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☑ ☐ UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 Form 10 - K ( Mark One ) ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Fiscal Year Ended December 31 , 2020 or TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number : 000-29959 Cassava Sciences , Inc. Delaware ( Exact name of registrant as specified in its charter ) ( State or other jurisdiction of incorporation or organization ) 91-1911336 ( I.R.S. Employer Identification Number ) 7801 N. Capital of Texas Highway , Suite 260 , Austin , TX 78731 ( 512 ) 501-2444 ( Address , including zip code , of registrant's principal executive offices and telephone number , including area code ) Securities registered pursuant to Section 12 ( b ) of the Act : Title of each class Common Stock , $ 0.001 par value Trading Symbol ( s ) SAVA Name of each exchange on which registered NASDAQ Capital Market Securities registered pursuant to Section 12 ( g ) of the Act : None Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . Yes ✓ No □ Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Act . Yes □ No Indicate by check mark whether the registrant ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . Yes No ☐ Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( §232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) . Yes No □ . Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , smaller reporting company , or an emerging growth company . See the definitions of " large accelerated filer , " " accelerated filer , " " smaller reporting company , " and " emerging growth company " in Rule 12b - 2 of the Exchange Act . ( Check one ) : Large accelerated filer ☐ Non - accelerated filer ✓ Accelerated filer Smaller reporting company Emerging growth company If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 ( a ) of the Exchange Act . □ Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404 ( b ) of the Sarbanes - Oxley Act ( 15 USC . 7262 ( b ) ) by the registered public accounting firm that prepared or issued its audit report . Indicate by check mark whether the registrant is a shell company ( as defined in Rule 12b - 2 of the Act ) . Yes □ No The aggregate market value of the voting and non - voting common equity held by non - affiliates was $ 71,146,906 computed by reference to the last sales price of $ 3.08 as reported on the Nasdaq Capital Market , as of the last business day of the Registrant's most recently completed second fiscal quarter , June 30 , 2020. The number of shares outstanding of the Registrant's common stock on March 18 , 2021 was 39,898,325 . DOCUMENTS INCORPORATED BY REFERENCE Portions of the Registrant's Proxy Statement for its 2021 Annual Meeting of Stockholders ( the Proxy Statement ) , to be filed with the U.S. Securities and Exchange Commission , are incorporated by reference to Part III of this Form 10 - K Report . 1