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Technology and R&D Briefing October 19, 2026 Terumo Corporation
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©TERUMO CORPORATION 2 Primary colors Secondary colors Caution Terumo Green Main text Sub text Among the information that Terumo discloses, the forward-looking statements including financial projections are based upon our assumptions using information available to us at the time and are not intended to be guarantees of future events or performance. Accordingly, it should be noted that actual results may differ from those forecasts or projections due to various factors. Factors affecting to actual results include, but are not limited to, changes in economic conditions surrounding Terumo, fluctuations of foreign exchange rates, and state of competition. Information about products (including products currently in development) which is included in this material is not intended to constitute an advertisement or medical advice. Forward-Looking Statements and Use of Document
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©TERUMO CORPORATION 3 Primary colors Secondary colors Caution Terumo Green Main text Sub text Sources of Competitive Advantage Hikaru Samejima Chief Executive Officer
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©TERUMO CORPORATION 4 Primary colors Secondary colors Caution Terumo Green Main text Sub text Positioning of the Technology & R&D Briefing GS31 Dec. Where to Play Jun. IR Day How to Win Today Technology & R&D Briefing
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©TERUMO CORPORATION 5 Primary colors Secondary colors Caution Terumo Green Main text Sub text Organization Driving Innovation Global Sites Integrating R&D and Manufacturing Hikaru Samejima Chief Executive Officer Toshihiko Osada Director and Group Senior Managing Executive Officer, In charge of Innovation
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©TERUMO CORPORATION 6 Primary colors Secondary colors Caution Terumo Green Main text Sub text Sources of Competitive Advantage AI Monozukuri Excellence Execution Excellence Regulatory & Compliance Expertise External Technology Integration Knowledge Accumulation & Deployment Clinical Needs Translation Manufacturing Technology Metal Fabrication Plastic Molding Coating Technology Development Technology
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©TERUMO CORPORATION 7 Primary colors Secondary colors Caution Terumo Green Main text Sub text • Precision metal processing with minimal eccentricity • Thin-wall, small-diameter plastic molding • M coat TM technology for reduced friction • Continuous product improvement • Consistent reproduction of user experience in mass production Clinical Needs Translation Development Technology Manufacturing Technology • Reliable performance regardless of operator experience • A best-selling product franchise with over 40 years of market presence • Global market leader in vascular access and the world's No.1 guidewire market share • Expanded into balloon catheters, stents, and other vascular devices • Foundation for next-generation products and broader endovascular diagnosis and treatment applications Standardizing Procedures Through Consistent Performance and Quality at Scale Guidewires
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©TERUMO CORPORATION 8 Primary colors Secondary colors Caution Terumo Green Main text Sub text Intravascular Imaging System Dual Sensor System TM （DSS） • Enhanced treatment planning with two imaging modalities in a single catheter • Growing clinical evidence creates barriers to entry • Guideline support and rising imaging demand • U.S., Japan and India expansion; >3x Imaging revenue target by FY31 • Leveraging expertise for next-generation imaging products Leveraging Established Expertise and Market Leadership to Drive Adoption of New Technologies Knowledge Accumulation & Deployment Development Technology Manufacturing Technology • Precision microfabrication and metal joining • Thin-wall, small-diameter plastic molding • M coat technology for reduced friction • Leveraging expertise from IVUS and OFDI for DSS • Two functions in a single- catheter profile, reproducible at scale
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©TERUMO CORPORATION 9 Primary colors Secondary colors Caution Terumo Green Main text Sub text Intracranial Aneurysm Treatment Device Woven EndoBridge TM （W-EB） • Simplifying complex aneurysm treatment with a highly reproducible procedure • Expanding Neuro portfolio through WEB as a core growth product • 15+ years of clinical evidence and 50,000+ patient implants create barriers to entry • Leveraging Neuro platform to expand into adjacent markets • Supporting two decades of double-digit growth and profitability in Neuro Leveraging Acquired Technologies to Enhance Product Competitiveness • Ultra-fine wire braiding technology • Integration of acquired technologies into Terumo's platform • Consistent reproduction of complex structures at scale External technology Integration Development Technology Manufacturing Technology
