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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 Form 10 - K ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended January 3 , 2021 or TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number : 001-35406 illumina Illumina , Inc. ( Exact name of registrant as specified in its charter ) Delaware ( State or other jurisdiction of incorporation or organization ) Title of each class Common Stock , $ 0.01 par value 33-0804655 ( I.R.S. Employer Identification No. ) 5200 Illumina Way , San Diego , CA 92122 ( Address of principal executive offices ) ( Zip code ) Registrant's telephone number , including area code : ( 858 ) 202-4500 Securities registered pursuant to Section 12 ( b ) of the Act : Trading Symbol ( s ) ILMN Name of each exchange on which registered The NASDAQ Stock Market LLC No O No p Securities registered pursuant to Section 12 ( g ) of the Act : None Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . Yes p Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Act . Yes o Indicate by check mark whether the registrant ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . Yes p No O No o Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) . Yes p Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , or a smaller reporting company . See the definitions of " large accelerated filer , " " accelerated filer " and " smaller reporting company " in Rule 12b - 2 of the Exchange Act . ( Check one ) : Large accelerated filer p Accelerated filer Non - accelerated filer Smaller reporting company □ Emerging growth company If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13a of the Exchange Act . o Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404 ( b ) of the Sarbanes - Oxley Act ( 15 U.S.C. 7262 ( b ) ) by the registered public accounting firm that prepared or issued its audit report . Indicate by check mark whether the registrant is a shell company ( as defined in Rule 12b - 2 of the Exchange Act ) . Yes No p As of February 12 , 2021 , there were 145.9 million shares ( excluding 49.2 million shares held in treasury ) of the registrant's common stock outstanding . The aggregate market value of the common stock held by non - affiliates of the registrant as of June 28 , 2020 ( the last business day of the registrant's most recently completed second fiscal quarter ) , based on the closing price for the common stock on The NASDAQ Global Select Market on June 26 , 2020 ( the last trading day before June 28 , 2020 ) , was $ 46.2 billion . This amount excludes an aggregate of approximately 18.1 million shares of common stock held by officers and directors and each person known by the registrant to own 10 % or more of the outstanding common stock . Exclusion of shares held by any person should not be construed to indicate that such person possesses the power , directly or indirectly , to direct or cause the direction of the management or policies of the registrant , or that the registrant is controlled by or under common control with such person . DOCUMENTS INCORPORATED BY REFERENCE Portions of the registrant's definitive proxy statement for the 2021 annual meeting of stockholders are incorporated by reference into Items 10 through 14 of Part III of this Report