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Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 FORM 20 - F ( Mark One ) 0 REGISTRATION STATEMENT PURSUANT TO SECTION 12 ( B ) OR 12 ( G ) OF THE SECURITIES EXCHANGE ACT OF 1934 OR X ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( D ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31 , 2020 . 0 OR TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( D ) OF THE SECURITIES EXCHANGE ACT OF 1934 OR 0 SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15 ( D ) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of event requiring this shell company report Commission file number : 001-39997 Adagene Inc. ( Exact name of Registrant as specified in its charter ) N / A ( Translation of Registrant's name into English ) Cayman Islands ( Jurisdiction of incorporation or organization ) 4F , Building C14 , No. 218 Xinghu Street , Suzhou Industrial Park Suzhou , Jiangsu Province , 215123 People's Republic of China ( Address of principal executive offices ) Peter ( Peizhi ) Luo Chief Executive Officer + 86-512-87773616 Email : peter_luo@adagene.com At the address of the Company set forth above ( Name , Telephone , E - mail and / or Facsimile number and Address of Company Contact Person ) Securities registered or to be registered pursuant to Section 12 ( b ) of the Act : Title of each class American depositary shares , each ADS representing one and one quarter ordinary shares , par value US $ 0.0001 per share Ordinary shares , par value US $ 0.0001 per share * Trading Symbol ADAG N / A Name of each exchange on which registered The Nasdaq Stock Market LLC ( The Nasdaq Global Market ) The Nasdaq Stock Market LLC ( The Nasdaq Global Market )