in the value of our contracting versus the first half of prior year. The slowdown in biotech funding mean growth in demand was slower than expected for early-stage assets, leading to some underutilization. In small molecule, we saw strong sales growth compared to a lower base in H1 2022. Margin was driven by higher asset utilization and a favorable mix, but also reflect our focus on more high value and complex offering, including components for ADCs. With the favorable mix weighted towards the first half of the year, we anticipate that the full year performance will still sit in line with divisional midterm guidance. Turning to our Cell & Gene division, we saw good momentum in Bioscience, driven by a combination of a robust demand, operational efficiency, and strong pricing. As Philippe already explained, divisional performance was also supported by the termination of our engagement with Codiak BioSciences following the company bankruptcy filing. In Cell & Gene Technologies, we experienced weak performance, which was driven by lower early-stage demand and some customer clinical failure. Despite these short-term headwinds, we remain committed to this technology and see its long-term commercial potential. Over the year, we have built a significant presence around the globe, and our capability are recognized in the industry. This is reflected in our new collaboration agreement with Vertex. Let's turn to our Capsules & Health Ingredients division. Here, our global pharma capsule business remain robust with healthy business development, including price increase, particularly in APAC and EMA. This has been offset by decreased sales in our nutraceutical capsule and health ingredient businesses. Here, we have seen lower customer demand and customer destocking, particularly in the US. Turning to our margin, price adjustment and cost management has only partially offset adverse impact on our margin, driven by lower asset utilization and higher raw material and energy costs. Since last year, we have seen an increase over 30% in the price of gelatin, a major ingredient of many of our capsules. As we conclude our tour on the division, let's take a moment to review our outlook and midterm guidance. As we look toward H2, we anticipate that sales will accelerate from new biologic asset coming online, but be partially dampened by our capsule and Cell & Gene division. However, margin will be adversely impacted by some overcapacity in our early stage and nutraceutical asset. Finally, as mentioned before, we anticipate the favorable mix in small molecule to reverse in the second half of the year. Given these dynamics, we see it is prudent to update our sales goals to mid-to-high single-digit from our initial outlook of high single-digit. We have also updated our CORE EBITDA margin to 28%-29% from our initial outlook of 30%-31%. Looking at our midterm guidance, we are reconfirming the 3-year sales growth trajectory of low teens. We are updating the margin guidance to a range of 31%-33%, compared to the initial guidance of 33%-35%, set back in 2021. The lower growth in early stage asset in Cell & Gene Technologies and in Biologics will lead to some under assumption, resulting in lower margin than initially expected. In our capsule business, weakness in the market is continuing to deliver lower asset utilization. Getting back to the bigger picture, let's take a wider view on our business and industry. We are confident that Lonza is set up for success, we are continuing to execute on our strategy. Our business benefits from long-term commercial contracts. As you can see from the chart in the middle of this slide, commercial contract makes around 70% of our CDMO capacity. Our business model, which is based on long-term relationship and commercial business, is more resilient than ever and is a real strength for Lonza. Building on our extensive Western footprint, the expertise of our team across modalities, and our quality track record, we will continue to capture value for our shareholder, as well as delivering on our customer needs and expectation. As we come to the end of our update, I wanted to summarize some of our main points. We are continuing to see robust demand for commercial services across modality, with lower demand for early stage offering and nutraceutical capsule. The updates of our outlook reflect current market at wind. As we look toward H2, we will focus on ramping up our new commercial asset and optimizing our capacity with the focus on our early-stage business. We will also continue to focus on driving continuous improvement across our global network. Looking more widely at our business, we are well-placed for success with the leading commercial offering and a continuing commitment to growth. With that, I thank you for your time, and now Philippe and I would be pleased to take your question after two minutes to set up the room for doing that. Thank you. You can register for questions over the conference call and follow up the live video over the webcast. Anyone who asks a question may press star and one at this time. Please limit yourself to