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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 ( Mark One ) ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended : December 31 , 2020 FORM 10 - K TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No .: 001-34705 Codexis , Inc. ( Exact name of registrant as specified in its charter ) Delaware ( State or other jurisdiction of incorporation or organization ) 200 Penobscot Drive , Redwood City , California ( Address of principal executive offices ) Title of Each Class : Common Stock , par value $ 0.0001 per share Registrant's telephone number , including area code : ( 650 ) 421-8100 Securities Registered Pursuant to Section 12 ( b ) of the A : Trading Symbols ( s ) . CDXS Securities Registered Pursuant to Section 12 ( g ) of the Act : None Large accelerated filer Non - accelerated filer 71-0872999 ( I.R.S. Employer Identification No. ) 94063 ( Zip Code ) Name of Each Exchange on which Registered : The Nasdaq Global Select Market Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Act . Indicate by check mark whether the registrant ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( § 232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) . Yes Yes Yes Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404 ( b ) of the Sarbanes - Oxley Act ( 15 U.S.C.7262 ( b ) ) by the registered public accounting firm that prepared or issued its audit report . » Indicate by check mark whether the registrant is a shell company ( as defined in Rule 12b - 2 of the Act ) . Yes Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , a smaller reporting company , or emerging growth company . See the definitions of " large accelerated filer , " accelerated filer " and " smaller reporting company , " and " emerging growth company " in Rule 12b - 2 of the Exchange Act : No No Accelerated filer Smaller reporting company Emerging growth company If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 ( a ) of the Exchange Act . □ Yes Yes No The aggregate market value of voting and non - voting common stock held by non - affiliates of Codexis as of June 30 , 2020 was approximately $ 655.8 million based upon the closing price reported for such date on the Nasdaq Global Select Market . As of February 25 , 2021 , there were 64,400,716 shares of the registrant's Common Stock , par value $ 0.0001 per share , outstanding . No 0 ☐ 0 0 No 0 No