Page 1

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 FORM 10 - K × ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31 , 2020 OR □ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from : 001-38105 ( Commission File Number ) to 180 LIFE SCIENCES 180 LIFE SCIENCES CORP . ( Exact name of registrant as specified in its charter ) Delaware ( State or Other Jurisdiction of Incorporation or Organization ) 3000 El Camino Real , Bldg . 4 , Suite 200 Palo Alto , CA 81-3832378 ( I.R.S. Employer Identification No. ) ( Address of Principal Executive Offices ) ( 650 ) 507-0669 ( Registrant's telephone number , including area code ) Securities registered pursuant to Section 12 ( b ) of the Act : Title of each class Common Stock , par value $ 0.0001 per share Warrants to purchase shares of Common Stock Trading Symbol ( s ) ATNF ATNFW 94306 ( Zip Code ) Name of each exchange on which registered The NASDAQ Stock Market LLC ( NASDAQ Capital Market ) The NASDAQ Stock Market LLC ( NASDAQ Capital Market ) Securities registered pursuant to Section 12 ( g ) of the Act : None . Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . Yes □ No ☑ Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Act . Yes ☐ No ☑ Indicate by check mark whether the registrant ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . Yes □ No ☑ Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( § 232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the registrant was required to submit and post such files ) . Yes ☐ No ☑ Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , a smaller reporting company , or an emerging growth company . See the definitions of “ large accelerated filer , ” “ accelerated filer ” and “ smaller reporting company . ” and “ emerging.growth company . ” in Rule 12b - 2 of the Exchange Act .