one question and then re-enter the queue in case you have a follow-up question. For participants over the webcast, kindly note that you have the possibility to increase and decrease the size of the media player by placing the mouse between the slideshow and video. First question comes from Richard Vosser from JPMorgan. Please go ahead. Hi, thanks for taking my questions. One question to start with. Maybe you could give us a little bit more color on the bridge between the margins in the first half of last year and the second half this year, in terms of the contributions. I know you gave some high-level comments, but some more detail there would be helpful. Just that bridge from Sorry, 2023 to 2024, in terms of those margins as well. What are the moving parts of those margins around, I think, I suppose, the growth projects? Thanks very much. Thank you, Richard. Philippe, you take that one? Yes, absolutely. Thank you, Richard, for the question. As mentioned during the call, there are mainly three reasons that drive our margin decline of three percentage points between last year first half and this year first half. Number one is the drop in COVID-related mRNA sales, and we gave you an idea of as to how much of the growth this is. We also mentioned during the course of last year and this year, that these were profitable sales for us. Second, we have a couple of one-off effects and one-time effects that we did communicate last year. This includes the Allakos costs. This, of course, includes as well, things like the Codiak termination that we experienced this year. All of these effects have, of course, a negative effect for this year. Third, our recent market headwinds that were described by both Pierre and myself, both in the Cell & Gene Technologies area, where we see some underutilization of our assets, as well as in CHI, where in nutraceuticals, not all the lines are utilized. Each of these three have roughly the same contribution to the decline of 3 points. On top of that, of course, we continue to have a nice productivity gains, as well as operating leverage from growing our cost base less than sales. This was in this first half, offset by our usual divisional mix that is negative, some growth project dilution, and as well, a tiny bit of inflation to the same extent as we've seen in the prior year. If, if you want me to go now from 2023 to 2024, I think we communicated already that the biggest part of the increase would be coming from our growth projects. The growth projects, both in the Biologics division as well as in small molecules. These growth projects are ramping up. They are contributing to the sales acceleration we will see in this second half. This will then continue in 2024, and as these ramp up, the margin will be less dilutive and therefore driving margin. This is really the biggest driver. The rest is of course, continued productivity, and continued pricing to offset whatever remains of inflation in 2024. Thanks so much. The next question comes from James Quigley, from Morgan Stanley. Please go ahead. Great, thank you for taking my questions. Mine's on the biofunding infrastructure and what's happened here. Previously, you highlighted that there was a flight to quality in terms of the number of inbounds or inquiries had gone down, but your project wins hadn't changed. What was the trigger for that change, and what you're seeing is this further bankruptcies or more aggressive cost-cutting programs by your biotech customers? You mentioned in the second half, a priority is to secure early-stage opportunities to optimize the that capacity utilization, and how are you going to go about this, given that the biofunding environment doesn't seem to be picking up significantly? Thank you. Thank you, James. What we clearly have seen in Q2, that the number of requests and inquiries for early-stage services has decreased, and they were lower than expected. This is really what is driving the underutilization we are expecting now for the second part of the year. We always try to optimize our offering, and again, with the different service for early development, cell culture capability as well, and finish. We are trying to make sure we have attractive offer for our customer. All right, thank you. The next question comes from Vineet Agrawal from Citi. Please go ahead. Hi, thanks for taking my question. Just to invite in. I'm just trying to understand what sort of recovery have you baked in for the early-stage services and the nutraceutical markets to achieve those targets? Do you expect now the growth in these segments to recover only in 2024? Similarly, if you could comment, what sort of recovery have you baked in your 2024 targets? Thank you. We have a strong and long-term visibility of the commercial demand because we have long-term contract. Obviously, for early services, the visibility is shorter. We see we have a visibility around three to six months. Currently, we have seen, as I mentioned in Q2, a significant decrease compared to our expectation. We don't speculate when it's going to recover. If we look in the past, we have seen