We are live. Thank you for standing by. My name is Jordan, and I'll be your conference operator today. At this time, I'd like to welcome everyone to the Exact Sciences Corporation First Quarter 2023 Conference Call. All lines have been placed on mute to prevent any background noise after the speaker's remarks. There will be a question-and-answer session. If you would like to ask a question during this time, simply press star followed by one on your telephone keypad. If you would like to withdraw a question at any time, press star one again, and you'll be withdrawn from the queue. With me now is Vice President, Investor of Relations, Megan Jones. You may begin your conference. Thanks, Jordan. Thank you for joining us for Exact Sciences' First Quarter 2023 Conference Call. On the call today are Kevin Conroy, the company's Chairman and CEO, and Jeff Elliott, our Chief Financial Officer. Everett Cunningham, our Chief Commercial Officer, will also be available for questions. Exact Sciences issued a news release earlier this afternoon detailing our first quarter financial results. This news release and today's presentation are available on our website at exactsciences.com. During today's call, we will make forward-looking statements based on current expectations. Our actual results may be materially different from such statements. Discussions of non-GAAP figures and reconciliations to GAAP figures are available in our earnings press release, and descriptions of the risks and uncertainties associated with Exact Sciences are included in our SEC filings. Both can be accessed through our website. I'll now turn the call over to Kevin. Thanks, Megan. I'm incredibly proud of our team, their dedication to our mission, and the record quarter they delivered. During the first quarter, core revenue grew $148 million year-over-year, or 33%. We're raising our full year guidance for revenue by $110 million and adjusted EBITDA by $100 million. We now expect to turn free cash flow positive during this year ahead of our previous target of next year. In the fourth quarter of 2014, the first quarter we launched Cologuard, we tested 4,000 people. In the first full year after launch, we tested 100,000 people. It took three and a half years to screen our 1 million people with Cologuard. This year, we've already screened more than 1.2 million people. Cologuard has transformed the way that we screen for the number two deadliest cancer in the U.S. We still have a huge opportunity to make an impact with 60 million people who are not up to date with screening. The platform we've built will continue to change the way cancer is detected and treated. We're just starting to realize its full potential. Our first quarter results demonstrate the power of focusing on what is best for patients and our customers. At Exact Sciences, this means we develop tests based on a deep understanding of the biology of the disease and science, generate the highest level of clinical evidence supporting the test's use, and build the operations necessary to deliver an amazing customer experience. Combining these with an investment in strong brands enables durable revenue growth, industry-leading gross margins, and growing profits. A portion of those profits will support investments in the next wave of life-changing diagnostic advancements, creating an unstoppable innovation engine. Other highlights from the first quarter include delivering more than 1 million total tests, including a record number of Cologuard results, generating $46 million in adjusted EBITDA, an improvement of $136 million year-over-year, launching OncoExTra, our enhanced therapy selection test, and making progress toward completing BLUE-C, our pivotal study to support our next generation Cologuard and colon cancer blood tests. Jeff will now review our first quarter results. Thanks, Kevin. First quarter revenue of $602 million grew 24%. Core revenue of $598 million grew 33%, excluding COVID testing, the sale of our prostate business, and foreign exchange. Screening revenue of $443 million increased 45%. The majority of screening revenue upside came from broad-based momentum in Cologuard adoption with additional benefits from a relatively mild flu season and enhancements made last year to our patient compliance program and billing systems. During the quarter, 10,000 new healthcare professionals ordered Cologuard, bringing the total to over 312,000. Precision Oncology revenue increased 2% to $155 million. Growth was 8%, excluding the sale of our prostate business and a $1 million FX headwind. COVID testing revenue decreased 86% to $4 million. First quarter GAAP gross margin was 71%. Non-GAAP gross margin, excluding the amortization of acquired intangibles, was 74%. Gross margin benefited from fixed cost leverage in our lab and improvements made to the Cologuard patient compliance program and billing systems. GAAP net loss was $74 million. Adjusted EBITDA was $46 million, an improvement of $136 million, driven by better than expected revenue and gross margin. We ended the quarter with cash and securities of about $700 million. Turning to guidance, we expect total revenue between $589 million and $604 million during the second quarter and $2.38 billion and $2.42 billion for the year. This assumes screening revenue between $443 