Good day, and thank you for standing by. Welcome to the Akoya Biosciences third quarter 2022 earnings conference call. At this time, all participants are in a listen-only mode. After the speaker's presentation, there will be a question and answer session. To ask a question during the session, you will need to press star one one on your telephone and you will then hear an automated message advising your hand is raised. Please be advised that today's conference is being recorded. I would now like to hand the conference over to your speaker today, Priyam Shah, Head of Investor Relations. Thank you, operator, and thank you to everyone who is joining us today on this call. I'm Priyam Shah, Head of Investor Relations at Akoya Biosciences. On the call today, we have Brian McKelligon, Chief Executive Officer, and Joe Driscoll, Chief Financial Officer. Earlier today, Akoya released financial results for the third quarter ended September 30th, 2022. A copy of the press release is available on the company's website. Before we begin, I'd like to remind you that management will make statements during this call that include forward-looking statements within the meaning of federal securities laws, which are made pursuant to the Safe Harbor provisions of the Private Securities Litigation Reform Act of 1995. Any statements contained in this call that relate to expectations or predictions of future events are forward-looking statements. Actual results may differ materially from those expressed or implied in the forward-looking statements due to a variety of factors. For a list and description of the risks and uncertainties associated with Akoya's business, please refer to the Risk Factors section of our Form 10-K filed with the Securities and Exchange Commission on March 15th, 2022. We urge you to consider these factors. You should be aware that these statements should be considered estimates only and are not a guarantee of future performance. This conference call contains time-sensitive information and is accurate only as of the live broadcast today, November 7th, 2022. Akoya disclaims any intention or obligation, except as required by law, to update or revise any financial projections or forward-looking statements, whether because of new information, future events, or otherwise. We would like to inform listeners that Akoya will be participating in the upcoming Stephens Nash 2022 Investment Conference in Nashville. Additionally, we will be participating in the Canaccord MedTech and the Piper Sandler Healthcare conferences in New York this month. Please see our investor relations page for pertinent dates and webcast information. Lastly, we will be hosting our second annual Spatial Day virtual event on December 15th. Registration information can be found on our press release today. We hope to see many of you attend. With that, I'll now turn it over to Brian. Thank you, Priyam, and good afternoon to everyone, and thank you for joining us today. Akoya had a very strong third quarter of 2022 and continues to demonstrate success in revenue, total instruments placed, and publications spanning the discovery, translational, and clinical segments of the spatial biology market. We reported a record revenue of $18.9 million in the third quarter, representing a 40% growth compared with the third quarter of 2021. Akoya's robust growth quarter after quarter is a byproduct of three key drivers: strategic product development, commercial execution, and a balanced portfolio of revenues by product category, by market segment, and geography. We sold a total of 55 instruments in the third quarter, consisting of 17 PhenoCyclers and 38 PhenoImagers, representing a 67% growth in placements from the prior year period, and we ended the quarter with an install base of 863 instruments, on track to reach 1,000 in the next few quarters. The rapidly accelerating publication volume featuring Akoya's platform, now over 690 to date, and a near doubling from a year ago, is a key leading indicator that the adoption of our platforms will continue. Akoya's product portfolio is setting the industry standard for spatial biology and delivering meaningful value to our customers. Imaging-based approaches now dominate in spatial biology, which gives affirmation to Akoya's foundational cycling and imaging-based in situ technology on which the company was founded. We have built on this success, now delivering second-generation solutions that provide single-cell phenotyping through industry-leading optics and the fastest workflow available. Our platforms are each purpose-built for the discovery, translational, and clinical market segments, delivering meaningful discoveries in immunology, oncology, neurobiology, infectious disease, transplant medicine, and more. At the upcoming Society for Immunotherapy of Cancer conference, or SITC, taking place this week in Boston, and also announced today, we will be unveiling our new PhenoCode Signature Panels, previously referred to as our universal protein chemistry. The commercial launch will take place by year-end, and at SITC, we will outline these new validated antibody panels for