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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing Analytical & Measuring Instruments Business Briefing September 4, 2026 Masami Tomita Managing Executive Officer, General Manager, Analytical & Measuring Instruments Division Tairo Ogura Deputy General Manager, Analytical & Measuring Instruments Division, General Manager, Life Science Business Department Haruhiko Miyagawa Deputy General Manager, Analytical & Measuring Instruments Division, Chairman of the Board, TESCAN GROUP, a.s.
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing Agenda 1. Medium-Term Management Plan Strategy 2. Business Expansion in the Life Science Market 3. Business Expansion in the Semiconductor Market 4. New Products 2
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing Agenda 1. Medium-Term Management Plan Strategy 2. Business Expansion in the Life Science Market 3. Business Expansion in the Semiconductor Market 4. New Products 3
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing 1. Medium-Term Management Plan Strategy Overview of the Analytical & Measuring Instruments Market ◼ The analytical and measuring instruments industry serves a broad range of markets and is expected to deliver stable growth. FY2025 market size: approximately ¥13.4 trillion. ◼ In addition to data reliability, measurement expertise and long-term customer relationships are critical, creating high barriersto entry. ◼ Shimadzu is the only non-U.S. company among the industry’s leading players. * Source: SDi Global Assessment Report 2026 3.04.13.43.0Market Growth Rate (2025–2030) Market Size (USD billion, 2030) Analytical & Measuring Instruments Market 4.0 Shimadzu Product Coverage 〇 - 〇 〇〇 Molecular Spectroscopy Sample PreparationBioanalysis Materials Characterization Atomic Spectroscopy Surface ScienceChromatography - Automation & Informatics Mass Spectrometry Laboratory Instruments 4.0 - 〇 4.1 〇- Top 10 Global Analytical & Measuring Instrument Manufacturers (Instruments) 22 16 12 10 8 8 8 7 6 4 3.7 3.7 4.3 4 会社名 25年売上高 （MUSD） 本社所在地 Thermo Fisher 12,328 米国 Danaher 5,761 米国 Agilent 5,495 米国 Waters 3,032 米国 Bruker 2,561 ドイツ 島津製作所 2,014 日本 Mettler Toledo 1,616 米国 ZEISS 1,380 ドイツ PerkinElmer 1,357 米国 Bio-Rad 1,161 米国 Company 2025 Revenue (MUSD) Headquarters Location U.S. Shimadzu U.S. U.S. U.S. Germany U.S. Germany U.S. U.S. Mettler Toledo Japan
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing FY2028 Management Targets Enhance the Management Foundation Basic Policy Net Sales OP ¥680.0B (CAGR 6.7%) ¥100.0B Become an Innovative Company That Solves Social Challenges Together with Global Partners Sustainably Improve Profitability by Strengthening End-to-End Solutions Capabilities EBITDA ROE ROIC ¥135.0B 11.5% or higher 10% or higher Expand Core Businesses • Life Science • Clinical • Recurring Revenue Business Expand Businesses in Growth Markets • Semiconductor Expand Overseas Businesses • Strategic Regions: North America and India Evolve Foundation Businesses • Green / Materials Domains Business Transformation Toward a Customer-In* Model (* Providing optimal products and services tailored to the needs of each individual customer.) Strengthen AIX (AI Transformation) Accelerate New Business Creation Promote Human Capital Management 1. Medium-Term Management Plan Strategy FY2026-FY2028 Company-Wide Medium-Term Management Plan Enhance Governance Profitability Improvement Improve Sales Mix Optimize Pricing Optimize Underperforming Products and Improve the Profitability of Businesses Reduce Costs Expand the Value Provided to Customers * FY2028 figures in this material are calculated based on the assumption that the acquisition of Tescan will be completed and are subject to change depending on future circumstances. * FY2028 OP is presented on an IFRS basis. 5 ◼ In the Analytical & Measuring Instruments business, we will place the highest priority on the life science and semiconductor markets, taking into account their market size and growth potential.
