Ladies and gentlemen, welcome to the Lundbeck financial statements for the full year 2021. For the first part of this call, all participants will be in listen-only mode, and afterwards there will be a question and answer session. Today, I'm pleased to present Deborah Dunsire, President and CEO, Anders Götzsche, Executive Vice President and CFO, Johan Luthman, Executive Vice President, Research and Development, and Markus Kede, Senior Director Treasury. Speakers, please begin. Hello, everyone, and welcome to the full year financial results and business update from Lundbeck. Thanks for joining us. Today, as you've heard, I'm joined with Anders Götzsche, CFO; Johan Luthman, EVP of R&D; Jacob Tolstrup, the Chief Commercial Officer for Lundbeck; and unusually today, Markus Kede, our Head of Treasury, since we have another announcement in addition to the financial release that we'll be talking through today. Next slide, please. You've seen our forward-looking statements. I trust you've all read them, so I'm going to move right on. Next slide. We had a very solid year, although a difficult year, given the loss of exclusivity in Northera. We're very proud, in spite of that loss to achieve revenue of DKK 16.3 billion and to see our strategic brands up 15% with growth across all regions. Core EBIT reached DKK 3.5 billion, and the EBIT margin expanded to 21.6%. We also made significant progress reducing the debt, since we were able to save money so given that we were impacted by the pandemic. We've had some great progress in our pipeline, notably in January. Vyepti was fully approved in Europe and the U.K. We also had the supplemental NDA approved for Rexulti for the treatment of schizophrenia in adolescent patients aged 13-17 years. We are on track for the headline results from brexpiprazole agitation in Alzheimer's disease, and Johan's going to talk through that a little bit more. Very proud that we now have a replenished phase II pipeline with two novel molecules, our PACAP inhibitor and our alpha-synuclein inhibitor, both those trials initiated in Q4 of 2021, and Johan will be commenting further. Next slide, please. Today we announced a new share structure, splitting the Lundbeck share into A- and B- shares. That is done in order to increase financial capacity into the future to account for the growth of Lundbeck. We'll talk through that in more detail, but suffice it to say that all shares retain equal economic rights, but the A- shares will carry 10 votes, the B- shares will carry one vote. This is proposed and will be brought to an extraordinary general meeting of the shareholders for approval. We anticipate that the extraordinary general meeting will be in June of 2022. In the meantime, we work on a prospectus that will be published once it's been through the iterations with the Danish Financial Supervisory Authority. The Lundbeck Foundation did inform us that they will... They intend to offer an exchange offer, exchanging B- shares, their B- shares for A- shares for some investors who may choose to prefer to use B- shares. Next slide, please. Turning to the year. The strategic brands continue to be the major revenue contributors, up 18% in local currency, 15% reported. Notably, the fourth quarter of 2021 improved 23% over the fourth quarter of 2020. All four strategic brands showed double-digit growth in Q2, and they're now 61% of our revenue. We're glad to see that the impact of the pandemic is gradually abating, and we anticipate strong growth momentum going forward for these brands. Commenting on each of them. Next slide, please. Vyepti has continued to perform. We introduced it in a couple of new markets in the fourth quarter, UAE and Kuwait, where it's been well-received. As I said, we've achieved the approval in Europe and the U.K. We have 10 launches planned in the coming year. We saw very good momentum continue through the year for Vyepti subsequent to the U.S. launch. We've also made progress in expanding Vyepti, getting it ready for its global expansion in Asia with the SUNRISE and SUNLIGHT trials, and of course, bringing it to trials in episodic cluster headache to continue to expand that brand's ability to benefit patients. We saw the same strong profile of Vyepti reiterated in the DELIVER data which we spoke to you about earlier in the year. Suffice it to say that in the marketplace, we are very satisfied with how Vyepti continues to deliver for patients, giving very powerful relief over a three-month period with a single infusion. Next slide, please. Brintellix. Trintellix has also shown double-digit growth. Europe and international markets have significantly expanded. We continue to see great growth in Japan, achieving a market share of over 5%. We've also seen the profile continue to be supported in some of the phase IV studies we've had, both our real-world evidence trial showing the improved functioning of people taking Trintellix in our RELIEVE trial, and then showing in people who have major depressive disorder and concomitant generalized anxiety disorder a significant improvement in both depression and anxiety in our RECONNECT trial. We still have one ongoing trial in the phase IV suite of Vortioxetine versus Desvenlafaxine. Brintellix grew 14% over the year. Next slide, please. Rexulti, another product that's delivering a 14% growth in local currency over the year. The sNDA was approved for schizophrenia in adolescents. A recent launch in Brazil continues to show strong uptake, and we're on track for the pivotal headline data for Alzheimer's agitation in mid-2022. Johan will comment on our PTSD program. Suffice it to say we're seeking to redesign that program given the accrual delays based on the pandemic. Next slide, please. Abilify Maintena has continued to perform. It was a brand slightly less impacted by the pandemic, and so the growth continued in 2021, showing 8% growth in local currency. Health Canada approved an alternative initiation regimen that allows for two injections at the start and a less days of oral coverage required. We received our clinical pivotal data that will be required for the submission of the two-month formulation in the mid of 2022 when we consolidate with the manufacturing data that's needed for that submission. Next slide, please. Handing over to Johan. Yeah. Thanks, Deborah. Yeah, let's talk a little bit about R&D further. Let me start by commenting a bit further on Vyepti. The global rollout of Vyepti is progressing very well thanks to a very aggressive regulatory submission plan. As Deborah already mentioned, we are pleased to have obtained the European Commission approval for marketing authorization in EU and the European Economic Area countries. We got that on January 24th. This was followed shortly thereafter by approval in the U.K. on January 26th since the MHRA process was adopting the CHMP opinion and followed the timeline of the European Commission decision. The approved indication in those markets is identical with Vyepti indicated for the prophylaxis of migraine in adults who have at least four migraine days per month. The labels we have obtained so far validate the strong data we have on the drug. With these approvals, including the recent EMA centralized procedure approval, Vyepti is now authorized in 39 markets while review is ongoing