generally a slowdown lasting 18 months to 24, 30 months, and it's the kind of thing we are anticipating today. Geraldine, if I may just add to this. Vineet, just to underline the point, our early-stage business is still growing nicely in biologics, but we've been adding a capacity in the early stage space. We had very high expectations for this growth. We just see, now see high growth, but not very high growth. All right. Thank you. The next question comes from Jo Walton from Credit Suisse. Please go ahead. Thank you. Mine is about your comment about the healthy increase in biologics contract signings in the first half of 2023 versus the first half of 2022. Can you help us on how quickly you can turn that, those contract signings into revenue? Can any of them be run from existing capacity, or are these all longer-term contracts where you need to build capacity before they come online? And if you could give us any sense of what the basis of securing these contracts is. Is it still very largely driven by confidence in your execution, or is price coming more into play in getting this new business? Thank you. Jo, as you have seen in H1, we have a strong underlying growth coming from new asset coming online. Basically, we continue to ramp up this asset, and we have new asset continuing to come online. We are signing contract, which are filling this asset and will continue to drive growth in the months to come. It's really based on real customer projects, assets which are coming online, and we have a good visibility on that. Just to understand, that's people signing business which you're able to execute almost immediately, rather than people signing contracts that are gonna take you three or four years to execute. We have a mix of both. Basically, the manufacturing contract are long-term. We mention always five to seven years. Some will start relatively quickly, and some will start in the year to come with the asset, which are coming online. It's a mix of both. Okay. Next question comes from Patrick Rafaisz from UBS. Please go ahead. Thank you, and good afternoon, everyone. Can we go back to the bridge to 2024 on the margin? Can you explain to us the variables driving this downgrade, right? Because operating leverage is still there. You're ramping the growth projects. Early stage clinical is 10%-15% of the CDMO business, so it's. Versus your initial plan for 2024, which segments are really driving this downgrade? Is it really just the capsules with the underutilization, or is it spread over also to biologics? Or are your margins there also lower than what you were hoping for? Philippe, you take it? Yep. Thank you, Patrick, for the question. I think I'll go back to the growth projects, and this is really what's gonna be driving margin. Of course, in our initial 2024 midterm guidance, you know, back in 2021, the world did look certainly different. Overall, I think the increase from 2023 to 2024 is mainly due to the growth projects that we're gonna be ramping up in the second half and into next year, both in the biologics and small molecule division. This is the big driver. I think if you look at the guidance we're giving you for this year, for 2023, and the guidance we are now providing for 2024, the increase is the same. I think we see the same increase and the same drivers going from 2023 to 2024, but we're starting from a lower base in 2023. Why do we have a lower base in 2023? This is really now going back to the lower utilization of the early-stage assets, both in Cell & Gene Technologies as well as in biologics, and the weakness that we see in the nutraceutical market in capsules. Nothing has changed, if you want, between 2023 and 2024, but we start from a lower base in 2023, which therefore lowers the expectation for 2024. What changed is that originally, the bridge was supposed to be smaller from H2 to 2024, right? Now the bridge or the gap has widened from H2 to 2024. Yes. What really changed is what we have seen in Q2. It's a lower demand than expected, in early-stage services in biologics. This is what has changed. Okay, thank you. The next question comes from Daniel Buchta from ZKB. Please go ahead. Yes, thank you very much. Maybe we talk a little bit about strategically what you're gonna do in the two problem charts, as I would call it. I mean, on the first instance, first side, on Capsules & Health Ingredients, which at least in my view, the consumer part does not really match your CDMO offering. It's a lack on growth at the end, since a couple of years. I mean, what are the strategic alternatives? Could we imagine a sale of that business at some point, given that you acquired it just a couple of years ago? Then also similar question, Cell & Gene. I mean, I guess disposal here is not the case, but are you gonna adjust the cost base, at least? I mean, it was barely profitable before the weakness now, and I guess now it's loss-making, given that Bioscience is typically quite profitable. What are you gonna do there with those two businesses? Thank you very much. Thank you, Daniel. Regarding Cell & Gene therapy, our view has not changed