Please stand by. Good day, ladies and gentlemen, and welcome to the third quarter 2022 Illumina Earnings Conference Call. At this time, all participants are in listen-only mode. After the speaker's presentation, there will be a question and answer session. Please be advised that today's conference is being recorded. I would now like to hand the conference over to Salli Schwartz, Vice President of Investor Relations. Hello, everyone, and welcome to our earnings call for the third quarter of 2022. During the call today, we will review the financial results released after the close of the market and offer commentary on our commercial activity, after which we will host a question and answer session. If you have not had a chance to review the earnings release, it can be found in the Investor Relations section of our website at illumina.com. Participating for Illumina today will be Francis deSouza, President and Chief Executive Officer, and Joydeep Goswami, Chief Strategy and Corporate Development Officer, as well as Interim Chief Financial Officer. Francis will provide an update on the state of Illumina's business, and Joydeep will review our financial results, which include Grail. As a reminder, pending the outcome of the European Commission's investigation into Illumina's acquisition of Grail, the commission has adopted an order requiring Illumina and Grail to be held and operated as distinct and separate entities for an interim period. Compliance with the order is monitored by an independent monitoring trustee. During this period, Illumina and Grail are not permitted to share confidential business information unless legally required, and Grail must be run independently, exclusively in the best interest of Grail. Commercial interactions between the two companies must be undertaken at arm's length. This call is being recorded, and the audio portion will be archived in the investor section of our website. It is our intent that all forward-looking statements regarding our financial results and commercial activity made during today's call will be protected under the Private Securities Litigation Reform Act of 1995. Forward-looking statements are subject to risks and uncertainties. Actual events or results may differ materially from those projected or discussed. All forward-looking statements are based upon current available information, and Illumina assumes no obligation to update these statements. To better understand the risks and uncertainties that could cause actual results to differ, we refer you to the documents that Illumina files with the Securities and Exchange Commission, including Illumina's most recent Forms 10-Q and 10-K. With that, I will now turn the call over to Francis. Thank you, Salli. Good afternoon, everyone. Illumina delivered revenue of $1.1 billion in the third quarter, up 1% year-over-year and 3% on a constant currency basis, and in line with our expectations despite deepening macroeconomic challenges. Looking at our Q3 performance across platforms, in high throughput, we shipped 65 NovaSeq 6000s in Q3, down from the prior year, in line with our expectations. We had a fantastic customer response to the NovaSeq X series launch at the Illumina Genomics Forum, where we reached more than 12,000 viewers in our innovation roadmap sessions. Labs are excited by NovaSeq X's industry-leading power, efficiency, and cost effectiveness, and they love, in their words, its unexpected and revolutionary sustainability breakthroughs, including ambient shipping and a 90% reduction in packaging weight and waste. Customer traction for NovaSeq X is exceeding our expectations. We already have an advanced pipeline of more than 170 instruments, in addition to 50 orders that we have already received. Our manufacturing scaling is proceeding well, and we expect to ship 40-50 NovaSeq X units in Q1 2023, and over 300 units in the year. At the Illumina Genomics Forum, we also launched the NovaSeq 6000Dx, the first ever FDA-registered and CE-marked IVD high-throughput sequencer. We're excited to now provide Dx offerings across the throughput spectrum. In mid-throughput, we saw record NextSeq 1000/2000 shipments, which were up 40% year-over-year. This increase was driven by accelerated adoption of multi-omics, primarily in cancer research and cellular and molecular biology, both by new and existing customers. As part of our ongoing innovation roadmap, our launch of XLEAP-SBS chemistry on NextSeq 1000/2000 remains on track for 2024. Finally, low throughput shipments were up 13% year-over-year. These instruments continue to provide a great entry point to sequencing. This continued demand for our sequencing platforms across the throughput spectrum will contribute to a larger install base and drive future consumables revenue. We're also receiving positive feedback from early access customers of Illumina Complete Long Reads and Complete Long Reads with enrichment and are expanding to additional customer sites. Customer appreciates Illumina's unique ability to deliver a high quality, cost-effective, and complete view of