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing Agenda 1. Medium-Term Management Plan Strategy 2. Business Expansion in the Life Science Market 3. Business Expansion in the Semiconductor Market 4. New Products 6
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing LC LCMS GCMS LabSolutions Automation Recurring ◼ Our core business products are widely used across the full spectrum of everyday healthcare applications. 7 2. Business Expansion in the Life Science Market Life Science and Recurring Revenue — Overview Contributing to Infectious Disease Control through Rapid Testing Cloud Database Intraoperative Treatment Support Remote Diagnostic Imaging Realizing Personalized Medicine Reducing Healthcare Professionals’ Burden with AI Contributing to Dementia Care Remote Imaging Diagnosis Clinical Laboratory Equipment Daily Health Management Telemedicine Personalized Pharmaceuticals Functional Foods At-Home Blood Collection Regenerative Medicine Food Testing Cultured Meat Composition Analysis & Texture Testing Automation of Pharmaceutical Research
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing 4.0% 4.3% 2025–2030 CAGR Global Analytical & Measuring Instruments Market (USD billion) ◼ The overall global analytical and measuring instruments market, as well as the chromatography and mass spectrometry markets, are each forecast to grow at a CAGR of approximately 4%. ◼ The global analytical and measuring instruments markets for pharmaceuticals and food are also forecast to grow at CAGRs of 4% or more. ◼ Shimadzu plans to grow its core businesses at a 6% CAGR, outpacing market growth. • Core businesses: Key chromatography models (LC and GC), mass spectrometry systems (MS), and the recurring revenue business. 2,030 2,400 Core Business Plan (¥100 million) Products Recurring CAGR 6% +370 2025 2028 Maximize Customer Value with Chromatography and MS at the Core Chromatography & MS • Core analytical technologies supporting R&D and quality control • High-precision, high-quality data Recurring Consumables and Services • Expand consumables and reagents Sample Preparation & Automation • Labor-saving solutions and automation • High-throughput multi-sample analysis Analytical Package • Packaged solutions combining reagents, consumables, and software Living Laboratory with Analytical Intelligence 2. Business Expansion in the Life Science Market Market Trends *Source: SDi Global Assessment Report 2026 8 13 16 6 7 0 5 10 15 20 25 2025 2030 質量分析システム クロマトグラフ Mass Spectrometry System Chromatograph
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing ◼ Expand Our Business in the Small-Molecule Pharmaceuticals Market - Asian markets—particularly India—are growing, supported in part by demand for domestic pharmaceutical production. ➢ In India, where Shimadzu has a strong market share and brand presence, we will help improve operational efficiency with LC systems featuring enhanced usability. ➢ In emerging markets where future growth is expected, most purchases are for new installations. Customers are therefore not tied to existing systems, creating growth opportunities for all manufacturers. Leveraging our strong brand presence in Asia, we will capture these demand opportunities. ◼ Expand into the Biopharmaceutical Market - The market is expanding globally, driven by diverse regional needs associated with the diversification of modalities. We will advance R&D activities based on the needs of leading customers. ➢ Develop solutions through the R&D Center in North America to expand into the antibody therapeutics market. ➢ Collaborate with emerging companies in Japan and overseas to develop differentiated products targeting leading positions in niche markets. - Aim to expand our business across the workflow, from R&D through quality control. ◼ Expand our business by addressing R&D and quality control needs with LC and MS at the core. Addressing R&D and Quality Control Needs 2. Business Expansion in the Life Science Market Liquid Chromatograph (LC), Mass Spectrometry System (MS) Forecast FY2030 Market Size (trillion yen) vs. FY2021 +43% +77% ×18.4 * Source: Materials from the 2nd Working Group on Drug Discovery and Advanced Medicine, Cabinet Office, Government of Japan 9 0 20 40 60 80 100 120 遺伝子治療 抗体医薬 低分子医薬品 系列1 系列2 Small-Molecule Pharmaceuticals Antibody Therapeutics Gene Therapy 99 53 9 FY2021 Growth through FY2030