on the long-term potential of this therapy. We see really that we are able to fix unmet medical need, and we see that, and we will continue to do that. As we mentioned, we have already three product on the market, being a leading CDMO, and we have other product which probably make it in the months and year to come. We continue to do that. For sure, we make sure that we have the right cost base, and here we have. It's relatively not so capital intensive compared to biologics, and we'll make sure we have the right number of assets, and people to address that. Regarding CGT, I'm not going to speculate, but I think as company, we have always demonstrated in the past that we manage actively our portfolio. We acquire new business, we divest new business, and we'll continue to do what we have always done. That's helpful. Thank you very much. The next question comes from Charles Weston from RBC. Please go ahead. Hello. Thanks for taking the question. Mine relates again to guidance, please, and just a bit, this one really focusing on visibility for both 2023 and 2024. For 2023, it's the second time margin expectations have come down. Given where we are in the year, you've probably bought some raw materials, you've probably got orders in for certain batches. What's your visibility like for that second half to be a bit more a bit stronger than H1? In 2024, I know we've talked about revenues quite a bit, margins quite a bit, but in terms of revenues, the guidance implies something like 17% constant exchange rate growth. Can you again comment on the visibility you have into that, and what would be the sort of risks around that number? Thanks. Charles, happy to do so. As we mentioned, 70% of our business is commercial manufacturing, and we have extremely strong visibility to that. Again, what we do know, next year and the year to come has a high visibility. As we mentioned, for early stage, the visibility is more in the range of 3 months to 6 months, and it's why we have seen a decrease of request in Q2, and therefore updated our guidance. But for 2024, obviously we don't have for end of 2024, the visibility for early stage, but we have full visibility on the current business on commercial, as well as the business which continue to grow. Again, this has been demonstrated in H1, with the strong underlying growth coming from the commercial business. Thanks. Just to sort of clarify on the margin for this year, in terms of the visibility you have, what's essentially already booked in, given the forward orders of raw materials and energy and whatnot, is that margin now very low risk? Philippe, do you want to comment on it? Yes, Charles. You know, the CDMO business is a very fixed cost type business. You know, the real driver will be how much are we utilizing the assets that we have in place? The both the personnel which is very highly skilled, you know, is not something that we would trade off right now for this. We are really looking at driving demand and looking forward to seeing demand increase in our nutraceutical assets for capsules. This is really the key, the key driver for the year. Based on the visibility that we have, which Pierre-Alain mentioned is three to six months, we feel comfortable with the margin guidance we gave you for this year. That is both a mix of these, you know, faster turning businesses, as well as the more stable, commercial business. Energy prices don't really play a role in this for the rest of the year. Okay, thank you. The next question comes from Daniel Jelovcan from Stifel. Please go ahead. Good afternoon. My question was more related to pricing. I'm sure you have heard some comments by WuXi that they confirmed that Lonza's lowering price is. I take such things with a grain of salt, of course, but can you comment on that? Also related to that, what do you think about the current capacity in the industry, which seems to be a big concern for investors? Thanks. Thank you, Daniel. I will start with the second part. Current capacity at large scale for Lonza, we see a very high utilization rate for the years to come, and this is really secured by a long-term contract, and this is our philosophy. We see high utilization rate, and this will continue. If we believe, again, the market study as well as our data, which are going to a lot of detail, we see even higher utilization rates in large-scale asset. On that one, we don't see any changes. Obviously, as we mentioned, for small-scale asset, it's a little short term, but we see continuously see the business growing, and we believe it's just a cycle which will get take off sooner or later. Regarding cost, you know, we don't comment on what doing competition. Certainly when we discuss with customer, the key point which matter for most of them, it's delivering on time, it's expertise, it's quality and regulatory expertise. Cost are never the point first in the discussion. It's important, but it's not the first point. Okay, thanks. The next question comes from Peter Welford, from Jefferies. Please go ahead. Hi, thanks for taking my question. I wanna come back to the early stage. I'm