Morning. This is O'Reilly from the Global IR from the Takeda Pharmaceutical Industry. Thank you very much for joining us for the webinar today for the TYK2 inhibitor, NDI-034858. First, let me explain about the language setting. To listen to this call in English, please click the Language Select button. Okay at the bottom of the Zoom window and select English. Before starting, I'd like to remind everyone that we will be discussing forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Actual result may different materially from those discussed today. The factor that could cause our actual result of different materiality and discuss in the our most recent Form 20-F and in our other SEC filings. Please also refer to the important notice on page 2. Now I'd like to move on to the presentation today. First, we would like to invite our CEO, Christophe Weber, and also the R&D President, Andy Plump, who is going to give the presentation, and then followed by the question answers, answer session. Now I'd like to start. Thank you, Chris and Ayako. Good morning and good evening, everyone. It's my great pleasure to welcome you to this conference call to discuss Takeda announcement to acquire this late-stage potential best-in-class oral allosteric TYK2 inhibitors, NDI-034858, which will be called TAK-279 upon closing. In the following discussion, we'll use TAK-279. Adding this TYK2 inhibitor to our late-stage pipeline gives Takeda a very exciting program that has the potential to significantly expand our portfolio and patient impact while enhancing our growth strategy beyond ENTYVIO. This program is aligned with our therapeutic area strategy and with our strong background in immune-mediated disease. We are very confident that we can execute a broad development program and deliver our best-in-class therapy for patients that could also have significant revenue potential for Takeda. Now I go on slide three. Slide three is a summary of the strategic rationale and deal terms. We are very extremely excited to acquire TAK-279 because of its potential to demonstrate best-in-class efficacy as a consequence of its wide therapeutic margin. Andy will further explain. Its unique property should allow to demonstrate efficacy in multiple immune-mediated disease, including psoriasis, inflammatory bowel disease, psoriatic arthritis, lupus, and others. Considering the strong alignment with Takeda therapeutic area strategy and early data demonstrating the high selectivity of the molecule, we have been actually evaluating this asset for some time. Last month, Nimbus announced positive phase 2b data in the lead indication of psoriasis. After seeing the data, particularly the PASI score, we are very optimistic about its differentiation within the TYK2 class and potential to be transformative in the broader psoriasis market. We expect to initiate a phase 3 psoriasis study in 2023, with potential for regulatory filing in the fiscal year 2025 to 2027 timeframe. This means that the program could be generating meaningful revenue by the early 2030, enhancing our growth profile beyond ENTYVIO. Under the term of our agreement with Nimbus, we'll pay $4 billion upfront and two milestone payment of $1 billion each upon reaching annual net sales of $4 billion and $5 billion, which we believe, and I guess Nimbus also, are realistic milestones. Obviously, peak revenue should be higher than this milestone. We plan to fund the deal primarily through cash on hand and expect to close within this fiscal year, pending antitrust review. I'd like to now hand over to Andy to dive more deeply into the profile of the molecule. Terrific. Thank you very much, Christophe. I'd like to spend a few minutes sharing with you why we're so excited about TAK-279. Let's dive in firstly to the pharmacology, and then we'll speak a little bit to the clinical data that are out there. TAK-279 is a novel molecule that was discovered and initially developed by Nimbus. It's an oral pill. It's a highly potent and selective, importantly allosteric and unique allosteric tyrosine kinase or TYK2 inhibitor. Let's talk a little bit about the innate immune system and the role that TYK2 plays in innate immune signal transduction. TYK2 is a signaling molecule that pairs with JAK to help to mediate signaling from pro-inflammatory cytokines like IL-12, IL-23, or as you see also in this slide, interferon alpha or interferon beta. TYK2 historically has had a very strong human genetics association with inflammatory bowel disease. In fact, it's one of the most strong human genetic associations that's been a driver of multiple drug discovery programs. More recently, there's been pharmacological proof of concept in humans for the use of TYK2 to treat a number of autoimmune and inflammatory diseases. Let's talk a little bit about that. TYK2 pairs with JAK as a heterodimer, and when one of the cytokines IL-12, IL-23 or interferon bind to its cognate receptor, an