Hello, and welcome to Adaptimmune's third quarter call and business update. I will now turn the call over to Juli Miller. Juli, please go ahead. Good morning, and welcome to Adaptimmune's conference call to discuss our third quarter 2022 financial results and business updates. I would ask you to review the full text of our forward-looking statements from this morning's press releases. We anticipate making projections during this call, and actual results could differ materially due to several factors, including those outlined in our latest filings with the SEC. Adrian Rawcliffe, our Chief Executive Officer, is here with me for the prepared portion of the call. Other members of our management team will be available for Q&A. With that, I'll turn the call over to Adrian Rawcliffe. Adrian? Thank you, Julie. Thank you for joining us today. As evident in the separate data press release we issued this morning, the SURPASS trial with our next-generation SPEAR T-cell targeting MAGE-A4 continues to produce compelling response data across ovarian, bladder, and head and neck cancers, with increasing durability and a new complete response in bladder cancer. In addition, the recent pre-BLA meeting and the updated data from the SPEARHEAD-1 trial that we will be presenting at CTOS continue to demonstrate the value of afami-cel, our first generation MAGE-A4 cell therapy and a product for people with synovial sarcoma. Earlier this month, we announced we'll have full control of our PRIME program going forward. With ownership of affinity enhanced SPEAR T-cells against MAGE-A4 and PRIME, we are well-placed to deliver high-value products with two of the most broadly expressed, well-characterized and validated TCR T-cell targets in the solid tumor field. These developments, while positive, come during challenging economic times, and it's evident that we need to focus on three key priorities, advancing the MAGE-A4 franchise, the PRIME program, and progressing the allogeneic platform, since these represent the highest value creation opportunities. We've taken decisive action to pause, stop, deprioritize, and limit resources for non-core programs to concentrate our resources on these key priorities. We've also made the difficult and painful decision to restructure the company and will undergo a reduction in headcount of between 25% and 30% between now and Q1 2023. These actions taken together will extend our cash runway into early 2025. Although these were difficult choices, our shared sense of purpose and our confidence in the potential for afami-cel and our CD8 program to transform the lives of people with cancer, make it imperative that we take these steps to sustain the company and position ourselves to successfully deliver these cell therapies. Now I want to give a little more detail about the focus of the company going forward. For MAGE-A4, we will focus on the afami-cel BLA for synovial sarcoma and the SURPASS trials of our second generation CD8 product in ovarian, bladder, and head and neck cancers. For afami-cel, we are committed to submitting the BLA and will commence a rolling submission later this year. We plan to complete the submission in mid-2023. We've had positive interactions with regulators, caregivers, and others in the sarcoma space throughout our clinical development of afami-cel, and the need for and potential of this therapy is undeniable. For the next gen CD8 product targeting MAGE-A4 being developed in the SURPASS trials, the latest data from the SURPASS trial across a basket of late-stage solid tumor indications continues to demonstrate the value of this product with very positive trends since the ESMO data. The overall response rate across the entire trial is now 37%, and importantly, duration of response has improved. It's now at five months in this ongoing trial and will further evolve with patients in continuing and ongoing response. Within the SURPASS family of trials, we will focus on those indications where we have seen outstanding response data, namely ovarian, urothelial, and head and neck cancers. The ORR across these three tumor types is now 52%. In urothelial cancer, we are announcing a 57% ORR with one new complete responder, and we are pursuing a new cohort in the phase 1 trial in combination with a checkpoint inhibitor in the second line setting for these patients. Based on compelling efficacy reported at ESMO with three out of four responders, we will also proceed with a new cohort in head and neck cancer in combination with a checkpoint inhibitor in the first line setting. For ovarian cancer, the ORR is now 43%, and the phase 2 trial SURPASS-3 is initiating in monotherapy and in combination with a checkpoint inhibitor. Last Friday, we received FDA Regenerative Medicine Advanced Therapy or RMAT designation for ADP-A2M4CD8 for the treatment of patients with platinum-resistant ovarian cancer. By granting RMAT, the FDA agrees that the preliminary clinical evidence indicates that CD8 has the potential to address unmet medical needs in platinum-resistant ovarian cancer. RMAT