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EARNINGS P R E S E N T A T I O N Q3 2026 October 21, 2026
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This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve risks and uncertainties and reflect the Company's judgment as of the date of this release. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements. Some of these forward-looking statements may contain words like “will,” “believe,” “may,” “could,” “would,” “might,” “possible,” “should,” “expect,” “intend,” "forecast," "guidance," “plan,” “anticipate,” "target," or “continue,” the negative of these words, other terms of similar meaning or they may use future dates. Forward-looking statements contained in this presentation include, but are not limited to, statements concerning: the future business, operational and financial performance of the Company and the Company’s expectations and plans with respect to market opportunity, business and operational performance, strategic initiatives, capabilities, resources, manufacturing capabilities, product development, product availability and regulatory approvals, and the estimated impact of the flooding event at our Cincinnati, Ohio manufacturing facility (the “Cincinnati facility”), including on our financial condition and results of operations, and our expectations and progress in our recovery efforts, including timing, costs and expected insurance coverage and reimbursements. It is important to note that the Company’s goals and expectations are not predictions of actual performance. Such forward-looking statements involve risks and uncertainties that could cause actual results to differ materially from predicted or expected results. Such risks and uncertainties include, but are not limited to, the following: increased geopolitical instability and other macroeconomic factors, including trade barriers and related restrictions (including tariffs and related countermeasures), armed conflict and acts of terrorism, geopolitical tension and instability, supply chain disruptions, and interest rate and foreign currency rate fluctuations, on the Company’s suppliers, vendors and customers and on the Company’s business and financial condition, results of operations and cash flows; the Company's ability to execute its financial, strategic and operating plans effectively; the Company's ability to remediate quality systems violations; difficulties in implementing the Company’s compliance master plan; difficulties or delays in obtaining and maintaining required regulatory approvals, including the costs thereof potential difficulties, delays and disruptions in manufacturing, distribution or sale of products; difficulties or delays, including unexpected costs and the availability of insurance coverage and reimbursements, related to the Company's Cincinnati facility recovery efforts; the failure of the company’s suppliers, vendors, and other third parties to meet contractual, regulatory and other obligations; the anticipated development of markets the Company sells its products into and the success of the Company’s products in these markets; the Company’s ability to predict accurately the demand for its products and products under development; increasing industry competition; the coverage and reimbursement decisions of third-party payors; trends toward health care cost containment; difficulties in controlling expenses, including costs to procure and manufacture the Company’s products; the ability of the Company to successfully manage leadership and organizational changes and the impact of changes in management or staff levels; the impact of goodwill and intangible asset impairment charges if future operating results of acquired businesses are significantly less than the results anticipated at the time of the acquisitions, the geographic distribution of where the Company generates its taxable income; changes to applicable laws, regulations and enforcement guidance, including tax laws and global health care reforms; fluctuations in foreign currency exchange rates; the amount of our bank borrowings outstanding and other factors influencing liquidity; breaches, failures or