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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS Corporate Presentation January 2026 CorMedix Therapeutics
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS 2 This presentation contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, Section 27A of the Securities Act, and Section 21E of the Exchange Act of 1934, as amended (the “Exchange Act”), that are subject to risks and uncertainties. Forward-looking statements are often identified by the use of words such as, but not limited to, “anticipate,” “believe,” “can,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “will,” “plan,” “project,” “seek,” “should,” “target,” “would,” and similar expressions or variations intended to identify forward-looking statements. All statements, other than statements of historical facts, regarding management’s expectations, beliefs, goals, plans or CorMedix’s prospects should be considered forward-looking statements, including, but not limited to statements regarding financial guidance, sales, revenue and operating expense estimates, expectations regarding product utilization, product reimbursement rates, synergy estimates and timing, expectations and timing regarding clinical studies and development and expectations of CorMedix Therapeutics' product pipeline, results of the real-world studies, expectations regarding implementation and perceived benefits of CorMedix’s products, and estimates of total addressable market size.. Readers are cautioned that actual results may differ materially from projections or estimates due to a variety of important factors, and readers are directed to the Risk Factors identified in CorMedix’s filings with the SEC, including its most recent Annual Report on Form 10-K, copies of which are available free of charge at the SEC’s website at www.sec.gov or upon request from CorMedix and in the Quarterly Report on Form 10-Q for the quarter ended June 30, 2025. CorMedix may not actually achieve the goals or plans described in its forward-looking statements, and such forward- looking statements speak only as of the date of this presentation. Investors should not place undue reliance on these statements. CorMedix assumes no obligation and does not intend to update these forward-looking statements, except as required by law. Forward-looking statements involve estimates, expectations, projections, goals, forecasts, assumptions, risks and uncertainties. Actual outcomes or results may differ from anticipated results, sometimes materially. Factors that could cause actual results to differ include, but are not limited to: the strategies, plans and objectives of CorMedix Therapeutics (including it's growth strategy and corporate development initiatives); the status and timing of clinical studies, data analysis and communication of results; expectations regarding reimbursement rates, customer utilization, and other factors impacting the demand for CorMedix Therapeutics' products; the timing of regulatory approval of additional indications; and projections of revenue, expenses and other financial items; the timing, manner and amount of capital deployment; ; the ability of CorMedix Therapeutics to achieve the identified synergies; that operating costs, customer loss and business disruption (including, without limitation, difficulties in maintaining relationships with employees, customers or suppliers) may be greater than expected following the transaction; the retention of certain key employees; the expected benefits and success of Melinta’s products and product candidates; potential litigation relating to the transaction that could be instituted against CorMedix or its directors; rating agency actions and CorMedix’s ability to access short- and long-term debt markets on a timely and affordable basis; general economic conditions that are less favorable than expected; geopolitical developments and additional changes in international trade policies and relations, including tariffs; and the ability of our products and product candidates to compete effectively against current and future competitors. Disclaimer
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS Introduction 3
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS 4 CorMedix Therapeutics is a commercial pharmaceutical company focused on providing innovative products for institutional markets has a diversified portfolio of specialty injectable therapies that is built upon a scalable commercial platform • Multiple “shots on goal” via pipeline, potential label expansion, and government partnerships – DefenCath® (taurolidine and heparin) TPN indication would add an estimated 5MM annual infusions in the addressable market opportunity, an addressable market of ~$750MM data in early 2027 – REZZAYO ® (rezafungin) prophylaxis indication expansion would expand the addressable market 8x to over $2B data in 2Q 2026 • Institutional specialization enables bolt-on acquisitions in addition to organic growth – Products sold to 500+ hospitals, infusion centers and clinics to date – Integrated field-based commercial team focused on hospital and acute care • High visibility into revenue streams – Revenue guidance of $300 – 320MM and adjusted EBITDA guidance of $100 – 125MM in 2026 – Eight diversified products in the current portfolio, including DefenCath, six anti-infectives, and a mature branded product – Cash flow generating Attractive Financial Profile Scalable PlatformDiversified Growth Drivers