use on the PhenoImager platforms. The PhenoCode Signature Panels were created for the rapidly advancing immuno-oncology therapy landscape that includes nearly 6,000 ongoing clinical trials. With tissue-based biomarkers central to these trials, the need for a robust, rapid, whole-slide multiplex tissue imaging and analysis solution to identify prognostic and predictive biomarkers has never been more important. The PhenoCode Signature Panels are designed to run on our PhenoImager platforms. These pre-designed panels focus on distinct areas of tumor biology in response to therapy that are of greatest interest to translational and clinical researchers. Extensively tested by Akoya, and available in modules with the flexibility to customize, the PhenoCode Signature Panels will rapidly accelerate biomarker assay development and validation for our PhenoImager customers, particularly in the fields of cancer and immunotherapy. With the launch of these panels, Akoya now provides a complete end-to-end solution for our translational and clinical customers, now including the full suite of necessary antibody and reagents. To summarize, Akoya's new PhenoCode Signature Panels will, one, provide ready-made and customizable panels for our PhenoImager customers. The panels address distinct areas of tumor biology in response to therapy that are of greatest interest to translational clinical researchers in cancer immunotherapy. Two, they will simplify and accelerate biomarker assay development and validation by delivering a full end-to-end spatial phenotyping workflow. Three, they will drive higher system utilization and an increase in revenue per sample, resulting in expanded pull-through on our PhenoImager platforms. We are progressing several additional initiatives in the downstream translational and clinical markets, and our Advanced Biopharma Solutions CLIA lab out of Marlborough has become a valued resource for our biopharmaceutical partners, resulting in a material expansion of our pipeline and programs with leading oncology companies. As discussed last quarter, our agreement with Acrivon Therapeutics to develop and commercialize a first-of-its-kind spatial signature companion diagnostic for Acrivon's targeted oncology agent is an important milestone in developing an expanded clinical menu offering and indicates a clear path towards addressing the large spatial biology clinical TAM. Turning now to the upstream discovery market, we have several product innovations underway including adding new applications, further platform advancements to drive additional speed and productivity, and enabling expanded software solutions. First, we will be completing the automation of Bio-Techne's RNAscope on the PhenoCycler-Fusion by year-end. RNAscope is the industry's leading spatial transcriptomics technology, with a focus on targeted applications with nearly 6,000 publications to date and a massive customer base. By automating RNAscope on the PhenoCycler-Fusion and co-marketing the shared offering with Bio-Techne, Akoya and Bio-Techne can accelerate the adoption of both platforms to drive incremental growth. In parallel, we are on track to complete our upgrade to the PhenoCycler-Fusion by year-end. We will begin implementing this upgrade into production builds for new instruments by year-end and initiating field upgrades in early 2023 for existing customers. This upgrade further increases the platform's speed and capacity and includes improvements to the hardware, fluidics, and software. For example, we will be delivering a multi-slide carrier for parallel processing of tissue samples. The result will be a near doubling of sample throughput. This upgrade is also required to support the RNAscope integration, so the launch of both is synchronized. These PhenoCycler-Fusion speed and capacity increases, and the addition of the RNAscope spatial transcriptomics application are part of Akoya's ongoing efforts to simplify and accelerate our workflow while simultaneously expanding available applications. It is the combination of the two, more speed and more applications, that are central to driving increased utilization and system pull-through. Simultaneously, we continue to further develop our proprietary RNA technology, which we demonstrated at the AGBT conference in June. We highlighted a proof of concept for a 100-plex on the PhenoCycler-Fusion. At the conference, we also showcased the industry's first proof of concept of 100-plex RNA and protein on the same tissue section. In the months following AGBT, emerging market surveys suggest an overwhelming demand for multi-omic analysis on the same tissue sample. We will be providing more details on our RNA portfolio and the timing for early access and commercial launch at our Spatial Day in December. We do anticipate initiating early access by year-end. To summarize our third quarter, we are very pleased with our strong financial and commercial performance year to date as we continue to expand our leadership position in the spatial biology market. As we have outlined, we are focused on the following targeted initiatives for the balance of the