million and $453 million for the second quarter and $1.77 billion and $1.795 billion for the year. Precision Oncology revenue between $145 million and $150 million for the second quarter and $605 million and $620 million for the year. COVID revenue of $5 million for the year. We plan to discontinue COVID testing after the second quarter. This implies 19% core revenue growth with 25% growth in screening and 5% growth in Precision Oncology, excluding the sale of our prostate business and foreign exchange. We are increasing our adjusted EBITDA guidance by $100 million and now expect between $100 million and $125 million for the year. We now expect to turn free cash flow positive during the year, 12 months ahead of our original target. Generate full year positive free cash flow next year. I'll now turn the call back to Kevin. Thanks, Jeff. There are 60 million Americans unscreened for colon cancer. Cologuard is the only solution to get them screened accurately, easily, and in the privacy of their own home. Screening rates have been persistently low for decades. This problem has been intensified by the addition of nearly 20 million people to the screening population when the recommended start age was moved from age 50 to age 45. Capacity for screening colonoscopies in the U.S. is relatively fixed. Health systems are motivated to increase screening rates. We estimate it would take 10 years for gastroenterologists to screen everyone who is due today with colonoscopy alone. Health systems, which represent more than half the market, are recognizing the opportunity to partner with us to address their screening rates and related quality measures. They rely on Cologuard as an essential part of their screening toolkit and are embedding it in their workflows. We have implemented more than 275 electronic ordering interfaces connecting health systems to Exact Sciences. Our data show that Cologuard market share is about 50% higher in the largest 400 health systems versus independent practices in smaller systems. Cologuard will continue to screen more Americans and help eradicate this preventable disease. Our precision oncology portfolio guides treatment decisions for more than 200,000 cancer patients every year. Our Oncotype DX test helps early-stage breast cancer patients determine whether they will benefit from chemotherapy, and our OncoExTra test helps late-stage cancer patients determine their best treatment options. A consistent focus on high-quality tests, top-tier clinical evidence, and physician education has cemented Oncotype DX as standard of care. Our international team of 200 people is working to ensure women everywhere have access to this life-changing information. The Oncotype DX test generates durable high-margin revenue and cash flow. This supports adoption of new tests such as OncoExTra in molecular residual disease tests. We're making progress in our three most impactful pipeline programs: colon cancer screening, multi-cancer early detection, and molecular residual disease. In colon cancer screening, we are on track to share top-line data this summer from our BLUE-C trial for our next-generation Cologuard test. We recently ran next-generation Cologuard on approximately 7,700 blinded DeeP-C samples. The results give us confidence in our goal to improve specificity and precancer sensitivity. As a reminder, DeeP-C was our pivotal study supporting Cologuard's FDA approval in 2014. This second prospective study will provide valuable evidence supporting next generation Cologuard's clinical value and competitively unique position. In multi-cancer early detection, we plan to share two additional sets of case-controlled data this year, further validating our comprehensive multi-marker class approach. In molecular residual disease or MRD, we shared data detailing our tumor-informed and tumor-agnostic approaches at the American Association for Cancer Research Conference last month. We plan to enhance our algorithm and generate additional evidence before making our tumor-informed approach available in colon cancer. We will continue developing tests based on a deep understanding of the disease and science, generating the highest level of clinical evidence supporting their use, and leveraging the operations we've built to deliver the best customer experience. This innovation engine, built on the broadest, most capable platform in cancer diagnostics, will support continued revenue growth, industry-leading gross margins, and growing profits. This will allow us to solve the biggest problems in cancer care and deliver returns to our shareholders. We're now happy to take your questions. At this time, I would like to remind everyone, in order to ask a question, press star then one on your telephone keypad. We'll pause for just a moment to compile the Q&A roster. As another addition, there is only one question per participant. There will be no follow-up questions. Your first question comes from the line of Brandon Couillard from Jefferies. Hey, thanks. Good afternoon. Kevin, what would you say would be the one or two things that you think were most impactful in the first quarter in terms of driving the revenue outperformance? Jeff, as we look at the guide for the balance of the year, it seems implied your screening revenue is flat over the next three quarters