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS 5 CorMedix Therapeutics has a proven leadership team with a long track record of commercial outperformance PRIOR EXPERIENCEJOINED CORMEDIX THERAPEUTICS Joe Todisco Chairman & Chief Executive Officer 2022 • Chief Commercial Officer of Amneal Specialty • Co-founder and Chief Executive of Gemini Laboratories • Commercial Strategy and business development at Ranbaxy Beth Zelnick Kaufman EVP, Chief Legal and Compliance Officer, Corporate Secretary 2023 • Chief Legal Officer of Akorn Pharmaceuticals • Chief Legal Officer of The Broad Institute of MIT & Harvard • Assistant GC and Head of Government Affairs, Amneal • Actavis, Alpharma, Topcon America Liz Hurlburt EVP, Chief Operating Officer 2017 Led LOCK-IT-100 clinical study program • VP of Clinical Operations at Gemphire Therapeutics • Additional renal area experience from Rockwell Medical • Co-Founder of BRAHN (Biomedical Research Alliance at Hypertension & Nephrology LLC) Michael Seckler EVP, Chief Commercial Officer 2026 • Chief Executive Officer of Evome Medical Technologies • Chief Operating Officer of FerGene • VP, Global Marketing & Corporate Communications at Ferring Susan Blum EVP, Chief Financial Officer 2025 • CFO of Melinta (previously VP of Finance & Chief Accounting Officer at Melinta, Controller at Melinta) • VP and Controller, Textura Corporation (now Oracle) • Director, External Reporting and Revenue, PDL / Facet Matt David, MD EVP, Chief Business Officer 2020 • Previously CFO and Interim CEO of CorMedix • Head of Strategy at Ovid Therapeutics • Life science focused investment banker • Pharma research analyst at Lehman Brothers
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS 6 Financial highlights * 2025 unaudited and preliminary financial results are based on CorMedix Therapeutics’ current expectations and may be adjust ed as a result of, among other things, the completion of our internal review process and the completion of customary annual audit procedures, ** Excludes restricted cash (1) Pro Forma Net Revenue was prepared by combining the estimated financial results and for CorMedix and Melinta for the full fis cal year ended December 31, 2025, without further adjustment, as if the transaction had closed on January 1, 2025 (2) Adjusted EBITDA is a non-GAAP financial measure and excludes non-cash items such as stock-based compensation and certain non-recurring items. The Company expects to provide a reconciliation of Adjusted EBITDA to the most comparable GAAP measure in its earnings release relating to the fourth quarter and full year 2025 financial r esults. Such reconciliation is not included herein because CorMedix is finalizing certain amounts that would be required to be included in the U.S. GAAP measure or the individual adjustments for such reconci liation. GuidanceKey Financials Balance Sheet at December 31, 2025Key Statistics at December 31, 2025 FY 2025 Net Revenue (Pro Forma1) ~$400 million* FY 2024 Net Revenue (CorMedix) $44 million Q4 2025 Adjusted EBITDA2 $77 – 81 million* Q4 2025 Net Revenue ~$127 million* FY 2026 DefenCath Sales $150 – 170 million FY 2026 Adjusted EBITDA2 $100 – 125 million FY 2026 Revenue $300 – 320 million Market Cap $0.9 billion Common Shares Outstanding 79.3 million Exchange NASDAQ Global Market Convertible Debt $150 million* Cash and short-term investments** $148 million* FY 2027 DefenCath Sales $100 – 140 million FY 2024 Net Revenue (Melinta) $120 million Q4 2025 DefenCath Sales ~$90 million*
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS Product Current Therapeutic Area Product Class CRBSI Taurolidine and heparin catheter lock solution Candidemia and invasive candidiasis Echinocandin antifungal Serious infections including Acinetobacter Tetracycline antibacterial Complicated Urinary Tract Infections (cUTIs) Carbapenems/ beta-lactamase inhibitor Acute Bacterial Skin and Skin Structure Infections (ABSSSI) Lipoglycopeptide antibacterial ABSSSI and Community-Acquired Bacterial Pneumonia (CABP) Fluoroquinolone antibacterial Hypertension, Coronary Artery Disease, Heart Failure Beta-adrenergic blocker 7 The combined portfolio consists of a diversified and complementary set of assets Hospitals & IDNs Physician Office Infusion Centers Home Infusion Long Term Acute Care Centers Shared Call Points
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS Our Products 8
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS 9 DefenCath is well positioned to capture significant value across both outpatient and inpatient markets Source: CorMedix market research. DefenCath launched full scale for hemodialysis in July 2024 Strong commercial uptake with commercial agreements in place with 4 of the top 5 outpatient dialysis organizations, covering ~60% of the outpatient dialysis market Significant hemodialysis TAM of ~37MM vials outpatient and ~3.8MM vials inpatient 2H 2026 / 2027 Market Access Strategy TDAPA Buy & Bill Bundle Add-on • Drive continued volume with key partners • Pricing updates to reflect add-on payments GPOs/Health Systems – continued growth in access and utilization Medicare Advantage Contracting for long-term sustained pricingAnticipated changes to add-on payments in year 3 of TDAPA (Q3 ’26 – Q2 ’27) due to program mechanics