year. First, drive the continued adoption and improvements of the PhenoCycler-Fusion as the best-in-class in situ imaging platform. Second, continue to deliver new applications and drive further workflow and speed improvements across the instrument portfolio to drive expanded pull-through. Third, expand and advance our partnerships with leading biopharmaceutical companies and medical centers to drive the adoption of the PhenoImager HT in translational research and clinical diagnostics. As Priyam noted, Akoya will be hosting our second annual Spatial Day on December 15th. It will include a review of our new product introductions and presentations from top researchers in the discovery, translation, and clinical markets, all of whom have found tremendous value in Akoya's product offerings. With that, I will turn the call over to Joe to discuss our financial results. Joe? Thanks, Brian. Hello, everyone. As Brian highlighted, total revenue for the third quarter of 2022 was a record $18.9 million, as compared to $13.5 million in the third quarter of 2021, representing 40% growth. Year-to-date revenue of $53.6 million represents 38% growth over the prior year period. We see this as extremely strong performance year-to-date, given the challenging macro environment, and gives us increasing confidence that we are in a high-growth market that continues to be relatively insulated from the broader economic slowdown. Product revenue, which includes instruments, reagents, and software, was $14.4 million for the third quarter, compared to $10.9 million in the prior year period, representing 32% growth. Within product revenue, instrument revenue was $9.5 million compared to $7.1 million in the prior year period, an increase of 34%. We had another strong quarter with 55 instruments sold, of which 17 were PhenoCyclers and 38 were from the PhenoImager portfolio. This is 67% growth compared to 33 instruments sold in the prior year period. We have sold 166 instruments year-to-date, and the total installed base of instruments is now 863, which includes 229 PhenoCyclers and 634 PhenoImagers. As of September 30th, a total of 83 PhenoCycler-Fusion instruments have been shipped since the commercial launch at the start of the year, and we now have a total installed base of 72 for the combined PhenoCycler PhenoCycler-Fusion system, sold either directly as a combined system or upgraded from a previous standalone PhenoCycler instrument. The number of combined units is an important metric because this combination is projected to drive significant increases in reagent pull-through over the next few years. We continue to track a very impressive PhenoCycler-Fusion to PhenoCycler attach rate of over 75% on directly sold combined systems, which is ahead of our expectations of 50%-60% long term. Reagent revenue was $4.7 million for the quarter versus $3.4 million in the prior year period, an increase of 38%. With an annualized pull-through in the mid-$30,000 range per instrument for both the PhenoCycler and the PhenoImager HT today, we project the pull-through to increase significantly by as much as two to three times over the next several years across the instrument portfolio based on the following factors. First, as researchers become fully trained and expand the use of our rapidly expanding installed base of PhenoCycler Fusions. Second, new multi-slide and RNAscope upgrades on the PhenoCycler PhenoCycler-Fusion are up and running. Third, the new PhenoCode Signature Panels are utilized on the HT system. Finally, as our higher plex multi-omic content menus are rolled out commercially, we continue to project annual reagent revenue growth of approximately 40% per year for the next several years. Services and other revenue totaled $4.4 million as compared to $2.6 million in the prior year period, representing 69% growth. Our Advanced Biopharma Solutions CLIA lab continues to gain significant traction directed to large pharma and other meaningful clinical partnerships. Gross profit was $10.9 million in the third quarter, compared to $8.5 million in the prior year period. This resulted in gross profit margin of 58% for the quarter, consistent with the first half of this year. We continue to make investments in the CLIA service lab to support clinical trial enrollment and secure clinical diagnostic partnerships such as Acrivon Therapeutics, which has a near-term impact on margins. We have also experienced some impact on margin from inflationary cost pressures, consistent with what most other companies are experiencing. Instrument pricing continues to improve compared to the promotional pricing on PhenoCycler-Fusion in the first six months of the year. Operating expenses for the quarter totaled $27.6 million, as compared to $26.7 million in Q2 and $25.7 million in Q1, maintaining a consistently moderate increase in OpEx since the start of the year. Through the remainder of 2022 and in fiscal 2023, we will continue to make targeted investments in the company with a near-term focus on the commercial rollout of the PhenoCode Signature Panels. An R&D focus to further enhance our assay to analysis speed, multi-omic