the genome on a single platform, enhancing utility across our install base. Shifting to our market segments. Clinical sequencing consumable shipments were up 5% year-over-year, driven by continued growth in oncology testing and genetic disease testing. Sequencing run activity by our clinical customers remained robust. As expected, though, lab expansion delays and consumables inventory deleveraging have persisted due to broader macro dynamics. Oncology testing consumables grew 9% year-over-year. As our larger customers continue to shift towards high-throughput applications, our decentralized clinical testing customers ramped up business and new customers came online. Our market-leading TruSight Oncology assay, TSO500, grew 17% year-over-year as large customers took advantage of the assay's utility, reimbursement, and proficiency. TSO500 adoption continues to grow, with total accounts approaching 500. Also in oncology, Grail continued to make good progress in Q3, delivering clinical results and signing up a broad range of customers across the healthcare ecosystem, including health systems and life insurance providers. Grail announced a first of its kind partnership with Carrum Health, the first digital health company connecting employers and employees to centers of excellence through a value-based care platform. The partnership provides Galleri as part of Carrum's oncology offering to self-insured employers. Also, John Hancock, the U.S. division of Manulife, with over 1.5 million life insurance participants, recently became the first life insurance carrier to offer Galleri. The Grail team expanded its clinical sales force in Q3 and is seeing test orders increase. Evidence for Galleri's efficacy also continues to grow. In September at ESMO, Grail presented compelling final results from its PATHFINDER study. The study demonstrated that when added to standard of care screening, Galleri multi-cancer early detection testing more than doubled the number of cancers detected compared to standard screening alone. In fact, Galleri detected more cancers than all U.S. Preventive Services Task Force recommended single cancer screenings combined. Galleri's positive predictive value of about 40% is significantly higher than commonly used screening tests like the annual screen for colorectal cancer, which has a PPV of 8.7%, or the biennial mammography screen with a PPV of 4.4%. Galleri is the only multi-cancer early detection test available on the market. An analysis of the first 38,154 Galleri commercial test results in a real-world setting shows high concordance with the Pathfinder study results. In addition, Pathfinder study participants experience with the Galleri test has also been positive, with 97.1% of participants reporting a high level of satisfaction with the test. In genetic disease testing, sequencing consumable shipments grew 11% year-over-year. National health system funding for rare diseases is increasing in multiple geographies, including EMEA and China. Evidence generation continues to grow. For example, in September, Genetics in Medicine published a study from Karolinska Institute indicating that genome sequencing is a sensitive first-line test for neurodevelopment disorders. We're also seeing customer excitement around the potential for NovaSeq X to create efficiencies for both whole genome and whole exome sequencing. Turning to our research and applied markets, sequencing consumable shipments were down 8% year-over-year as customers continued to manage inventory and capital spend, and due to expected headwinds from COVID surveillance and the completion of the UK Biobank project in Q3 2021. We continue to support our customers through these dynamics and at the same time are making ongoing progress in facilitating genomic-based drug discovery. As this area continues to grow, we will partner with a range of pharmaceutical companies, like our recent collaboration with AstraZeneca, to help accelerate genomics and find promising drug targets based on omic insights. In our infectious disease and microbiology markets, we are broadening genomic opportunities across disease states. For example, we recently announced a partnership with GenoScreen to help countries impacted by tuberculosis to more effectively detect and combat multidrug-resistant strains. TB claims more than 1.5 million lives each year, and for the first time in a decade, deaths are on the rise after the pandemic. We hope that with this work, we can help vulnerable populations and make progress towards eliminating TB worldwide. Turning now toward the end of 2022 and entering 2023, we expect the macroeconomic challenges we have previously discussed to persist into 2023 and feel that it's prudent to adjust our near-term guidance accordingly. Joydeep will address our revised FY 2022 guidance shortly. Despite the near-term challenging macroeconomic environment, we remain confident in our long-term growth trajectory. Customers around the world continue to share their excitement for our latest innovations. We're staying focused on supporting them