just a little bit confused because we seem to sort of jump between biologics and Cell & Gene on a number of occasions. I mean, presumably, if we look at the business mix, given you say 70%'s commercial, 10-15 phase I, I mean, presumably, those Cell & Gene is much more skewed than that. I wonder if you can just talk about perhaps for biologics, what the split is of revenues. Equally, perhaps give us, if we can, an underlying biologics growth off of that, you know, for that 10% figure you give us for the first half. When you're talking about the early stage, therefore, you know, you said you've added capacity in biologics, and that was sort of being underutilized. Equally, I think in the margin comment, there was comment about your low utilization in Cell & Gene early stage. Could you talk about, is it both those early stage, or where is it, which one is, in particular is the more challenging one? Thank you. Thank you, Peter. One important point to remember as it's the proportion. In Cell & G ene therapy, we have close to 150 program, and only three of them are commercial. Obviously, all the other ones are clinical. The proportion is much larger, and I think it's what we have seen already end of last year, early this year. It's less demand in early stage, and you see, obviously, a larger impact. As Biologics is a bigger part of our business, you can derive from the slide that I show that probably the proportion of phase I, pre-clinical, as well as phase I, is this range of 10%-15%. It's why we have seen in Q2, less demand than initially expected. You can just make the math to understand what is more or less the impact. Next question comes from Paul Knight, from KeyBanc. Please go ahead. Thank you. Have you changed your capital expenditure plan for this year, in your view, on the long term for capital expenditure? The second part of that question would be: What's your fastest highest priority, I should say? Is it fill-finish? Is it ADCs? Some color on that. Thank you. Yeah. Thank you, Paul. You know, most of our capital project, and Philippe will provide a little more detail, are project which lasts between three and four years. Again, we have initiated a large project a couple of years ago, and they continue. There is no plan to change this project, because as we mentioned, they are secured by customer, and they come online with the good business, so we are not changing that. Regarding our priorities, and you can see that with the breakdown of investment, most of investment are going in biologics, and probably we are investing in three key area in biologics. It's large-scale mammalian, it's fill and finish, as well as ADC. I think we believe it's a strength of our business to have multiple approach and multiple business where we see strong demand from our customer. Yes, Pierre, I'll just add, something. Thank you. To your question, Paul. If you look at our capital investments, these are multi-year plans, of course, and you saw that for 2023 at least, our growth investments are 80% of that amount. Out of that 80%, the majority is for what we call commercial-stage assets. That's one. I think most of our investment is going into these more stable, large type of manufacturing contract. The second thing that I would add, is that we don't see this weakness in the early-stage business to be a long-term weakness. These are transient or temporary weaknesses that don't change our strategy. We said we remain committed to the Cell & Gene Technologies business, and so the investments will continue both in biologics and in Cell & Gene. You know, last question would, of leading- association for the industry in Cell & Gene is saying that after a decline in trials last year, there's a slight increase again this year. Do you see that? Do you think Cell & Gene is getting a little bit better? What we have seen definitively is a stabilization. This is clear and obvious. If somebody very positive can see start of increase, I would say we see normalization, and I would just wait one extra quarter to speak about fully recovering. Definitely we have seen a clear stabilization. Thank you. The next question comes from Sebastian Bray from Berenberg. Please go ahead. Hello, good afternoon, and thank you for taking my question. It's on the two to three-year outlook for capacity in the industry. I think Lonza has gone on record, or at least informally indicated in the past, that it sees a broadly balanced outlook for supply-demand in the biologic CDMO space on a seven-year view starting around 2020. Is that still the case? If not, is the 33%-35% EBITDA margin target off the table for the foreseeable future? By foreseeable future, I mean the next three years. Thank you. Thank you, Sebastian. clearly, we are extremely confident about the utilization rate of our large asset, because, again, we don't build them without having a contract. what we are saying is 100% valid and is not changing. Philippe, you want to comment on the margin? Yeah, no, I just finish by saying that we are constantly looking at even the longer-term capacity utilization of these large-scale