with 13 regulatory agencies, and we expect five more submissions based on the current data package. I also like to add that the Asia programs are progressing well with the SUNLIGHT, SUNRISE, and SUNSET studies. The SUNLIGHT study actually already reached last patient first visit in mid-January despite escalating COVID situation in China, restrictions posed by the Olympics, and ahead of the Chinese New Year. We are therefore on track for the headline results from this study after the summer. Overall, the current progression of the SUN trials are keeping us on the expected timelines for regulatory submissions in China and Japan. On Rexulti, the supplemental new drug application for treatment of schizophrenia in adolescents was approved by FDA on December 28th, as Deborah mentioned. There is a significant unmet need in the treatment of adolescent schizophrenia patients, and the approval of Rexulti provides a valuable treatment option for this population. The submission was completed a year earlier than planned based on clinical data and an extrapolation and modeling of PK data. Indeed, this represented the first application for treatment of schizophrenia in pediatric patients to be reviewed by FDA's accelerated extrapolation pathway. As you probably recall, the enrollment of patients in agitation Alzheimer's disease trial was extremely affected by the COVID-19 pandemic. Through a very strong effort across the Otsuka and Lundbeck teams, we have now been close to concluding the last patients in that trial. Thereby, we can look forward to the headline data of this pivotal trial as we promised by mid this year. The two phase III trials of brexpiprazole in PTSD are extremely affected by the pandemic still, and enrollment of patients is severely affected. Thus, we have an ongoing discussion with FDA, which we are outlining the different redesign proposals of the program, and we're looking forward to have a good conclusion of those discussions. Our alpha-synuclein program, Lu AF82422, I presented last quarter. The phase II AMULET study for potential new treatment on multiple system atrophy has now been initiated. It's still too early to judge the trial progression, but we are up and running now with several sites. I will however comment a little further on Lu AG09222 program in the upcoming slides. Next slide, please. Lu AG09222 is an investigational monoclonal antibody designed to bind and inhibit pituitary adenylate cyclase-activating polypeptide, PACAP for short. Lu AG09222 is targeting biological pathways in migraine that are distinct from the CGRP drug class. PACAP and its receptors are broadly expressed in the nervous system, including at sites implicated in migraine pathophysiology. In preclinical and clinical studies in healthy subjects, Lu AG09222 has shown to bind with high affinity to PACAP, thereby preventing PACAP from activating those receptors. Next slide, please. Lu AG09222 has indeed gone through a rigorous phase I evaluation on not only its PK safety and tolerability, but also verifying its target engagement and mechanism of action in an elegant experimental medicine study. This paved the way to enter into a proof of concept study. The initiated proof of concept study, the HOPE trial, is an interventional multinational double-blind parallel group study designed to investigate whether Lu AG09222 can be effective for migraine prevention. A total of 230 subjects will be randomized to one of three treatment groups. Two doses of Lu AG09222 or placebo. We are excited about the potential of Lu AG09222. We are looking forward to expanded program and looking forward to completion of this HOPE trial by 2023. By initiation of the HOPE study, we are advancing our neurology pipeline and adding another program into phase II that Deborah already mentioned, as well as further expanding our investment in biotherapeutics. Next slide, please. This depicts our current status of the development pipeline organized according to our four strategic areas. While we are in full force working to deliver on our late development activities, including Vyepti and supporting the marketed products, we are working in a very determined manner in steadily building a strong and longer-term sustainable pipeline. I've already commented on several of the programs, but I'd like to highlight a few activities from this slide. On Vyepti, the ALLEVIATE trial, which is an indication expansion study on cluster headache, it's now fully ongoing and enrollment is reasonably well ongoing in spite of initiation in the midst of the pandemic. As we have described earlier, all clinical bridging studies on aripiprazole two-month long-acting formulation were successfully completed a while back. We're still progressing according to plan with generating the required CMC data, such as stability and scale up and document the manufacturing process before submission to FDA and EMA that is expected mid this year. Our MAGL program, the Lu AG06466 program, is progressing with a systematic evaluation of the biology through early development studies in patient populations. We are currently learning a lot about the potential of the molecule and the target class. We will be determining the possible path forward during this year. Last quarter, we announced a partnership with AprilBio on their anti-CD40 ligand monoclonal antibody with a modified Fc binding domain property. Lu AG22515 is now progressing into first in human studies in the coming weeks. We are thereby opening up our neuroimmunology effort with the development program. Next slide, please. We have during the last couple of years systematically worked on transforming our R&D organization. That included a change in our R&D strategic focus to the focus areas outlined in the previous pipeline slide. The selected four areas represent biological clusters that have strong potential to deliver innovative therapies for diseases of the nervous system. Because of this strategy change, we have made several tactical changes that necessitated an extensive retooling of our R&D organization and technical platforms, bringing in many new competencies and capabilities. We are now fully active in all strategic biology areas across R&D with the start of the AprilBio partnership. Indeed, 2/3 o ur development programs are new since 2019. At the general level, we act modality agnostic, meaning that we go for drug candidates needed to target the most promising neuroscience. As a sign of this, we have now established biotherapeutic competencies across the entire R&D value chain, from early research to the market. We have established an experimental medicine capability aiming at de-risking programs early in development, as well as integrated the patient voice more extensively throughout R&D. In addition, we have systematically worked on enhancing our operational excellence and streamlining governance and decision-making. We see now signs that those efforts are translating into enhanced R&D productivity, both in terms of quality and speed. As one example, we have substantially increased our regulatory interactions, and we also have now many more programs eligible for special designation regulatory pathways. Moreover, we do see great signs of significant reduction in timelines, exemplified by the fast Vyepti rollout, as well