content menus, and CLIA service capabilities. We ended the quarter with approximately $82 million of cash and cash equivalents. We project that cash will be more than $70 million as of the end of fiscal 2022, which provides us ample runway to continue to invest in the business. Common shares outstanding are 37.9 million as of September 30th, and fully diluted shares, including the impact of outstanding options and unvested restricted stock awards, totals 39.7 million. To summarize, we had another record-breaking quarter with $18.9 million in revenue, a 40% increase over the third quarter in 2021. We sold 55 instruments across the product portfolio this quarter, 166 instruments year to date, and now have a total install base of 863 instruments. The sale of 83 Fusions in the first nine months of the launch demonstrates the robust demand for our new instrument offering. We remain very confident in our ability to deliver continued growth this year and are increasing our full year 2022 preliminary revenue guidance range to $73 million-$75 million as we continue to see tailwinds for our business and the spatial biology market. Now I'll turn it back over to Brian for closing remarks. Thank you, Joe. In summary, we're pleased to report a strong quarter and announce exciting new developments across the portfolio. We are thankful for the hard work of our fellow dedicated Akoyans, as well as for the support of our customers and shareholders. Akoya remains very well positioned for growth, and we're excited about the opportunities that lie ahead as we deliver new spatial solutions from the discovery to clinical markets. At this point, we will open the call up for questions. Operator? As a reminder, to ask a question, please press star one one on your telephone. Please stand by while we compile the Q&A roster. Our first question comes from Mason Carrico with Stephens. Your line is now open. Hey, guys. Thanks for taking the question. How's everyone doing? Good, Mason. How are you? I'm doing good. Good. Maybe to start off here, how are demand trends across geographies in Q3, and how have they trended in the fourth quarter so far? Have you seen any strengthening or weakening worth calling out, or has demand across most geographies been relatively steady sequentially? I don't think we'll really comment on Q4 yet, what we're seeing in the relative geographies is I think sort of reflective of our numbers. North America, really strong, EMEA, APAC delivered solid performance. I think as you noted from others, as we had indicated prior, there's some increased scrutiny on capital purchases. That's more a commentary on sales cycle versus demand. There's nothing that we're seeing in either direction, certainly in terms of headwinds, that would cause us meaningful concern. I think that's why we took our numbers to the point where Joe talked about in raising our guidance slightly. Got it. That's helpful. Then maybe just to follow up here, a two-part question. One, with the PhenoCycler-Fusion 2.0 launch, universal chemistry, RNA and multi-omics, what are your expectations for throughput per instrument next year, as much as you can give there, and maybe even qualitatively. Are you thinking about that increase over the next two to three years to be more linear, or should we expect a more moderate step-up next year and more material ramp in 2024 and 2025? Yeah You're starting to roll out? Yeah. I think what you'll see is, with all of those things sort of additive to driving application utility, to driving samples pre- into time, to driving $ per sample. Given that we're sitting on an install base of HPs plus Fusions, that's in the 380 range and 230 PhenoCyclers out there, it's going to be a conversion process for all of these things to get out and drive utilization. With that, we expect the pull-through to grow consistently over time, and I think we've talked about that before. With the PhenoCycler-Fusion 2.0, there's a pretty big range, and this is where it gets difficult for you all. There's a pretty big range on throughput as you think about number of markers and tissue size. You can maybe just think about the PhenoCycler-Fusion 2.0, you making your kind of 10-15 whole slide samples a week, fairly straightforward. I'm talking about a kind of a whole tissue slide at single cell. Got it. Thanks, guys. Thank you. Please stand by for our next question. Our next question comes from Tim Chang with Capital One. Your line is now open. Hey, thanks. Brian, I wanted to just ask you, obviously, you guys are doing well with the PhenoCycler PhenoCycler-Fusion launch. Could you talk a little bit, or provide a little bit of granularity on how you expect that product to ramp, not only in the U.S. but outside the U.S.? It seems like you're doing pretty well with that ramp up in the States, but I was just curious how much visibility you can provide outside the U.S. Yeah, I'll let Joe chime in. We don't really break down units ex-U.S. I think we expect it to ramp with equal contribution, given the numbers I just mentioned, Tim, on the large install base. Still lots of room to upsell our existing customers, but