other disruptions of our or our vendors’ or customers’ information technology systems or products; and the economic, competitive, governmental, technological, and other risk factors and uncertainties identified under the heading “Risk Factors” included in Item 1A of Integra's Annual Report on Form 10-K for the year ended December 31, 2025 and information contained in subsequent filings with the Securities and Exchange Commission. These forward-looking statements are made only as of the date hereof, and the Company undertakes no obligation to update or revise the forward-looking statements, whether as a result of new information, future events, or otherwise, except as otherwise required by applicable law. Safe Harbor Statement IART Q3 2026 Earnings Presentation2
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In addition to our GAAP results, we provide certain non-GAAP measures, including organic revenues, adjusted earnings before interest, taxes, depreciation and amortization ("EBITDA"), adjusted EBITDA margin, adjusted net income, adjusted gross profit, adjusted gross margin, adjusted earnings per diluted share, free cash flow, adjusted free cash flow conversion, and net debt. Organic revenues consist of total revenues excluding the effects of currency exchange rates, revenues from current-period acquisitions and product divestitures. Adjusted EBITDA consists of GAAP net income excluding: (i) depreciation and amortization; (ii) other income (expense); (iii) interest income and expense; (iv) income tax expense (benefit); (v) impairment charges; and (vi) those operating expenses also excluded from adjusted net income. The measure of adjusted EBITDA margin is calculated by dividing adjusted EBITDA by GAAP revenues. The measure of adjusted net income consists of GAAP net income, excluding: (i) structural optimization charges; (ii) divestiture, acquisition and integration-related charges; (iii) EU Medical Device Regulation-related charges; (iv) charges related to the transition of Boston-related manufacturing operations to the Company’s Braintree, Massachusetts facility (the "Braintree transition"); (v) charges related to the flooding of the Company’s Cincinnati, Ohio manufacturing facility, including inventory losses, asset write-offs, remediation costs, plant restart costs and other directly related costs, net of associated insurance reimbursements, as applicable (the “Cincinnati flood and recovery”); (vi) intangible asset amortization expense; (vii) income tax impact from adjustments; and (viii) impairment charges. The measure of adjusted gross margin is calculated by dividing adjusted gross profit by total revenues. Adjusted gross profit consists of GAAP gross profit adjusted for: (i) structural optimization charges; (ii) divestiture, acquisition and integration-related charges; (iii) charges related to the Braintree transition; (iv) EU Medical Device Regulation-related charges; (v) charges related to the Cincinnati flood and recovery; and (vi) intangible asset amortization expense. The adjusted earnings per diluted share measure is calculated by dividing adjusted net income attributable to diluted shares by diluted weighted average shares outstanding. The measure of free cash flow consists of GAAP net cash provided by operating activities less purchases of property and equipment. The adjusted free cash flow conversion measure is calculated by dividing free cash flow by adjusted net income. The measure of net debt consists of GAAP total debt (excluding deferred financing costs) less short-term investments, cash and cash equivalents. Reconciliations of GAAP revenues to organic revenues, GAAP net income to adjusted EBITDA and adjusted net income, GAAP gross profit to adjusted gross profit, GAAP gross margin to adjusted gross margin, and GAAP earnings per diluted share to adjusted earnings per diluted share all for the three and six months ended June 30, 2026 and 2025, GAAP total debt to net debt for the quarters ended June 30, 2026 and December 31, 2025, and GAAP operating cash flow to free cash flow and adjusted free cash flow conversion for the for the quarters and twelve-months ended June 30, 2026 and 2025, appear