gives us the advantage of increased opportunities to meet with the FDA, as well as early meetings to discuss potential surrogate or intermediate endpoints. It also allows for expedited pathways such as rolling review and priority review. Although RMAT is for platinum-resistant ovarian cancer, this designation will benefit the entire CD8 program. We now have PRAME as a wholly owned asset with great potential, as shown by data from our peers as well as our own research. We aim to have the PRAME program IND-ready by the end of 2023. Finally, we'll continue to advance the allogeneic platform, both wholly owned and in partnerships with Genentech and Astellas. You can refer to this morning's press release for more details with respect to our decision to delay our first allogeneic IND until 2025 as we change cell lines for our MAGE-A4 allogeneic program, a decision that will not impact the work that we're doing with our collaboration partners. Simplistically, anything that I've not just outlined as a priority will be paused or stopped. We will stop the SURPASS-2 trial in GE cancers and stop work on the TIL IL-7 program. We will cease further investment in additional non-core activities, including work on pre-clinical pipeline projects such as the HiT program, additional targets and broader HLA coverage. We will also delay investment in the commercialization of afami-cel based on the BLA timelines, and we'll provide further guidance on a likely commercial launch date after the BLA has been submitted. Until we understand the terms of the transfer from GSK and the data package, we will not invest in lete-cel targeting NY-ESO. With resources focused on these key priorities and the corresponding restructuring, we anticipate that our cash runway will extend to early 2025. This will enable us to deliver the following. One, a filing of the BLA and subject to regulatory discussions, approval for afami-cel in synovial sarcoma, the first engineered cell therapy for a solid tumor. Two, a complete dataset for the monotherapy arm of our ongoing phase 1 SURPASS trial. Three, an initial dataset from the SURPASS phase 1 combination arm across late-stage tumors. Four, an initial dataset for the new cohort in second-line urothelial cancer patients in combination with a checkpoint inhibitor. Five, initial dataset for the new cohort in first-line head and neck cancer patients in combination with a checkpoint inhibitor. 6, complete recruitment of the phase 2 SURPASS trial for people with ovarian cancer as monotherapy and in combination with checkpoint inhibitor. 7, initiating clinical development for our PRAME program, and lastly, continued progress on our allogeneic platform for our wholly owned and our partnered programs. The business of developing engineered cell therapies for solid tumors is challenging and complex, but the strengthening data from afami-cel and our CD8 program demonstrate we are succeeding in something that has not been done before. We've made the difficult decisions to focus the company, prioritizing our pipeline and reducing our headcount to extend our cash runway into 2025. We will continue to make the choices necessary for Adaptimmune to successfully develop cell therapies to transform the oncology landscape, starting with afami-cel for people with synovial sarcoma and CD8 for people with ovarian, urothelial, and head and neck cancers. With that, I'll turn over to the operator for questions. Operator? Thank you. We will now begin the question-and-answer session. To join the question queue, you may press star then one on your telephone keypad. You will hear a tone acknowledging your request. If you are using a speakerphone, please pick up your handset before pressing any keys. To withdraw your question, please press star then two. We will pause for a moment as callers join the queue. The first question comes from Marc Frahm with Cowen and Company. Please go ahead. Hi. Thanks for taking my questions. Maybe just to start, you know, the response rates are kind of broadly similar across the three focused tumor types going forward, you know, being in the refractory setting. If some of those tumor types are being advanced as monotherapy and others only in combination right now, can you just walk through kind of strategic rationale for why some of those are moving only as combinations and others as monotherapy as well? Thanks, Mark. I'll ask Elliot to take a stab at that. Yeah. I mean, we could probably have a lengthy discussion going through tumor type by tumor type, and maybe we should find the time to do that. In general, you know, the monotherapy arm of the SURPASS trial is relatively mature, and we're really focusing on getting additional data in combination in the phase 1 trial. With respect to, I would say that in the target indications, we have not eliminated the possibility of continuing with monotherapy in late-line indications. We think that the greatest benefit to patients with this type of therapy is likely in earlier lines and likely in combination with checkpoint inhibitors. That's