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS 0.46 0.13 0.0 0.2 0.4 0.6 Control (n=397) DefenCath (n=397) CRBSIs per 1,000 CD 10 DefenCath is the first and only FDA-approved catheter lock solution with significant risk reduction in catheter-related bloodstream infections (CRBSI) CRBSIs result in significant patient morbidity, mortality, and cost to healthcare systems demonstrated significant reduction in CRBSI risk in Ph III LOCK-IT-100 Study -71% p=0.001 of CRBSIs occur in hemodialysis patients with CVC access 1 Rajagopalan K, Massey K, Rajagopalan S, Imperiale-Hagerman S, Chew, P. Hospitalization Risk and Long-Term Complications Associated with Catheter-Related Bloodstream Infection Among Hemodialysis Patients [Abstract]. J Am Soc Nephrol 32, 2021: 350 2 Invasive methicillin-resistant Staphylococcus aureus infections among dialysis patients--United States, 2005. MMWR, 2007. 56(9): p. 197-9 3 Massey K, Rajagopalan K, Rajagopalan S, Grossman A, Chew, P. Catheter-Related Bloodstream Infection Incidence and Associated Mortality Risk: Analysis of Merged USRDS-Medicare Claims [Abstract]. J Am Soc Nephrol 32, 2021: 344 70% ~4x longer hospital stays1,2 ~2x more hospitalizations per year1 ~2x higher cost of hospital stay1,2 ~3x more likely to die within 90 days3
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS 11 DefenCath – US Renal Care positive real world evidence interim results Design Retrospective analysis of outpatients receiving dialysis through a CVC at USRC • 23,663 patients in pre-intervention (July 1, 2022 – June 30, 2024) • 7,051 patients that received at least one dose of DefenCath (July 1, 2024 – Sept. 30, 2025) Outcomes • CRBSI Definition: ICD-10 diagnosis coding for bloodstream infection due to CVC; This represents the most definitive measure of CLABSI • Hospitalization secondary to CRBSI was defined as hospitalizations with CRBSI listed as the primary admission and/or discharge diagnosis. Data were annualized to account for differences in study periods Study Population 7,051 matched patients in each cohort • Patients were matched based on age (18-64 or ≥65), sex, minority status, and Charlson Comorbidity Index Interim Results 72% reduction in CRBSI (infection rate/1,000 catheter days) 70% reduction in the annualized number of hospitalizations secondary to CRBSI
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS Next generation echinocandin with once-weekly dosing schedule – highly simplifies management of candidemia and invasive candidiasis Strong commercial uptake – On formulary at 55+ large health systems – 100+ new accounts purchased in Q4’25 – 200+ repeat customers TAM for treatment indication is ~$250MM, and expanded indication for prophylaxis of invasive fungal infections is underway with a significantly larger TAM of >$2B Patent coverage through 2038 – NCE exclusivity with GAIN extension until 2033, plus ODE until 2035 – Composition of matter patent coverage until 2032, potential PTE to 2036 – Composition and treatment patent coverage until 2038 12 REZZAYO disrupts the standard of care of daily echinocandins with its once-weekly dosing schedule, highly simplifying management of candidemia and invasive candidiasis Source: CorMedix market research, Datamonitor; Cancer.org; bloodstemcell.hrsa.gov. REZZAYO – Product overview
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS • Achieved ~$39MM revenue in 2024 & ~$47MM revenue in 2025 • Highly differentiated tetracycline with safety, tolerability and strong placement (1L/2L) in IDSA guidance as key drivers of usage – One of limited treatment options indicated for infections from Acinetobacter species • Achieved ~$20MM revenue in 2024 & ~$26MM revenue in 2025 • Meropenem and vaborbactam combination specifically designed to address the challenge of CRE – Demonstrated differentiated outcomes for patients with complicated UTIs with CRE and unsurpassed coverage for KPC-producing bacteria • Differentiated triple MOA that treats ABSSSI caused by gram-positive pathogens in adult patients – Single, one-time infusion avoids burden of multi-dose infusions and ensures adherence without requiring a PICC line or hospital stay – KIMYRSA is a 1-hour infusion, while ORBACTIV is a lower-cost, 3-hour infusion, providing flexibility based on account needs • Method of treatment patent coverage until 2031 • Drug product formulation patent coverage until 2032 • NCE exclusivity with GAIN extension until 2027 • Compound patent coverage until 2031 • Method of treatment patent coverage until 2039 • Single-dose method of treatment patent coverage until 2029 • High-purity composition patent coverage until 2035 13 MINOCIN, VABOMERE, and the ORI franchise (KIMYRSA/ORBACTIV) are highly differentiated anti-infectives with IP coverage IP & Exclusivity Overview & Highlights Note: CRE = carbapenem-resistant Enterobacterales, KPC = Klebsiella pneumoniae carbapenemase, IDSA – Infectious Diseases Society of America, ABSSSI = acute bacteria skin and skin structure infections, MRSA = Methicillin-resistant Staphylococcus aureus, PICC = peripherally inserted central catheter. Source: IDSA guidelines, UpToDate.