in the financial tables in this presentation. The Company is providing forward-looking guidance regarding organic revenues, adjusted EBITDA, adjusted gross margins, and adjusted earnings per diluted share but is not providing a reconciliation to the most directly comparable forward-looking GAAP financial measures because certain GAAP expense items and the impact of changes in foreign exchange rates are highly variable and management is unable to predict them with reasonable certainty and without unreasonable effort. Specifically, the actual impact of changes in foreign exchange rates and the financial impact and timing of divestitures, acquisitions, integrations, structural optimization, efforts to comply with the EU Medical Device Regulation, and income tax impact from adjustments are uncertain, depend on various dynamic factors and are not reasonably ascertainable at this time. The unavailable information could have a material impact on GAAP results. The Company believes that the presentation of organic revenues and the other non-GAAP measures provide important supplemental information to management and investors regarding financial and business trends relating to the Company's financial condition and results of operations. For further information regarding why Integra believes that these non-GAAP financial measures provide useful information to investors, the specific manner in which management uses these measures, and some of the limitations associated with the use of these measures, please refer to the Company's Current Report on Form 8-K regarding this presentation filed today with the Securities and Exchange Commission. This Current Report on Form 8-K is available on the SEC's website at www.sec.gov or on our website at www.integralife.com. Non-GAAP Financial Measures 3 IART Q3 2026 Earnings Presentation
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Executing Our 2026 Priorities Drive supply chain reliability Accelerate growth Ignite innovationDeliver best-in-class quality OUR STRATEGIC IMPERATIVES Strong cash generation and operational progress amid revenue headwinds 4 IART Q3 2026 Earnings Presentation Q3 2026 HIGHLIGHTS • At the low end of guidance • Specialty Surgery performed ahead of expectations, offset Tissue Reconstruction performance • ~$7M Headwind from Cincinnati flood $411M Reported Revenue • Within guidance range • Supported by strong cost management • Strong cash generation and lower leverage $0.59 Adj. EPS (0.3%) - 0.9% Organic Growth Updated $2.30 - $2.40 Adj. EPS Updated FULL YEAR OUTLOOK TRANSFORM TO EXCEL AND CONSISTENTLY DELIVER OUR FINANCIAL COMMITMENTS $1.63 - $1.65B Reported Revenue Updated + Completed $2.1 billion refinancing, extending debt maturities and enhancing financial flexibility
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$411 $402 Q3 26 Q3 25 2026 Q3 Financial Highlights $0.59 +9.3% vs. 2025 ADJUSTED EPS 19.4% (10) bps vs. 2025 ADJUSTED EBITDA MARGIN 2.5% vs. 2025 ORGANIC Q3 REVENUE (in $M) Note: Adj. EBITDA margin, adj. EPS, and FCF conversion are non-GAAP financial measures. Growing margins and cashflow 2.3% vs. 2025 REPORTED 61.1% (180) bps vs. 2025 ADJUSTED GROSS MARGIN $96.0M and 184.6% FCF Conversion OPERATING CASH FLOW 5 IART Q3 2026 Earnings Presentation
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SPECIALTY SURGERY Q3 Revenue REPORTED $304.1M $292.6M 3.9% Q3’26 Q3’25 Growth ORGANIC1 $304.9M $292.6M 4.2% Q3’26 Q3’25 Growth NEURO INSTRUMENTS ENT3 INTERNATIONAL 6.5% (0.9%) (1.1%) HIGH SINGLE- DIGIT GROWTH Momentum from CereLink®, Certas Plus®, Bactiseal® and DuraSeal®, partially offset by Cincinnati disruption Low-single digit decline due to order timing Low-single digit decline in sinus ballons Continued demand strength Improved product availability and continued demand strength Q3 2026 GROWTH AND PERFORMANCE DRIVERS Q3 2026 Revenue Composition Neuro 70.4% ENT 13.3%Q3 2026 REVENUE 1 Q3 2026 excludes $0.8M in foreign exchange; Comparisons are to prior year, taking into account some shifts across the portfolio 2 Percentages based on organic revenue; Commentary represents organic performance; Comparisons are to prior year 3 Includes MicroFrance® ENT instrument and Acclarent® ENT 2 6 IART Q3 2026 Earnings Presentation