inflammatory signal is sent to the cell. We know that you can inhibit this signal with antibodies that block IL-12 or IL-23. These antibodies have efficacy across a range of autoimmune diseases, including psoriasis and inflammatory bowel disease. Similarly, you can inhibit this signaling cascade by blocking one of the JAKs. These inhibitors have benefits across a range of autoimmune diseases. The challenge is, with the JAKs has been safety. JAKs contain black box warnings for cardiovascular side effects as well as other side effects. Why are we so excited about the TYK2 mechanism? TYK2 is related to JAK. It's very difficult to make a highly selective inhibitor of TYK2. Nimbus has done just that. As you look to the left, you get a sense for the potency of the TAK-279 molecule, NDI, as well as its selectivity. You can see that TAK-279 has exquisite biochemical selectivity to TYK2. It is a unique TYK2 inhibitor with 1.5 times 10 to the 6th. That's 1.5 million-fold selectivity of TYK to JAK, so it does not inhibit JAK. Relative to the first in class agent, deucravacitinib, our selectivity, TAK-279 selectivity is significantly greater. It's 1.3 times 10 to the 4th. Why is this so important? Because it means that we can dose up to the highest levels of inhibition for TYK and not worry about inhibiting JAK and thereby not picking up JAK-related toxicities. This pharmacology provides one of 3 levels of rationale for why we believe TAK-279 has the potential to be a truly best in class agent. One, as I've mentioned to you, it's the selective pharmacology. The second are the dose ranging data, the phase 2B data that have been published for DUPIXENT. We know that when DUPIXENT is dosed up to higher levels with higher levels of inhibition of TYK2, there's more efficacy, more clinical response in psoriasis. The third is that we've had a chance, in a confidential manner, to look obviously at the Nimbus phase 2B data for TAK-279. We believe that put together the pharmacology, the experience with DUPIXENT at higher doses than it's marketed and labeled indication, and the blinded data for TAK-279 in its phase 2B study, that we have a best in class agent for psoriasis and likely other autoimmune conditions. With that, Christophe, I'll hand it back to you. Thank you, Andy. We really believe that this asset has a potential for best in class efficacy and safety, as Andy just explained, in multiple immune-mediated disease and a broad range of indication could represent obviously a very high revenue opportunity. The first indication is psoriasis, for which Nimbus announced positive top line phase 2B result last month. The detailed result of the study will be disclosed early in 2023, we had access to these results. We plan to initiate a phase 3 study next year. This give us a projected regulatory filing timeline within fiscal 25-27 for this indication, meaning that this asset could be on the market and generating meaningful revenue before the end of the decade. Beyond psoriasis, our other priorities indication are inflammatory bowel disease, psoriatic arthritis, and lupus. Additionally, this mechanism also provides the opportunity to consider a range of other immune-mediated disease, such as rheumatoid arthritis, multiple sclerosis, and atopic dermatitis. We'll explore this additional indication with discipline and speed to deliver value for both patients and our business. Takeda has the expertise in-house to execute a clinical development plan in this immune and in-inflammation indication. It might not be obvious to you that we have this expertise, but we have. Why? Because we are in GI, we are in IBD. ENTYVIO obviously is a very good selective product, so it doesn't have a broad indication. Our team are specialized in GI and many member of our team has worked on assets in this field who have broad indication and therefore in-house through our GI specialized unit, we have the expertise to develop this asset. Actually we have the expertise to assess this asset in the first place, and we are very confident that we will be able to develop it. Of course, we have also a global scale which will allow us to commercialize this asset globally. In summary, by virtue of its unique allosteric mechanism of action, TAK-279 is both a potent and highly selective TYK2 inhibitor with exceptional clinical activity, strong tolerability profile, and wide therapeutic margin. We have seen the phase 2 data. We are very excited by the differentiation of this molecule and believe that it has the potential to be best in class. It will offer a transformative combination of efficacy, safety, and convenience across a wide range of immune-mediated condition. Thank you, we'll now open for Q&A. We would like to move on to the Q&A. Please indicate by show of your hands. The first question was from Yamaguchi-san from the Citigroup. Hi, can you hear me? Yes. Yes, we can hear you. Yeah. Good morning from Tokyo. Yamaguchi