Dear ladies and gentlemen, welcome to the Merck Investor and Analyst conference call on first quarter 2024. As a reminder, all participants will be in a listen-only mode. I am now handing over to Constantin Fest, head of investor relations, who will lead you through this conference. Please go ahead, sir. Thank you very much, Heidi, and a very warm welcome to this Merck Q1 2024 results call. My name is Constantin Fest. I'm head of investor relations here, and I'm delighted to be joined by Belén Garijo, Group CEO, as well as Helene von Roeder, Group CFO. For the Q&A part of this call, we will also be joined by Matthias Heinzel, CEO of Life Science, by Peter Guenter, CEO of Healthcare, as well as Kai Beckmann, CEO of Electronics. In the first couple of minutes of this call, we'd like to run you through the key slides of this presentation, which will then be followed by Q&A. With this, I'd like to hand over now to Belén to start. Over to you, Belén. Thanks, Constantin, and welcome everybody to our Q1 earnings call. I am now on slide number 5 of the presentation, and we'll start with the highlights. So, as you have seen earlier today, we delivered a very solid quarter despite the observed slight organic revenue decline, and we are trending in the right direction with two of our three business sectors having shown a very strong performance in Q1. And we expect growth to continue to improve from here. Organically, group sales declined by 1%, and EBITDA pre went down by 5%. This, paired with a 2%-point currency headwind, leads to reported sales of EUR 5.120 billion, which is a decline of 3%. The currency had a slightly diluted effect on EBITDA pre, which was down by 8% to EUR 1.454 billion. EPS pre of 2.06 decreased 13% year-on-year. Healthcare was the top performer with 10% organic sales growth driven by Erbitux, by Mavenclad, and Bavencio. Electronics also showed a positive organic sales development in Q1 of 6%, and this was driven by Semiconductor Solutions, which returned to growth year-on-year at an increase of 8%. As expected, Life Science showed an organic sales decline against a particularly high base. As you may remember, we had not yet seen the full impact of the customer de-stocking in our Process Solutions business in Q1 last year. Therefore, Life Science was down by 13%. While we no longer segregate the effect of COVID-related sales, it still represents a headwind for Life Science as well as for the group in 2024. In Life Science, we also saw positive signals from order intake in our Process Solutions business in quarter one. Order intake grew both sequentially and year-on-year. Book-to-bill went up to around 1, reflecting the sequential increase in order intake. With the presentation of our financial results last year, we confirmed our goal of returning to growth in 2024. Q1 showed an overall positive business momentum and confirmed our previously anticipated trajectory for the remainder of the year and the guidance. Talking about the guidance, and as usual at this time of the year, we are farther specifying that. We now anticipate net sales in a range of EUR 20.6 billion-EUR 22.1 billion, EBITDA pre of EUR 5.7 billion-EUR 6.3 billion, and EPS pre of EUR 8.05-EUR 9.10, thereby confirming our qualitative guidance with a slightly more positive tonality on EBITDA pre. We will share more details on our assumptions later. Turning to slide number 6, we will provide a bit more color on our business sector. As you can see, Healthcare and Electronics contributed positively to organic sales growth in Q1, largely offsetting the decline in Life Science. Our key growth engines in the quarter were, first, our new Healthcare products, our new launchers, as well as Semiconductor Solutions within the Electronics business sector. In fact, in a still challenging operating environment in Q1, Healthcare took the lead with a strong organic growth of 10%. And this was driven by 15% growth from recent launches, with Bavencio up by 14% and Mavenclad up 12% in Q1, and further supported by a strong performance of our established product portfolio with a stellar performance of Erbitux. Our established product portfolio increased by 9%. From a franchise perspective, oncology was the highlight, again with an organic growth of 19%. Life Science showed a decline of 13% organically against a strong base as we flagged already in March, with all three businesses being down in the quarter. Process Solutions declined organically by 19%, Science and Lab Solutions was down by 7%, both against very tough comparables in Q1 2023. In Electronics, our semi-business was up 8% in the quarter, driving the growth of the sector, which was up 6% organically in Q1. Display Solutions and Surface also showed positive organic growth in Q1. FX was a headwind across the board on sales, with a minus 2% impact on sales at group level, in line with the guidance that we provided in March. On earnings, EBITDA pre came in at EUR 1.45 billion, down organically by 5%, or -EUR 82 million in absolute values, and this was due to Life Science, where organic EBITDA pre was down by -30% in Q1 against high comparables. EBITDA pre in Healthcare was up strongly by more than 28% organically in Q1, driven by a strongly leveraged growth as well as the positive impact of the Bavencio repatriation. EBITDA pre in Electronics was up by 4% organically due to positive mix in advanced nodes in semi-materials and in DS&S, combined with volume effects. Last, FX was a stronger headwind on EBITDA pre than on sales, and this is mainly due to Healthcare. With this, let me hand it over to Helene for a more detailed review of our financials. Thank you very much, Belén, and a warm welcome also from my side. I am now on slide eight for an overview of our key figures in the first quarter. Let me emphasize: we had a solid start to 2024 in a still challenging business environment. Taking into account currency headwinds, net sales declined by 3.3% to EUR 5.120 billion. EBITDA pre was down by 8.4% to EUR 1.454 billion, with a slightly higher FX headwind on EBITDA pre compared with sales. EPS pre declined by 12.7% to EUR 2.06. Operating cash flow came in strong at EUR 1.035 billion, which is an increase of 21.4% over the year earlier period. Now, that's attributable mainly to lower bonus payments, lower tax payments, as well as a lower cash outflow from net working capital. Net financial debt was stable compared with the end of December, mainly due to short-term investments in non-financial assets. Let me also briefly comment on our reported results. With that, I'm now on slide 9. EBIT was down by 10% year-over-year. This was above the decline in EBITDA pre, mainly due to the high level of D&A. The financial result was down by EUR 11 million, mainly driven by lower income from financial investments. The effective tax rate came in at 22.2%, which is in line with our guidance range of 21.2%-23%, but above the effective tax rate of 21% of the earlier year period. Now, as mentioned previously, this was mainly due to additional Pillar Two tax expense having increased our effective tax rate by roughly one percentage point. Reported EPS came in at EUR 1.60, which represents a decline of 12.6% year-over-year. With that, let's move on to the review by business sector. I'm starting with Life Science, which is on slide 10. As we mentioned