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WOUND RECONSTRUCTION SOLUTIONS CORPORATE PARTNERSHIPS2 INTERNATIONAL (2.9%) 0.3% LOW DOUBLE- DIGIT DECLINE DuraSorb® growth and the PriMatrix® relaunch offset by declines in UBM portfolio and Integra Skin In-line with expectations for the quarter Growth in Integra Skin offset by Corporate Partnerships TISSUE RECONSTRUCTION Q3 Revenue REPORTED $107.1M $109.5M (2.2%) Q3’26 Q3’25 Growth ORGANIC1 $107.1M $109.5M (2.2%) Q3’26 Q3’25 Growth DuraSorb® and PriMatrix® gains offset by UBM pressures and slower Integra Skin recovery. Q3 2026 GROWTH AND PERFORMANCE DRIVERS Q3 2026 Revenue Composition ENT 13.8% Q3 2026 REVENUE 1 Percentages based on organic revenue; Commentary represents organic performance; Comparisons are to prior year 2Beginning this quarter, we are referring to our Private Label business as Corporate Partnerships, a name that better reflects the nature of these customer relationships. Wound Reconstruction Solutions 76.2% 1 7 IART Q3 2026 Earnings Presentation
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Balance Sheet and Cash Flow Performance Note: Adj. FCF conversion is a non-GAAP financial measure; Numbers may not add due to rounding ~$90 million year-over-year improvement in operating cash flow through Q3 2026 12/31/25 9/30/26 CASH AND CASH EQUIVALENTS $235 $252 SHORT-TERM INVESTMENTS $29 $60 TOTAL DEBT $1,859 $1,829 NET DEBT $1,596 $1,517 AVAILABLE CREDIT $252 $247 TOTAL AVAILABLE LIQUIDITY $516 $559 CONSOLIDATED TOTAL LEVERAGE RATIO 4.5X 3.8X FCF Capex 61.9% 184.6% (2.5%) 43.9% (4.5) 85.8 93.8 54.6 Q3'25 TTM Q3'26 TTM $89.3 25.8 85.7 15.2 10.2 Q3'25 Q3'26 $40.9 $96.0 SUMMARY BALANCE SHEET ($M) Adjusted FCF Conversion OPERATING CASH FLOW, FREE CASH FLOW ($M) & ADJUSTED FCF CONVERSION (%) 8 IART Q3 2026 Earnings Presentation $140.4
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Q4 2025 Organic Growth FX Q3 2026 Outlook 2025 Organic Growth FX 2026 Outlook Q4 and FY 2026 Outlook Note: Organic growth and adj. EPS are non-GAAP financial measures. ~0.2% $1,635 ~0.3% $1,634 - $1,654 ~(2.7%)$435 $413 - $433~(0.1%) Organic Growth (at mid-point) Organic Growth (at mid-point) Guidance reflects Cincinnati disruption, softer Tissue Reconstruction and refinancing Q4 2026 REPORTED REVENUE GUIDANCE BRIDGE ($M) FY 2026 REPORTED REVENUE GUIDANCE BRIDGE ($M) Q4 2026 $413M - $433M REPORTED Reported Growth -5.2% to -0.5% Organic Growth -5.1% to -0.4% $0.61 - $0.71 ADJUSTED EPS FY 2026 $1.634B - $1.654B REPORTED Reported Growth -0.1% to 1.2% Organic Growth -0.3% to 0.9% $2.30 - $2.40 ADJUSTED EPS 9 IART Q3 2026 Earnings Presentation
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Key 2026 Guidance Assumptions and Considerations REVENUE OUTLOOK ▪ Q4 Specialty Surgery outlook (ex Cincinnati), in-line with July Guidance ▪ Cincinnati flood impact of $15-20M in Q4, primarily impacting Neurosurgery ▪ Q4 Revenue outlook adjusted to reflect lower than expected growth in Tissue Reconstruction ▪ Immaterial impact from FX in updated guidance ADJUSTED GROSS MARGINS EXPECTED TO BE FLAT VS. 2025 ▪ Margin improvement initiatives offset by unfavorable mix and Cincinnati impacts ADJUSTED EBITDA EXPECTED TO BE FLAT VS. 2025 ▪ Due to unfavorable mix and business interruption insurance for Cincinnati impact revenue recorded in other income KEY TARIFF ASSUMPTIONS (included in guidance) ▪ Section 301 tariff rates for balance of year ▪ Reflects a 14% tariff applied on U.S. exports to China ▪ ~10 cent full-year adj. EPS impact from tariffs REFINANCING IMPACT ON Q4 ▪ Structure: $2.1B refinancing with $600M revolver, $600M Term Loan A, $450M Term Loan B and $450M senior secured notes. ▪ Maximum allowable leverage of 4.50x in Q4 2026, stepping down to 4.25x in 2027. ▪ Interest rate: Increase near the high end of the 100–200 bps range versus pre-refinancing levels. FY 2026 FX RATES ▪ EUR/USD ▪ USD/JPY ▪ USD/CNY 1.15 159 6.82 ADJ. TAX RATE 19.0% AVG. SHARES OUTSTANDING 77 – 78 MILLION 10 IART Q3 2026 Earnings Presentation Note: adj. EPS, adjusted gross margins and adjusted EBITDA are non-GAAP financial measures.