from Citi. Quickly, two questions. The first one of this regarding this deal. I think you saw the data on the Phase 2B, which is not published yet. I understand the drug works very actively compared to placebo. Can you give me some overall impression how it works versus uncertain, which already is launched by Bristol Myers Squibb? That's the first question. This data is showing your pharmacological kind of assessment in a clinical setting. That's the first question. The second question is the $4 billion of the late-stage asset may be okay, but it's a big deal over cash. Will this cash payment have an impact to your potential shareholder return impact for, especially for next fiscal year? Thank you. Thank you, Yamaguchi-san. I think the first question can go to Andy, and then Costa for the second question. Yeah. Thank you very much, Chris. Thanks, Yamaguchi-san. Thank you. We have in fact seen the, of course, seen the phase 2b data, those data will be disclosed in early calendar year 2023. You'll have a chance to see them as well. You know, what we can say really at this point is two t hings. One is that we believe based on what we've seen, that it has the potential to be a best-in-class asset versus deucravacitinib. The second is you can go back and look at the published phase 2b data from deucravacitinib, and you can get a sense for what efficacy looks like as deucravacitinib dose is higher above the marketed dose. There was a dose range that was studied by deucravacitinib in its phase 2b study Ultimately, the decision was made to take a sub-optimal, sub-maximal efficacious dose into phase 3, potentially for safety reasons. We think given the selectivity of our molecule, we can dose higher, avoid JAK-related safety effects, and pick up that additional efficacy. So far, what we've seen in the phase 2b study confirms that the hypothesis. Thank you. Good morning, Yamaguchi-san. Morning. Andy here. Thank you very much for your question. Let me just start by saying that, you know, we're very pleased with the progress in reducing our debt ratio towards low 2 times. Even with this acquisition, we expect to close this fiscal year with a net debt ratio in the low to mid 2s, and with a weighted average interest rate fixed at 2%, so that doesn't change. Just wanna remind everyone that the majority of the payment for this deal, the upfront, is paid through cash on hand. If you remember, in the first half of this fiscal year, we had cash on hand of approximately JPY 800 billion. Why is that the case? Well, we have strong and abundant free cash flow, and we believe this will continue on a moving forward basis as well. Overall, you know, there's no change to our capital allocation policy in particular around, you know, investing for growth, de-leveraging, getting down to the low two times. We're still committed to that, of course, very much committed to shareholder returns. Thank you. Thank you. Thank you, sir. We'd like to move on to Muraoka-san, Morgan Stanley. Next question, please. The floor is yours. Good morning. Muraoka is from Morgan Stanley. I'm speaking in Japanese, can you hear me? Very clear, sir. My first question is economics related. Regulatory milestone is not written here. You do not anticipate any hitch with the regulatory basis. No problem with the regulation and tolerability that you mentioned, and also that there is going the publication published on the doctor's association as well. From the point of how about the briefing meeting for the investor for us, 868 included? If there is going to investors briefing meeting in spring, that will be greatly appreciated. Number three, you use the JPY 4 billion, excuse me. How about the tuck in? There is going to be that for some time that no acquisition, but well, can we anticipate in a rather short frequency of the $1 billion or $2 billion more or some longer interval? That's all. Thank you. Perhaps the question on the regulatory milestones or the deal structure, perhaps Christophe can take that. Also the final question. about what our future M&A strategy looks like, having done this $4 billion deal, perhaps, I don't know, Andy, you could maybe comment on when we may expect to announce more data on the profile of this product? Yeah. Thank you very much, Muraoka, it's Christoph. Good morning. You know, first I would like to say that, as we mentioned, we have been following this compound for quite a while, because we are in this therapy area. We felt that this is now the right time to have this type of acquisition. Why? Because deucravacitinib has been approved with a very strong label actually. We have seen a lot of data on the NDI-034858, TAK-279, both clinical data as well as pharmacological. We think that the compound itself, the class also, is very much de-risked in that regard. By the way, it was a competitive process to acquire this asset. We were not alone. The revenue milestone felt the right one