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS Expansion & Growth Opportunities 14
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS 15 CorMedix Therapeutics is well positioned to continue to create value as a diversified specialty pharma business with a compelling growth path Inflecting Commercial-Stage Company Strong Initial DefenCath Launch Broad Dialysis Market Penetration Strategic BD and financial flexibility to pursue growth opportunities Durable, Diversified Revenue Streams Melinta Acquisition, Expanding Portfolio REZZAYO Label Expansion into Prophylaxis DefenCath Indication Expansion (TPN) Track Record of Successfully Bringing Drugs to Market Platform for Full Suite of Institutional Products Operating at Scale High-Growth, Cash Flow Generating Business Life-Cycle Management Diversified Commercial Leader Single Indication Dynamic Institutional Platform Diversified Portfolio with Multiple Indications & Assets Past Today Near Term Longer Term
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS Product Therapeutic Area Expansion Pre-Clinical Ph I Ph II Ph III / Registrational Commercial Prophylaxis* Pneumocystis Pneumonia in HIV Adults* Chronic Pulmonary Aspergillosis* Total Parenteral Nutrition (TPN) Hemodialysis (Pediatric) 16 CorMedix Therapeutics development stage pipeline has potential to drive meaningful value over coming years Pipeline and Growth Opportunities Ph III Ph II/III Ready Ph III *Study being run by Mundipharma Ph II Ph II
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS 17 Expanded indication Ph 3 study (ReSPECT) for prophylaxis of invasive fungal infections is underway • Study for the prevention of invasive fungal diseases in subjects undergoing allogeneic blood and marrow transplantation (BMT) • Primary Endpoint – Non-inferiority of Rezafungin vs. SAR for fungal-free survival at Day 90 (+/- 7 days) (FDA) – Then assess superiority of Rezafungin over SAR for fungal-free survival at Day 90 (+/- 7 days) (EMA) • Select Secondary Endpoint – Evaluate discontinuation of Rezafungin compared to the SAR secondary to toxicity or intolerance at Day 90 (+/- 7 days) • Study site locations: • Company announced completion of enrollment in late September 2025. Standard Antimicrobial Regimen (SAR) Arm US Canada Belgium France Germany Italy Spain Turkey UK 2:1 randomized double blind • 13-week treatment of Rezafungin IV • 400mg loading dose in Week 1 • 200mg once weekly • Placebo for SAR • Fluconazole (400mg QD) • Posaconazole (300mg BID D1/daily) • Trimethoprim/sulfamethoxazole (TMP/SMX) • Placebo for Rezafungin injection ReSPECT Ph III Global Multicenter Study (Data Expected Q2 2026)
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS Allogenic BMT, 10 MDS, 22 AML, 26 MM, 39 SOT, 16 NHL, 23 0 20 40 60 80 100 120 140 Patients (000s) >$2B TAM Across all hematology/oncology and transplant patient usage Expands portfolio and reach into hematology/oncology and transplant markets Larger patient population, with potentially ~130k additional addressable patients for prophylaxis annually (vs ~50k receiving antifungal treatment) Longer treatment course (13+ weeks for prophylaxis vs. 4 weeks for treatment) Lower barriers to access as utilization is less dependent on hospital formulary approval process 18 REZZAYO’s label expansion into prophylaxis will unlock an opportunity of an additional ~130k addressable patients, representing a >$2B TAM Note: BMT = Bone Marrow Transplants, MDS = Myelodysplastic Syndrome, AML = Acute Myeloid Leukemia, MM = Multiple Myeloma, SOT = Solid Organ Transplant, NHL = Non-Hodgkin’s Lymphoma. Source: Internal market research, Datamonitor, Cancer.org, bloodstemcell.hrsa.gov. Prophylaxis Addressable Patient PopulationGrowth Opportunity REZZAYO label expansion – Prophylaxis