in our qualitative guidance from March, H1 compares against a high base. Hence, overall sales in Life Science were down 12.6% organically in Q1. We do expect Q1 to be the softest quarter for our Life Science business sector in 2024. In fact, it also had the toughest comparative quarter in Q1 of last year. Also, bear in mind that while we no longer specify the effect of COVID headwinds, COVID-related sales still represent a headwind for Life Science in 2024. All three businesses in Life Science declined organically in Q1. So, looking at Process Solutions first, sales were down 19% organically in Q1, which is actually a similar level compared with Q4 2023. We are comparing against tough comps as we only started to see the first effects of customer de-stocking during Q1 last year. As we already mentioned in March, we're seeing positive signals from order intake. Order intake this quarter was solid and went up sequentially as well as year on year. I am happy to state that book-to-bill increased to around 1. Now, taking a closer look at Science and Lab Solutions, here sales were down by 6.9% organically. That is because of demand from pharma companies remaining soft both in North America as well as China. China overall has remained a challenge, but we saw signs of stabilization sequentially. In addition, academic research spending was impacted in North America by Q1 in the delayed signing of the NIH budget. Do not forget that Q1 last year was unaffected by the temporary headwinds such as the muted spending behavior by pharma companies and the macro environment in China we have been experiencing since Q2 2023. Notably, sales in Science and Lab Solutions were up sequentially, underlining our expectation of a gradual recovery during 2024. Turning to the third sector, which is Life Science Services, our third and smallest business, which is within Life Science, sales were down 16.6% organically, driven by the streamlining of the supply chain by one of our CDMO customers and an organic sales decline in our CDMO activities, which was mainly due to negative project phasing. EBITDA pre declined 30% organically in Q1, mainly due to lower volumes and negative mix effect. Q1 2024 had the highest margin comparator also. Sequentially, EBITDA pre increased slightly, with the margin having moved up by 220 basis points, which was mainly on positive product mix effects driving the gross margin. So, I am now on slide 11 for an overview of the performance of the Healthcare business sector. Healthcare did deliver strong organic sales growth of 10.1% in Q1, which is above the level we have guided for for the full year in our qualitative guidance from early March. Wave One projects grew by 15% organically, and the established portfolio was up 9% organically. By franchise, oncology was the star performer with a 19% increase organically, which was mainly driven by Erbitux growing 19%. Here, China in particular stood out positively with prior year sales impacted by a spike in COVID infection rates while supported by continued strong commercial uptake. Bavencio was up 14% in line with our expectations. Our NNI franchise was also up by 9% in Q1. That was driven by Mavenclad, which actually increased 12% organically. Rebif grew as well by 4% organically in Q1. That was due to channel dynamics, which led to a low base. On the latter, I do want to reiterate that we are not seeing a trend change for the interferon market. Fertility performed strongly again with an 8% organic sales growth against a lower base in China. In general, and as projected, we are also seeing that stockout effects of our competitor products are beginning to moderate. We are also very pleased with the performance of our CM&E portfolio, resulting in 4% organic growth supported by a positive contribution across all segments. Within endocrinology, the strong growth of the past quarters was driven by stockouts of a major competitor. As we are at manufacturing capacity for Saizen, we do not expect a continuation of double-digit growth rates, even if the market supply remains constrained. Now, regarding our pipeline, for Xevinapant, we are on track for the interim analysis of TrilynX, our phase 3 study in locally advanced squamous cell carcinoma of the head and neck in cisplatin-eligible population. In addition, we are seeing positive momentum built in our early oncology pipeline for ADC and DDR assets. We will present new data at ASCO. And in addition, I can recommend that you join our R&D update call on June 3rd, which will focus on early oncology assets. The strong organic sales growth in Q1 helped us to achieve an even stronger performance on EBITDA pre. EBITDA pre was boosted by higher operating leverage and benefited from the repatriation of Bavencio, which came into effect only as of July 1st, 2023, and amid ongoing cost discipline. Overall, EBITDA pre amounted to EUR 708 million in Q1, which resulted in a margin of 34.6%, which is 370 basis points above Q1 2023. As a result, organic EBITDA pre increased by 28.3%, which is well above the organic increase in sales. So, moving on to our third sector, Electronics, which is on slide 12. The Electronics sector had a strong start to the year, with all businesses having performed positively. Organically, sales increased by 6.3% in Q1. The key driver was the core business within Electronics, Semiconductor Solutions, which was up by 8% organically. Both our DS&S and our semi-materials businesses contributed to this development. In DS&S, we generated revenues towards the end of a large project in the US. We have seen customers push out the timing of new fabs, but we are already building a strong pipeline for 2025 and 2026. Our semiconductor materials business has now delivered 3 quarters of sequential growth in a row, driven by thin-film applications in advanced logic nodes in semiconductors. Mainstream semiconductor end markets, particularly 3D NAND and analog, have, however, remained weak in Q1. There was early buying behavior from some customers, which has yet to become a broader trend. Therefore, we did see an encouraging start to the year, while we do not call it an inflection yet. Our Display Solutions business also saw a sales increase of 4% organically. That was mainly due to volume growth, having overcompensated continuous price pressure against low comps for Q1 2023. Surface Solutions were up by 2% organically, driven by increased demand for cosmetics, pigments, and automotive coatings, which overcompensated weaker demand for the industrial pigments. While the EBITDA pre-margin went down by 19 basis points year over year to 25.5% compared to a still high base in Q1 2023, we did see a 370 basis points margin increase sequentially. The sequential margin increase was mainly driven by positive mix effects from advanced semiconductor nodes and the sales increase, especially in semi-materials, and the resulting positive leverage amid strict cost discipline. For the further margin evolution during 2024, please do have in mind that we continue to have ongoing price pressure in the liquid crystal business and higher underutilization costs due to the ongoing site ramp-up in semi. As we continue to be convinced of the long-term secular growth of semiconductors, we also sustain higher R&D and are continuing with our capacity expansions. So, before handing