why we're pursuing the two indications, in particular, head and neck cancer and bladder cancer, in earlier lines in combination with checkpoint inhibitor. We outlined some of that, you know, back at the call in September. There are several, you know, reasons for considering that. That's helpful. Maybe just on a modeling question with the kinda organizational changes you announced, but also, you know, there's some of these cohorts are moving forward. Can you just walk through some of the pushes and pulls over the next few quarters in terms of expenses? Should we expect them to go down short term and then rise again? Or are the investments in some of the trials gonna happen quickly enough that they kinda overwhelm some of the organizational changes? I'm gonna ask Gavin, the CFO, to talk about push and pull as we go forward with the restructuring. Gavin? Yes. Thanks, Marc. I mean, as we move into the restructuring that we arranged or announced today, we're gonna have to think fairly carefully about the puts and pulls that you talked about. I think as we think about the shapes of spend over the next two years, it's likely that we're going to try and make those broadly similar between years one and year two, not least because we believe in the intervening time the data we're delivering will continue to drive value. I think there are some spikiness probably in Q1 as we get over some of the CapEx investments that we've been making here in the UK and our genetic facility that's nearly complete, but also in finishing off the Navy Yard expansion. As we think through the shapes, we'll be able to update you in more detail early in the new year. Okay. Thank you. That's helpful. Thanks, Marc. The next question comes from Tony Butler with ROTH Capital Partners. Please go ahead. Thanks very much. Adrian or Elliot, as you alluded to a few minutes ago, if you move into lesser lines of therapy, less refractory patients, in SURPASS, especially in urothelial and head and neck, can you provide some information as to what becomes the hurdle rate that suggests, hey, this is where we need to be, and we're gonna continue to advance those patients in those particular cancers? Thanks very much. I think the strategy in both of those indications is that there are patients in both first-line head and neck and second-line bladder cancer for whom checkpoint inhibitors, while indicated for those patients, have a relatively low response rate as monotherapy. You know, in the 20% range, depending on patients. The intent is that we would be able to dramatically transform that rate based on the response rates that we're seeing. In combination with checkpoint inhibitors as standard of care, but also mechanistically as a way of continuing the efficacy of the T cells and both that our T cells and the T cells recruited to the tumor by our T cells can then extend those responses to be durable with an ultimate desire to impact not just on a sort of response rate basis, but on a time to event endpoints, progression-free survival and overall survival. The strategy is to drive very high response rates in those settings where the current response rates are low and for those responses to be durable. Yeah. Thanks, Adrian. May I ask one more follow-up, and this is, Please. With respect to headcount reduction. To the degree that you've made this public internally, can you provide some information as to what areas in R&D or other where the reduction may be most felt? In other words, provide some color on the balance of the company post the reductions, if you can. Yeah. I think what we can say is obviously we're embarking on this process internally, and this process is obviously subject to an appropriate process both in the U.S. and in the United Kingdom, and will complete at the beginning of next year. It would be, I think, inappropriate for me to go into more detail externally as we work through the details and the structure internally. What I can say is that we anticipate that most areas of the company will be impacted by this. Also, at the end of it, we will be not the 550-person company that we currently are, but more like 400-person company. Still split between the U.K. and the U.S. We will still be a transatlantic company in that regard, but a smaller one, and focused on the priorities that I outlined in my comments earlier in the call. Appreciate the comments. Thank you. Great. Thanks, Tony. The next question comes from Mara Goldstein with Mizuho. Please go ahead. Great. Thanks so much for taking the question. On the rolling submission for afami-cel, can you speak to the totality of the data that you'll be able to have in the submission as it goes into the agency in terms of, you know, the duration and what you'll be able to submit? I'm just curious, on the allogeneic cell line, how did you discover the chromosomal abnormality? Certainly. I will ask, Dennis, who leads our late-stage development and has been responsible for delivery of afami-cel, to talk about the first of those questions. I will ask Joanna Brewer, the CSO, to