Page 1

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON , D.C. 20549 FORM 20 - F ( Mark One ) REGISTRATION STATEMENT PURSUANT TO SECTION 12 ( b ) OR ( g ) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 for the fiscal year ended December , 31 2020 OR ° TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 for the transition period from to OR ° SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of event requiring this shell company report Commission File Number : 001-39777 NANOBIOTIX S.A. ( Exact name of registrant as specified in its charter ) France ( Jurisdiction of incorporation or organization ) Nanobiotix S.A. 60 rue de Wattignies 75012 Paris , France ( Address of principal executive offices ) Mr. Philippe Mauberna Chief Financial Officer Nanobiotix S.A. 60 rue de Wattignies 75012 Paris , France Tel : +33 ( 0 ) 1 40 26 04 70 , Fax : +33 ( 0 ) 1 40 26 04 44 ( Name , Telephone , E - mail and / or Facsimile number and Address of Company Contact Person ) Securities registered or to be registered pursuant to Section 12 ( b ) of the Act : Title of each class American depositary shares , each representing one ordinary share , nominal value € 0.03 per share Ordinary shares , nominal value € 0.03 per share * * Not for trading , but only in connection with the registration of the American Depositary Shares . Trading Symbol NBTX Name of each exchange on which registered The Nasdaq Stock Market LLC The Nasdaq Stock Market LLC *