back to Belén, let me also briefly comment on our balance sheet as well as cash flow statement. As you can see on slide 13, our balance sheet increased by EUR 1 billion compared with the end of December 2023. Now, let's take a closer look on the asset side. Cash and cash equivalents increased by EUR 2.2 billion from EUR 2 billion at the end of December 2023, and that was driven by strong operating cash flow in this quarter. Inventories went slightly up, as did receivables. Property, plant, and equipment increased, driven by investments. Lastly, intangible assets increased due to FX effects on our goodwill. Turning to the liability side, financial debt increased slightly. Pension provisions were down due to changes in interest rates. Payables decreased from EUR 3.4 billion to EUR 3 billion due to in-license deals, which were signed in the prior period and resulted in payments in Q1 of this year. Net equity increased by EUR 1.3 billion thanks to growth in profit after tax and higher gains recognized in equity, mainly driven by FX. As a result, our equity ratio strengthened further from 55% at the end of December 2023 now to 57%. So, turning to cash flow on slide 14. Operating cash flow came in strong at EUR 1.035 billion and was up more than EUR 180 million compared with Q1 last year despite a decline in profit after tax. This was mainly due to changes in other assets and liabilities, in turn, driven by lower bonus payouts and taxes in the quarter amid a slower increase in working capital. Cash out for investing activities decreased primarily due to lower investment of our excess liquidity in non-financial assets. CapEx on property, plant, and equipment went down slightly, while we do continue to invest for capacity expansions. Last but not least, the difference in financing cash flow can be explained mainly by proceeds from bank loans in the year earlier quarter. Now, with that, let me hand back to Belén for the outlook. Thank you, Helene. So, let's take a look at our guidance on slide number 16. Let me emphasize that back in March, when we provided qualitative targets for 2024, we also confirmed our confidence to return to organic growth in 2024. I am happy to confirm this goal with our first quantitative guidance for 2024. We are now expecting group net sales in 2024 in a range of EUR 20.6 billion-EUR 22.1 billion, EBITDA pre in a range of EUR 5.7 billion-EUR 6.3 billion, and EPS pre in a range of EUR 8.05-EUR 9.10. And this is based on organic sales growth of +1% to +5% in line with our qualitative outlook provided in March. Regarding organic EBITDA pre-development, we have become slightly more optimistic than we were in our qualitative outlook for March, and we expect +1% to +7%. This is mainly driven by the strong performance of our Healthcare business sector. We continue to expect FX to have an impact of -3%-0% on revenues and -4% to -1% on EBITDA pre. For some additional detail by business sector, please take a look at slide 17. Our Q1 performance is providing increased confidence in the 2024 period. Therefore, we broadly confirm our qualitative guidance from March for Life Science and Electronics, and we have become more optimistic about Healthcare. So, for Healthcare, we now guide for organic sales growth of +4% to +7%, slightly above the qualitative guidance from March, with a number of drivers playing in our favor, including the continued strong performance of our established product businesses. We raise our guidance on organic EBITDA growth to +13%-18%, and this is mainly in relation to the strong leverage growth combined with continued cost discipline in the Healthcare business sector. Moving on to Life Science, we confirm our guidance for organic sales growth and expect an organic sales development between -2% and +2%. For organic EBITDA pre, we guide to an organic year-on-year change of -6% to +1%, thereby broadly confirming our qualitative guidance from March. We continue to expect a gradual recovery during 2024 with organic sales growth turning positive in the second half of the year. We see Q1 as the softest quarter in 2024, both in absolute terms as well as on a year-over-year basis, given the high comparables in 2023 that we mentioned several times. For Electronics, we forecast an organic sales development between 0% and 4% and an organic EBITDA pre-development between -3% to +4%. Once again, broadly confirming our previous qualitative guidance range. We have had a positive start to the year, but the general market inflection is yet to come in semiconductors, and you know that we continue to base our guidance on the semiconductor market returning in early 2024. Overall, I'm very pleased to say that Q1 is providing increased confidence in our return to organic growth in 2024. And as a group, we also have the ambition to return to profitable organic growth in 2024 as our guidance ranges imply. With this, let me thank you for your attention, and we will be happy to take your questions. Hello, Heidi. First question, please. Thank you. We will now begin our question and answer session. If you have a question for our speakers, please dial *11 on your telephone keypad now to enter the queue. Once your name has been announced, you can ask a question. If you are using speaker equipment today, please lift the handset before making your selection. One moment, please, for the first question. Your first question comes from the line of Richard Vosser from JP Morgan. Please go ahead. Your line is open. Thanks very much for taking my two questions. Too, please. Firstly, on Process Solutions. When we're thinking about the pace of recovery, how are you seeing the consumables ordering? Richard. Excuse me, Mr. Vosser, your line is cutting out. Thank you, Heidi. We shall move to our next question. Please stand by. Your next question comes from the line of Sachin Jain from Bank of America. Please go ahead. Your line is open. Hi there. Thanks for taking my question. Sachin Jain, Bank of America. First one from Matthias. Just wonder if you'd be willing to quantify some of the positive commentary. So, book-to-bill around 1. Has that been above 1 at any point? And then order intake growth in Q1 sequentially. Again, are you willing to quantify low single digit, mid-single digit sequentially? Some of your peers have made comments. And then second question, just for Peter. Obviously, very strong quarter from a sales perspective at 10%. Just wonder if you could touch on factors you see through the rest of the year from a phasing perspective. That means that guide is 4%-7%. I think you've called that Rebif and Saizen then, but anything else we should bear in mind? Thank you. Yeah. Thanks, Jennifer Matthias, for your question. No, I don't want to quantify at this point. I mean, we certainly see the positive momentum, right, both in terms of order intake, sequentially year over year. We see also the absolute number going, absolutely, in the right direction and steering us towards the guidance for the full year. So I think that's sending, I think, a clear signal. Yes, Sachin. I would agree with you. Very, very strong quarter across the board in all product lines or franchises and geographies. It is true, though, that beyond this very good structural performance, we had a bit of one-timers. Helene already mentioned in her speech Rebif, yeah? So some