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Use these links to rapidly review the document TABLE OF CONTENTS Index to consolidated financial statements Table of Contents ( Mark One ) 0 ý 0 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 FORM 20 - F REGISTRATION STATEMENT PURSUANT TO SECTION 12 ( b ) OR ( g ) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31 , 2020 . OR TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to OR SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of event requiring this shell company report Commission file number : 001-36619 The Netherlands ( Jurisdiction of incorporation or organization ) AFFIMED N.V. ( Exact name of Registrant as specified in its charter ) Technologiepark , Im Neuenheimer Feld 582 69120 Heidelberg , Germany , ( +49 ) 6221-6743-60 ( Address of principal executive offices ) Copy to : Sophia Hudson Kirkland & Ellis LLP 601 Lexington Avenue New York , NY 10022 Phone : 212 446 4750 Fax : 212 446 4900 Securities registered or to be registered pursuant to Section 12 ( b ) of the Act : Title of each class Common shares , nominal value € 0.01 per share Trading Symbol AFMD Securities registered or to be registered pursuant to Section 12 ( g ) of the Act : Adi Hoess , Chief Executive Officer Tel : ( +49 ) 6221-6743-60 Technologiepark , Im Neuenheimer Feld 582 69120 Heidelberg , Germany ( Name , Telephone , E - mail and / or Facsimile number and Address of Company Contact Person ) Name of each exchange on which registered The NASDAQ Stock Market LLC None ( Title of Class )