for the balance of the year. Is that informed by March or April orders or just being conservative given where we are at this point in the year? Thanks. Yep. Why don't I take it and hand it over then to Everett, who will hand it over to Jeff. There are just many drivers that have seen the strength in Cologuard testing. It's investments that we've made over the last nine years, and it's also just tremendous execution over the past few quarters. It's really wonderful. You hand it to the entire team to make this work. These are investments in our commercial team, an incredible sales team and marketing capabilities. Our labs, operations, the brand building we've done, the R&D team who have brought innovations into our lab, into the product, our digital compliance team, analytics. It's just so exciting to see so many strengths across the entire company, Cologuard, Oncotype, and the PreventionGenetics business. Everett. Yeah, I'll add some color to that. As Kevin said, we've made many investments over the years. I've been out in the field over the last few quarters, and one thing I'm seeing that momentum of the investments pick up. The confidence in our sales organization, the messaging that they have around the products is just so clear with the customers. The other thing I'll mention is the or with the customers. The customers are now realizing, especially in the screening space, that we can partner with them. They're trying to hit screening, and other metrics out there around quality, and they know that they can't do it alone. How they partner with Exact Sciences and our organization to hit those metrics, we're seeing that pick up over the last few quarters. The last thing I'll mention is around just our targeting around our top customers. Our health systems, as Kevin said in his statement, you know, they drive a lot of our volume. The focus that we have with calling on the right health systems with the right message and ensuring that we're being, again, a partner in ensuring that they can screen the right people, to me, I see that picking up over the last few quarters. I'll pass it to Jeff. Yeah. Thanks, Everett. Brandon, on your question on the phasing and guidance, I would just take a step back and look at what we've built here. Over nine years, we've built out Cologuard to over $1.7 billion of revenue. Again, here we are nine years into launch growing over 25% for the year. We feel really good about the quarter we just delivered. We're raising the top-line guidance by well north of the Q1 beat, that speaks to the optimism for the rest of the year. On the phasing, two things to keep in mind. One is really around first quarter. First quarter beat our own internal expectations, a very strong quarter. The majority of that was underlying momentum that Kevin and Everett just talked about. We also got some benefit from a mild flu season. Impossible to quantify that, but it did help, as we talked about on our last earnings call. There was a couple of smaller things that contributed. We also previously talked about the carryover benefit from enhancements to our patient compliance engine and our billing systems. Those went in place last year, we got a little bit of benefit in Q1 from that. When I think of the rest of the year now, there's a typical summer seasonality. During the summer, fewer people go out for physicals, so that therefore there's incrementally less growth between Q1 and or Q2 and throughout the year because of that summer seasonality. This year, there's one new dynamic to lay on top of that. That's related to the impact from COVID three years ago, hurt the Cologuard business primarily in second quarter and third quarter of 2020. Flash forward to 2023, when rescreens are about 20% of Cologuard revenue, the contribution from rescreens is somewhat muted this year because of that COVID impact from three years ago. The brunt of that takes place in the second and third quarters. From a phasing standpoint, you would expect a flatter year this year. When you jump ahead to next year now, three-year rescreens re-accelerates because next year now you go from having 1.2 million people eligible this year, newly eligible Cologuard rescreen patients, which is the same as last year. Next year, you jump up to 1.6 million more people. That rescreen contribution should accelerate again next year. Yeah. Jeff, if you're not too nervous about me referring to numbers here. In Q2 of 2020, there were about 275,000 Cologuard tests. In Q2 of 2021, there were about 575,000 Cologuard tests. That bounce back, it, you know, is going to occur. This is just a one-time artifact- that will have, you know, some impact. You know, the team is awfully excited about the year. If I could encapsulate the biggest change that has occurred is health systems are coming to us asking for help. That has strategic implications for everything we're doing at Exact Sciences, addressing the entire cancer continuum. That's exciting with every product in our pipeline that we're working on, and it fires up the R&D team and the commercial team and the lab teams. We can't wait. Your next question comes from the line of Patrick Donnelly from Citi. Hey, you got Jason on for Patrick. Maybe just one on the adjusted EBITDA guide moving up $100 million. Just wondering if you can talk about