channel dynamics that will not repeat itself in the quarters to come. And then you should also bear in mind that, as also mentioned already in the prepared remarks, that there was a spike in COVID in Q1 last year, which benefited especially Erbitux and fertility. But I would understand and then, of course, there is the yet-to-come effect of Padcev in the U.S. for Bavencio. I think these are the big, let's say, moving pieces for the rest of the year. But again, overall, structurally, very strong performance. If you think about Erbitux and the growth rate, bear in mind that this is also real performance. Erbitux becoming more and more the backbone in several combinations. We have the head-and-neck performance in China post-NRDL and so on and so forth. So I hope that gives you a little bit more color. Thank you. Thank you. We will take our next question. Your next question comes from the line of Richard Vosser from JP Morgan. Please go ahead. Your line is open. Thanks very much. I hope you can hear me now, and apologies for that line drop. So just a question on Process Solutions. When we're thinking about the pace of recovery, how are you seeing the improvement in consumables ordering? Is this more sort of low or pace going forward? And then a second question on display. Could you give us context how important the conversion of iPads to OLED is? Hey, Richard. It's Matthias. Your line, we're still a bit out, but I think I got your question about consumables sales trending for PS. Look, the way I see it unfolding is that Q1 certainly was the lowest quarter in PS for the year. We will see a gradual improvement quarter-over-quarter throughout the year. Certainly, what I mentioned before, the order intake, absolute increase from last quarter to this quarter, expected to continue, will drive that. So now, how much quarter-over-quarter, that's hard to predict, but I would see a gradual improvement and certainly then come H2 having and demonstrating for PS, again, positive growth year-over-year. Yeah, Richard, on the OLED question. So, of course, we don't disclose any specific customer interactions, and that's why I can't comment on the specific point on the iPad. But as a leader in the OLED materials space, I think there's always a pretty high likelihood that we are involved in the most sophisticated end products. And I think this confirms the validity of our assumptions in the OLED technology development. And it's good news for us all, yes. Thanks very much. Thank you. We will take our next question. Your next question comes from the line of Colin White from UBS. Please go ahead. Your line is open. Hi. First question from me. It's Colin White from UBS. The first question was about the upcoming interim analysis for Xevinapant. Clearly, we've not had it yet. It's still on track for the threshold of events, perhaps, to be met in the second quarter. What I wanted to do is ask what the current best estimate is of when the interim analysis is carried out, when we might hear from that after you've had the interactions with IDMC, and when the best guess still is for the full final readout. And then a second question on bioprocessing, please. Last quarter, we heard about the customer survey that you had done and the expectation that CDMOs would reach their target level and start ordering earlier. And so just any update on what you've seen in terms of that and if you've already seen evidence of this and CDMOs reordering and your latest thoughts on how that's likely to progress? That's it. Thanks. Yes, Colin. Thank you. I will take the Xevinapant question. So I can confirm to you that we have the number of events that we need to go for the interim analysis. We have those events accrued. So now there are a couple of steps to be taken: database lock, data cleaning, and then the DSMB will look at the data. There are two scenarios. I remind you that the base case scenario is that the study continues. And the upside scenario is that, indeed, we have overwhelming efficacy according to the DSMB. Then our teams, a cross-world team, would be unblinded, and then we would have a conversation with the FDA. So, in other words, in the base case scenario, no news is good news, and the study continues. It's only in the upside scenario that we will communicate. In terms of timing, to completely answer your question, we do expect to have, let's say, a view on that by the end of the second quarter or early third quarter. So end of June, early July. Yes. And on your BIOP question, indeed, we see the ordering patterns unfolding more or less in line with the survey we took a couple of months ago. So yes, we do have CDMOs kind of going back to more normal ordering patterns, but also other customers. So the answer is yes. Thank you. Thank you. We will take our next question. Your next question comes from the line of Peter Verdult from Citi. Please go ahead. Your line is open. Thank you. Peter Verdult, two questions, please. Peter, just can we dig into Bavencio a little bit more? I know you don't disclose geography, but I would like to understand the dynamics. Could you give any soft commentary on that sort of U.S. versus Europe and Japan? So basically, what I'm trying to get at is, is this Padcev and Keytruda playing out as you expected and being fully offset by what's going on in Europe and Japan, or is the U.S. actually holding up better? So that's question number one. And then number two, Belén, on the M&A environment, it's almost two years since management started articulating a message that your appetite had increased and the firepower that you were willing to deploy. Now, I realize you're not going to identify targets on a Q1 conference call, but can you at least characterize the current M&A environment and whether you think conditions are more conducive than they perhaps were in 2023 to actually see that balance sheet deployed? I'd just be interested in your latest thoughts there. Thank you. Yeah, Peter, let me take the Bavencio question first. So just if, again, if you take a step back, you will remind that we have always characterized without giving precise numbers that actually the U.S. part of Bavencio was less than 30%, yeah? So that's number one. What we see is what you anticipated is that if you look at internal sales in Q1, we don't really see an impact yet. We slightly grew our sales even in Q1 in the U.S. But, of course, that is more a factor of what was initiated in Q4 by platinum-based chemotherapy. And then, as you know, the maintenance therapy with Bavencio and the responders is then started a little bit later. So what we do see is, indeed, a decrease of platinum-based chemotherapy in Q1. So we should anticipate, indeed, some impact in Q2. But we need a couple of more data points to really try to quantify that impact in the U.S. But, of course, there will be an impact. What I can also tell you is the brand continues to grow very strongly in Europe and Japan. So that from an overall guidance for this year for Bavencio, we still are confident that the brand globally will continue to grow. Now, perhaps one or two qualitative points, yeah? First of all, we always said, and we stand by that, is that it will take time and effort for EV-302 to get priced and reimbursed in Europe. That's number one. Number two, in Japan, chemotherapy is really extremely well