also driving into new customers. I don't think there's any sort of material or meaningful regional difference in terms of how we think about scaling the product, just differences in scale, frankly. Tim, with about 50% of our revenue in North America and the rest equally split between EMEA and APAC. Joe, I don't know if you want to add anything beyond that. No, I think that's right on the money. I think we would expect this rollout to be comparable to the rest of our business. As Brian just said, 50% North America, 25% EMEA, 25% APAC. That's the way we're looking at it right now. Okay, great. Just one quick follow-up. I noticed your ASPs, they did increase. Actually, I think they were, what, north of $170,000. Is this a number that you expect to continue to grow as we head into 2023? Yeah. Joe, you want to take that? Yeah, sure. We had promotional pricing in the first six months of this year on the F usion Launch to really try to take market share and get a lot of excitement in the marketplace. Yes, the ASPs did go up in Q3. I think you'll see them tick up again in Q4, then probably stabilize after that. I think we're finding where our sweet spot is in terms of pricing. Okay, super. Thanks much. Please stand by for our next question. Our next question comes from Mark Massaro with BTIG. Your line is now open. Hey, guys. Thanks for the questions. Congrats on your third straight beat and raise this year. Maybe the first question is for you, Joe. You just put up 40% growth here in Q3. Recognizing that you guys are doing a great job executing this year, I do want to ask about the outlook for Q4. It looks like it's a range of about 20%-32% for Q4. Is there any reason for us to use some degree of caution because you're coming off of growth rates in the mid to high 30s to low 40s? How should we think about the slight decel in Q4? I think there's a couple of factors there. One is, last year's Q4 was extremely strong, that makes a little bit of a tougher comp. This year, the revenues have been, I guess, more balanced by quarter, you're not seeing the massive spike between Q3 and Q4 that we've seen in prior years. I just think we've gotten more regular streams of business throughout the year this year as opposed to last year, where there was a pretty big discrepancy between Q3 and Q4 last year. We're not concerned or anything like that. We're just trying to maintain a conservative posture in our guidance. Okay, great. Nice to see the PhenoCode Signature Panels rolling out here. Recognizing that the plan here is to now increase your reagent pull-through per box on the PhenoImager HT, can you give us a sense for how you're thinking about pricing this? Then, how should we think about incremental contribution to growth in 2023? To the pricing question, maybe just directionally, as you look at, let's say, one of our customers on an HT system that is building a panel, prior to PhenoCode, they would just get that fluorescent detection reagents from us and largely source the antibodies themselves. In terms of their total spend, again, antibody prices can vary quite dramatically, but assume it's somewhere between 20%, 30%, 35% our portion of that revenue. As you look at the pricing of the PhenoCode, knowing that we're going to price additional value into those, because a lot of the validation work that we've done, I'm not going to give you a dollar price yet. That should give you a directional sense as we drive conversion of some existing panels. Primarily, Mark, it's going to be people developing new panels, where this will help accelerate that work. I think it's going to be similar to Mason's questions, kind of a step function as we walk through the year and see those conversions, but also getting new HT customers up and running a little bit faster. Okay, great. Just last one for me, maybe for you, Brian. Can you just speak to any other developments going on in companion diagnostics with your business and any next catalyst to look for with the Acrivon partnership? Final question is, I know you have links to some of the events at SITC, but is there anything in particular we should be looking out for? Thanks. In terms of Acrivon specifically, we're going to follow, obviously, their lead as they reveal advancements of their clinical program, because we're really sort of tied at the hip to that. In terms of milestones, I think it's going to be more qualitative commentary from us, as we noted in the earlier comments, that since the launch of ABS last year, the capabilities highlighted and codified with the Acrivon announcement, it's really just about, Mark, just expanding that portfolio of clinical trials we are participating in so that we have a higher probability of another CDx deal, while most importantly, at the same time, it's driving additional service revenue, but it also drives additional system placements. That's how I would address that again, qualitatively. At SITC, there's just going to be a lot of detail around these PhenoCode panels and their validation and their work. There's a large number of poster presentations. I think that would be probably the core event, but I'd