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©TERUMO CORPORATION 10 Primary colors Secondary colors Caution Terumo Green Main text Sub text Prefilled Syringe PLAJEX TM Integrating Technology, Expertise, and Regulatory Capabilities for Faster and More Reliable Development • Integrated support spanning pharmaceuticals and medical devices, from design to regulatory approval • Greater development speed and certainty for pharmaceutical partners • High switching costs foster long-term customer relationships • Leveraging more than 700 million units shipped to capture growth in customized and high-value production Regulatory & Compliance Expertise Development Technology Manufacturing Technology • Tapered needle technology • Adhesive-free COP polymer design • Silicone oil-free i-coating • Extensive drug development and evaluation experience • Proven regulatory engagement and approval track record • Consistent performance with high-viscosity formulations at scale
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©TERUMO CORPORATION 11 Primary colors Secondary colors Caution Terumo Green Main text Sub text Feedback Toward Sustainable Growth Monozukuri Excellence Execution Excellence AI Regulatory & Compliance Expertise External Technology Integration Knowledge Accumulation & Deployment Clinical Needs Translation Manufacturing Technology Development Technology Products of Choice
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©TERUMO CORPORATION 12 Primary colors Secondary colors Caution Terumo Green Main text Sub text Monozukuri Excellence Toshihiko Osada Director and Group Senior Managing Executive Officer, In charge of Innovation
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©TERUMO CORPORATION 13 Primary colors Secondary colors Caution Terumo Green Main text Sub text Overview of “Monozukuri Excellence” AI Manufacturing Technology Metal Fabrication Plastic Molding Coating Technology Development Technology
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©TERUMO CORPORATION 14 Primary colors Secondary colors Caution Terumo Green Main text Sub text Development Technology：Metal Fabrication Ultra-Fine Processing Precision Stamping Rolling Reducing metal diameter Shaping with dies Precision shape control Dissimilar Metal Joining Joining different metals Integrated Design and Optimization of Processing & Joining Technologies Superior Handling Performance Consistently Preferred by Physicians Minimizing patient pain through thinner and sharper designs Combining precise torque response and minimally invasive performance
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©TERUMO CORPORATION 15 Primary colors Secondary colors Caution Terumo Green Main text Sub text Development Technology: Plastic Molding Extrusion Injection Molding Blow Molding Multi-layer Molding Forming continuous profiles Forming shapes with dies Creating hollow structures Combining different materials Precision technologies that meet clinical needs through meticulous attention to detail Continuous Refinement Through Monozukuri Excellence Biocompatibility and clinical usability beyond measurable specifications
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©TERUMO CORPORATION 16 Primary colors Secondary colors Caution Terumo Green Main text Sub text Development Technology: Coating Technology Technologies That Enhance Product Performance and Competitiveness Expanding Development Capabilities in the U.S. to Strengthen Global Competitiveness Real-Time Optimization Across Development, Manufacturing and Coating Efficiency Through Integrated In-House Manufacturing
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©TERUMO CORPORATION 17 Primary colors Secondary colors Caution Terumo Green Main text Sub text Manufacturing Technology Enabling trust and long-term adoption through a consistent user experience Development-Manufacturing Integration Real-time collaborationDelivering the same user experience every time ScalabilityConsistency High-quality products produced at scale A Culture of Continuous Improvement in Manufacturing Processes and Equipment Consistent Mass Production of High-Quality Products
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©TERUMO CORPORATION 18 Primary colors Secondary colors Caution Terumo Green Main text Sub text PoC Results Risk identification & analysis: Several months → ~2 weeks Toxicity assessment report: 1 month → ~10 minutes AI Utilization AI Transforming Development Productivity Through an AI-Native Approach Accelerating Time-to-Market Manufacturing Technology Development Technology Design Enhancement Evaluation & Analysis Efficiency Risk Identification
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©TERUMO CORPORATION 19 Primary colors Secondary colors Caution Terumo Green Main text Sub text Feedback Loop Sustainable Growth Cycle Competitive Advantage Model Competitive Advantage Model Competitive Advantage Model Competitive Advantage Model Competitive Advantage Model Creating Diverse Competitive Advantage Models Feeding Back Insights and Experience to Drive Sustainable Growth Monozukuri Excellence Execution Excellence AI External Technology Integration Regulatory & Compliance Expertise Knowledge Accumulation & Deployment Clinical Needs Translation Manufacturing Technology Development Technology Culture of Continuous Improvement
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©TERUMO CORPORATION 20 Primary colors Secondary colors Caution Terumo Green Main text Sub text Closing Remarks GS31 Dec. 15 Five-Year Growth Strategy Where to Play Jun. IR Day How to Win Today Technology & R&D Briefing