embedded, and the market is very sensitive to toxicity. And talking about toxicity, you know that, of course, many patients treated with EV-302 got pretty nasty side effects, very burdensome for the patients. So thinking about skin toxicity, thinking about neurotoxicity, which also led a lot of editorials and comments by KOL that we have to be careful and also take into account quality of life considerations, preferences of the patients, and so on and so forth. Last but not least, you will remember that we also published at ASCO-GU the sequencing data where we have a real-life cohort coming from France, where we actually demonstrated that if you start with maintenance with Bavencio, followed by Padcev in second line, that you also come to more than 40 months of overall survival. So we are battling very hard to get these messages across. I would say, so far, so good. Hi, Peter. On your M&A question, you know us very well. We have discussed this several times. First of all, as you know, we are a cash buyer, preferably, and our cash situation is good, is allowing for us to allocate our capital according to our priorities, which we have outlined many, many times with a top priority on life science, both SLS and PS. Obviously, continues in licensing in Healthcare, as we have seen as you have seen, we have progress on that late last year and early this year, and obviously, identification of potential technology opportunities in Electronics. So the environment is, in terms of multiples for life science, became a bit more accessible, multiples coming down a bit. Number of targets is really not a problem. But as you know, confirming a timing, right, for our portfolio moves, mainly for acquisition, is almost mission impossible because it takes two to tango. And you know that we have a very good track record on right time, right price, right target. So we aim to keep that. We have a very clearly defined financial frame, which is as well as a strategic frame. So first of all, supporting our profitable growth strategy is our main priority, followed by keeping our credit ratings, delivering an IRR of the acquisition, which is above our WACC, and then, obviously, EPS pre-acquisition. So that goes as a high-level frame. And have no doubt that we will keep you informed whenever we have relevant news to communicate. But this is really occupying us. Thank you. Enjoy the tango. Thank you. Thank you. We will take our next question. Your next question comes from the line of Emily Field from Barclays. Please go ahead. Your line is open. Hi. Thank you for taking my questions. I'll ask two. The first is a follow-up question on the earlier answer to the Xevinapant scenarios. Peter, you mentioned two scenarios, I think, continuation of the study or early stoppage, but you didn't mention three. And obviously, that would be the bad one of that, the study being futile. So is that still a plausible scenario, that the drug could fail at interim? If you could just clarify that. And then secondly, in the prepared remarks, going back to Life Science, sorry, you mentioned the impact of softness in China is impacting SLS in the quarter, but that you saw some signs of, I believe, stabilization sequentially. Could you provide some more granularity on what you're seeing here and what sort of that path is expected for China? Also, if you could confirm that China is 10% of the life sciences business overall? Thank you. Yes, Emily. So on Xevinapant, of course, you are totally right. In this unlikely scenario that futility would be hit, of course, then that would be the worst-case scenario, and we would then also communicate, yeah? So you are totally right. Hi, Emily. It's Matthias. So on your China question, yeah, indeed, total China sales for total life science is below 10%. Obviously, we are very active in China, and we wanted to have the situation. We are still down year-to-year in sales for the first quarter. At the same time, what we see in our sales is somewhat stabilizing. So if I look at quarter by quarter, I see a stabilizing trend. Now, the question is, how will that unfold throughout the year? We do believe that things will progress positively throughout the year. But obviously, that depends on the macro situation in China. Thank you. Thank you. We will take our next question. Your next question comes from the line of Thibault Boutherin from Morgan Stanley. Please go ahead. Your line is open. Yeah, thank you. First question is on the negative product mix impacting the margins in Life Science in the first quarter. Just if you could tell us if this is about the shift in mix between the subsegment of Life Science or if you're talking about product categories within segments. The second question is on the Healthcare growth, so solid outlook on top line this year without new launches but also some positive one-offs or base effects. Just conceptually, when we think beyond 2024, do you have a strong confidence in the ability to grow the portfolio and pipeline? So basically, it's kind of base portfolio and wave one on the next couple of years, at least until the loss of exclusivity on Mavenclad. Yes, Matthias. Let me try to answer your first question. I was not sure on what reference you're taking. So year-over-year, first quarter was last year, indeed, we do have a substantial decline in our margin following, if you will, the volume drop, right, losing the COVID sales, which had a higher margin profile. So that is kicking in. However, I think sequentially, and we mentioned that before, Q4- Q1, we already see a sequential margin improvement, about 2020 basis points. That, if I look at the sequential improvement, is also partially due to mix but on a positive side, if you will, because the share of our PS and SLS business is a bit higher in Q1 versus Q4 because LSS is a bit weaker. So I hope with both answers, I address your question because it's a bit whether you look at Q1 last year or sequentially. Yeah, thank you. That's clear. Yeah, Tibo, sorry. Yeah, Tibo, on your outlook beyond 2024, we actually already characterized that, and I think Belén did it in the last call, that if we include Xevinapant, that we're still confident to be at the lower end of the mid-single-digit growth, so without Evobrutinib. But of course, obviously, you see the pipeline maturing. You see the pipeline getting larger. We will have readouts of Enpatoran coming up in SLE and CLE later this year or early next year for SLE. We have the R&D update call on the earlier oncology portfolio, so lots of news there on the DDR portfolio, on the ADCs. You have seen that we have been quite active in the in-licensing space. We have added a phase three asset, Pimicotinib, to our pipeline. So we are confident, of course, in the long-term outlook for our product. We will start Cladribine in MG in phase 3 and Q3. As you can see, we are working hard and making a lot of progress to further enhance the growth profile of the company. Thank you. Thank you. We will take our next question. Your next question comes from the line of Oliver Metzger from Oddo BHF. Please go ahead. Your line is open. Yes. Good afternoon. Thanks for taking my questions. The first one is on SLS. So you mentioned in your comments weaker pharma spending and also governmental funding delays in the U.S. Can you give us your view of the situation, whether