Hello, and welcome to the annual meeting of stockholders of Amylyx Pharmaceuticals, Inc. Please note that today's meeting is being recorded. During the meeting, we'll have a question- and- answer session during which we will address questions pertinent to the matters included in the agenda. You can submit questions or comments at any time by clicking on the Q&A tab. It is now my pleasure to turn today's meeting over to Joshua Cohen, Co-Chief Executive Officer of Amylyx. Mr. Cohen, the floor is yours. Thank you. Good morning. I am Josh Cohen, Co-Chief Executive Officer of Amylyx, I will act as chairman of this meeting. I am pleased to welcome you to the Amylyx 2026 Annual Meeting of Stockholders. Before I call the meeting to order, I would like to note that the meeting will be conducted and questions will be considered in the manner outlined in the rules of conduct available on the virtual meeting website. Stockholders can submit questions related to the proposals that are the subject of this meeting through the virtual meeting platform. I would also like to introduce you to the members of our Board and our Executive team who are with us today. The members of the board with me today are Justin Klee, our Director, Co-Chief Executive Officer, and Co-founder, Dr. George Milne, Paul Fonteyne, Daphne Quimi, and Dr. Bernhardt Zeiher. The other executive officers of the company with us today are James Frates, our Chief Financial Officer, Gina Mazzariello, our Chief Legal Officer and General Counsel, who will act as Secretary of this meeting and will record the minutes. I would also like to introduce Joseph Apke, Audit and Assurance Partner, and Kara Seamon, Audit and Assurance Senior Manager of Deloitte & Touche LLP, the company's independent registered public accounting firm. The meeting will now officially come to order. The meeting is being held in accordance with the company's bylaws and Delaware law. Will the secretary please report at this time with respect to the mailing of the notice of the meeting and the stockholders list? I have at this meeting a complete list of the stockholders of record of the company at the close of business on April 10, 2026, the record date for this meeting, which is and will be available for examination by any stockholder on the virtual meeting website throughout this meeting. I also have with me an affidavit certifying that commencing on April 24, 2026, a notice of Internet availability of proxy materials was deposited in the United States mail to all stockholders of record as of April 10, 2026. The notice provided that stockholders could access and review our proxy materials, including the proxy card, proxy statement, notice of meeting, and 2025 annual report, or alternatively, request a print copy of the proxy materials. At this time, I'd like to introduce Stephanie Simeone, who has been appointed to act as Independent Inspector of Elections at this meeting. Ms. Simeone has taken and subscribed the customary oaths of office to execute her duties with strict impartiality, which will be filed with the records of the meeting. Her function is to decide upon the qualifications of voters, accept their votes, and when balloting on all matters is completed, to tally the final votes. Will the Inspector of Elections please report at this time with respect to the existence of a quorum? I have been informed by the Inspector of Elections that proxies have been received for 102,074,387 of the 111,085,857 shares of common stock outstanding on the record date, which represents approximately 91.89% the total number of shares entitled to vote at this meeting. This constitutes a quorum for the meeting today. I declare that quorum is present. We will now proceed with the formal business of this meeting. The following proposals are to be considered by our stockholders at this meeting. Proposal one is the election of George McLean Milne, Jr., PhD, and Paul Fonteyne as Class II Directors to serve on the Board of Directors until the 2029 Annual Meeting of Stockholders, and until his successor is duly elected or qualified, or until his earlier resignation or removal, all as set forth in the proxy statement. The company's bylaws require that a stockholder provide advance notice to the company of the stockholder's intent to nominate persons as Directors. No such notice was received. As such, I declare the nominations for directors closed. The board of directors recommends that stockholders vote in favor of the election of each of the directors named in this proposal. Proposal two is the ratification of the appointment of Deloitte & Touche LLP as the independent registered public accounting firm of the company for the fiscal year ending December 31, 2026. The Board of Directors approved the selection of Deloitte & Touche LLP and has asked the stockholders to ratify the selection. Stockholder ratification is not required by the company's bylaws. However, the Board of Directors is submitting this to the stockholders for ratification as a matter of good corporate governance. If the stockholders do not approve the selection of Deloitte & Touche LLP as the company's independent registered public accounting firm, the board of directors and the audit committee will reconsider the appointment. The Board of Directors recommend that stockholders vote in favor of this proposal. Proposal three is to approve on a non-binding advisory basis the compensation of our named executive officers. The Board of Directors recommends that stockholders vote in favor of this proposal. Mr. Cohen, Mr. Klee, and Mr. Frates were designated as proxies by certain stockholders. Such shares represented by proxy will be voted in accordance with the instructions given. If no instructions were given, such shares will be voted for the nominees listed in proposal one, for proposal two, and for proposal three. The Secretary will now describe the voting procedures. The time is now 9:06 A.M. Eastern Time on Thursday, June 4, 2026. The polls are now open for voting on each of the proposals described by the Chairman. Voting is by proxy and virtual ballot. You do not need to vote again if you have already voted your proxy by telephone or by mail, or by internet. We will now address pertinent questions that have been submitted via the virtual meeting platform. As a reminder, all questions should be limited to the proposals that are the subject of this meeting. Will Lindsey Allen, our Vice President of Investor Relations and Communications, please advise if we have any questions? We have no questions. If anyone attending the meeting, whether or not you already submitted a proxy, wants to complete the ballot virtually, please do so now. The time is 9:07 A.M. Eastern Time, and the polls are now closed for voting on each matter presented. No additional ballots, proxies, or votes, and no changes or revocations will be accepted. May we have the results of the voting? The report of the Inspector of Elections covering the proposals presented at this meeting is as follows. With regard to proposal one, each of George McLean Milne Jr. PhD, and Paul Fonteyne, have been elected to serve as class II Directors of the company until the 2029 Annual Meeting of Stockholders and until their successor has been duly elected and qualified, or until such Director's earlier death, resignation, or removal. With regard to proposal two, the ratification of the appointment of Deloitte & Touche LLP as the independent registered public accounting firm of the company for the fiscal year ending December 31, 2026, has been approved. With regard to proposal three, the compensation of our named executive officers has been approved on a non-binding advisory basis. Thank you. I declare that all of the proposals presented at the meeting have been approved or ratified by the stockholders. The final results of voting, including any ballots and proxies recorded during the meeting, will be set forth in the report of the Inspector of Election and will be also included in the minutes of the meeting. The final results will also be included in our reports filed with the SEC. There being no other business to properly come before this meeting, this meeting is now adjourned. Thank you for attending the company's 2026 Annual Meeting of Stockholders. I would like to turn it back to the operator. This meeting is now concluded, and you may now disconnect.