considering that it's a de-risk class and the potential. I think the milestone are reflecting very well the potential of the assets. Regarding future acquisition, first, I would like to say that we are extremely disciplined, when we assess products. We have always, we look at return on invested capital, we look at the risk. We are extremely disciplined when we go into these assets. We are also committed to our low 2s net debt to EBITDA, and to shareholder returns. I think any future BD deal will be need to be taken into consideration the overall picture that we are committed to our low 2s, we are committed to our margin, and we are committed to shareholder return. Muraoka, it's Andy. Right now obviously Nimbus still owns the molecule, and they're still managing disclosures and their program. We're working very closely with them. That's a part of our deal, so that we can accelerate the start of the phase 3 studies, which will be under our control starting next year. Our hope is that we'll be able to close the deal by the end of this fiscal year. What Nimbus has disclosed is that they will be sharing the phase 2b data at an upcoming academic medical conference in early calendar year 2023. Our expectation is that we would, you know, once that transition occurs to Takeda, that we would follow through with that disclosure. We're also obviously getting our heads around the extent of this study. Are moving full speed ahead with psoriasis next year, phase 3 studies in psoriasis. Read out from an ongoing phase 2b study in psoriatic arthritis, where there's already proof of concept for this mechanism. Starting to build a strategy to expand in the range of autoimmune indications that Christophe mentioned earlier. We'll be starting proof of concept studies next year in ulcerative colitis and Crohn's disease, we'll be looking carefully at a range of other indications, including lupus, where interesting proof of concept data have also emerged. Thank you very much. The next question is from JP Morgan, Miss Wakao-san, please. This is Wakao from JP Morgan. Good morning. From my side, my first question is regarding this acquisition, the background of this acquisition. Is there any change about the forecast for the future development? Also that biosimilar of ENTYVIO will not come into the market in 2020s, and also the existing pipeline, you have acquired a confidence. You don't have, you know, any concerns about the future development, but you decided to have the acquisition of this spending the $4 billion. That's why I'd like to ask this question first. Second question is regarding for the future development. For this, the deucravacitinib head-to-head phase 2 study, are you expecting that? Since you have the very high confidence, maybe the head-to-head will be better. Also timing for the filing is 2025-2027. Why you have such a range? That's all. Thank you for the question. Perhaps Christoph can answer the first question about whether this deal reflect a change in the future growth outlook for the company. Perhaps Andy can comment on the second question regarding future development strategy, including potential head-to-head, and why the range for the filing timeline 2025-2027. Yeah. Thank you very much for the question. This acquisition is reinforcing the certainty of our future growth in... I would just step back detailing our growth outlook. We know that next year is a year during which we will be flattish because of very significant generic exposure. We know that. We will manage it. The year from 2024 until the end of the decade, until in fact ENTYVIO is facing biosimilar, we'll grow because of our growth on launched product, our existing growth on launched product. After the end of the decade, potentially starting in 2032, we know that ENTYVIO will face biosimilars, and by then it would be a significant product. We just upgraded its peak outlook between... It will peak at between $7.5 billion and $9 billion. We have a significant pipeline. Our pipeline is progressing. We had very positive readout. We have some very significant assets like subasumstat, like TAK-861, but it's not certain. It's possible that this pipeline is enough to grow past 2030, but there is no certainty because we are not completely sure that every asset will make it in this pipeline. This acquisition is reinforcing our pipeline, is reinforcing our certainty to growth, to grow post 2030, when ENTYVIO will start facing biosimilar. That's how strategic it is, and it's also strategic because it fit very well within our therapy area focus. Yeah, and then regarding the development plan, TAK-861, the. We don't need to run a head-to-head study to register this product. And our focus will be on the most rapid path to market for psoriasis. We'll be running parallel Phase 3 studies that won't include deucravacitinib comparator, but we absolutely are considering a head-to-head study. We'll have to look more carefully