cover the question on allogeneic after that. Dennis. Yeah, sure. The clinical package that we are proposing to include in the BLA, which we discussed with the FDA at the pre-BLA meeting, and they're in agreement that it supports a BLA submission for that indication, will include a longer duration of follow-up of all the patients, right? That reflects the data that we're gonna present at CTOS, where, you know, the median duration of response by independent review is around a year, and patients are still with ongoing responses. That data cut is about 10 months more mature than what we originally prepared that we took last year. We're sort of writing up that application, that aspect of the application now. Hopefully that answers your question about the BLA. A lot of that data here again will be presented at CTOS later this month. You'll have an opportunity to see what the efficacy and safety data looks like, as well as some translational data that we're putting into that presentation. I will hand it over to my colleague, Joanna Brewer, to talk about your question about the allo. Hi. Yeah. Thanks. As we go through the allo program, we're constantly looking at the genetics of the line. It's something that we should do because it's a stem cell program. We're looking at what changes within the field and what is currently best practice. We've been aware of this. It's in an area of chromosome 20, which is very common. It's a hotspot in iPSC lines, and so we've been looking at this region very carefully. It's something we've been aware of for a while, but what has changed is our view on the balance of risk, and that's from more recent analysis. It hasn't happened because of the editing methods that we're using. It hasn't happened because of the expansion protocols we use in the banking technology either. It's been a very stable change that's been there for a long time. It's just a change in how we view the risk of that particular level of mutation, which is why we've decided to switch to a different cell line. Okay. Thank you very much. If I could just on the additional data on SURPASS-1. At this point, are you able to glean out any commonalities between ovarian cancer patients that are responding? That have had responses. This is Dennis Williams again. I would say we see responses in a wide array of ovarian cancer patients. You know, they're in SURPASS, there is some heterogeneity on the duration of their platinum-free interval. There's heterogeneity in their MAGE-A4 expression. There's heterogeneity in their tumor burden. But we do see you know responses across a large number of these attributes. Certainly for the phase 2 trial that's in SURPASS-3, which is in platinum-resistant ovarian cancer, we're looking to have a more homogeneous patient population. You know, we're really defining you know the And- the platinum-free interval periods. I'm sorry. Did you have follow-up? No, I'm sorry. Okay. Yeah, I mean, hopefully that addresses your question. Okay, thank you very much. Thanks, Mara. The next question comes from Jonathan Chang with SVB Securities. Please go ahead. Current responses in our response rates. Got it. If I recall correctly at ESMO, you guys mentioned there were two unconfirmed responses in urothelial and melanoma. Have those been confirmed? The melanoma response did not confirm. The urothelial responses did. It's why we don't- Got it. Is that- Report unconfirmed response. It's why we don't report unconfirmed responses in our response rate. Got it. Is that the same urothelial- Is that the same urothelial patient? Yes, that is one of those urothelial patients is the complete responder. Correct. Yeah. Understood. Then just one more question from me. Earlier you guys announced the transfer of the PRAME and NY-ESO programs from GSK. Can you provide any color on the reasons behind this and what the status next steps for these programs are? On the reasons behind that, I think you'll have to refer to GSK statements on their portfolio prioritization. All I can say is that we are delighted that their strategic decision has resulted in such credible programs returning to their mothership. Then in terms of development, I think I mentioned it earlier, we are looking forward to putting the PRIME program into the clinic, and it should be IND ready next year. We think that is a very significant target, and I think that is a view generally held by others in the field as well. We're very excited about that. With respect to lete-cel, we need to understand both the terms of the transition back from GSK, and ultimately the data arising from the trials that they have conducted in order to be able to determine next steps for lete-cel. Got it. Thanks for taking the questions. Thanks, Jonathan. The next question comes from Michael Schmidt with Guggenheim. Please go ahead. Hey, this is Paul on for Michael. Thanks for taking our questions. Just a couple from Michael. First on the afami-cel submission, could you provide some updates on the non-clinical data BLA components that were in progress, as of