you see it rather as a temporary, means Q1 effect, or potentially more prolonged? And also in this context, do these delays trigger some pent-up demand afterwards in your view? That's number one. The second one is on your guidance. So if I look on the midpoints of the segmental guidances and compare it with the group organic growth guidance, the midpoint of the group guidance appears a notch too high. Mathematically, range should be rather 0%-5%, which would describe the sum better. Can you therefore elaborate for which segment you see a more positively skewed outcome of your guidance range? My last one is a strategic question on Healthcare. So the guidance for 2024 looks pretty good, in particular on the bottom line. I understand that the healthy top line provides some attractive funding, and the leverage for existing portfolio is quite good. So I don't want to focus too much on the EV-302 failure. But can you make a comment whether you're looking more intensified on strengthening the overall portfolio outlook through the internal or external innovations so that also from a pure portfolio perspective, the segment does not become smaller versus the other segments over time? So it's basically also an active decision, not growing a segment not so aggressively in future anymore, and therefore, it can become smaller. So these are my questions. Thank you. Yeah. Hello, Oliver. It's Matthias on your first question around SLS. Indeed, we have experienced a somewhat softer market situation for SLS, especially in North America and in China for the last several months or even a couple of quarters. Q1 was also somewhat impacted due to the delayed release of the NIH funding, which came a little bit later during Q1. All of that, I would say, is more temporary. We expect also here a gradual improvement. If you look at SLS also here sequentially, our business grew from Q4- Q3 and now Q1- Q4 quite nicely. We expect that trend to continue. If there is a catch-up effect, it's hard to predict. I probably would not bank on that, but a solid continuous improvement with the market conditions also going in the right directions. So on your guidance question, let me basically emphasize that we are offering our best view of expectations, and we capture the business assumptions that are visible to us as accurately as possible for the three sectors. And then something that you have to take into consideration is that the three sectors do not need to add up very precisely, right? So you need to understand that when we talk about Healthcare, for example, we are now raising the guidance versus the qualitative guidance that we gave in March simply because we have further visibility and expectations on the way our base portfolio is going to move. Take this as an example. But in slide 16 of your presentation, you can see all the details and the drivers behind our guidance, and do not expect that everything adds up. Yeah, Oliver, on your third question, we've actually already introduced the concept that we want to become, and we have become, much more aggressive on the in-licensing front. And again, I don't want to repeat, but we have seen actually a flurry of deals end of last year, early this year. And the aim is really to have a pipeline that is at least 50% coming from external innovation to increase our shots on goal and to live up to the expectation to launch at least one new product or one major indication every 18 months. So this is very high on our agenda. And we are convinced that by doing that, we will continue to drive growth in Healthcare, as I mentioned earlier. Okay. Thank you very much. Thank you. We will take our next question. Your next question comes from the line of Ed Hall from Stifel. Please go ahead. Your line is open. Perfect. Thanks, guys. Just a couple of questions on Life Science. So firstly, more on the Process Solutions. You touched on China market slowdown, but could you necessarily talk about the U.S. and Europe ordering patterns, especially in the U.S. in terms of the Biosecure Act uncertainties? Did this play any sort of impact in customer ordering patterns? And then second question would be, you mentioned book-to-bill of around 1. I was wondering if you could qualitatively talk about Q2 and what you've seen so far. Is this tracking in line with expectations, and is this above Q1? Thank you. All right. So on your first question, there was a few things mixed in. Maybe I start with Biosecure Act. Obviously, we are monitoring that very carefully. There's a lot of dynamics there. I think it's really too early to assess the real impact. What I certainly can say, we feel we are very well positioned. Our in-region, four-region supply chain model works well, and I think it's positioning as well, our broad portfolio as well. Also, none of our customers has more than 2% of sales. So at the same time, and maybe you're pointing also to that direction, what could it mean on the upside? It's too early to tell. And for sure, we don't see it yet in order patterns or in sales. What I can say is that there's probably more inquiries coming in around the topic, but we need to see in the next few months how that really unfolds. Broader questions from you around the order pattern. I think I talked about that before. In general, we see the trend unfolding as expected, that come Q2, the majority of our customers should be having the destocking behind them, both on the CDMO but also on the other customers, also large customers. And yes, we see already larger customers already going back to an ordering pattern. They're also anticipating and seeing from us shorter lead times. That's an important component. So by and large, we are seeing things unfolding as expected. And I think then your question around the book-to-bill. Look, it's around 1, right? We are monitoring carefully every week, if you will, every month. It's not the right time now, obviously, to talk about Q2. I think I gave enough indications based on the Q1 dynamics and the momentum. Our expectation is that, as I mentioned before, the momentum continues, and we will see a strong H2 versus H1. Perfect. Thank you, guys. Thank you. We will take our next question. Your next question comes from the line of Gary Steventon from BNP Paribas Exane. Please go ahead. Your line is open. Hi, there. Thanks for taking the questions. A couple on Life Science, please. So first one, just on science and lab. You noted that customer orders were impacted by the SAP migration back in the second half of last year. So the question is more about what you're now seeing in that customer base, whether you're seeing those customers who needed to go elsewhere coming straight back to order, or whether you think there could be a longer-lasting impact from those lost sales. And then secondly, actually, just on Life Science Services, you made a comment in the slides and in the prepared remarks as well about one of your CDMO customers streamlining their supply chain. So could you provide a bit more color here? Is this a customer that's moving away from you as a dual source of supply? Is this something you're generally seeing a bit more of now as supply chain pressures ease? And then linked to that, is that something that could also potentially impact dynamics in Process Solutionss if there are changes to supply chains? So your thoughts