as clear reductions in the clinical trial application approval timelines. I will now turn over to Anders for the financial comments. Thank you very much, Johan. Next slide, please. We as a team believe we delivered a very solid financial performance during 2021. We had a 3% growth. If we are excluding Northera, and as some of you recall, we actually predicted 50% decline of Northera due to generics. It ended up with 74%. We actually despite that were ending in the high end of the range for core EBIT. If you exclude the restructuring that we did during the year to also accommodate that we had lower revenue and creating a more fit organization for the future, then we were actually ending in the upper end of the core EBIT. EBIT, of course, were actually impacted by the sum DKK 250 million restructuring provision booked in the first quarter. We are also really happy to report that the goal that we set in the beginning of the year to deliver double-digit growth for the strategic brands was achieved by a 15% growth across the brands. Next slide, please. For 2022, we are now having the down year behind us, and therefore we also expect that we will have a revenue growth of 4%-5%. We expect that that will lead into earnings improvements, both from a nominal perspective but also from a margin expansion perspective. We will see double-digit growth again in the strategic brands, but we also anticipate that some of the mature brands, like Cipralex, will see a more normal erosion than we have seen in the pandemic. Anticipating the underlying decline of 5%-10%, that will of course mute the growth. We anticipate a total growth of 4%-5%. It is important to highlight that we will see improvement in our EBIT. If you look at EBIT and look at the mid-range, we will have improvement around DKK 400 million in total. The revenue improvement will of course come with higher contributions, gross profit contribution, and then we don't anticipate to have restructuring. At the same time, we will also invest more behind Vyepti. We will invest a bit more behind the other products because we anticipate that we are getting more into a normal situation where the pandemic is easing out. Of special note, please see that financial expenses will be higher in 2022, approximately DKK 300 million higher, and that is due to a value adjustment of the CVR that we are going to pay to the former shareholders in Alder BioPharmaceuticals. We have to pay in the first quarter DKK 1.5 billion that was dependent on the approval of Vyepti in Europe, which has actually happened. With that, I will hand back to Deborah to go through the share split. Thanks, Anders. Today we announced the new share structure for Lundbeck, a split of the Lundbeck share into A- and B- shares, with the intent that over the long run, the B- shares could be a new long-term funding source. Another tool, if you like, in the toolbox, to be able to pursue our expand and invest to grow strategy. The Lundbeck Foundation introduced this, and we have worked up together with The Lundbeck Foundation this share split. The purpose is to enable a growing Lundbeck to have access to capital and be able to use equity as a tool as Lundbeck grows in the future, given that Lundbeck will eventually become of a size that the foundation may not be able to match pro rata in any equity issuance. There is no change implied by this to our existing strategy or to the level of selectivity that we'll put behind any transactions that we look at. We've also explicitly stated that we do not have anything on the table at this time where we anticipate the use of this financial tool, and we want to be clear with all of you that this is being put in place for the long term. The foundation also intends to offer eligible shareholders a one-to-one exchange of their A- shares with the foundation B- shares if various shareholders would prefer to hold the B- share. To take you through the technicalities, I'm going to ask Markus Kede to take you through that. Thanks, Markus. Next slide. Thank you, Deborah. I will provide some more detail on the proposed share split and timing. The proposed split means that each existing share will be replaced with one A- share and four B- shares. Existing shareholders will not need to take any actions to enact the split of their shares. This will happen automatically when adopted by the general meeting. Post-split, one A- share and one B- share will have the same economic rights. This means, among other things, that each share will be entitled to the same dividend per share. The only difference in the share classes relates to voting rights. Each A- share will be entitled to 10 votes, and each B- share will be entitled to one vote. Since each shareholder will get the split of A- and B- shares, each shareholder will hold the same proportion of overall votes after the share split as they do immediately before the split. A- shares and B- shares cannot be converted one for another. However, as Deborah earlier alluded to, the Lundbeck Foundation has informed us that as a service to shareholders, they expect to offer to eligible shareholders a one-to-one exchange of A- shares with the equivalent number of B- shares held by the foundation. Further details of this exchange and the mechanism will be issued in due course. Further, there will be no lock-up or standstill in relation to the split. This will allow free movement within the share classes. Please go to the next slide. With today's announcement, Lundbeck's board of directors have asked management to engage with the Danish Financial Supervisory Authority and commence a listing document approval process. The review process with the FSA is expected to take several months. Following this, Lundbeck will issue invites to an extraordinary general meeting to facilitate the shareholder votes on the proposed share split. Depending on the listing document process, we expect this AGM to be held in June 2022. If approved by the general meeting, the share split will take effect one to two days after the AGM. With that, I hand it back to you, Deborah, for concluding remarks. Thanks, Markus. Next slide, please. As we go forward, we have good growth visibility into the coming years with no major patent expiries for several years into the future. We have a strong suite of strategic brands that will continue to grow. We have a strong brand that's developing in Vyepti that will continue its global rollout. We look forward to being a sustainable and profitable growing company into the years ahead. Next slide, please. Right now, our focus in 2022 is to maximize those growth drivers that we have in our hands in Abilify Maintena, Rexulti, Brintellix, and Vyepti while we continue to stand on a base of very strong cash generative mature products. Vyepti’s global rollout will continue to offer substantial growth opportunities. We will launch in 10 markets this year, but I emphasize that those launches will probably be happening towards the second half of the year, given time to get packages into the market. Rexulti has the opportunity to grow substantially with Alzheimer's agitation data readout and subsequent submission in 2023. That gives us good growth visibility from these brands into the next five to seven years. I'm very pleased with the way that we've been