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS 19 Expanded indication Ph 3 study (NUTRI-LOCK) for CLABSIs in adult TPN patients is underway Program Overview: A Ph 3, randomized, double-blind, adaptive, 2-arm, study assessing the safety and efficacy of DefenCath in reducing central line-associated bloodstream infections (CLABSIs) in adult patients receiving total parenteral nutrition (TPN) via central venous catheter (CVC) Subjects 200 Total Sites in the U.S. & Turkey 25 Ph 3, Duration of treatment 12 months Randomization 3:1 (150:50)Efficacy of DefenCath as a CLS, when compared to heparin, in delaying time to index CLABSI Primary Endpoint
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS 20 Infections are a major concern in TPN • 1-4 episodes of infection per 1,000 catheter days • CLABSIs occur in up to 26% of TPN patients with a CVC • TPN is associated with a 4-fold increase in odds ratio for CLABSI • CLABSIs are associated with an excess hospital length of stay of 2-3 weeks • Patients who develop a CLABSI are 35-40% more likely to be readmitted Note: TPN = Total Parenteral Nutrition. CLABSI = Central Line Associated Bloodstream Infection. CVC = Central Venous Catheter. Source: CorMedix Market Research, CDC, UpToDate, Ross 2016 American Journal of Infection Control, Opilla 2008 American Journal of Infection Control, Thomas Jefferson University Hospital, Beghetto 2005 Journal of Parenteral Nutrition, Duke Health, Milstone 2010 Infection Control and Hospital Epidemiology. Infection Risk in TPN US Total Parenteral Nutrition Total Addressable Market (2024E) 1.55 3.130.25 0.51 1.80 3.64 0 1 2 3 4 Inpatient Home Total Infusions (MM) Ports or IVs CVCs, PICCs, or Midlines DefenCath Addressable Infusions ~4.7MM Total Potential Infusions $500-750MM Total Addressable Market DefenCath label expansion – TPN TPN represents an opportunity of ~4.7MM infusions per year across outpatient and inpatient settings, an addressable market of $500-750MM
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS Strategic Investment in In 2025, CorMedix Therapeutics made a strategic investment in Talphera in return for the right of first negotiation. This period will be triggered by Niyad (nafamostat mesylate) achieving the primary endpoint in its Ph III NEPHRO study. Niyad provides an opportunity to acquire a significant improvement to standard of care in continuous renal replacement therapy (CRRT) which could provide an additional growth driver in 2027 and beyond. 21 CorMedix Therapeutics has strong financial flexibility to pursue business development opportunities Strong Cash Position CorMedix Therapeutics as of December 31, 2025 has a strong cash position consisting of ~$148MM of cash and short-term investments and sustainable profitability from currently marketed products. The strong cash position in tandem with a strong base of sustainable profitability puts CorMedix Therapeutics in a position to continue to pursue accretive business development opportunities.
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS 22 Anticipated company milestones 2 H 2026 / 1H 2027 1 H 2026 • CorMedix Therapeutics Analyst Day on February 10th • CorMedix Therapeutics 4Q / 2025 earnings • REZZAYO prophylaxis study clinical data • Medicare Advantage updates • Conference presence at TANDEM, ASDIN, NKF, MAD ID, and APIC • CorMedix Therapeutics earnings and business updates • Talphera Niyad study clinical data • TPN study updates and clinical data • REZZAYO prophylaxis sNDA submission and potential approval • CMS updates for 2027 add-on payments for FFS patients
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NOT FOR DISTRIBUTION WITHOUT THE PRIOR WRITTEN PERMISSION OF CORMEDIX THERAPEUTICS 23 CorMedix Therapeutics key highlights Commercial specialty pharma business with portfolio of products, revenue scale, and a dynamic commercial platform in acute care poised for organic and inorganic growth1 Portfolio of differentiated hospital and acute care products2 Strong financial position; sustained profitability5 DefenCath launch has been successful; recent positive RWE study data3 Two significant growth opportunities in pipeline, including DefenCath TPN indication and REZZAYO prophylaxis indication4 Highly experienced leadership team6