Page 1

Table of Contents ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended June 30 , 2021 OR UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 FORM 10 - K TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 001-38247 Aytu Delaware ( State or other jurisdiction of incorporation or organization ) 373 Inverness Parkway Suite 206 Title of Each Class Common Stock , par value $ 0.0001 per share Englewood , Colorado ( Address of principal executive offices ) Large accelerated filer Non - accelerated filer AYTU BIOPHARMA , INC . ( Exact Name of Registrant as Specified in Its Charter ) BIOPHARMA X ( 720 ) 437-6580 ( Registrant's telephone number , including area code ) Securities registered pursuant to Section 12 ( b ) of the Act : Trading Symbol AYTU 47-0883144 ( I.R.S. Employer Identification Number ) 80112 ( Zip Code ) Securities registered pursuant to Section 12 ( g ) of the Act : None Indicate by check mark if the Registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . Yes No Indicate by check mark if the Registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Exchange Act . Yes No Indicate by a check mark whether the Registrant : ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the Registrant was required to file such reports ) and ( 2 ) has been subject to such filing requirements for the past 90 days . Yes No Name of each exchange on which registered The NASDAQ Capital Market Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) . Yes No Indicate by check mark whether the Registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , or a smaller reporting company . See definition of " large accelerated filer " , " accelerated filer " and " smaller reporting company " in Rule 12b - 2 of the Exchange Act . ( check one ) : Accelerated filer Smaller reporting company Emerging growth company 0 0 0 If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13a ) of the Exchange Act . Indicate by check mark whether the Registrant is a shell company ( as defined in Rule 12b - 2 of the Exchange Act ) . Yes No The aggregate market value of common stock held by non - affiliates of the Registrant as of December 31 , 2020 was $ 88.4 million based on the closing price of $ 5.98 as of that date . As of September 10 , 2021 , there were 27,555,120 shares of common stock issued and outstanding .