and advancing our innovation roadmap to accelerate the genome era. I'll now turn the call over to Joydeep for more detail on the quarter and our year-end outlook. Thanks, Francis. As a reminder, our third quarter financial results include the consolidated financial results for Grail. I'll start by reviewing our consolidated financial results, followed by segment results for Core Illumina and Grail, and then conclude with additional remarks on our current outlook for 2022. I will be discussing non-GAAP results, which include stock-based compensation. I encourage you to view the GAAP reconciliation of these non-GAAP measures, which can be found in today's earnings release and in supplementary data available on our website. In the third quarter, consolidated revenue was $1.12 billion, up 1% year-over-year or 3% on a constant currency basis, net of the effects of hedging. As expected, our core business growth was impacted by anticipated headwinds from customer supply chain issues that delayed lab expansions, as well as tighter customer inventory and capital management due to the challenging macroeconomic environment, including inflation and the negative impact of FX. These dynamics have persisted and, in some cases, accelerated through the third quarter, leading to our guidance reduction for the full year 2022, which I will address later in my remarks. For the third quarter, GAAP net loss was $3.82 billion, or a net loss of $24.26 per diluted share, which includes goodwill impairment of $3.91 billion related to the Grail segment, primarily due to the negative impact of current capital market conditions and higher discount rates, including a standalone risk premium on the fair value calculation of the Grail segment. Non-GAAP earnings were $54 million or $0.34 per diluted share, including dilution from Grail's non-GAAP operating loss of $148 million for the quarter. Our non-GAAP tax rate was 43.2%, which increased from 25.8% last quarter and 13.2% in Q3 2021, primarily due to the increased impact of R&D expense capitalization requirements implemented by the Tax Cuts and Jobs Act of 2017. Our non-GAAP weighted average diluted share count for the quarter was approximately 159 million. Moving to segment results, I will start by discussing the financial results of Core Illumina. Core Illumina revenue of $1.11 billion was approximately flat year-over-year or up 3% on a constant currency basis, net of the effects of hedging. Core Illumina sequencing consumables revenue of $725 million was approximately flat year-over-year. As expected, growth driven by the increased install base was muted by the year-over-year impact of customer inventory and cash management, headwinds from foreign exchange rates, the conclusion of the UK Biobank project in quarter three of 2021, and the anticipated decrease in COVID surveillance revenue. Sequencing activity on our connected instruments for clinical customers remains strong, while the pace of research sequencing activity was tempered by various macroeconomic challenges Francis mentioned. Sequencing instruments revenue for Core Illumina declined 10% year-over-year to $162 million, driven by lower NovaSeq shipments due to expected customer lab expansion delays and capital management, as well as purchasing delays in advance of next year's availability of NovaSeq X. This decline was partially offset by record NextSeq 1,000, 2,000 shipments, which grew 40% year-over-year as we continue to see strong adoption by new to Illumina customers. During the third quarter, COVID surveillance contributed approximately $28 million in total revenue, comprised of $23 million in sequencing consumables and $5 million in instruments. This was in line with our expectations and down nearly 50% year-over-year, driven by lower testing samples and a decline in instrument shipments as COVID surveillance capacity was largely established in 2021. Core Illumina sequencing service and other revenue of $123 million was up 12% year-over-year, driven primarily by higher instrument service contract revenue on a growing install base and an increase in core licensing revenue. Moving to regional results for Core Illumina. Revenue for the Americas was $592 million, up 2% year-over-year, primarily driven by NovaSeq consumables growth due to demand from genetic testing, oncology testing, and cancer research customers. As expected, growth in the region was largely offset by customer lab expansion delays and inventory and capital management, as well as a decline in COVID surveillance revenue. EMEA revenue of $290 million represented a 7% decrease year-over-year or a 2% decrease on a constant currency basis, net of the effect of hedges. Strong growth in mid throughput instrument shipments driven by clinical demand was more than offset by the conclusion of the UK Biobank program and a decline in COVID surveillance revenue. Greater China revenue of $133 million represented 9% increase year-over-year or a 14% increase on a constant currency basis. Record quarterly revenue in the region was driven by a growth in sequencing