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APPENDIX Non-GAAP Reconciliations
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Third Quarter 2026 Financial Results (1) These are non-GAAP financial measures. Please see the slides appearing below for a reconciliation to the nearest GAAP measure. Note: Numbers may not add due to rounding 12 IART Q3 2026 Earnings Presentation % of Revenue Q3 2026 Q3 2025 Change Q3 YTD 2026 Q3 YTD 2025 Change Total Revenues $411.2 $402.1 2.3% $1,221.9 $1,200.3 1.8% Gross Margin 51.0% 51.5% -40BPS 52.9% 50.9% +200BPS Adj. Gross Margin (1) 61.1% 62.9% -180BPS 62.1% 61.9% +20BPS Net Income $14.9 ($5.4) 374.8% $14.7 ($514.8) 102.9% Adj. Net Income(1) $46.4 $41.6 11.6% $131.7 $107.7 22.3% Adj. EBITDA Margin(1) 19.4% 19.5% -10BPS 19.2% 17.8% +140BPS Diluted Shares Out (M) 78.6 76.9 2.2% 77.9 76.7 1.6% Earnings per Share $0.19 ($0.07) 371.4% $0.19 ($6.72) 102.8% Adj. Earnings per Share (1) $0.59 $0.54 9.3% $1.69 $1.40 20.7%
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Third Quarter 2026 Organic Growth Reconciliation (1) Revenue from acquisitions Note: Numbers may not add due to rounding 13 IART Q3 2026 Earnings Presentation (In millions) Q3 2026 Q3 2025 Q3 YTD 2026 Q3 YTD 2025 Neurosurgery $214.1 $201.6 $625.6 $601.0 Instruments $49.7 $50.2 $151.7 $154.7 ENT $40.4 $40.9 $119.3 $121.6 Total Specialty Surgery $304.1 $292.6 $896.5 $877.3 Wound Reconstruction Solutions $81.5 $84.0 $242.5 $243.5 Corporate Partnerships $25.5 $25.5 $82.9 $79.5 Total Tissue Reconstruction $107.1 $109.5 $325.3 $323.0 Total Reported Revenues $411.2 $402.1 $1,221.9 $1,200.3 Impact of changes in currency exchange $0.8 $0.0 ($4.1) $0.0 Total Organic Revenues $412.0 $402.1 $1,217.8 $1,200.3 Organic Revenue Growth 2.5% 5.0% 1.5% 0.0%
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Third Quarter 2026 Free Cash Flow & Adjusted Free Cash Flow Conversion Reconciliations Note: Numbers may not add due to rounding 14 IART Q3 2026 Earnings Presentation (In millions) Q3 2026 Q3 2025 TTM 2026 TTM 2025 Net Cash from Operating Activities $96.0 $40.9 $140.4 $89.3 Purchases of Property and Equipment ($10.2) ($15.2) ($54.6) ($93.8) Free Cash Flow $85.7 $25.8 $85.8 ($4.5) Adjusted Net Income $46.4 $41.6 $195.5 $180.9 Adjusted Free Cash Flow Conversion 184.6% 61.9% 43.9% (2.5%)
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Third Quarter 2026 Adjusted EBITDA Margin Reconciliation Note: Numbers may not add due to rounding (1) Acquisition, divestiture and integration-related charges are associated with the Acclarent acquisitions and includes banking, legal, consulting, systems, and other income and expenses. 15 IART Q3 2026 Earnings Presentation (In millions) Q3 2026 Q3 2025 Q3 YTD 2026 Q3 YTD 2025 GAAP Net Income $14.9 ($5.4) $14.7 ($514.8) Depreciation 10.3 11.3 31.7 32.7 Intangible asset amortization 26.8 26.9 80.8 80.1 Goodwill impairment charge - 0.0 - 511.4 Other (income), net (5.5) 0.8 (14.2) 2.9 Interest expense, net 17.7 17.3 54.3 47.2 Income tax expense/(benefit) 0.8 (1.4) 3.3 (53.0) Cincinnati Flood 0.8 - 0.8 - Acquisition, divestiture and integration-related charges (1) (3.0) (6.6) 1.2 4.6 Structural optimization charges 5.7 11.1 22.5 27.7 Braintree Transition 8.8 14.0 26.4 42.4 EU Medical Device Regulation 2.6 10.6 12.9 32.2 Total of non-GAAP adjustments: 64.9 83.9 219.7 728.1 Adjusted EBITDA 79.8 78.5 234.4 213.3 Total Revenues 411.2 402.1 1,221.9 1,200.3 Adjusted EBITDA Margin 19.4% 19.5% 19.2% 17.8%