at the data and the patient-by-patient data once we bring this program in-house to understand exactly what a study like that would look like. That's something that we're seriously considering, and it's quite unusual, as you know, to run a direct head-to-head study against a comparator in the same class when looking at diseases that register off clinical endpoints and not off of surrogate biomarkers. With respect to your question on timing of submission, you know, we're giving a rough range right now because we haven't done all of the detailed work in designing the Phase 3 program, understanding exactly what the size of that program will look like and the feasibility of operations. At this point, it's safer for us to provide a range. Once we bring the program in-house, we've designed those studies, we've gotten our sites up and running, we'll have a better sense for what enrollment will look like and what a more precise timelines will look like. Thank you. Thank you very much. Okay, moving to the next question. We go to the next questions. We ask Ken Cacciatore from Cowen and Company. Ken Cacciatore-san. Can you hear me okay? Yes, we hear you fine. Yeah, just wanted to say congratulations. This seems like a fantastic transaction for you. We hear wonderful things about the Nimbus team, and we know in your hands, you'll do wonderful things as well. We're excited to see the data. A question for you is given the lead indication is psoriasis, just wondering as you drill down on some of the questions around business development, should we expect maybe a little bit more business development tilted towards derm as we await the hopeful commercialization of this over the next few years? That's question one. Then Andy, obviously this is gonna be some costly development still ahead of us. Is this going to lead to a little bit more prioritization within the pipeline? Can you talk about how you can fit this in and do it in a way that's still cost effective? Thanks so much. Thank you, Ken. Perhaps Christophe, you'd like to answer around our future ambitions in psoriasis and dermatology, and then maybe Andy could add some comments on that and then talk about our R&D prioritization going forward to fit this asset into the pipeline. Thank you, Ken for your comment. First, regarding BD, I would like to say that we put the bar very high when we assess assets across our therapy areas. We look at. We know pretty much every single asset in development in the therapy area we are in because that's our model. That's the benefit of being focused. We have been following these assets for months, by the way. If you look at the way we put the bar in term of the innovation of the assets, we end up with a list, but the list is not super long neither. That's the first point. Second point is that with this asset, you look at our GI franchise, we are getting very busy. You know, we have TAK-999, we are developing efavaleukin alfa, we have the celiac programs, we are now TAK-279. Doesn't mean that we cannot get more assets, but we are quite busy for the year to comes. I also mentioned earlier that we are financially disciplined, and so we are now doing this deal. It does not mean that we will not do more deals, but at the same times, we are very much committed to our deleveraging target as well as our margin target moving forward. That's, that's the equation, if you like, that we need to manage. In addition to our financial discipline, we're highly disciplined, as you know, Ken, in decision-making around our pipeline. You know, and we've made actually decisions around nine programs over the last year to discontinue those programs. Some of which, as you know, we've spun out into companies because they just don't meet either our innovation bar or are not aligned strategically with our, with our trajectory. We've been quite disciplined. There. We can absorb fully the costs of this program next year. We've been preparing and we've been signaling around the need to bring in and bolster our later stage pipeline with some BD as our mid to early stage pipeline matures. You know, after 23, we'll have to look in a data-driven way as to how we make decisions. You know, the situation I'd like for us to be in in 2024 and 2025 is to have too many good programs and to have to make either difficult decisions on which ones to move forward or to look to, you know, to expand our investment in R&D. Okay. Congratulations again, folks. This seems like a really good transaction. We're excited to see more of the data. Thank you. Thank you, Ken. Okay. Next question I would like to call upon Stephen Barker from Jefferies. Stephen, please go ahead. Yes, hi, it's Steve Barker from Jefferies. Thanks for taking my questions. I have two. Firstly, thanks for the comments regarding the efficacy of this program versus the Bristol Myers deucravacitinib program. I was wondering if you also might have some comments on some other