consumables for routine NGS-based research that resumed after the COVID restrictions that began in March this year were lifted, as well as strong sales of NovaSeq 6000, primarily to clinical customers for oncology testing. We continue to expect base business growth to be impacted by headwinds from the zero COVID-19 policy, exchange rates, and slowing GDP growth in the region. Finally, APJ revenue of $95 million grew 6% year-over-year or 10% on a constant currency basis, net of the effects of hedges. Growth in the region was driven by strong demand in emerging markets, notably in India, Indonesia, and Thailand, and continued strength in NIPT and oncology testing. Moving to the rest of Core Illumina P&L. Core Illumina non-GAAP gross margin of 68.9% decreased 240 basis points year-over-year, primarily due to less fixed cost leverage on lower manufacturing volumes and higher freight costs, partially offset by favorable product mix. Core Illumina non-GAAP operating expenses of $514 million were up $36 million year-over-year, due primarily to headcount growth and investments we are making in R&D to support the continued advancements of our innovation roadmap. Despite the year-over-year increase, non-GAAP Core Illumina operating expenses were approximately $25 million lower than we had originally planned. As a result of lower performance-based compensation expense given our lower revenue outlook, as well as cost containment initiatives focused on prioritizing hiring and discretionary spend, including travel. Transitioning to the financial results for Grail. Grail revenue of $10 million for the quarter consisted primarily of Galleri test fees. Grail non-GAAP operating expenses totaled $149 million for the quarter and consisted primarily of expenses related to headcount and clinical trials. Moving to consolidated cash flow and balance sheet items. Cash flow used in operations was -$52 million, a net outflow due to a one-time payment related to the litigation settlement with BGI mentioned to you last quarter. DSO was 51 days compared to 50 days last quarter due to revenue linearity. Third quarter 2022 capital expenditures were $67 million and free cash flow was -$119 million. We did not repurchase any common stock in the quarter. We ended the quarter with approximately $1 billion in cash equivalents, and short-term investments. Moving now to 2022 guidance. We now expect full year 2022 consolidated revenue to be flat to up 1% year-over-year, including approximately flat Core Illumina revenue compared to 2021 and Grail revenue in the range of $55 million-$65 million. Our revised outlook for the full year reflects the more challenging expected macroeconomic headwinds we observed through October. For Core Illumina, approximately one-third of the reduction in our 2022 guidance from our previous expectations is primarily driven by delayed recruitment for some large research projects in the Americas and Europe and the impact of inflation on research customers in Europe. The remaining two-thirds of this reduction is split approximately 70/30 across two higher than expected factors. One, delays in instruments and consumables purchases, primarily due to the excitement around NovaSeq X and two, negative FX impact and consumables inventory deleveraging. For the full year, we now expect Core Illumina sequencing revenue to be approximately flat year-over-year. This continues to include intercompany sales to Grail of approximately $25 million, which are eliminated in consolidation. Within Core Illumina sequencing revenue, we now expect instrument revenue to be down slightly year-over-year, and consumables revenue to be approximately flat, which reflects NovaSeq pull-through slightly below our guidance range of $1.1-$1.2 million per system for 2022, primarily driven by recruitment challenges at some large research and PopGen customers. The remainder of our pull-through ranges are in line with the historical guidance ranges that we have previously provided. For full year 2022, we now expect consolidated non-GAAP operating margin in the range of 9.5%-10% and Core Illumina non-GAAP operating margin of approximately 23%, reflecting our lower revenue outlook. We expect a consolidated non-GAAP tax rate of approximately 7%, which continues to assume that the R&D expense capitalization requirements implemented by the Tax Cuts and Jobs Act of 2017 will be repealed in Q4. We now expect non-GAAP earnings per diluted share in the range of $2.35-$2.50, which includes a lower than previously expected non-GAAP operating loss dilution from Grail of approximately $600 million. Lastly, we continue to expect diluted shares outstanding of approximately 159 million shares for 2022. We expect the macroeconomic headwinds we are experiencing to persist into 2023. As we noted in our last earnings call, we are proactively and prudently managing operating expenses with a continued focus on sustainable long-term revenue growth. We are well-positioned to seize opportunities to scale in key areas that align to customers' future needs and our innovation