transforming in R&D to set us up well for the expanding future in neuroscience as the biology is becoming better understood with more targets and more modalities to achieve transformative outcomes for patients. Lundbeck is dedicated to restoring brain health, and to do so, we stand on a strong financial foundation, and of course, we'll continue our customary focus on making sure that all our investments are efficient. With that, we'll close the presentation and open for questions. Thank you. Ladies and gentlemen, if you have a question for the speakers, please press zero one on your telephone keypad. Once again, it is zero one to register for a question on your telephone keypad. Our first question comes from the line of James Gordon from JP Morgan. Please go ahead. Your line is open. Hello. James Gordon, J.P. Morgan. Thanks a lot for taking the questions. One on the share split and then one on Vyepti, please. So on the share split, I've heard a comment about no change to strategy, but I also noted previously talking about not buying anything that require lots of R&D or marketing step-up, such as the 2024 margin target couldn't be at risk. So why have you changed this now and could you consider doing something that would mean you wouldn't get the 30% margin? And how much firepower could you have? Would you do something transformational that could mean lower profitability in 2024 but much more pipeline, for instance? So that's the first question, please. The second question was about Vyepti. We did see quite a sharp sequential slowdown in Q4, only about 6% sequential growth. How much of that is patients first trying all CGRP before getting Vyepti? Could that be an ongoing issue, or do you think it's more COVID? How much acceleration should we expect to see moving into 2022? Would Q1 also see disruption sequentially? I think you have done in previous years with products like this. How comfortable are you? You could do consensus, which I think is about DKK 1.2 billion for Vyepti in 2022, please. Okay. Lots of questions there, James. Two categories of questions. Around the share split, this is something that was introduced by The Lundbeck foundation as they think about the long-term growth of Lundbeck, and we've said that there's nothing explicitly on the table right now that would require us to use equity. Up until now, we have been talking about how we would grow principally in thinking about our financial capacity with respect to raising debt and remaining investment grade, which requires us to pay down debt to the 2x EBITDA by the two-year timeframe. Yes, having an additional tool in our financial toolbox, in the share split does afford this company going forward, and I say, you know, from today and into the years and decades ahead, the opportunity to think about equity and think about what type of combination, partnership, license, what type of external innovation would be most appropriate to continue to build Lundbeck, both using our internal pipeline and external to deliver sustainable, profitable growth. I think one of the questions you had was, you know, why is this being done today? That's in the interest of being prepared for something before you need it. As you heard from Markus, it takes some time for all of the mechanics of this to be put in place. At this time when we don't have anything specific that would require equity, we can take the time to go through that process. With respect to talking about the 25% margin by 2024, we've always specified that would be with the current pipeline with the current Framework of our business. We will always look at external innovation and look to what it will deliver in the short, medium, and long term for Lundbeck's shareholders and how it will contribute to Lundbeck being a sustainably growing profitable company into the future. I'll stop there, and I'm gonna hand over to Jacob to take the Vyepti question. Thank you very much. James, good questions obviously. I will try to give you an answer. It may be a little bit of a longer one, but try to give you an answer. I think it's difficult sometimes to look at quarters. I think that for all brands, but I think especially for Vyepti, especially also in the beginning of a launch. On top of that, you have a Q4, which is impacted by Thanksgiving, U.S. holidays. I think in general, it sometimes is difficult to look at individual quarters to look at an uptake of a drug. I think what's important for me is to look at the overall strategy and positioning of Vyepti. We have a unique drug. We have a very efficacious, powerful drug, and I think with the brand positioning that we have in the U.S., also outside of the U.S. that we'll be working on, it sets us apart also in terms of the treatment algorithm and the patients that we're going for. I think when you look into 2022, first quarter will naturally be a little slower compared to the rest of the year. It has to do with a reset of deductibles, also authorization of patients coming in the beginning of the year. That takes a little bit longer time. I think the real sort of traction with Vyepti will come towards the remaining quarters of 2022. Not to comment anything on sales targets for next year, but I actually feel quite confident and comfortable about Vyepti, also going forward. As you can tell, I could probably talk a lot more about that, but I think I will end it there and then see if there are further questions coming regarding Vyepti. Next question. Thank you. Our next question comes from the line of Michael Leuchten from UBS. Please go ahead. Your line is open. Thank you very much. Michael Leuchten from UBS. Two questions, please. One, thank you for the details on the share split and timing. In terms of the decision processes to allocate capital, if and when, does that change at all with that structure? So does the foundation get more involved in decisions further down the line, or is the decision process the same and it's just another option that you can choose as you wish? So in a way, what's in it for the foundation to allow you to have that flexibility? And then a question on Vyepti. If we look back to the Alder acquisition, what's the level of Vyepti revenues when the deal starts to hit hurdle rates, given that we're still in this lower part of the launch curve and now the delay in Canada? Thank you. Okay. Michael, I'll start on the decision process to allocate capital. The Lundbeck management would propose deals as we always do. We survey the external landscape. We discuss the strategy with our board, the Lundbeck board, on an ongoing basis. It's the Lundbeck board that will make the decisions. Of course, the foundation does have representation on the Lundbeck board, but it is overall the Lundbeck board that governs the decision-making on how appropriate any use of capital is to support the strategy and to support the long-term profitable and sustainable growth of Lundbeck. There's really no difference than there is today. There is an additional tool within the toolbox to be able to use. Let me be clear, we could use equity today. It is a tool that is available to us. What the foundation, when it initiated this discussion, made clear is that over the years and decades ahead, Lundbeck will grow into a bigger and bigger company and therefore may outstrip