assets, and I think we remain confident that the utilization is either stable or increasing for the industry. Second, I think the industry hasn't seen yet the impact of large volume therapies around Alzheimer's, for example. I think this is still to be seen how much this will do to the industry. I think for now, we do not share the concern on the large scale business, certainly not for our assets. Now, in terms of margin, I think we have never provided guidance beyond 2024, I will not comment on the two to three-year margin. I think, we have a CMD plan for later this year, where we will be very happy to welcome all of you to share our plans on strategic direction for the company. That's probably the more appropriate place to discuss that. That's helpful. Just as a follow-up, we're speaking about pre-commercial and commercial capacity as if these are entirely separate things, but a number of the pre-commercial producers have apparently said they want to try and reallocate capacity to the commercial market. Is this a risk in your eyes, or are the two largely separate? Yeah. No, we see that slightly differently because, again, the preclinical and clinical phase are asset which are mainly used for these purposes. Yes, you can use from time to time to produce a small volume commercial product, but we see the small scale asset mainly towards phase one and phase two supply. I think to be maybe more precise, I'll use my layman finance terms. But I think Sebastian, if you look at probably 1 K, 2 K, 1,000 liter, 2,000 liter assets is what we would call, you know, early stage assets, done for phase I and II. Then you get into the mid-scale and large scale. These are probably the more kind of assets we call commercial, and that's how we delimitate between these different segments. Helpful. Thank you for taking my questions. The next question comes from Yifeng Liu from HSBC. Please go ahead. Hello, thanks for taking my question. I have a question on bioconjugate business. On the split of that, how much would you say, a bit of color on that would be great. How much would you say it's commercial, and how much would be on the early stage? Thank you. No, it's a mix of both. Some of the recent growth you have seen in H1 is definitely driven by the new asset coming online, which are mainly commercial. We see a strong demand in both direction, and it's also why we have invested in Synaffix, which is further strengthening our position by bringing a quite unique technology, which help our customers to have even more efficient ADC. Right. Thanks. Also just to follow up on that, and how would you see that split will evolve over the next couple of years and that effect for the margin? Thank you. We are, at Lonza, very excited with the potential of bioconjugate for multiple reason. You know, it's driving demand in biologics with the antibody. It's driving demand in the small molecule with difficult-to-avail toxic product, with interesting margin, as well as producing the linker. Last but not least, it's giving us the opportunity to put all of them together. We also are investing in fill and finish for that. Basically, for us, it's an opportunity to a reoccurring business with a very interesting margin. Thank you. The next question comes from Max Smock from William Blair. Please go ahead. Hi, thanks for taking our questions. I just wanted to follow up on a couple within the Cell & G ene therapy business. Looking at results in the quarter, I guess without the Kodiak cancellation fee, revenue looks like it was down about 10% during the first half of the year. I know when we spoke in mid-May, you did note that you had seen some pullback, but it seems like things are much worse than maybe you let on a couple months ago. Just wondering if you can provide any detail around whether you've seen things dramatically fall off here over the last couple of months, or whether this has been more of a sustained trend throughout the year? What we have seen is similar to what you can see on the market. Obviously, due to the funding, much less phase I than before. As it's a early phase business, so mainly clinical phase, we have seen the normal attrition happening with customer. You compile the attrition of ongoing project with less incoming, which is having what we have already highlighted in Q1. At the same time, I want to emphasize that we have a couple of project going ahead, and we are still very excited of the potential of these therapies and technology. We are very well positioned, as shown by a company like Vertex, so really trusting us to go as partner and together to address these challenges of these new therapies. Okay. Thank you, I'll leave it there. Thanks. The next question comes from Naresh Chouhan from Intron Health. Please go ahead. Hi there, Naresh Chouhan from Intron Health. Thanks for taking my question. Just one on utilization. In the past, you said that it takes about 36 months to reach peak utilization on new plants. Given the slowdown we're seeing in biotech, should we be pushing out those assumptions for the new EDS lab in Cambridge? Thank you. No, the 36 months