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing ◼ Expand our business with LC and MS at its core to address R&D, quality-control, and labor-saving needs. ◼ Provide next-generation automation and analytical and measuring solutions to support drug discovery and clinical development in the AI era. Secure and Reliable Systems Data Management Support for Diverse Operating Requirements Support New Ways of Working Improve Operational Efficiency through a User-Friendly Operating Environment Optimize Analytical Workflows and Laboratories Automation AI-Based Method Generation Automated Laboratory LabSolutions Method Development Synthesis and PretreatmentAnalysis Data Analysis Liquid Chromatograph Mass Spectrometry System Liquid Chromatograph Provide high-quality data and measurement technologies suited to AI-driven prediction and validation cycles. AI-Based Analytical Method Development Methodintelligence for LC AI-Based Automated Peak Processing Peak intelligence for LC/LCMS/GCMS Automated Generation of Analytical Conditions AI-Based Peak Processing and Integrated Analysis 2. Business Expansion in the Life Science Market Sample Preparation and Automation — New Initiatives to Enhance Added Value Using AI Automated Laboratory 10
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing Analyzer 3) Optional Equipment 4) Column 5) Reference Standard 6) Application (Method) 2) Analytical Instrument 7) Consumables 8) Report, etc. 2. Business Expansion in the Life Science Market Proposing Analytical Product Packages Provide products that package analytical know-how for customers adopting new analytical methods or analytical instruments for the first time. 1. Provide packages that include not only the analytical instrument itself, but also the optional products, consumables, and other items required for analysis. 2. Offer customers an integrated proposal covering methods, consumables, and other requirements. 3. Aim to provide added value by addressing challenges faced by less- experienced operators and enabling customers to select solutions with confidence. Example: FluoroSuite for PFAS LCMS-8065XE Tubing, etc. PFAS Option Kit Analytical Columns Vials with Inserts, etc. Application or Method Products 1) Sample Preparation System ◼ Provide short-term solutions (analytical product packages) to support laboratory analysis. Brevis GC-2050 GI-30 Auto Injector Consumables such as Columns Application (Method) Example: GC Gas Analyzer BID and TCD Detectors Jetanizer Single Filament Helium Plasma 11
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing Expand the LabTotal Business • Globally expand products for laboratory design, reagent management, and other applications developed by Group companies in Japan and overseas in collaboration with external partners. Strengthen Service Capabilities and Advance Maintenance Services 1. Establish service training centers at overseas sales subsidiaries. 2. Expand MVS in North America. 3. Globally roll out instrument relocation and other high-value services. 4. Expand the maintenance business using AI-based failure prediction, refurbishment, and partial upgrades. ◼ Expand our offerings across each phase of customers’ development and manufacturing workflows to maximize the value we provide. Maximize Value Provided to Customers Strengthen Consumables Portfolio and Sales Capabilities 1. Expand the business by broadening the product portfolio and accelerating market launches. Divide responsibilities for in-house reagent development between Europe and Japan. Broaden the product portfolio through collaboration with other companies. 2. Expand applications. 3. Globally roll out products developed by overseas Group companies. Initiatives in the Purification Business 1. Provide high-precision preparative chromatography products. 2. Expand column-packing business for purification applications. 3. Sell consumables for preparative chromatography. Systems and Products 1. Launch products that address leading-edge needs. 2. Launch systems that address automation needs. 3. Support workflows end-to-end, from sample preparation through consumables. 2. Business Expansion in the Life Science Market Recurring Revenue — Consumables and Services 12
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing Agenda 1. Medium-Term Management Plan Strategy 2. Business Expansion in the Life Science Market 3. Business Expansion in the Semiconductor Market 4. New Products 13
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing Semiconductor scaling, 3D integration, and higher performance for AI applications. As semiconductors become smaller and more highly stacked, demand is growing for the ability to “measure smaller features consistently” and “measure hidden internal structures in three dimensions.” Analytical and Measuring Technologies Supporting the semiconductor industry as a whole across development, process development, volume production ramp-up, yield improvement, failure analysis, and more. 14 3. Business Expansion in the Semiconductor Market Market Trends ⚫ An increasing number of control parameters for materials, interfaces, and impurities. ⚫ The need for internal inspection associated with 3D structures, stacking, and bonding. ⚫ Growing demand for higher yields, greater reliability, and better thermal design. ⚫ Growing demand for in-line measurement, nondestructive testing, data integration, and automation.