invite you to look at our earnings press release. There's a link there to the SITC event and what we're doing. Okay. Thank you. Thanks, Mark. Please stand by for next question. Our next question comes from Tejas Savant with Morgan Stanley. Your line is now open. Hi, this is Neil on for Tejas. Considering the strong demand some of your peers have begun to see as they've begun to launch in tissue imagers of their own, any color on how this growing interest has translated for your own order books? What gives you confidence that your incumbent advantage in terms of using an imaging approach will continue to resonate just as strongly going forward, even after these new in-tissue platforms launch on the market? Maybe to your last question regarding, is imaging kind of the long-standing methodology, just for clarity, our approach and our imaging methodology, we think that on its own, the way we do the imaging, is a significant competitive advantage. The underlying microscopy technology, again, I'm a little bit biased, I think it's the best fluorescent imager system on the market in terms of speed, resolution, and quality. With that imaging system tied to our assays, that's what gives us the power and the speed and the quality from the HT to the Fusion. The commentary on imaging, what I would say is, every single platform that's getting launched is an imaging-based approach. That's sort of now universally what's accepted in terms of next-generation spatial biology is doing it via imaging. With respect to the competitors, a growing competitive environment, largely, I would assume that we are still going to be highly competitive and preferred with those that come in with a cell biology protein-based approach and will become increasingly competitive for those customers in spatial that are focused on RNA and spatial transcriptomics with the paired solution we've talked about historically. I think the competitive environment is sliced differently depending upon the different market segments, there specifically within discovery. I would reiterate that our platform, the PhenoImager HT, the new systems that are coming out from our friends at 10x Genomics and NanoString Technologies, those are really competing in the discovery market, largely within genomic segment. The HT system is decidedly different, and that sort of stands on its own in the translational and clinical markets. Got it. Thank you. Given the recent revisions of the product timelines, can you speak to what underpins your confidence in that decision and, any updates on that thinking over the last couple of months in light of some of these moving pieces in the macro? I'm sorry, which changes are you referring to, Neil? The reprioritization on the product roadmap. Yeah. I think the product roadmap. I apologize if there's some confusion, that's on me, but the roadmap, the priorities have remained really solid. I think what we announced today with the Fusion 2.0 hitting into production and that being tied to RNAscope, I think that's a refinement of our timeline. Hopefully you see that as consistent with prior. Then the second part of your comment, Neil, was what? Your question, rather? I guess, just kind of an idea on how that thinking has evolved over the last couple of months in light of some of these moving pieces in the macro, whether it be budgetary concerns in Europe or some of the reagent headwinds in China. Yeah, it's a good question. Nothing has really changed in terms of how we prioritize. Obviously, as we all kind of are looking in the face of a recession, just during our current strategic planning and budgeting process, you just become even more focused on every dollar in and the return on capital that comes out of that. It just is forcing a lot more rigor. I think you see that reflected in that decision-making is already reflected in the commentary Joe gave around our asymptotic spend quarter-over-quarter, quarter after quarter, rather, sequentially in terms of our OpEx this year. Got it. Thank you. Then, one last from me. As you begin to make that push into the genomics market segment, what do you see as the key drivers there to really start building awareness around the offerings, given that this customer set is likely less familiar with Akoya? Would that introduce another ASP dynamic, thinking about 2023, or? Yeah. You cut out right with your money question. I think you said spatial transcriptomics is the market segment you're asking about? Correct. I think for us, the way we look at that is how can we deliver with our existing core capabilities and expertise to protein, how can we think about delivering something that has differentiated value? Some of the feedback that I alluded to coming out of AGBT in the opening comments is really part of our current voice of customers and product roadmap decision-making, which is how do we build a platform that leverages the best of our capabilities with proteomics and our growing capabilities in the RNA, both in the discovery setting and the validation setting with our own technology and RNAscope respectively. With that, we've been really exploring and doing a