we have mentioned, actually for large asset. The reason behind, without going into too much detail, is you start some validation batches, you put them on stability, and you wait until you get the approval of health authority. For smaller scale asset, and EDS is really a lab where we do very small type of activity for early phase customer, we don't have that. Thank you. We have a follow-up question from Richard Vosser from JPMorgan. Please go ahead. Hi, thanks for taking my follow-up. Just to ask on CapEx, I think it's been asked before, but just on definitive CapEx, are we still expecting CapEx in the midterm to decline to high teens% of sales over the next few years? How should we think about that? Or is CapEx, you know, are you gonna be a little bit more cautious on CapEx spending going forward, particularly in the early stage biotech area? I realize that's not a huge amount of your CapEx, as you said earlier, but just how should we think about that overall budget and the development of that? Thanks very much. Philippe? Yeah, thank you, Richard, for the question. As I said before, I think a lot of the next few years in terms of CapEx are, of course, already decided and ongoing and mainly in construction. I think I don't see the current market sentiment to change that trajectory. Again, we very much see the current weakness in early stage as something being temporary. Again, the business we do in early stage, and I think it's worthwhile to reiterate, the business we do in early stage is still growing. The assets will continue to be more utilized as we go. They just have not been utilized as quickly as we want them to be. It's not that we are sitting forever on too much capacity. There's just a slight delay as to how, when, by when we will have them fully filled. Again, this is repeat business, so you have to constantly replenish your early stage pipeline. Again, Richard, I wouldn't see the trajectory of CapEx to change. I think what we do is within CapEx, maybe to highlight, we are not inactive. If you think about CHI, we are, you know, moving capital more into automation, into efficiency type projects rather than capacity projects. We are, of course, constantly relooking at the projects if they make sense or not, but that would not have a big change on the overall envelope of CapEx for the next few years. Perfect. Thank you. Okay. Sandra, we will take the last question. The last question comes from Anja Pomrehn, from Mirabaud Securities. Please go ahead. Good afternoon, gentlemen. I also have a follow-up question regarding the early stage pipeline. You mentioned, sorry, you mentioned several times that there was further slowdown which impacted your performance in the first half. At the same time, you did state, and it's also highlighted on page nine of the presentation, that you want to secure early stage opportunities. My question is: What will you do different, and what measures will you take in order to get the turnaround, especially in the second half, which is specifically mentioned? As I believe that the add-ons, which you have done to get further early stage opportunities in-house might be more in the midterm. What will trigger the short term, sort of upscale that you highlighted on slide nine? Thank you. Thank you, Anja. What we are going to do it's to double down on our effort on commercial and marketing effort in this space. We have a couple of unique advantage that some customers understand, but some other are not yet fully aware, and we will continue to double down on that. We see that the strength of our location is definitely some point which is appealing to our customer, and the capability for early stage company to really offer both drug substance as well as drug product. We will continue to work on that to reinforce our presence in early stage. If I can add color, just Anja, to make sure, you know, you understood our comment properly. There's no turnaround assumed in the financials. I think if you, if we are looking for additional early stage opportunities, we're gonna be capturing them in the second half. They will be revenue driving and margin driving in the next year. This is not like we find somebody in the month of August, then they start generating revenue in September. There's no turnaround for the guidance that we provided in 2023. However, we want to secure 2024, and therefore, we're gonna double down on marketing efforts. Basically, these measures are being taken on the second half, which then will sort of have an impact, more in 2024 and the years after? That's correct. Okay. Thank you. I would like to thank you very much for attending today and for your attention. I would like to come back to the clear message that we see us as in a strong position. The commercial demand is strong, is secure for long term. I think we have seen the underlying growth in the first part of the year, and the headwind we see in early stage leading to underutilization of early asset, both in Cell & Gene therapy as well as in Biologics, to be more on temporary time. Thank you for your attention, and I wish you an excellent day.