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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 ( Mark One ) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31 , 2020 British Columbia , Canada ( State or Other Jurisdiction of Incorporation or Organization ) PO Box 13628 , 68 TW Alexander Drive Research Triangle Park , NC ( Address of Principal Executive Offices ) FORM 10 - K TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from _to_ OR Title of each class Common Shares , no par value Commission File Number : 001-32295 FENNEC PHARMACEUTICALS INC . ( Exact Name of Registrant as Specified in Its Charter ) 20-0442384 ( I.R.S. Employer Identification No. ) 27709 ( Zip Code ) ( 919 ) 636-4530 ( Registrant's telephone number , including area code ) Securities registered pursuant to Section 12 ( b ) of the Act : Name of each exchange on which registered Nasdaq Capital Market Securities registered pursuant to Section 12 ( g ) of the Act : None Indicate by check mark if the Registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . YES ¨ NO ý Indicate by check mark if the Registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Act . YES ¨ NO ý " Indicate by check mark whether the Registrant : ( 1 ) has filed all reports required to be filed by section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . YES x NO¨ Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( §232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) . YES X NO Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , a smaller reporting company , or an emerging growth company . See the definitions of " large accelerated filer , " " accelerated filer , " " smaller reporting company , " and " emerging growth company " in Rule 12b - 2 of the Exchange Act . Large accelerated filer ¨ Accelerated filer Non - accelerated filer x Smaller reporting company x Emerging growth company