that strength in the quarter, the embedded assumptions for the rest of the year. I think GAAP OpEx declined slightly in the quarter. Just the gross margin. Thanks. We're pleased with what the team could deliver in the first quarter, $46 million, which, you know, exceeded the original guidance for the year. I'd point back to what Kevin talked about. We've been at Exact Sciences building for nine years now, this foundation. A foundation that allows for robust top line growth, margin expansion, cash flow generation. This foundation is scalable, it's robust, and you're seeing it now. You're seeing it in the numbers, and you should continue to see it in the years to come. We're pleased with how that unfolded in the first quarter. That allowed us to raise the EBITDA guidance by $100 million, just 1 quarter in. When you think about the, I would highlight the incrementals. The incremental adjusted EBITDA margin this year is about 80% now. You're seeing the efficiency of this platform. What we've assumed is, you know, we talked through the top line numbers. No change to the assumptions baked in for gross margin, around 73%. For OpEx, no change there, still on a GAAP basis in the mid-single-digit range. Again, you're seeing the power of this platform really unfold. We can deliver top line growth, gross margin expansion, OpEx leverage, and now free cash flow for the first time. Your next question comes from the line of Catherine Schulte. Hey, guys. Thanks for the questions. I guess could you just talk to the cadence of Cologuard orders throughout the quarter and any commentary on trends you saw in April and May so far? Sure, Kat. This is Jeff. Happy to take that one. We typically don't get into intra-quarter commentary, you know, you can hear from our comments that the majority of the upside was driven by broad-based momentum, which speaks to, you know, there is no kind of big one-timer at the end of the quarter. Some of this is, you know, broad-based throughout the quarter. The commercial team did just a fabulous job of staying disciplined, week on week on week, driving the growth, continued to advance the marketing campaign. This was just a really strong quarter top to bottom. There's not like one big thing that came in. Obviously when you look at the guide here, we beat, you know, by call it $50 million-$60 million. We're raising guidance by $100 million. That speaks to the optimism, that we're seeing, in the numbers and for the rest of the year. Your next question comes from the line of Vijay Kumar. Hey, guys. Thanks for taking my question. I had a two-parter, Kevin. First one for you on your comment on health systems. Is that what we're seeing when we look at this Q4 and Q1 uptick in Cologuard numbers? Any sense on what percentage of revenues or perhaps physicians are employed by health systems? Are we at the early stage here or can you talk about penetration of health systems where we are? My second one, Jeff, for you on the EBITDA guide. You know, the $100 million-$125 million, and it looks like you guys have achieved half of it in Q1. Why wouldn't that Q1 sustain into the back half given the revenue guide raise? Let me start. I'll take the first part of that question. Health systems have seen a dramatic increase in the electronic ordering rate. The dynamic is typically about halfway through the year, the health systems get hyper-focused on their quality, colon cancer screening quality measure. They are increasingly reaching out to us to ask us to help in a holistic way address the challenge that exists when you add 20 million people to the, to the screening population and you have a fixed colonoscopy infrastructure. Today, if you focus on the 400 largest health systems of almost two-thirds of them have implemented electronic ordering and resulting. That keeps getting better over time, the ease of use, the reporting, the data they get, and then how we use that together fuels a deeper relationship with those health systems. Everett, do you want to add to that? Yeah. When I think of health systems and our execution over the past couple of years, I think about the investments that we've made. We've increased our strategic account management towards our top health systems. We have a very disciplined way that we review our plans for health systems, all the way from Kevin, all the way down to the people that are calling on health systems. The other thing I would mention with health systems are it's a local strategy. We have not only calling on the C-suite of the health system, but the way in which we're deployed, the pull-through of the representatives with affiliated positions of those health systems, that team is all one team. We've seen better execution because everybody is embedded together in making sure that we can execute that health system strategy that's leading to more growth. Vijay, it's Jeff. I'll take the rest of it. From a% of revenue standpoint, for Cologuard, think of in the 60% range for health systems, and that number is up nicely from where it was say three to five years ago. The team has done a nice job there. Overall penetration rate for Cologuard is in the 10% range. In based on what Kevin talked about for health systems, it's probably a bit higher. The key takeaway here is there's a long ways to go here. With 60 million people