the foundation's ability to participate pro rata in an equity split with the in an equity usage or equity issuance. With the share split and the use of the B- shares as the equity issuance, the foundation can continue to give a long-term stabilization ownership, which is commonly used within Denmark and within Scandinavia that has allowed companies to grow and thrive in over the very long term. It is with that perspective of building a long-term profitably growing company that this is initiated today. I'll stop there. With respect to the thinking about Vyepti and hurdle rates, I don't know whether, Anders, you would actually comment on that, and Jacob, you comment on the brand. Of course, what we have seen due to the pandemic is that there has been a parallel shift in the revenue uptake, but we have also used way lower cost level, or we have had way lower cost levels than we anticipated, which actually means that Vyepti has been more profitable in the first couple of years than we anticipated in the business case. We have also made some major improvement in the future costs. We have optimized our COGS 30%. It has been declined 30%-40%. There has been a lot of improvements done from a profitability point of view. From a revenue point of view, it's fair to say that we are waiting for; there's a pricing discussion ongoing in Canada, so that has been delayed. We have seen a shift in uptake due to that. It has been more difficult to get out there during the pandemic. I don't know if you want to add. Yeah, true. I think that's absolutely fair. The pandemic has impacted Vyepti. But coming back to also what I said in the beginning, I think we feel quite confident about where we are with Vyepti today, with the brand positioning that we have, with the plans that we have going forward, also in terms of optionality that we offer in infusion strategies in the U.S. We do see traction, also feedback coming back to us of the benefits of the drug. We are quite confident that Vyepti will become an important product for Lundbeck over time and the blockbuster that we had imagined. Thank you. Thank you. Our next question comes from the line of Michael Novod from Nordea. Please go ahead. Your line is open. Yeah, thanks a lot. It's Michael Novod from Nordea. Just a few follow-up questions. Maybe to the U.S. and North America, is there any risk, given your latest restructuring, that you are actually starving the sort of market dynamics your marketing in the U.S.? Or is that something that is set to change? You are guiding, I can see, an increase in sales marketing costs. I'm just worried that you may be starving your sales organization in the U.S. Then secondly, to the new share structure. It's obviously indicating, as was previously said, some more transformative stuff. I'm just trying to, from a management perspective, what would you prefer? Is it, say, fully accretive and immediately accretive commercial acquisition if you should do an acquisition, or is it the more sort of R&D focused? I'm just also trying to understand, and I don't think the answer was so clear earlier, whether you're sort of walking away from the midterm target of margin that you put in place. Just to get some feelings of what we could expect if you were to do and what you prefer in terms of acquisitions. Thanks. Jacob will start. Yeah, I'd be happy to talk to that. I don't see that issue, Michael. If you look at 2022, that will be for us a big Vyepti year, not only in the U.S., but also outside, where we're investing in the build-out of capabilities behind Vyepti across the world where we're launching. In the U.S., we are going to invest quite a bit more into Vyepti. I think we are targeted in our approach, and I think we have the resources available to make our brands a success also in the U.S. I would say also, if we look a little bit back in time, there's no doubt our profitability in the U.S. was higher than it is today. We have totally accepted that because we want to invest into our brands and we're building out. I don't see a U.S. resource perspective that is underserved in that way. Yeah. On your second question, I think we have consistently said that we are in a period where we have a pretty high R&D investment as we globalize Vyepti, bring on the CHO cell line, finish up the Rexulti, move forward the pipeline. At the same time, investing behind the launch of Vyepti, both getting back to a more normal level of spend in the U.S. and then gearing up for the launch outside the U.S. In 2021 and 2022, we knew those costs were going to be high. The focus was on either early-stage R&D deals being absorbed within the R&D budget or on late-stage, more near-term accretive deals that would help us grow the top line and grow the EBIT in that near-ish term. We want to be a company that expands towards the long-term profitable growth. Anything that we look at will really have to be geared in that way. I think in 2022, we still are looking at that near-term accretive landscape. We've also always said that we would need to continue to think about how do we supplement the mid-stage pipeline. We made good progress last year in our own portfolio, bringing two new molecules in. Of course, we will need to consider over time continuing to add to the mid-stage pipeline also for that growth in the late twenties and early thirties. As we always do, we look at the landscape, near-term accretive early stage and mid-stage with a discipline of saying, "What's the right timing to do any of those particular deals?" Timing has to do not only with what we're doing internally, but also what's happening in the external world. There has been a significant change in the valuations of biotech companies. That doesn't mean we're rushing out, you know, doing mid-stage deals. We're still looking for, you know, how do we bring in near-term accretive assets. We need to do the right things for Lundbeck short, medium, and long term, so we keep an eye on the landscape broadly at all times. I still don't really get clarity on sort of the mid-term margin target. Is it in place? Is it not in place? It's just maybe it's just me not hearing it. What we've said is that we aim to be at 25% in 2024 with the current portfolio, and then we would look at near-term accretive deals. Will they be accretive by that particular date? Ideally, yes. If it delayed it a year but did better in the long term, we would also think about that. But with what we currently have in place, we would like to be at 25% in 2024. Okay. Thank you very much. Thank you. Our next question comes from the line of Sachin Jain from Bank of America. Please go ahead, your line is open. Hello there. Sachin Jain, Bank of America. Two topics, and I'm afraid they're the same topics you've had. Firstly, on Vyepti, could you just comment on how much you think you're being impacted by aggressive couponing of orals, and where do you expect that to continue into next year, and what visibility you have? Then, secondly, what metrics you're tracking at the patient level that give you the clear confidence that you're relaying? I mean, I think on the 2Q call you mentioned vial demand, but just any color on what are the metrics that give you confidence, given the lack of sequential growth we're seeing. Then on the M&A commentary, Deborah, why don't