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company announcement Financial report for the period 1 January 2021 to 31 March 2021 5 May 2021 Novo Nordisk's net profit increased by 6 % in the first three months of 2021 • • novo nordisk Operating profit decreased by 8 % in Danish kroner and increased by 3 % at constant exchange rates ( CER ) . Sales remained unchanged in Danish kroner and increased by 7 % at CER to DKK 33.8 billion . Sales in International Operations increased by 2 % in Danish kroner ( 9 % at CER ) , and sales in North America Operations decreased by 3 % in Danish kroner ( increased 6 % at CER ) . Sales growth is negatively impacted by COVID - 19 - related stocking in 2020 , partially offset by inventory changes and timing of shipments in 2021 . Sales within Diabetes and Obesity care increased by 1 % in Danish kroner to DKK 28.8 billion ( 9 % at CER ) , driven by GLP - 1 growth of 13 % in Danish kroner ( 23 % at CER ) reflecting the uptake of OzempicⓇ and RybelsusⓇ . Biopharm sales decreased by 6 % in Danish kroner ( increased by 1 % at CER ) . • Within R & D , Novo Nordisk decided to initiate phase 3a development with 50 mg oral semaglutide in obesity . Following the Refusal to File letter in the US covering the label expansion application for once - weekly semaglutide 2.0 mg for the treatment of type 2 diabetes , Novo Nordisk is working towards resubmission in the second quarter of 2021 . ⚫ For the 2021 outlook , sales growth is now expected to be 6-10 % at CER , and operating profit growth is now expected to be 5-9 % at CER . The ongoing share buyback programme will be expanded to DKK 18 billion . PROFIT AND LOSS DKK million Net sales Q1 2021 Q1 2020 Growth as reported Growth at CER * Operating profit Net profit Diluted earnings per share ( in DKK ) * CER : Constant exchange rates ( average 2020 ) . 33,804 33,875 0 % 7 % 14,982 16,302 ( 8 % ) 3 % 12,623 11,897 6 % N / A 5.45 5.05 8 % N / A Lars Fruergaard Jørgensen , president and CEO : " We are very encouraged with the sales growth in the first three months of 2021. Sales growth was driven by all therapy areas and across geographical areas within International Operations as well as North America Operations where growth has accelerated in the US . We were also pleased to announce plans to develop oral semaglutide as a convenient and effective treatment option for people with obesity , complementing our injectable obesity medications . The solid financial performance in the first three months of 2021 has enabled us to raise our outlook range for the full year . " On 5 May 2021 at 13.00 CEST , corresponding to 7.00 am EDT , an earnings call will be held . Investors will be able to listen in via a link on novonordisk.com , which can be found under ' Investors ' . Novo Nordisk A / S Investor Relations Novo Allé 2880 Bagsværd Denmark Telephone : +45 4444 8888 www.novonordisk.com CVR Number : 24 25 67 90 Company announcement No 30/2021