unscreened, we've got years and years of strong growth for Cologuard ahead of us. Your question on the adjusted EBITDA number, you know, thanks for noticing. You know, $46 million really strong results in the first quarter. That came in better than we expected. That's in part due to the higher level of revenue and gross margin in the first quarter than we expected. It's also in part due to the way that our operating expense assumptions phase through the year. Our plans call for us to hire throughout the year. That's part of why you're not going to have, you can't take the first quarter and multiply it 4x and get to the adjusted EBITDA number for the year. Also, we've chosen to reinvest some of the incremental margin that we're generating into accelerate programs. One I'd highlight here is MRD. That market is unfolding and our R&D efforts have reached a point where the team said, "Hey, now is the right time to up the investment here to accelerate our path to market." That's part of why the phasing for adjusted EBITDA, you can't just take Q1 and assume that that level holds. Understood. Thanks, guys. Your next question comes from the line of Andrew Brackmann from William Blair. Hey, guys. Good afternoon, thanks for taking the question. Kevin Conroy, appreciate the commentary around Cologuard 2.0 running that against samples from DeeP-C. Can you maybe just sort of give us a bit more color on around what you saw in those results compared to previous data that we saw? I guess as we just get closer to the top line readout here this summer, can you just sort of level set us on how you're thinking about any degradation from those previous studies to this pivotal? Thanks. Thanks, Andrew. We'll release that data, and all I will say is the data gives us confidence going into the BLUE-C study. As you remember, the main goal is to improve the specificity. Specificity is calculated two different ways. One is if you take a look at kind of all comers, that in Cologuard, the current version of Cologuard is 87%. Our goal is to improve that to 89%. If you only look at people with what we would call clean colons, no small polyps, non-adenoma polyps which still send off some signal. If you exclude those, then we would expect the specificity to be 90% or greater. So that's. We also, you know, remain, we continue to expect cancer sensitivity to be equal to or better than Cologuard and the pre-cancer sensitivity to be, you know, we hope to see an improvement there. That would be a great result. Andrew, I just want to drive home the point. We ran the study against all of the available samples that we had from DeeP-C. That study was from 10 years ago, so we didn't have access to all of the samples. We ran them against all of the samples that we had available and didn't, you know, select out any for any particular reason. That was blinded. That gives us a second prospective study, which as you know, when you're looking at guidelines and evidence development is very, very important. Your next question comes from the line of Jack Meehan from Nephron Research. Thank you. Good afternoon. I was hoping you could talk a little bit about the regional dynamics for Oncotype DX that you're seeing at the moment. Just looking at the 10-Q, it looks like the international growth in the quarter was really strong. Was just wondering if that was offset if, you know, how the U.S. performed as well. Just any commentary as to what's going on would be great. Sure. Jack, you know, thanks for the question. This is Jeff. When you look at the growth in the U.S., given our strong market share there, you know, I think the way to think about growth is somewhere just north of incidence. Incidence in this, the U.S. is probably around 3.5% growth per year. Somewhere in that kind of low to mid-single digit range is for the Oncotype franchise is the right way to think about it. Internationally is a different story. Internationally, the overall penetration rate there is probably in the 25% range. We expect strong double-digit growth for years to come internationally. The next big driver of growth would be launch in the Japan market, which we expect mid-year. That should open up the second largest market outside the U.S. That one can be a little choppier given the, you know, the dynamics of new markets coming online, but there's still a long runway ahead. Longer term, perhaps the most exciting opportunity for the broader Precision Oncology growth comes to some of the pipeline tests that, you know, Kevin talked about MRD. That market is, as you know, much larger even than the Oncotype market. That's a big driver that we're looking forward to. Also don't forget that within the broader PO umbrella, we have our broader advanced therapy selection platform that is growing nicely. Your next question comes from the line of Dan Arias from Stifel. Afternoon, guys. Kevin, wanted to look out a little bit and ask about this Braidwood case that looks like it's working its way towards the Supreme Court here and is relevant for these USPSTF recommended tests. It sounds like it has the potential to jam up the works for Cologuard, but it also sounds like some of these industry groups are coming out and expressing confidence in just continued coverage. I mean, obviously nothing's finalized there, but what are you