we just follow on? I understand your comments that there's nothing immediate, but I assume that in doing this, some size criteria were discussed with the board. Given your balance sheet structure and your very attractive cash flow generation, I guess the balance sheet without equity allows a mid-single digit DKK billion size deal by the end of next year into 2024. Two questions. One, what size of deal is potentially being considered in the midterm or to have put this equity change in place? And then secondly, just to understand your timeframe comments. I understand there's nothing immediate, and the commentary is very much you're putting this in place for the long term. But in the answer to the last question, you've talked about current equity valuations. Just wondering very simply if you're able to rule out an equity-based deal in the next 18-24 months, or is that a possibility to any point at which this share structure is changed beginning in the middle of the year? Thank you. Okay, maybe you'd like to start on Vyepti. I can certainly start on Vyepti. Thank you very much for the question, Sachin. Again, it will be a little bit of a longer answer. I think the U.S. market in general is, I would say quite impacted by the orals entering the market. They are, as you've seen, quite aggressive. They're sampling heavy. They also have big sales forces and are doing a lot of promotion in the market. That said, coming back to the positioning of Vyepti, as I said in the beginning. I think it's important that we look at the treatment of migraine. If you look at the spectrum from acute to entering prevention to episodic, frequent episodic, and then chronic patients, where we are focusing Vyepti and where we're going to win is on patients that are in the chronic or high frequent episodic segment. That's also where we believe we are getting the most patients. It's also where the profile of Vyepti is very strong. We have a very powerful drug that is also delivering in terms of the feedback that we are getting. On the orals, they are obviously approved for acute and we also have one that is only approved for early prevention. They are mostly playing in the field of acute going into prevention or the earlier stage of prevention. I know, of course, that that also impacts later stage of prevention, but I would expect that what you're going to see over time is a bigger impact on the sub-Qs than on Vyepti when it comes to oral impact. There is no doubt that what we see now is a market that is heavily impacted by the orals entering the market. I think over time you will see, and that's where you're going to judge the success of Vyepti is also going to win, more focused on chronic high episodic patients. On top of that, we are the only anti-CGRP that has medication overuse headache on its label. That's also something that we will talk about, especially outside of U.S., but also in the U.S. talk about the use of acute meds for patients, and how Vyepti can benefit that in a potential treatment. I think we have a good positioning that sets us aside and is different to the orals. Obviously, we look at vial demand growth in the U.S. We also look at utilization of the 300 mg in the treatment algorithm for Vyepti. With respect to the many questions around the use of equity. What we have communicated is that if we use the more traditional methods of raising debt, we had a ticket size depending on the acquisition target and whether it brought revenue and EBIT of $1 billion-$2 billion in order to retain an investment grade rating, recovering the net debt to EBITDA within 24 months. With respect to equity, that's not the choice of currency one uses for an acquisition of that type of size. Equity would only be contemplated if it were something that were a larger transaction to be funded. Then it depends on that on the type of transaction, what type of entity would you be using that capital to invest in? It could be something that also brings revenue and EBIT as well as pipeline. There's so many different options of how that could be deployed. I would say that we don't have anything on the table now. Would I guarantee that it would never be used in 18-24 months? I cannot see far enough into the future to be able to make that guarantee. All I can say is we don't have anything on the table now. Very clear. Thank you. Thank you. Our next question comes from the line of Matt Weston from Credit Suisse. Please go ahead. Your line is open. Thank you very much. Two questions, please. I'm gonna stick to the time-old theme of the share structure and Vyepti. I do think it is very unusual, and certainly the feedback from the market is that it's been very unusual that a shareholder proposes a change in capital structure. I'm just mindful that the foundation has a goal to double its wealth by 2030 in order to deliver on its commitments to distribute to the causes that it supports. Is this the foundation saying that you don't have enough in-house to achieve their goal, and so they want you to do more because they need more? Should we therefore expect the foundation is taking more of an activist role in your growth, or am I just overinterpreting? The second question on Vyepti, you obviously have a number of readouts coming in migraine prevention and cluster headache. Can you remind me of how that scales up the current opportunity? If you see what the current opportunity is with the current label, how much do you add with prevention, and then how much you add again incrementally with cluster headache? Thank you. Okay. Thanks, Matt, for the questions. I think the foundation have been very clear that they are a long-term owner, and they believe that long-term ownership gives the company the stability to continue to prosecute growth in neuroscience. They sit on the board, they understand where Lundbeck is. They have supported the strategy of building our pipeline both internally, the refocused innovation strategy, the advancement of molecules within the pipeline, the acquisitions of Abide and Alder, and they have agreed with the strategy that we'll continue to build not only internally but through external innovation. All of those tenets are in place and are supported by the Lundbeck board, which is the decision-making body for Lundbeck, but of course, we have foundation representatives on that board. When we look out into the future, Lundbeck is a company that's 107 years old. It's been operating in neuroscience for 70 years, and the foundation takes a decades-long perspective. They do think about what this company will look like, not just a year or five years, but 10 and 20 and beyond years into the future. It is with that in mind that they want to retain that stable long-term ownership, but enable the company as it grows to be able to deploy equity as a financial resource. Are they an active participant in the board of Lundbeck in that representation? Absolutely. Always have been, always will be. The use of the word activist has a different quality, and I would say that that is not what we're seeing. We're seeing the same active engagement together with management around the strategy to build Lundbeck into a sustainably, profitably growing company. We've always said that we do need to continue to look externally as well as foster the growth of our