roadmap. At the same time, you'll see us gain additional scale and efficiencies from other areas. We will continue to adapt our investments and expenses to support our customers, drive further progress in the genomics industry, and enable our long-term growth. I will now hand the call back over to Francis for his final remarks. Thanks, Joydeep. As Joydeep shared, we will continue to identify opportunities to mitigate the near term effects of the global economic environment. At the same time, we're prioritizing our innovation roadmap and remain confident in our long-term growth trajectory. As I shared earlier, we're hearing high praise for the innovations we announced at the Illumina Genomics Forum, from Illumina Complete Long Reads to our most powerful and most sustainable sequencer yet, the NovaSeq X Series. These innovations will continue to evolve the genomics industry, and we look ahead with tremendous optimism over the long term. We will help our customers through the current challenges and seize the potential of the genome era together. I'll now invite the operator to open the line for Q&A. Thank you. If you would like to signal with questions, please press star one on your touchtone telephone. If you're joining us today using a speakerphone, please make sure mute function is turned off to allow your signal to reach our equipment. Again, that will be star one if you would like to signal with questions. As a reminder, please limit yourself to one question so that we can accommodate as many analysts as possible. You're welcome to re-enter the queue if you have additional questions. Our first question will come from Dan Brennan with Cowen. Thanks for taking the questions. I wanted to. There's a lot to talk about, but I guess I'll focus on the NovaSeq X and the 300 shipment guide, including the 50 in 1Q, which is ahead of our model. Maybe Francis deSouza and Joydeep could you speak about some color regarding early customer activity. Where are the orders coming from, you know, in terms of large research customers like genome centers versus smaller customers in the clinical side. Secondarily, you know, with 50 orders in hand, and you mentioned a 170 advanced order books, so you're north of 200 already. Would you characterize the 300 shipments while very attractive as possibly conservative, given expected future order momentum that you would expect to get over the next 6-9 months? Great. Thanks for the question, Dan. Let me work through those questions. First of all, you're right. We are very, very pleased with the very strong response we've gotten from customers around the NovaSeq X. Frankly, it's been stronger than we expected, and we had high expectations going into the Illumina Genomics Forum. The customers are coming from a sort of broad swath of customer segments. We're seeing more of a mix from clinical in addition to the usual genome centers that you'd expect to be some of the early adopters. We're seeing a mix both from U.S. customers as well as customers from outside the U.S. A sort of a nice broad brush of early adopter customers, and maybe even a little bit more on the clinical side than we saw when we first launched the NovaSeq 6000 a few years ago. As you pointed out, the initial orders we've got with 50 orders already in hand, that means that our Q1 shipments are already sold out. We're really entering the year in a really strong position for NovaSeq X shipments, and we have a very healthy pipeline of 170 customers that are, you know, down the pipeline already. When you look at the shipment number for the year, the number that I called out, the 300 units, I mean, it's clear that the shipment number is gonna be more constrained by supply availability next year than it is for demand. Because as you point out, we're entering the year with a very strong demand book. The way we think about it is that, you know, over the first couple of quarters of the year, you can expect us to have, you know, more demand than we can ship, just as we continue to ramp up the manufacturing capability for NovaSeq X, and we'll start to service that backlog as we get into the second half of the year. Our next question will come from Vijay Kumar with Evercore ISI. Hey, guys. Thanks for taking my question. Francis, if I had a two-parter, if you will, just on the prior NovaSeq X. The constraints here are the two mentioned. Can you give us some color on how the cycle compares to the prior NovaSeq? Because, I mean, we're like a month into product announcement, north of 200 orders. This looks like it could be a really big year for you guys from an order perspective next year. So maybe compare versus the prior cycle and you know the implied Q4 guidance here, one for Joydeep. I think revenues are minus 13%. If I think about first you know Q1 of next year being in the negative territory, maybe next year shaping out to be maybe a mid-single to high singles top line. Any color on how to think about fiscal 2022 would be helpful. Thank you. Yeah, sure. Thanks for the question, Vijay. You know, as I said to the last question, you're