hearing? How are you handicapping the risk to the out years? You know, even if you don't think it's meaningful to coverage, do you think it could be a factor on pricing at all? Would love to just get your thoughts there. No, I don't think that Supreme Court decision is going to have a negative impact on Cologuard. The main reason for that is the preventive services and HEDIS measures and the incentive structure around preventive services remains intact regardless of what the Supreme Court might do there. Since Cologuard is embedded into those quality measures, there is still a very strong bias in the health systems to screen people with tests that are recommended tests. That doesn't change anything. Health payers aren't going to change their view about whether to cover Cologuard because of the Supreme Court case. They love the benefit of Cologuard in terms of it's less expensive than colonoscopy. They save money in any given budget year, and that's a real positive. I don't think that that's going to impact us. I sure hope the Supreme Court, you know, leaves that law in place. I think it's very positive for other tests that may come down, you know, through the arduous process that Cologuard went through. It's certainly not going to have an impact on Cologuard. Policy makers in D.C. too are evaluating avenues to moot the plaintiff's arguments in that case, and I think are looking at ways to even reform the oversight and appointment of USPSTF members. There's a lot in the works, the whole healthcare ecosystem relies on USPSTF as a critical part of guideline recommendations. I don't think that's going to go away. Your next question comes from the line of Derik De Bruin from Bank of America. Hi, this is Will phoned for Derik. Thanks for taking questions, and congrats on a really solid quarter. I was wondering if you could offer some color on the 45 to 49 group. Where is penetration at compared to the 8% that you posted last quarter? Can you talk to what kind of contribution you saw this quarter and how you expect that group to play out for the balance of the year? What I love about the 45 to 49 is it gives us a really good entrée into the office to talk about this cohort. We are in line with delivering on our full 45 to 49 rescreen priorities. The reason why we're executing well is because it's been a consistent focus area of ours over the last couple of years. We've done a good job of not proliferating growth strategies, but making sure that we stick to the 45 to 49. Just to mention rescreen. Rescreen this year will be 20% of our revenue. These are big growth opportunities for us. It's consistent messaging that we have with our physicians, making them aware of the new screening age, and we're going to continue to do that for the full year. This is Jeff. Just to add to what Everett said, penetration has really been a highlight for this younger age group. No surprise, Cologuard really fits into that, a younger person's lifestyle, very well. Overall penetration rate there now is 10%, so it's in line with Cologuard for all ages. It just shows you the demand that this younger age group has, and we see that continuing. In fact, if you look out just three years, the combination of rescreens and 45, we expect to contribute around $1 billion of revenue. This is a huge driver for us today, and it will be for years to come. Your next question comes from the line of Matt Sykes from Goldman Sachs. Good afternoon. Thanks for taking my questions. Congrats on the quarter. Everett, maybe one for you, just going back to the health systems. Could you maybe talk about sort of how that market is shifting in terms of sort of the larger system versus the independent practices? Just how much scale and infrastructure it takes to actually gain a new health system? I would assume there's many different decision points, and an enterprise-led sale is very different than sort of what you're doing with independent practices. Can you maybe talk about how you've kind of gone after the newer health system clients that you've brought on board and how much scale and infrastructure that actually takes to do? Yeah. Thanks for that question. What we've seen, especially after the pandemic, is we see kind of a consolidation of health systems. Health systems buying other health systems. We feel that we are well staffed, if you will, and deployed to make an impact at health systems. As I said earlier, we have a strategic account management team in all of our businesses: screening, Precision Oncology, and PreventionGenetics. We've invested in this team, not just in the number of strategic account managers, but in the way in which we train them, the marketing materials that allow them not just to call on physicians, but it allows them to call on the C-suite of those organizations, because that's where a lot of decisions are made. In terms of scale, I love the way that we're structured because the health systems team with the strategic account managers and the representatives are on the same team now. When a decision is made at that health system highest level, it is so much easier for us to now pull that through and generate growth. The last thing I'll just reiterate that Kevin said, health systems are now coming to us. They know that they can't do this alone. The relationships that