around those kind of points would be helpful. Thank you. Yeah, thank you. Great questions. So on the first one, SAP, look, the issue is behind us, right? Some of the customers who needed their products within 48 hours, obviously, those sales are gone in that period last year. But we are not seeing an impact anymore. So if you will, the SLS dynamics is independent from the SAP situation we had last year. Then the other point, and I think it's very specific, which you picked up. Let me explain that. And so it was a specific customer situation where during COVID, we helped the customer to organize their supply chain, essentially to purchase the raw materials, and we had it like a pass-through. And we kind of phased out that specific situation because it was needed anymore. So it was very specific. We footnoted it to be transparent, but it's not a, if you will, a trend or whatever. To be clear, in LSS, and we talk especially about the CDMO part, not about the testing part, the CDMO part, it's more volatile, right? We are focusing on more the customers in the novel modalities, which are by nature in the early phases, right, depending on their, if you will, win as they go through their development phases. And that's what's driving a lot of the volatility. We have not lost customers, and that's not driving that volatility. And as such, that has not any, if you will, parallel effect on what we see on the PS side. Perfect. Clear. Thank you. Thank you. We will take our next question. Your next question comes from the line of Brian Balchin from Jefferies. Please go ahead. Your line is open. Hi there. Sean Hamer from Jefferies. I'll be asking on behalf of Brian. So just two from me, please. On Electronics, can you help us understand which type of chips you'd expect to lead the early 2H recovery? Is it early pickup in logic? Is it likely to drive a greater rebound alongside memory? So that's the first question. And then secondly, I understand there's been quite a few questions on reordering in Life Science. But perhaps could you give us a percentage on the customers that have begun to restock? Thank you so much. Well, let me take the Electronics question. So the recovery is typically defined by a return of the mainstream technologies, and this is predominantly 3D NAND that defines volume in our industry, as well as mainstream logic, as well as analog. These are the three technologies that we need to recover volumes and to set the inflection point. The current early trend is defined by high-end AI-related technologies where we are specifically benefiting from. This is an atypical cycle where one technology is leading the pack early. And this is all related to the current trend towards AI. Yeah. On your PS question, look, we already have a substantial base of customers who are in the kind of reordering trend. We have others which are kind of getting there. As I mentioned before, by and large, we expect that the majority of the customers, the broad base of customers we have in PS, will have destocking behind them come end of Q2, right? Some of them will still come in Q3. By and large, I would say we are exactly in that pattern which we expected. Some are back to normal already, and some are kind of in the process there. I think that's exactly what we have anticipated and also what we communicated in our prior call. Thank you. We will take our next question. Your next question comes from the line of Rajesh Kumar from HSBC. Please go ahead. Your line is open. Hi. Good afternoon. The first question is on Process Solutions guidance. If we look at your guidance, how much of it requires the demand to sequentially improve from the current run rate versus the comps in the second half being softer? You could choose to answer it at the Life Science group level and Process Solutions, or if Process Solutions is a more helpful answer, please share that. And then the second question is around the margin improvement in Electronics. You clearly have said that there are capacity ramp-ups and therefore expect the operational gearing more second-half weighted. And then can you characterize the nature of the gearing? So do you expect the incremental margins to be similar to previous periods of growth, or can it be a little higher or lower? I know you've given a full-year guidance range, but not just for this year. Going forward beyond 2024, how should we think about the incremental margin in Electronics? Thank you. Yeah. On your first question, indeed, the guidance, if you will, reflects a mix, right? I mean, first of all, indeed, second half last year, obviously, provides a lower base than first half last year because in Q1, we still had the lack of the effect of the destocking, all this stuff we discussed a lot. So that's one component. But indeed, the bigger component, and I think more relevant, is the expectation that gradually we are going back to the more normalized order pattern, several of the topics I mentioned already before. And think about the momentum we are building, which I explained before, with a book-to-bill around 1, with order intake sequentially increasing quarter-over-quarter, some more, some less. That will get us into the range of the guidance. So I think that's the way I would look at it. That's the math and how it works. But certainly, we are expecting a solid book-to-bill around one, including order intake to increase and also including that customers are acknowledging our shorter lead times so that the orders we are getting in a quarter are delivered sooner than during COVID times when we had much longer lead times. So that's kind of how, if you will, if you look at it holistically. Sorry. In that context, can you sort of give us some color on what proportion of that business is driven by order books versus bought business? Because if we look at 1, then we might be tempted to assume the whole business is order book-driven, but surely that's not the case. Well, look, I mean, I'm not sure I fully understand your question. Of course, there's run rate business, right? But still, customers place an order. So maybe happy to follow up with you, but I'm not exactly sure I'm clear about the question. Okay. On your margin question for Electronics, the midterm guidance of around 30% is intact. This is what we always communicated on the midterm margin development. Now, talking about short term, what happens in 2024? You see, on the positive side, a positive mix effect of the Synchronous technology for advanced technologies, advanced nodes. That is a positive mix effect. We see the volume leverage kicking in over the quarters this year, especially after the inflection of the mainstream technologies mid of the year. And then on the more conservative side, we see, of course, additional ramp-up costs coming in as we ramp up new capacity for our semiconductor materials. And that new capacity impacts the margin negatively. So don't extrapolate from Q1 because then you would exclude the ramp-up effects in your calculation. Thank you. Thank you. We will take our next question. Your next question comes from the line of Simon Baker from Redburn Atlantic. Please go ahead. Your line is open. Thank you for taking my questions. Two, if I may, please. Firstly, on Electronics, I'm just trying to triangulate performance and guidance here. So 6.3% organic growth in