programs that are out there, for example, the Pfizer PF-06700841, which has also done a Phase 2 for psoriasis. Secondly, around the therapeutic strategy and commercial strategy, Christophe said that this does fit into your program. I do appreciate that your experience working with autoimmune treatments in IBD does position you very well for the development side. This is a dermatological asset, at least in its first indication. How does that fit into Takeda's commercial strategy? Thank you. Thank you, Steve, for your question. First on the competitors in development, then perhaps Andy would like to add some comments on that. Regarding the commercial strategy, we also have the head of our U.S. business unit, Julie Kim, on the call. Perhaps Julie can add some commentary around our commercial strategy for this asset. Stephen, thanks. Not to dive too deeply into the broad competitive landscape, I'll just say that what I would suggest doing is just looking at the published literature at the TYK versus JAK selectivity of the competitor molecules. What you'll find is, you know, certainly with molecules that are in phase 2 or on the market, there's none that come close to TAK-279 in terms of its selectivity profile. Many of these molecules are in all likely are going to be limited in terms of how far they can dose up, therefore how much TYK2 inhibition they're able to gain, and therefore how much clinical efficacy they're going to be able to derive. We think that we're not gonna have a limit on dosing, at least not by JAK-related toxicities. Allow us to push the dose range up to a point where we can get near maximal TYK2 inhibition and therefore greater efficacy than what's out there in the competition. Hi, Steve, it's Julie. Thanks for the question. Let me start by saying that we are extremely excited about being able to have this opportunity to launch TAK-079 at some point in the future. In terms of our capabilities commercially, what I would say is this: We would be building on a number of our core competencies that I think we've done a good job in displaying in recent times. If you look at what we've done with LIVTENCITY, transplant was a new area for us, but we relied on our ability to understand the market, to understand patient journey, and create a go-to-market model that was appropriate for transplant. In psoriasis, there are a number of competitors in this space already. We are studying what they are doing, how they are doing it, and we will continue to leverage our core competencies in regards to digital and understanding, patient insight to make sure that we can, you know, support this product that has the potential to be best in class appropriately. If I would add one thing, Steve, it's Christophe here. Thank you very much, Julie. We are very confident that we'll be able to commercialize it, and I would just add one thing is that we have now the scale in the U.S. to compete against pretty much everyone, anyone. We didn't have that scale before. In the last four years, we tripled our size in the U.S. Whether it is to manage the managed care space or to attract talent, we are very much stronger company now than before. That's why we can contemplate to launch a new therapy like that in, you know, very competitive marketplace. We believe it. With the combination of the best-in-class profile of this molecule with our strength now in the U.S. market, we are very confident that, we, you know, we'll be able to win in this space. Understood. Thanks very much. Thank you, sir. Our next question, Hashiguchi San from the Daiwa Securities, you're next. Hashiguchi from Daiwa Securities. Good morning, sir. I have two questions. The first question is IBD's development. The possibility of the success of the IBD, they did not produce the very good data of the IBD. For the IBD development of this molecule, if you are so positive about it, selectivity, is that the only forte, if I may say so? Are there any other strengths that you are so confident about? That is the first question. Second question is a sales related. I, myself, indication other than IBD, how to overlap with the core areas of the Takeda, I'm not very sure if I can understand. Listening to that the explanation that for the necessity of the investment of the sales, well, you are considering that it is not so significant a investment on top of the sales base. The first question around the likely success in development for IBD indications, considering the data that we saw for the other TYK2 inhibitor. Is it just the selectivity that gives us confidence, or is there anything else that could make us successful? Perhaps Andy could answer this question. The second question around the commercial footprint in indications outside of IBD. What kind of investment is going to be required in ramping up that footprint? Perhaps Julie could also comment on this. We focus on the selectivity because it's a major differentiator for