we have at that health system, because of the many years of investments that we've made, the relationships that we have, they're coming to us for how can we help them hit their quality metrics? How can we help them get and hit their screening percentages? We're seeing that just gain momentum over the last year. Your next question comes from the line of Dan Brennan from TD Cowen. Great. Thanks for, thanks for taking the questions. Maybe just on profitability and free cash flow. You kind of pulled forward the free cash flow to 2023. Obviously profitability a lot stronger in Q1. Can you just give us a sense of, you know, some of the trade-offs here? Top line growth is really strong, as we look ahead, say beyond 2023, you know, kind of how much of this kind of progression, path is sustainable? Obviously, you'll remain positive. I'm just wondering kind of where margins, you know, could get to and kind of remind us as we get towards the Investor Day, kind of what kind of outlook we could expect to get in terms of timing. Thanks. Thanks, Dan. What you're seeing here is a fundamental turning point. What you saw in Q1 was the power of the platform that we've been building for many years. We've been investing. By the way, very much appreciate the support of investors along the way there because we're building something special, and it's a platform that allows us to both grow and generate profitability. We don't have to make significant trade-offs going forward. We continue to invest right now in a bright future. If we see opportunities to drive revenue growth by making investments, we'll continue to do that. We're in a position to do that, and we want to do that to achieve our mission. Jeff? Yes. Dan, when you look at the first quarter, I think this is indicative of what's to come. You saw strong top line growth, strong gross margin improvement and disciplined OpEx. In fact, you know, when you look at total revenue of 24%, OpEx down 1%, that speaks to the power of the platform that we've developed over a nine-year period. You know, going forward, this platform was designed to scale efficiently. You know, we've been front-loading investments for years in things like our lab, our sales and marketing teams, our IT and digital infrastructure, that will allow us to scale. I can't comment on future years right now, but, you know, our goal wasn't just to get the free cash flow positivity. Our goal is to get there, punch through, and keep generating incremental growth year on year. That is the plan. Your next question comes from the line of Puneet Souda from SVB Securities. Hey, guys, and congrats on a strong quarter here. First one, and I'll keep it to one, actually. You know, I don't know if you had an opportunity to look at this, but any data that you're seeing in terms of the feed or the feedback from the field in terms of the 45 to 49-year-olds, are they gravitating, you know, more towards the Cologuard versus colonoscopy? Sort of help us understand the, you know, dynamic there. This is a new population that's entering the market. Maybe just give us a sort of sense of the performance of the test there too, for 45 to 49-year-olds with respect to methylation. It would be helpful if you can provide color on those points. Thank you. Sure. Puneet, this is Jeff. I can start, and others may want to jump in. When you look at the relative demand here, look, it's strong across the board. You know, Cologuard has been the fastest diagnostics launch in history, you know, the first diagnostic to get over $1 billion and still generating very strong top-line growth. The demand is significant. You know, look, there's a long ways to go with 60 million people that are unscreened. From a relative standpoint, if you compare 45 to 49 versus 50 and over, we've talked about 45 to 49 achieving the same penetration rate in about one and a half years, two years, that it took the 50 and over age group to get to in closer to nine years. The demand there is robust. If you just think about it, I'm in this age group now. I know that I've got a lot of commitments with family, you know, with kids and outside of work. I don't want to take off two days for a colonoscopy. That's why. You know, that's one of the reasons I choose Cologuard. It fits into my lifestyle better. Actual, you know, survey work and real-world demand supports that. From a performance standpoint, you know, the label is the label, and that was established with Cologuard in DeeP-C that we've referenced today on the call. We have run an additional prospective study in this younger age group. The study wasn't designed to demonstrate cancer sensitivity, so it's not something that we talk about. The label is the label and, you know, look forward to continued success in this younger age group. I'll just add what Jeff said in terms of the 45 to 49-year-olds. Our messaging in the field is fantastic. They are the Cologuard patient. You talk about the only solution from a screening standpoint that has accuracy, effectiveness, you can do it in the privacy of your home. A lot of 45 to 49-year-olds, they're on the go. This is the perfect product, not just from a selling standpoint, but we're also messaging from a marketing standpoint. Our latest campaign, the MyWay campaign, and our messaging is geared towards this younger