The annual meeting of stakeholders of Denali Therapeutics Inc. is called to order. My name is Ryan Watts, President and Chief Executive Officer of Denali, and as provided in the company's bylaws, I will act as Chair of the meeting. Alex Schuth, Chief Operating Officer and Financial Officer, and Secretary of Denali, will act as Secretary of the meeting. As in prior years, we are holding a virtual annual meeting of stockholders. We hope that this virtual format continues to provide greater access for all of our stockholders to participate, no matter where they are located in the world today. At this time, I'd like to introduce other directors in attendance. Jennifer Cook, director. Peter Klein, director. Nancy Thornberry, director. Tim Van Hauwermeiren, director. I'd also like to introduce the other representatives of management who are in attendance. Cindy Dunkle, Chief People Officer. Dr. Dana Andersen, Chief Technical and Manufacturing Officer. Dr. Chris Walsh, General Counsel. Also with us today are Joe Muscat, Tom Matroney, and Nick Zango, representing Ernst & Young LLP. Tony Jeffries and Jennifer Knapp, representing Wilson Sonsini Goodrich & Rosati, our outside corporate counsel, and Peter Descovich, representing Broadridge Financial Solutions, Incorporated. Now I will ask our secretary to make his report. Thank you, Ryan. I want to remind you that attendance at this meeting is by invitation only, and I trust everyone has registered prior to joining this meeting. If there is anyone who is not a stockholder of the company, a designated proxy of a stockholder of the company, or expressly invited by the company to attend this meeting, please leave the meeting. I confirm that the notice of Internet availability of proxy materials was mailed, and the proxy statement and annual report were made available beginning on or about April 21, 2026, to the holders of our outstanding common stock of record at the close of business on April 9, 2026. The list of the stockholders of record entitled to vote at this meeting has been certified by Broadridge Financial Solutions, Inc. as transfer agent for the company and is available on our virtual meeting website. Please note that this meeting is being recorded. However, no one attending via the webcast or telephone is permitted to use any audio or video recording device. Peter Descovich has been authorized to act on behalf of Broadridge Financial Solutions, Inc. as Inspector of Election for this meeting, and he has signed an oath to execute faithfully the duties of Inspector of Election at this meeting. The Inspector of Election has advised me that we have present, in person or by proxy, a sufficient number of shares to constitute a quorum. Thank you, Alex. I therefore declare a quorum to be present and that this meeting is duly convened and ready to transact business. Thank you, Ryan. As set forth in the notice of Internet availability of proxy materials made available to each of the stockholders and further described in the company's proxy statement, the business of this meeting is to, one, elect three directors to the company's Board of Directors as Class III directors. Two, ratify the appointment of Ernst & Young as the company's independent registered public accounting firm. Three, approve on an advisory basis the compensation for the company's named executive officers. The first item of business is the election of directors. The company's board of directors is divided into three classes, each with a three-year term. The Class III directors will be elected at today's meeting. The three nominees receiving the highest number of votes of the shares present in person or represented by proxy at this meeting and entitled to vote will be elected as directors to hold office until the 2029 annual meeting of stockholders or until their successors are duly elected and qualified. As indicated in our proxy statement, the following three individuals are nominated by the company's board of directors to serve as Class III directors: Jennifer Cook, Dr. David Schenkein, and Dr. Ryan Watts. Ms. Cook and Dr. Schenkein and Watts currently serve as directors of the company. The board of directors unanimously recommends a vote for each of its nominees. The second item of business is to ratify the appointment of Ernst & Young as the company's independent registered public accounting firm for the fiscal year ending December 31st, 2026. The audit committee of the board of directors has selected Ernst & Young as the company's independent registered public accounting firm for the fiscal year ending December 31st, 2026. While stockholder ratification is not required by the company's bylaws, the board of directors is submitting this to the stockholders for ratification as a matter of good corporate practice. If the stockholders do not approve the selection of Ernst & Young as independent auditors, the audit committee will reconsider the appointment. The board of directors unanimously recommends a vote in favor of the ratification of Ernst & Young. The third item of business is to approve the compensation of the company's named executive officers as directed in the proxy statement. This proposal is a non-binding stockholder advisory vote. The board of directors unanimously recommends a vote in favor of this proposal. We will now proceed to the question and comment period. I remind you that the meeting has been called for the purpose of considering the items of business previously described. Please confine your questions and comments to those matters. If anyone has any questions or comments regarding the proposals previously described, please submit your question or comment through the online voting portal, and if appropriate, we will read them aloud. If there are no questions or comments, we will now proceed with the voting. I direct that the vote be taken by ballot among all those who have not already voted upon the matters before the meeting. The polls are now open at 10:06 AM. Please note that we will vote by proxy and by ballot. Each holder of common stock is entitled to one vote for each share held of record at the close of business on the record date. If you have previously submitted your proxy and you do not intend to change your vote, you don't need to do anything else. Your vote will be counted. If you're eligible to vote and have not submitted your proxy, or if you want to change your vote, please do so now by clicking on the Vote Here button on your screen. Now that everyone has had the opportunity to vote, I hereby declare the polls closed at 10:06 AM. with respect to each matter to be voted on at this meeting. The Inspector will now tabulate the votes. At this time, I'm pleased to report that the preliminary tabulation of the votes by proxy and at this meeting indicate that, one, all three nominees have been elected to the board of directors as Class III directors. Two, the appointment of Ernst & Young to act as the company's independent registered public accounting firm for the fiscal year ending in December 31, 2026, has been ratified. Three, the compensation of the company's named executive officers has been approved on an advisory basis. These are the preliminary results of voting. The final results will be reported in a Form 8-K filed with the SEC and in the report of the Inspector of Elections, which will be filed with the minutes of this meeting. I want to thank you all for attending Denali's 2026 Annual Meeting of Stockholders. This concludes the meeting, and the meeting is now adjourned. Thank you.