last quarter, including the vector and T-cell PPQ? And just to clarify, does starting that rolling BLA process mean some of your remaining sort of components will be ongoing in the next quarters, or do those have to be sort of completed to begin the process? Yes. Yeah, sure. Thanks for the question. Vector PPQ, those lots have been filled, and they're in analysis and recording presently. T-cell PPQ, those batches have been harvested, and they're also in testing and analysis presently. To answer your question, yes, some activities will be ongoing during the process of which the first part of the application would have gone out the door. There are a number of, you know, additional validation studies, some of which influence the last piece of the submission when it will go in, that will be ongoing during that time. Some authoring of Module 3, the CMC module, the quality module, will be ongoing at the time that we are, you know, the first part of the rolling review starts. That's part of the advantage of rolling review, right? I mean, you could. Parts of the application that are complete can go in and start the process, the FDA re-review process while the additional pieces are being finalized. I'll just pause there and you know, for any follow-up questions. Got it. That's helpful. Thanks. And then just a second question on the PRIME program that you recently gained full rights to from GSK. Just wondering how that recent transition impacts, you know, your near or midterm development plans, you know, versus what was planned, I guess previously. Maybe talk about, you know, sort of where you see the opportunity across PRIME-expressing indications, particularly with, you know, a couple other competing programs in the clinic right now. Thanks. Maybe I'll start on that and then on the terms, and then I'll hand over to Jo to talk about how we see PRIME going forward. I'll just touch on the PRIME program was being developed by us. We have yet to hand it over to GSK, although that decision was imminent in our consideration. There is no transfer back to us because we currently have that program in-house. All the transfers back is the future rights. We're very pleased about that, and we can get going on that, move that into the clinic as the IND ready, going into next year. I'll ask Jo to comment about where we see the opportunity for a PRIME therapy going forward. Thanks, Ed. Yeah, as I'd said, we have the data in hand, and the team is very excited actually at being able to accelerate the program forward. We were getting it to the stage where we were ready to pass that across to GSK. There may be a few changes, the differences between our manufacturing process and theirs that we will need to tweak up. We are ready, and we have full control of the platform means that we can go through CMC in the way that we're used to, that we've put all our previous TCRs through that same process. We know what we have to do for PRIME. We've done it before with other TCRs, so that's quite relatively easy for us. We don't have to deal with a different manufacturing process. This is what we would have had to do if it had stayed with GSK, and that would have been their choice. From that point of view, it's kind of come back into the fold and under our control. PRIME in itself is a really complementary target to MAGE-A4. It's obviously present in multiple places where MAGE-A4 is as well, and I think we will use our existing clinical experience to really try and Maximize the leverage that we have there. PRAME's expressed in a wide range of indications and in the indications that we're familiar with and already have those clinical links, that's where we'll probably start. That will be part of the process as we go through getting IND ready, fully understanding the clinical path forward. Great. Thank you for the question. The next question comes from Peter Lawson with Barclays. Please go ahead. Great. Thanks for taking these questions. Couple of questions, clarifying questions, I think mostly for Gavin and just on how should we think about the scale of the sales force in light of the restructuring and should we be thinking the majority of these cost savings are happening in R&D? Hi, Peter. In terms of sales force, we were beginning to think about how we were gonna stand that sales force up towards the back end of the year. Since you've been thinking quite hard about that. As a result of the timings and the BLAs, as Ed touched on earlier, we're gonna be pausing that investment. At the moment, we won't be making the hiring in the same profile as we had been anticipating before this announcement. In terms of the restructuring, that will be across the organization. We're just at the beginning of the consultation with people. I don't want to get too far ahead of our skis just at the moment. One would imagine with a reduction of approximately 25%-30% that most areas of the organization will be impacted. Gotcha. Thank you. How are you thinking about the use of partnerships to help finance the company? Just your thoughts about what