internal pipeline. That's completely consistent with the strategy that we've worked on with the board over the years. Thank you. Thank you. Vyepti It's on the Vyepti. [chip in], yeah. Maybe. On the question on Vyepti, of course, as you know, Vyepti is fully approved in prevention. The studies that we're doing there is more to sustain our profile, give us an edge in the field, even more than what we have today. The real sort of label expansion that we're looking at here is the ALLEVIATE trial in cluster headache, and we haven't said what that opportunity brings, and I don't think we will comment on that today. What I could add to that is obviously we continuously monitor what beyond the ongoing activities we could do. One thing we already talked about is that we'll do some additional like phase IV activities on medication overuse headache to really build on what we already have in the label that differentiates us to build even stronger case there. Obviously, we're also looking at other potential line extensions. We tread very carefully there. It's a much higher R&D risk when you go further out, and we already have a big investment in R&D in Vyepti to deliver the more harder core data that we need to deliver right now, including the Asian expansion. Yeah. Just a last comment from me, Matt. You said, you know, how much do we think the expansion in prevention would bring. We have the label in prevention. We're amplifying it with you know, the trial and medication overuse, but that already exists in the label. We have prevention in both episodic, frequent episodic and chronic migraine, and we know Vyepti is being used in the most heavily impacted patients given the powerful efficacy that it demonstrates. Then episodic cluster headache would of course be a new indication, but migraine is the major indication, and we're at the beginning of the global rollout and growth in migraine. Thanks, Deborah. I should have asked it more differently. I should have asked what if you see any incremental reach from the new data. I guess that's what I was trying to get across. With the new prevention studies, it sounds that you don't. You see that as reinforcement, and then the new reach comes from cluster headache. I would say that's accurate. Yes. Yeah. Obviously, we talked about the DELIVER study previously, where we gave a good data set to support that it can work when you fail on two to four previous treatments, and that's of course important also to position the drug. Others have that type of data, but it was very critical for us in, particularly in Europe, but also beyond to build on that case. We had tremendously good data out of that study. Extraordinary good data. We're building on what we have a lot. Thank you. Thank you. Our next question comes from the line of Emily Field from Barclays. Please go ahead. Your line is open. Hi. Thanks for taking my question. Just a couple quick ones. Vyepti, how are you thinking about the launch trajectory in Europe? Obviously relative to the U.S. launching at a more favorable time in the pandemic. However, I would imagine that's somewhat offset by the need to obtain reimbursement in the various jurisdictions. Also a non-Vyepti business basis question, sort of, you know, where we're at in terms of the pandemic on the base MDD market. You know, where do psychiatry visits stand relative to baseline? You know, are you still seeing depressed switches or new medication starts, due to more telehealth? Just sort of how that trajectory is shaping up. Just a very mechanical question on the share split. You know, just, and this is for my own understanding. Ordinary shareholders will get their A- and B- shares, and then I would imagine the incentive to exchange shares with the foundation is that the super voting A-shares likely in the market will trade at a premium, and that is an open-ended offer. I would imagine that, you know, the extent to which those shares change hands will just depend on the premium of the super voting A- shares to the B- shares in the market. Thank you. Okay, great. Jacob, you'll start. Yeah, I can. Markus, you'll take the question on the share. Yeah. Thanks very much for the question. Vyepti for Europe rollout in Europe, not only for Vyepti but for, I would say, every new brand that you introduce takes time. We have full regulatory approval and now begins the process of obtaining market access and price and reimbursement. Depending on markets that can take anywhere between a few months and up to some years. That's also what you should expect for Vyepti. We will launch in the first markets in Europe before the summer. Then it will start to accelerate as we get into the second half, and then into 2023, and there will even be markets that are not launching before 2024. That is sort of a usual picture for Europe. When it comes to the MDD market, I agree with you. We have seen a contraction of the market, especially in the U.S. We've also seen it a few other places, but not nearly to the same degree. There are slight signs of recovery in the U.S., toward the end of 2021. Hopefully, we will see that continue so that the branded MDD market comes back to growth in 2022. We're building our assumptions on a world that will be even more open in 2022 than what we've seen last year, and also providing us more access in terms of coming out and detailing our products. Just adding a bit to that, I think we've seen more of an impact in the broad MDD market, including the GP segment more, which obviously is where Trintellix is positioned versus the adjunct market where Rexulti is positioned. Both were affected by telehealth, where new to brand prescriptions are less frequent. We're seeing more of the recovery in the adjunct section and the beginnings of recovery in the broad MDD section. That market has only now returned in total TRxs across brand and generic to where it was in 2019. We hope that market will return to growth this year. Markus, maybe I can ask you to comment on Emily's question on the mechanics. Yes, absolutely. It's fully correct that all ordinary shareholders today will get A- shares and B- shares, and the exchange offer by the foundation will be an offer for each shareholder to, or each eligible shareholder to, take into account. Obviously, if the A- shares were traded in the market to a premium, that could be an advisable thing to execute in the market instead of accepting the exchange offer. Yes, it will be an exchange offer that each shareholder can take into account. Thank you very much. Thank you. Our next question comes from the line of Susanne Kirk from Handelsbanken. Please go ahead. Your line is open. Hello. Thank you for taking my call. I have two questions concerning Vyepti. First of all, given Vyepti holds a share of about 4% of the CGRP market, where do you see this heading post the pandemic? Keeping in mind the oral CGRPs availability in the U.S. and now Biohaven seeking approval outside of the U.S. with the Pfizer backing. The second question, when looking at your typical Vyepti patient, are these patients CGRP naive patients, or have they had previous failures with the orals of the subcutaneous CGRPs? Jacob? Yeah, thanks very much. Let me try to see if I can answer your question. If we take the last question first on the typical patients. As I