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing 3. Business Expansion in the Semiconductor Market Applications and Products Required at Each Stage of Semiconductor Process Laser Processing Technology Laser Processing Only Cleaning after Laser Processing Laser Processing Using FemtoChisel ⚫ Tescan’s proprietary intelligent gas control and protective-layer technologies. ⚫ Prevents the formation of debris, redeposition, and heat- affected layers even during high-speed femtosecond laser processing. ⇒ Enables high-speed processing. FemtoChiselTENSOR UNITOM HR 2SOLARIS 2 AMBER X 2 Design Manufacturing Process Testing Back-End Process ReliabilityR&D / Advanced Exploration Applications Instrument Type Tescan Products Use-Case Diagram Circuit Editing High-Resolution Cross-Section Preparation Defect Control Inspection / Measurement Nanoprobing Voltage Contrast Ablation Delayering X-ray μCT Ion Beam Laser Technology Micro-CT 15
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing 3. Business Expansion in the Semiconductor Market Semiconductor Device Failure Analysis 1. Non-Destructive Localization Micro-CT Identify the ROI in 3D. 2. High-Speed Rough Processing FemtoChisel Rapidly process millimeter-scale regions. 3. Precision Processing FIB-SEM Prepare targeted cross-sections and thin sections. 4. Sample Transfer EXLO Reduce FIB system occupancy. 5. Nanoscale Analysis TENSOR Analyze structure, composition, and strain. Streamline the Workflow • Transfer ROI coordinates, images, and recipes between instruments to reduce repeated localization and manual work. • Link process conditions with cross-sectional, structural, compositional, and strain data to accelerate feedback to development. Millimeter-scale Nanometer-scale Combine high speed with high resolution. Reduce the impact of laser-processing artifacts. Enable precise cross-sectioning by reducing curtaining. The world’s first automated system combining patented precession electron diffraction with real-time analysis of multiple data sets. *ROI: Region of Interest ◼ Treat “locate → process → analyze” as a single workflow. 16
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing 3. Business Expansion in the Semiconductor Market Leveraging the TMP Service Network to Strengthen Customer Engagement ミュンヘン オースティン ◼ Expand the service network to meet strong demand for advanced semiconductors. ➢ Turbomolecular pumps (TMPs) are high-performance vacuum pumps installed in semiconductor manufacturing equipment. ➢ They are used by major semiconductor manufacturing equipment manufacturers, and Shimadzu holds the leading global market share. ➢ We provide 24/7/365 service for TMPs operating around the world and are continuously strengthening our engagement with semiconductor manufacturers. ➢ Leveraging the strength of our TMP service network, we will combine Shimadzu’s analytical and measuring technologies with Tescan electron microscopes, including FIB-SEM and TEM systems, to maximize the value provided to customers. TMP Service Network Production Sites: Japan (Kyoto and Kanagawa) / China (Tianjin) Magnetically Levitated Turbomolecular Pump ⚫ Creates a high vacuum inside semiconductor manufacturing equipment. ⚫ Magnetically levitates and rotates the impeller at high speed to efficiently evacuate air and gas molecules. ⚫ Because the moving parts do not make contact, wear and vibration are minimized, while oil contamination is also reduced. ⚫ Semiconductor manufacturing involves extremely fine circuitry, where even minute particles or residual gases can affect quality. Magnetically levitated TMPs are therefore used to maintain a clean and stable vacuum. 17 Yongin Xi’an Wuhan Shanghai Taiwan, Hukou, Tainan Austin Munich
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing 3. Business Expansion in the Semiconductor Market Shimadzu Integrated Analysis Solutions for Semiconductor R&D and Manufacturing TMP Morphological Observation Micro- and Nanostructures Micro-CT FIB-SEM / TEM Components Vacuum / Optics Components and Monitoring Devices for Semiconductor Manufacturing Equipment Inorganic Analysis Surface Analysis Reliability Evaluation Organic AnalysisMechanical Properties Environmental Monitoring Quantification of Elements and Impurities Composition and State of the Outermost Surface Organic Compounds / OutgassingStrength / Elasticity / Hardness ICP-MS EPMA SPM XPS GCMS LCMSTesting Machine Hardness Tester GCMS LCMSTOC Ultrapure Water Monitoring / Clean Environment Monitoring / Wastewater Monitoring ◼ Provide integrated analytical solutions combining structural analysis, chemical analysis, and process measurement. ◼ Complete a surface observation platform incorporating Tescan products and other analytical and measuring instruments, and ultimately evolve it into a Process Intelligence Platform, with the aim of becoming a data-driven analytical and measuring instruments company that optimizes the entire semiconductor process. 18