could be partnered and areas you'd kind of seek out partnerships for, whether it's geographically or indication. Yeah. I'll start, and perhaps Helen will take over. I mean, we clearly, as a company of our size and scale, then geographic partnerships, perhaps outside of the U.S. and Europe will always be attractive. We've got a broad range of assets. You know, there are certain ones which are very close to our hearts, but others that we'd be more interested in partnering, having those partnering conversations. I'll hand over to Helen to discuss a little further. Yeah. Thanks, Gavin. Hi, Peter. This is Helen Tayton-Martin. I think one dimension I would emphasize is the co-development, co-commercialization strategy that we've applied in our most recent partnerships with Astellas and with Genentech in relation to assets that we develop. Given the stage and potential value creation that we can achieve with a broad indication asset like MAGE-A4, we clearly have a lot on our hands in terms of development demands and commercial opportunity. We'll be thinking quite carefully about working with partners where there is a potential win-win on how we think about co-development and co-commercialization. That would clearly be part of the thinking as we continue to build the capabilities to accelerate these assets. Clearly, we're always talking to potential partners, but there's got to be an alignment on how we continue to build value in the company in those discussions. Great. Thanks so much. Those are my questions. Thanks, Peter. The next question comes from Soumit Roy with Jones Trading. Please go ahead. Hi, everyone. Congratulations on all the progress, and thank you for taking the question. Two quick ones on ovarian cancer, if you can provide any color on these. Do we know the baseline CA-125 levels of these patients as they were coming into your trial? Yeah. Thanks for the question. Actually, given the fact that SURPASS-1, its original design was a basket study, we did not necessarily have detailed information that you might collect if the trial would have been, you know, ovarian specific. CA-125 originally was not a pre-specified item that we collected. The response criteria that we used, it did not incorporate, you know, a CA-125 response. I think since that time, as we started seeing signals, we started to collect CA-125 data, right, 'cause it's standard of care in this disease. We don't have that across all the patients, I don't think we're in a position to comment. Certainly for the phase 2 trial, that will be pre-specified. That is something we'll be collecting. I see. Can you characterize, like, were these patients, the ovarian cancer patients, had a higher tumor burden or they were, like, soon after they relapsed from the previous, prior line of therapy? Yeah. It's pretty heterogeneous. The ones who responded at least. Yeah. It's pretty heterogeneous. I mean, we see responses in folks that have tumor burden of, let's say, you know, 34 mm up to, like, over 100 cm, right? So I don't know that I could definitively say that responses are more likely in one group versus the other than, you know, in general, I would say those with lower tumor volume tend to do, you know, have better responses than those that have higher tumor volume. That's true for afami-cel, and that's almost certainly true for CD8. It's almost certainly true for most cancer therapies. We do see responses across, here again, a wide range of tumor burdens. This is not unique to ovarian cancer. Great. One last question. Do you see the level of MAGE-A4 expression? Is it homogeneous? Are the levels similar across the patients in ovarian cancer or head and neck, or is it widely varying? You know, there's certainly heterogeneity in MAGE-A4 expression. I think, you know, the interesting thing that I would say is, generally speaking, in some of these indications, if you have MAGE-A4 expression, you have a lot of MAGE-A4 expression, right? So when we present data, you know, by H-score or P score, in some cases, the value that we have for this trial is actually higher than in like we have for SPEARHEAD-1, where MAGE-A4 expression is very commonplace in synovial sarcoma. It just happens to be that in this, you know, in a lot of these tumor types, if you have it, you have a lot of it. I see. That you see in a third of the patients, or less? Based on the trial entry, for these tumor types, so for ovarian cancer, it's about 25%. For head and neck, it's around the same number. For bladder, it's a little bit higher than that. Thank you. Really helpful. Congrats on the progress again. Thank you. Thanks. This concludes the question and answer session. I would like to turn the conference back over to Adrian Rawcliffe for any closing remarks. Thank you for your time. Thank you for your questions today. I look forward to further conversations, and please do reach out if you would like to discuss further. Have a great day. This concludes today's conference call. You may disconnect your lines. Thank you for participating, and have a pleasant day.