patient, this younger population. Our customer experience lever that we have in terms of surround sound outreach, not just through TV, but through digital and social media, is very well geared towards that 45 to 49-year-old. Your next question comes from the line of Kyle Mikson from Canaccord Genuity. Yeah. Hey, guys. Thanks for taking the questions. Congrats on the great quarter here and the cash flow news as well on EBITDA. Just question on next generation Cologuard. With this BlueC readout coming up pretty soon here, I'm just curious about precancer sensitivity. Just given, you know, the importance of that metric as you include it in a bunch of these DDW posters this past week, where I think you noted a threshold of, like, 40% as like a, as like a, you know, baseline there. Do you think that the precancer sensitivity in BlueC is going to be like a game over for some of the emerging options? I mean, obviously, it probably means blood, but I mean, that's kind of open-ended. Just one other question on next generation Cologuard. What's the path there for HEDIS? It took Cologuard a few years, but that's been a huge tailwind, I think. Would be curious to hear that. I'm sorry, what's the path forward to HEDIS for what? Cologuard's next generation. Yeah. Let me take that one first. I think that Cologuard 2.0 fits within the current definition of USPSTF. It doesn't really have to go through another cycle. It just is an improvement on the current technology that's already included in those guidelines. Presumably, it will be. We'll wait until this summer to share the data. In terms of the importance of the evidence that Cologuard set, I'll go back to what we have said. From a regulatory standpoint, Cologuard is a PMA-level product. That means it's the highest level of rigor for any medical device or diagnostic because it's cancer. The way the regulatory the agency FDA looks at this is typically you need to have at least as good as performance. You can't have degradation in a, in a product. Or at best, you would get a secondary screening claim, which hampers your ability to commercialize that in a meaningful way. Precancer sensitivity is important. You think, well, how important could it be? Well, you can see from our DDW poster or abstract, 80% of the benefit of screening comes from finding and removing precancerous polyps. 80% of the benefit. If you look at on a population level, the difference between, let's call it, like, 15% precancer detection and 40% precancer detection is you are, on a population level, that inferior test only, you know, achieves somewhere around 40% of the life years gained of 60%. 60% of the life years gained as a test with +40% precancer detection. It's critically important. This is what the guideline group looks at. They looked at very sophisticated models which answer the question, what's the impact of a new screening modality? I believe that the BLUE-C data has the potential to set a new bar. Now, what do we think about our blood program? Because I think there's an embedded second question there. Our blood program is if we end up with a secondary screening claim with a test that's built on a proprietary PCR platform, we can deliver at cost testing to patients who just refuse other forms of screening. I think that we all know family members, friends who have avoided screening and they've been diagnosed. We, at Exact Sciences, happen to know who those patients are. In combination with our health system partners, we can deliver a solution to people who refuse other, more, better forms of screening. We're in a great position with Cologuard as the leading product. Adding a blood test, we think, is going to help save lives because we know who the refusers are. Your final question comes from Alex Nowak of Craig-Hallum Capital Group. Okay, great. Good afternoon, everyone. Maybe to end on a note here about the upcoming Analyst Day. You have a lot going on, whether it be the BLUE-C study, MRD, focus on profitability. You shared a lot with us so far with these earnings calls here. What new do you want to unveil at the Analyst Day? Any preview? Oh, Alex, you have to come here for the good stuff. You know, we really can't wait to show off our team, our lab, our pipeline products, the commercial activities. We haven't had an investor day in, I think it's seven years, so we're really excited to bring everybody together and look forward to hosting you and other investors here in Madison. Thanks for the update. There are no further questions at this time. I'll now turn the call back over to Mr. Conroy for its final moment. Since joining Exact Sciences in 2009, there are many accomplishments that bring me pride and make me thankful for being part of this team. Today's announcement of our Q1 results marks a high point. We made incredible progress in our mission of eradicating cancer and delivering great results for the shareholders who have supported and believed in us. The Exact Sciences team takes pride in innovation, quality, integrity, accountability, and most of all, we believe that teamwork fuels the culture that leads to superior results. The best part is yet to come in the Exact Sciences story. Thank you to all of the team members who made Q1 such a powerful quarter, and we look forward to delivering again in the future. Thank you