Q1, guidance for the year 0%-4%, guidance also for a second-half inflection. You did talk about DS&S phasing, but that would suggest that Q2 would be considerably lower growth than we saw in Q1. Is that the case? Is there any other factor at play, or is this simply prudent guidance at a still relatively early stage of the year? And then secondly, a quick question on Healthcare. Among the drivers, you cited strong growth of Tepmetko. I couldn't see a sales number in any of the releases. I wonder if you could possibly give us the Tepmetko sales number for Q1. Thanks so much. Simon, let me start on Electronics. So first of all, I think you have to take into account a bit the low comps that we had in Q1 2023 in terms of factoring in the growth trajectory for the coming quarters. Second, the market reports, the very recent market reports, as well as our customers communicating on their quarter, they have shown a more cautious outlook into the rest of the year, which we had to take into account looking into our guidance. Then you already mentioned the DS&S shift of one or the other invoice from one quarter to another or potentially even at the end of the year into early next year. That could have an impact on our growth. So this defines a bit the lower end, the lower end of the guidance. And the upper end of the guidance is defined, of course, by the current adoption of new technologies and especially our involvement here in AI and, yeah, highest-end technology that gives us the confidence on the positive side. It defines the full frame of the guidance. And depending on what comes when, then we see us landing within those different boundaries. Yes, Simon, to your question on Tepmetko, we have never disclosed it, but I guess you can calculate it by subtracting total oncology minus Erbitux and Bavencio. So it's a little bit shy of EUR 30 million in the first quarter. It's growing strongly. It's our first endeavor in the targeted therapy space. And we have actually very good performance in Japan, also picking up seriously in the U.S. and also in the European countries where we have reimbursement. I've also told you in the past that I think that the potential of the drug is somewhere around EUR 150 million. I can now say that very confidently. And when I see the development, it may even go a little bit above EUR 150 million. Perfect. Thanks so much. Thank you. We will take our next question. Your next question comes from the line of Florent Cespedes from Bernstein. Please go ahead. Your line is open. Good afternoon. Thank you very much for taking my questions. Florent Cespedes, Bernstein. Three quick ones. First for Peter. On the pipeline, Peter, please, could you give us a little bit more color on what we should expect for the 3rd of June call on early oncology? And is it an area where we should still see some in-licensing activity? And the second question on pharma, on fertility, could you give us, please, a little bit more color on how we should see the rest of the year? We see quarter-over-quarter, the sales kind of plateauing on the fertility. Do you see more pricing pressure or some volumes are slowing down due to the competitive environment? And my third question, if I may, is on life science services. It's just a follow-up to make sure that we understand on the CDMO business. You flagged on your slide that there is an unfavorable batch phasing. So is it a kind of one-off impacting this quarter? And we should see some recovery in Q2, or is it something that should impact also the rest of the quarters? Any clarification on this one would be great. Thank you very much. Yes. Thank you, Florent. So your first question on the R&D call. So what you can expect is really early oncology in focus, no focus on Xevinapant this time around. So it's about our very, very nicely advancing ADC technology with Anti-CEACAM5 as a frontrunner, as you know. We will talk about the DDR portfolio with Tuvusertib, as you have seen in the R&D catalyst slide, moving into phase two in combination. Of course, also updates on the selective PARP1 inhibitor that we in-license from Hengrui. And we'll also give you some more color on Pimicotinib. So I think it's going to be really interesting to get that better. And of course, we will also talk there about the future continuation of in-licensing strategy. Your question on fertility, I think the way you should think about it is that the stockout of the competitors is really fading out relatively quickly now and that the growth that you have seen in Q1 is largely driven, not exclusively, but largely by the low comparators in Q1 in China. In other words, moving forward for the rest of the year, I think you should think about a flat to slightly growing fertility business for the year to go. And then we think that as of 2025, we will resume a "normal" situation with competition back, and then we would return in principle to a mid-single-digit growth rate. Thank you, very clear. Thank you very much for all of your. Sorry, continue on the LSS question. One more apologies. Yeah. Let me give you the chance to explain that. Indeed, thanks for your question. So look, in the CDMO business, we are serving compared to other businesses, we have a much smaller set of customers. Those are much more in the early phases, right? Early biotechs, which are developing those novel modalities. So by definition, we are depending, and I mentioned that before, a bit more on how their development goes through the different phases, right? Will they hit the milestone? And that triggers then what we call the batch phasing, right? Do I get some of their batches in this quarter? If they have a delay of six months, it will come two quarters later. That's why the way I would look at the LSS business, especially the CDMO portion, is much more volatile. It could go up a quarter, right? If you get a batch in, it could go down, then the next quarter if the batch is kind of delayed. So you will see that business a little bit more volatile quarter-over-quarter. We're still expecting towards certainly the midterm, as the business grows, getting a little bit more stable. But that's kind of the dynamics of that business. Thank you very much. Very clear. Thank you for all of your questions. Belén, any closing words from your side? Yeah, very briefly. So thank you very much, and thanks everyone for your continued interest in Merck. I think we can say very firmly that 2023 has confirmed indeed as a transition year. And with Q1 2024, we have begun our journey to return to organic sales and EBITDA pre-growth now in 2024. So we remain highly committed to continuously execute our strategy and, most importantly, to delivering on our commitments for profitable growth and sustainable value maximization. So we look forward to meeting many of you at the upcoming roadshows and conferences, including ASCO 2024 and, as Peter mentioned, our R&D update call in early June. Please also note that we will be hosting our Capital Markets Day on October 17th, and it will be here, our beautiful headquarters in Darmstadt, as you might have already seen on our web page. So Constantin will send an invitation with all details, and we would be absolutely delighted to welcome as many of you as possible here in our headquarters. With this, thank you so much for your attention and support, and goodbye.