this particular molecule. The molecule also has outstanding pharmaceutical properties in terms of its bioavailability, in terms of its PK, and also importantly, in terms of its potency on TYK2. What the selectivity does is it allows us to dose the molecule up to high enough levels where we're able to obtain near maximal inhibition of TYK2. We know that translates to very significant efficacy in psoriasis. We know from the deucravacitinib data that it contributes to significant efficacy in psoriatic arthritis and in lupus. There's still a question, you're correct, as to whether this will be effective in ulcerative colitis and Crohn's disease. Why, in light of DUPX's failure, are we still optimistic? Well, for two reasons. One is that, if you just look at this signaling cascade, whether it's inhibition of every other member of the signaling cascade, whether it's IL-12 or IL-23 or JAK, has benefits in IBD. It would be surprising to me, based on what we understand of the role that TYK2 plays in signaling and the genetics of TYK2, for it not to work in IBD. I would be quite surprised. The second reason is that we're able to dose it up to a point where, you know, we believe we can drive inhibition at a level that's probably necessary to see that efficacy. Of course, that's something that we'll learn about over the next couple of years as we run our phase 2 studies, but we're all quite optimistic about the potential of this molecule in IBD. Thanks. In terms of your question in regards to the commercial footprint, we're still a number of years from launch. What I can tell you is that we are in the midst of conducting some benchmarking to understand what other companies have in the psoriasis space. In addition, as I mentioned earlier, we are also implementing a number of new digital platforms within our existing therapeutic areas, particularly in GI and neuroscience. We intend to learn from that over the next couple of years and apply those learnings to what the footprint, appropriate footprint can be for psoriasis at the time of launch. We fully expect to be able to do it in an efficient and productive way. Thank you for the response. For the interest of time, I think the next question is our last question to entertain. It's Sakai from the Credit Suisse. Floor is yours. Thank you. Good morning and good evening. This is Sakai from Credit Suisse. I hope you have made the good Christmas shopping this time of the year. My question is quite simple. First one, accounting procedure for this. Nothing fancy. You capitalize $4 billion and commence amortizing the cost after psoriasis launch. So that could be after 2025, 2026, that kind of time horizon. That's my first question. Second question. When you do feasibility study of this project, I'm sure that you have made some assumptions, like internal rate of return, cost of capital, blah, blah. At this moment, on slide 5, I think, you mentioned about multi-dollar, multi-billion dollar revenue opportunity. How far you could go, I mean, as far as peak's concerned, multi-billion is a very much ballpark number. Can you give us the, I said not accurate, but rough figure? How far by Well, Christophe, you said meaningful revenue by 2030. What about meaningful revenue by 2035, 2040? Any indications would be much appreciated at this point. Thank you. Thank you, Sakai-san. The first question around accounting treatment for the deal, perhaps Costa could answer that. The second question around how big could the asset be, we talk about a multi-billion dollar opportunity, but can we be any more specific on the opportunity? I'd like to ask Christophe to comment on that question. Thank you very much. Okay. Good morning. Exactly to your point, you know, it's the same. It's a simple asset acquisition. We capitalize it and amortize once we start commercializing the asset. Thank you. Thank you, Sakai-san. It's Christophe. I think the best way to answer your question is look at the milestone. Again, it was a competitive process so actually very competitive process. The milestone are a $1 billion payment when we hit $4 billion and $1 billion payment when we hit $5 billion. You can imagine that on the selling members, they were looking at that and say, "Okay, are these milestone realistic, one? Are they far away or not too far away?" I think this is an indication of the potential of the molecule, is that these milestones are kicking at the level of $4 billion revenue and $5 billion revenue. Obviously the peak will be higher than that. Otherwise, we wouldn't have this type of milestone. It's not a very precise answer to your question at this stage. Just give you a sense about the potential of the programs. Okay. Hopefully, that will work. Thank you. Thank you, Sakai-san. Thank you very much. Today we'd like to close this webinar. Thank you very much for your participation to this program. Looking forward to have you with Ono Corporation again. Thank you.