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing 3. Business Expansion in the Semiconductor Market Future Synergies with Tescan ◼ By combining Tescan’s advanced imaging and processing technologies with Shimadzu’s analytical technologies, we will bridge the gap from “seeing” to “understanding” and expand opportunities to create new value. Imaging / Cross-Section Processing / 3D Analysis Nanostructure / Crystal Orientation Analysis Surface Research under Ultra-High Vacuum Non-Destructive 3D/4D Analysis Precision Processing with Low Thermal Impact Automated TEM Sample Preparation MS Imaging Mass Spectrometry Imaging FTIR / Raman Molecular Structure / Chemical State EPMA Elemental Analysis / Micro-Area Evaluation SPM Surface Topography / Physical Properties Evaluation XPS Chemical Bonding Evaluation Semiconductors Battery Composite Materials Materials / SurfacesLife Sciences FIB-SEM Cross-Section Imaging / Processing ↓ EPMA / EDX Elemental Analysis ↓ TEM Circuit / Defect Analysis Enhance Failure Analysis and Reliability Evaluation FIB-SEM Cross-Section Imaging / Processing EPMA/ Raman Elemental / Compositional Analysis XPS / SPM State Analysis Accelerate Next-Generation Battery Development SEM Surface Structure Analysis Micro-CT Internal Structure ↓ FTIR / Raman Molecular Structure Integrate Contaminant, Fracture- Surface, and Surface Analysis ↓ FIB-SEM Morphological / Structural Analysis Raman Chemical State Analysis ↓ MS Imaging Molecular Distribution Analysis Correlative Analysis of Structural and Chemical Information ↓ Tescan’s Six Technology Platforms Shimadzu Analytical Technologies — Measurement Capabilities — ↓ ↓ 19
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing Agenda 1. Medium-Term Management Plan Strategy 2. Business Expansion in the Life Science Market 3. Business Expansion in the Semiconductor Market 4. New Products 20
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing 4. New Products Product Portfolio Liquid Chromatograph Fourier Transform Infrared Spectrophotometer Precision Universal Testing Machine Reagents Columns Culture Media Three Key Models (LC, MS, GC): 56% Other Models: 44% Service & Maintenance: 59% Consumables: 41% Inspection / Calibration Services UV-Vis Spectrophotometer Preventive Maintenance Supercritical Fluid Chromatography Analytical / Preparative / Extraction System Gas Chromatography Mass Spectrometry System High-Performance Liquid Chromatograph Mass Spectrometer (Quadrupole Time-of-Flight LCMS) Microfocus X-Ray CT System Energy Dispersive X-Ray Fluorescence Spectrometer Gas Chromatograph Scanning Electron Microscope High-Performance Liquid Chromatograph Mass Spectrometer (Triple Quadrupole LCMS) ◼ We offer a diverse product portfolio while strengthening the key chromatography models (LC and GC) and mass spectrometry systems (MS) that form the core of our business. 21 High-Performance Liquid Chromatograph Mass Spectrometer (Quadrupole Time-of-Flight LCMS)
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing 4. New Products Recently Released New Products Trace-Level Analysis, High Speed, and High Separation Performance for R&D Laboratories ➢ Low dispersion for sharp peaks. ➢ Reduces analysis time to one-third of the conventional level. ➢ Supports trace-volume samples. ➢ Reduces solvent consumption to one-ninth of the conventional level. AI Method Search and Generation Service Methodintelligence for LC ➢ Proprietary automation functions. ➢ Streamlines the entire workflow from sample preparation through data analysis. ➢ New AI functions reduce downtime. Streamlines workflows from sample preparation and analysis through data processing Ultra High Performance Liquid Chromatograph Nexera X4 Ion Chromatograph Nexera IC Transform workflows with high-speed processing, high sensitivity, and stability ➢ Five injection modes improve efficiency and reduce waiting time to one-eighth of the conventional level. ➢ Five detector operating modes accommodate diverse laboratory environments. ➢ A detector offering the highest sensitivity enables high-speed trace analysis. ➢ Automatic energy-saving operation helps save energy by reducing electricity and gas consumption. “The Culmination of 70 Years of GC Development” ➢ Among the world’s smallest and lightest in its class. ➢ Provides stable measurement of organic content at 1 μg/L or below. ➢ Helps meet cleaning standards and improve yield. High-sensitivity urea detection helps improve manufacturing yield ➢ Designed for use with the Nexis GC-2060. ➢ Industry-leading sensitivity, delivering up to a 25% improvement over conventional models, enables the detection of ultra-trace components. ➢ AI-powered data analysis support improves analytical quality while reducing operator workload. On-Line TOC Analyzer for Ultrapure Water TOC-1000e S ➢ Generative AI automatically searches the literature and evaluates conditions to propose optimal analytical conditions. ➢ Reduces the time required to determine analytical conditions. Gas Chromatograph Nexis GC-2060 Gas Chromatography Mass Spectrometry System GCMS-TQ8040/8050RX Series 22
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Copyright © Shimadzu Corporation. All Rights Reserved. | Analytical & Measuring Instruments Business Briefing Excellence in Science & Best for Our Customers Contact Contact: Investor Relations Group Corporate Communication Department Shimadzu Corporation Email: ir@group.shimadzu.co.jp Actual results may differ materially from the forecasts regarding future performance contained in this presentation due to various external factors, including economic conditions, foreign exchange fluctuations, and technological developments.