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Third Quarter 2026 Adjusted Gross Margin Reconciliation Note: Numbers may not add due to rounding (1) Acquisition, divestiture and integration-related charges are associated with the Acclarent acquisitions and includes banking, legal, consulting, systems, and other income and expenses. 16 IART Q3 2026 Earnings Presentation (In millions) Q3 2026 Q3 2025 Q3 YTD 2026 Q3 YTD 2025 Reported Gross Profit $209.9 $207.0 $646.6 $610.8 Cincinnati Flood 5.7 - 5.7 - Structural optimization charges 3.5 8.4 9.4 17.9 Acquisition, divestiture and integration-related charges (1) 0.1 0.2 0.1 0.8 Braintree Transition 8.8 13.4 26.2 41.4 EU Medical Device Regulation 0.3 0.8 1.7 3.3 Intangible asset amortization expense 23.1 23.1 69.5 69.0 Adjusted Gross Profit $251.3 $253.0 $759.3 $743.1 Total Revenues 411.2 402.1 1,221.9 1,200.3 Adjusted Gross Margin 61.1% 62.9% 62.1% 61.9%
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Third Quarter 2026 Adjusted EPS Reconciliation Note: Numbers may not add due to rounding (1) Acquisition, divestiture and integration-related charges are associated with the Acclarent acquisitions and includes banking, legal, consulting, systems, and other income and expenses. 17 IART Q3 2026 Earnings Presentation (In millions) Q3 2026 Q3 2025 Q3 YTD 2026 Q3 YTD 2025 GAAP Net Income $14.9 ($5.4) $14.7 ($514.8) Cincinnati Flood 0.8 - 0.8 - Acquisition, divestiture and integration-related charges (1) (3.0) (6.6) 1.2 4.6 Structural optimization charges 5.7 11.1 22.5 27.7 Braintree Transition 8.8 14.0 26.4 42.4 EU Medical Device Regulation 2.6 10.6 12.9 32.2 Goodwill impairment charge - - - 511.4 Intangible asset amortization expense 26.8 26.9 80.8 80.1 Estimated income tax impact from adjustments and other items (10.1) (8.8) (27.6) (75.9) Total of non-GAAP adjustments: 31.6 47.0 117.0 622.5 Adjusted Net Income $ 46.4 $ 41.6 $ 131.7 $ 107.7 Adjusted Diluted Net Income per Share $ 0.59 $ 0.54 $ 1.69 $ 1.40 Weighted average common shares outstanding for diluted net income from continuing operations per share 78.6 76.9 77.9 76.7
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Third Quarter 2026 Adjusted SG&A Reconciliation Note: Numbers may not add due to rounding (1) Acquisition, divestiture and integration-related charges are associated with the Acclarent acquisitions and includes banking, legal, consulting, systems, and other income and expenses. 18 IART Q3 2026 Earnings Presentation (In millions) Q3 2026 Q3 2025 YTD 2026 YTD 2025 Reported SG&A $165.3 $169.0 $516.0 $530.4 Structural optimization charges 1.3 2.8 11.5 10.3 Acquisition, divestiture and integration-related charges (1) 2.2 (6.2) 5.1 3.9 Braintree Transition 0.0 0.5 0.2 1.0 EU Medical Device Regulation 0.8 5.4 5.1 14.4 Adjusted SG&A $161.0 $166.5 $494.0 500.8 Total Revenues $411.2 $402.1 $1,221.9 $1,200.3 Adjusted SG&A (% of Revenues) 39.2% 41.4% 40.4% 41.7%
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Third Quarter 2026 Net Debt Reconciliation Note: Numbers may not add due to rounding 19 IART Q3 2026 Earnings Presentation ($ in millions) 9/30/2026 12/31/2025 Short-term borrowings under senior credit facility 48.4 38.8 Long-term borrowings under senior credit facility 1,697.0 1,729.6 Borrowings under securitization facility 81.2 87.8 Deferred financing costs netted in the above 2.1 3.3 Short-term Investments (59.7) (28.7) Cash & Cash Equivalents (252.3) (235.0) Net Debt 1,516.8 1,595.6 Capitalization