said, our focus is primarily on patients in the higher frequent episodic migraine cases and chronic patients. That means naturally you will have a larger proportion of patients that have been through other treatments before. It doesn't have to be that way, and I think also, still early days, so I'm leaning out a little bit here, but what we also start to see is a growing confidence in using Vyepti that over time may also trigger earlier use of Vyepti. That's still early to speculate in. Naturally, when you have that position, you will see patients coming in that have tried other treatments before. Your other question around the ex-U.S. Pfizer backing on Biohaven's drug Nurtec. I think we have to await what happens with the regulatory process. Still no outcome there. I know they have filed for both acute and prevention. Let's wait and see what that outcome is. It is perhaps more difficult to imagine a European market that will be acceptable for a price level than what we've seen in the U.S., but what that means for their plans is anyone's guess at this time. I think you had one more question that I didn't note down, maybe. It was the patient, but I think you sort of answered. Yes. Okay. I mean, right now, just to be clear, the patients have typically, as with any new launch, are patients who have tried something else that hasn't worked as well for them. The initial patients that we saw were often coming off subQ CGRPs and were taken into Vyepti. We also have seen people coming off orals into Vyepti, but because the orals are relatively new, there are fewer of those. As Jacob said, as people use Vyepti and see its power in those most impacted patients, it can open up for them to use it earlier. Yeah, great. Thank you. Thank you. Our next question comes from [audio distortion] from Goldman Sachs. Please go ahead. Your line is open. Hi. Thank you so much. A couple of kind of broad topics, I suspect. The first one is just coming back to this, capital structure. Deborah, thank you so much for providing all the details so far. I'm just wondering, and maybe I'm sure I'm missing something, but can you help me understand why this is a good thing from the perspective of the non-foundation shareholder at Lundbeck? You're inherently proposing, you are the foundation, to kind of dilute their voting rights, in the event you were to do a transaction. I'm sure kind of you paid enough thought to why that is good for the shareholders. Just wondering what I'm missing there. Linked to that, are you expecting any impact from the perspective of inclusion in various indexes kind of across the Danish exchange or kind of the broader European markets as a function of this structural change? Separately, as I look at the two-month formulation for Abilify Maintena, how should I think about your plan to kind of commercialize that? Should I think about it as moving the existing patients onto the new formulation? Should I think of it as a switch market or should think of it as new patient starts? Just any kind of insight there from a commercial perspective would be very helpful. Thank you. Thanks, [Carra]. Perhaps we'll start with the third question first, and Jacob will take it away on Abilify Maintena. Yes, absolutely. Thanks very much. Abilify Maintena two-month, I think is a very good addition to our portfolio. Also fits very well into the LOE landscape that we've seen, so we're really pleased to be able to offer that option going forward. I think, naturally you should expect something which we've also seen in the market, which is a conversion from the one-month to the two-month to a higher level than capturing new patients. That is the picture that you should expect. Great. As we think about the share split, remember that the economic value for every shareholder that currently owns Lundbeck is the same the day after the split is approved, should that happen at the extraordinary general meeting. Because of the same economic value in each share, the ability to appreciate value from those shares is also equivalent going forward. We will see the minority shareholders' point of view on this, but they also have come into the share knowing that there is a majority shareholder whose stated position is that they are a long-term owner of Lundbeck, and they wish to remain a long-term owner of Lundbeck. They have stated that they want to see their foundation grow. For that, they anticipate Lundbeck will be growing. We anticipate Lundbeck will be growing. This share structure is put in place to enable the foundation not to limit the possibilities as Lundbeck becomes bigger, and it may be more difficult for them to participate pro rata. I think it is with the perspective of enabling Lundbeck to grow, which benefits all shareholders, that this is undertaken. Then I'll ask Markus to answer the question on the listings. Yes. In relation to the inclusion in indexes, that is of course a consequence of the market cap and the trading in the shares. What we understand is that it will be included both the A- and B- shares in the indexes in Denmark as a starting point, and then it will depend on the development and trading and size of the shares going forward. Thank you. Thank you. Our next question comes from the line of Rajan [Sharma] from Deutsche Bank. Please go ahead, your line is open. Hi. Thanks for the question. It's just one last [audio distortion]. Could you just give us an update on the discussion that you're having with the FDA on the PTSD study design? And maybe if you could just kinda talk about your, you know, realistic expectations of conclusions of those discussions. Okay. That's probably for me. We have an ongoing conversation with FDA. We actually had the meetings with them already and discussed the plan forward for a redesign. I'm not going into the details of the redesign at this time point, but I can say that they have been very productive conversations we had with the regulators, and we're looking forward to be able to come up with some redesign that may help us to conclude these trials. The current enrollment rate is basically prohibitive to continue as we're doing it right now. We need to redesign and obviously see a sample resizing of the trials. The prospect of this being positive, whatever design we have, of course, is completely unknown because there were two ongoing phase III trials that we expect to support any approvability. I like to remind you, we had a phase II study that we did some years back and even some additional activities within this indication. They were all supportive of going into this phase III program. This was on top of standard of care or SSRI. That's the comparator we have, SSRI versus brexpiprazole. The data from phase II was encouraging enough for us to initiate this program. That's why we did it. Obviously we have to see when and how we finish the trials, but if the redesign is successful, hopefully can do that in the foreseeable future. We can see the data, basically. Great. Well, we're well beyond the scheduled time for this meeting. If there's one last question, we don't see any further questions. With that. We have no more questions registered. Great. Thank you all for attending. We appreciate your interest. This now concludes our conference. Thank you all for attending. You may now disconnect.