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TABLE OF CONTENTS ( Mark One ) UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 FORM 10 - K ☑ ☑ ☑ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31 , 2020 Or TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 Delaware State or other jurisdiction of incorporation or organization For the transition period from Commission file number 001-37990 to LEAP THERAPEUTICS , INC . ( Exact name of registrant as specified in its charter ) 47 Thorndike Street , Suite B1-1 Cambridge , MA ( Address of principal executive offices ) Title of each class 27-4412575 ( I.R.S. Employer Identification No. ) 02141 ( Zip Code ) Registrant's telephone number , including area code ( 617 ) 714-0360 Securities registered pursuant to Section 12 ( b ) of the Act : Common Stock , par value $ 0.001 Trading Symbol ( s ) LPTX Securities registered pursuant to Section 12 ( g ) of the Act : None Name of each exchange on which registered Nasdaq Global Market Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . Yes □ No Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Act . Yes □ No Indicate by check mark whether the registrant ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . Yes > No □ Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( §232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) . Yes > No ☐ Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , a smaller reporting company , or an emerging growth company . See definitions of " large accelerated filer , ” “ accelerated filer ” , “ smaller reporting company " and " emerging growth company " in Rule 12b - 2 of the Exchange Act . Large accelerated filer □ Accelerated filer □ Non - accelerated filer Smaller reporting company ☑ Emerging growth company If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 ( a ) of the Exchange Act . □ Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404 ( b ) of the Sarbanes - Oxley Act ( 15 U.S.C. 7262 ( b ) ) by the registered public accounting firm that prepared or issued its audit report . Indicate by check mark whether the registrant is a shell company ( as defined in Rule 12b - 2 of the Exchange Act ) . Yes □ No ☑ The aggregate market value of the voting and non - voting common stock held by non - affiliates of the registrant , computed based on the closing price for such stock as reported on the Nasdaq Global Market on June 30 , 2020 , the last business day of the registrant's most recently completed second quarter , was approximately : $ 108.6 million . As of March 9 , 2021 there were 59,657,742 outstanding shares of the registrant's common stock , par value $ 0.001 per share , which is the only outstanding capital stock of the registrant . DOCUMENTS INCORPORATED BY REFERENCE : Portions of the registrant's definitive proxy statement for its 2021 Annual Meeting of Stockholders , which is expected to be filed with the Securities and Exchange Commission not later than 120 days after the end of the registrant's fiscal year ended December 31 , 2020 , are incorporated by reference into Part III , Items 10-14 of this Annual Report on Form 10 - K . With the exception of the portions of the registrant's definitive proxy statement for its 2021 Annual Meeting of Stockholders that are expressly incorporated by reference into this Annual Report on Form 10 - K , such proxy statement shall not be deemed filed as part of this Annual Report on Form 10 - K .