lot of work on exploring multi-omics solutions where you contemplate your protein content and your RNA content simultaneously so that they become really catalytic in terms of the value they both bring to the scientist. Not so much focused on some sort of arbitrary plex war, but really focusing on the science and the panel development. Got it. I appreciate the time and congrats on a strong quarter. Thanks, Neil. Thank you. Please stand by for the next question. Our next question comes from Yichun Qin with J.P. Morgan. Your line is now open. Hi, this is Yichun for Julia. Thank you for taking my question. First, congrats on the quarter. Very impressive. I did a quick math about the placement for Fusion this quarter. It seems like it's 21 compared to the last two quarters, it's a slight drop. I'm just curious, how should I, or should we think about the driver for Fusion placement moving forward? Is it more relying on the attachment with the Cycler or it's more relying on the standalone orders? We don't really report out the PhenoCycler-Fusion separately, but I'll let Joe take it from there. I think what you see, as Joe alluded to, we have a fairly consistent, total instrument number for each of the quarters this year. There's always going to be a slight mix shift, as you go from a Q1 to Q2 to Q3. Overall, I think what we look at is that overall instrument number. The PhenoCycler-Fusion placements are being driven both from paired with PhenoCyclers, but also, to some extent, selling into our existing install base, where they're upgrading from a third-party scope to the PhenoCycler-Fusion. Joe, I don't know if you want to add anything. Yeah. Really the first six months of this year, we really went out with promotional pricing on the PhenoCycler-Fusion to really try to get market share, really try to convert existing PhenoCycler users to buy a PhenoCycler-Fusion. That was really the driver of the units that you're looking at for the first six months of the year versus Q3. I'd say Q3 is a more normal quarter, I guess, in terms of PhenoCycler-Fusion placements. Once again, just to reiterate, when we're selling a PhenoCycler, the attach rate with a PhenoCycler-Fusion to sell it at the same time is exceeding 75% right now, which is way above our expectations. We're selling a lot more bundled PhenoCycler-Fusions than what we had expected. In the first six months of the year, you're really seeing the impact of that promotional pricing to truly try to drive market share. Okay. Thank you. That's very helpful. My next question is about the ramp for the universal chemistry and the RNA panel next year. I'm just curious, how should we think about their adoption on the PhenoCycler-Fusion customers compared to those PhenoCycler-Fusion or HyFlex standalone customers? Yeah. Actually, I really appreciate that question to help provide some more clarity. Just a little bit on the science. The PhenoCode chemistry is really essentially a hybrid between some of the underlying CODEX chemistry that runs on the PhenoCycler and the historical OPAL chemistry. That assay, the PhenoCode assay, is really for the high throughput capabilities, not the high plex. That PhenoCode chemistry is really it will probably be most widely adopted on the HT system. You can think about the adoption of PhenoCode, again, qualitatively happening the fastest with new customers as they get new panels up and running, and with existing customers as they migrate over from the historical OPAL chemistry to the new PhenoCode chemistry. It really is a solution for the HT system and the PhenoCycler-Fusion to some extent. Okay. I have one last question. I haven't had the chance to look at the SITC posters. Maybe you guys can share with me on a high level about the PhenoCode, like how many biomarkers are there, how many are fixed, how many are customizable? Are the customizable panels specific to tumors or patients? Any end stages, or is it scalable to clinical in the future or to other diseases such like infectious or neuro diseases? Just give me a high-level overview of it. Yeah. The high level I will tell you is that we looked across several hundred publications, and what you see is this histogram where 10-15 particular antibodies dominate the cancer landscape. Many of those are deployed across multiple cancers. What we have are a series of panels that are generally about a five plex, which allows you to customize an open position or so. They're designed to answer specific questions. For example, one is designed to look at immune cell exhaustion. Another one is to look at macrophage polarization. Another one is to look at tumor-infiltrating lymphocytes. They're sort of thematically designed. Really highly validated. You could pick across one of those themes and then plug in kind of an antibody or so for yourself to customize. It's sort of a hybrid between fixed panels and customizable panels that are designed to really accelerate the time to get those new panels up and running. Okay. That's very helpful. Thank you. Okay. Please stand by for our next question. Our next question comes from Kyle Mikson with Canaccord. Your line is now open. Hi, this is Alex I appreciate the question, and I appreciate you kind of seeing all that come out today. Maybe just to reiterate, as Joe noted, we've got $82 million in cash at the end of the quarter. Really strong cash position. We do not have any pressing need at all for additional cash. I think as we noted in prior calls, we've been indicating that we sort of intended to be opportunistic. One of those mechanisms is really non-dilutive capital, and we announced with that filing our expanded MidCap facility that provides really cost-effective capital. They've been really a longstanding partner of Akoya, and we worked with them recently, as you'll note in the filing, a restructured debt facility that provides not only access to additional funds, but a longer interest-only period. That MidCap restructuring sort of further solidifies our cash position. Until today, we didn't have a shelf in place, a shelf registration in place. The filing today with that ATM is really commonplace, and we sort of look at it as simply sort of good corporate housekeeping. Again, I just reiterate, we don't have a pressing need for cash. There's nothing immediate. It's really, as I noted, taking advantage of our partnership with MidCap to give us another path for non-dilutive capital, restructuring that interest-only period, and just being prepared, and staying close to watch the markets if there's an opportunity. Thank you very much for that color. Just one last one. You previously discussed that the promotional pricing was one of the key drivers for this higher attach rate that we're seeing for the PhenoCycler-Fusion. I was just curious, how much longer do you think that we should expect to see this higher inflated attach rate of 70-plus% range, which is above that 50%, 60% range that you quoted previously, in terms of just trying to think about how we should model it out. Thank you. Yeah. Joe, you want to take that? Yeah, sure. It seems like that attach rate has been relevant now for the last several quarters. We're still watching it closely, but I believe we are going to end up kind of increasing our 50%-60% long-term attach rate to something more like 70%, maybe even more to 70%-80% attach rate over time. That's what we're seeing now. People really see the value in buying the PhenoCycler and the PhenoCycler-Fusion as one combined unit. I think that attach rate is going to be probably higher than what our long-term estimates have been. Got it. Thank you very much. As a reminder, to ask a question, please press star 11 on your telephone. Please stand by for our next question. Our next question comes from Jon Petersen with Piper. Your line is now open. Hi, guys. This is Jon on for David. Thanks for taking the question. Could you just tell us about any differences in pull-through between the customers who have Fusions, versus those who aren't currently utilizing them? Thank you. Yeah, thanks for the question, Jon. I think as we said on the last quarter, it takes a few quarters to get sufficient data to be quantitative around the pull-through differences. What I would say is that directionally, we're seeing a pretty active shift now within many of our larger customers from running some of their larger projects on the PhenoCycler versus the PhenoCycler on the PhenoCycler-Fusion. You don't really want to change platform midstream. I think as we get into perhaps next quarter, we can start being a lot more, at the end of next quarter, increasingly quantitative around tracking those differences. We do expect, as we've noted, for the pull-through number on the PhenoCycler-Fusion to be higher than the PhenoCycler alone, just because of the speed, the increased flex capabilities, et cetera. Great. Thank you. Could you just talk about the appetite for pharma spending generally? The appetite for what? I'm sorry. For pharma spending. Yeah. The pharma spending, our HTs are actually increasingly going into large pharma. That's an area we're actually seeing more penetration than historically. Whether it's pharma or other market segments, as I noted, there's some increased diligence around capital spend. We're not heavily reliant, and I assume this might be kind of behind the question. We're not really heavily reliant nor largely penetrated into some of the small emerging biopharma. It's overwhelmingly the large, kind of more well-funded biopharma that have multiple projects in queue and multiple biomarker projects where we're seeing a lot of our penetration. Not a lot of the emerging biotech, where there's been some commentary around funding challenges. All right, great. Thanks for taking the question. At this time, I am showing no further questions. I would now like to turn the conference back to Brian McKelligon for closing remarks. Yeah. We already kind of spoke a little bit on the closing. I just wanted to reiterate and thank everybody for their time, their attention, the insightful questions. Michelle, thank you for your help and support. We'll talk to you all soon. Thank you so much. Thank you. Conference call. Thank you for participating. You may now disconnect.
Loading workspace