right in the sense that the customer reaction to NovaSeq X has certainly been stronger than we anticipated. We modeled the reaction based on our previous launches, which have been really strong. You know, if we look at the number of orders we have already, the 50 orders we have, the 170 in the advanced pipeline, if I were to compare to where we were at similar time with previous launches, I'd say we are, you know, better off than we've been with some of the other previous launches. Certainly in a very strong position going into next year. Again, the next year, NovaSeq X shipments number is going to be supply constrained. You know we've ramped up an entirely new manufacturing line because we've redone every component of this instrument, right? Entirely new chemistry, new FPGA, new flow cells, new manufacturing process for the flow cells. We're really happy with the way that scale-up is happening. If I compare the number I gave you for the Q1 shipments, that would be ahead, so the 40-50 shipments we expect in Q1, that would be more shipments than we did in the first quarter when we launched the NovaSeq 6000. Slightly ahead of where we were before. The 300 units that we're expecting to ship would be ahead of where we were with the first year of NovaSeq 6000 as well. That's how it compares with previous launches. Maybe I'll turn it over now to Joydeep. Yeah. Maybe just one thing on the, what's changed for NovaSeq, right? We are seeing, as Francis mentioned earlier, strong demand, early strong demand from clinical customers as well, right? This we attribute to the trend of continued strong clinical research coming in, which is now shifting to NovaSeq X for some of these studies. I think that's a positive trend. I think your next question was about the relationship with for Q4 and then into 2023. A few things on Q4 as we pointed out right towards the end of Q3 and early into October, we have seen a deepening of some of the macroeconomic conditions we talked about, including inflation and FX. That caused us to be prudent for the reasons I mentioned earlier to take a more conservative approach into our call for Q4. Also we now see these conditions persist into 2023. We're taking a look at some of those conditions. You know, as we know, some of the factors that have changed to the negative, FX has definitely worsened and accelerated for us and, you know, we expect will be a continued headwind into 2023. I talked about the macroeconomic conditions. We've already mentioned that COVID surveillance is likely to decline further into 2023. This kind of, you know, it is some of the factors that moderate what we had expected earlier for, you know, and continue to see in terms of the interest in NovaSeq X. Of course, some of the other technologies that we mentioned during IGF, including the Illumina Complete Long Reads. Overall, Dan, I think we feel at this point, and we haven't gone to guidance and budgeting yet, but at this point, I feel like we are probably expect revenue growth in 2023 to be closer to the 10% range, rather than where we had guided before. Our next question will come from Dan Arias with Stifel. Afternoon, guys. Thanks for the questions. Francis, can you just touch on the lab delay issue a little bit? It sounded like last quarter, the delays were a 2Q to 3Q phenomenon more than they weren't. You were in line this quarter, so the fourth quarter assumption is obviously getting adjusted here, which just seems a little bit more extended than we would think. Can you just sort of talk to what's going on there, and then when your expectations call for some of these labs actually getting going and being where they need to be? Yeah, sure. When we talked about the results last time on the call, we talked about the fact that we'd seen some delays that we're looking to get ramped up later this year and some that we're going into next year. What we found is, in both of those cases, they ended up being a little later than those customers had expected. We're seeing a push-out from what was expected to come this quarter being pushed out into next year. Even the dates for next year opening have been pushed out somewhat too. The pandemic-related effects around supply chain are definitely persisting and are impacting those lab delays. Our next question will come from Puneet Souda with SVB Securities. Hi, Francis, Joydeep, thanks for taking the question. First one, just wanna clarify that 10% growth that you mentioned for 2023, that's on the entire top line. Just wanted to also get a little bit around the 10B and the 25B sort of flow cells. 10B is launching earlier, 25B is gonna be later in next year. It appears to us that the 10 billion read flow cell could be most meaningful in your portfolio, just given that it can turn around samples in 24 hours and then still give the NovaSeq capacity that is delivered through NovaSeq 6000 today on an S4. Maybe just walk us through, you know, you know, how do you see the ramp for that, and what does that all mean in terms of, you know, sort of pull through into 2023? Thank you. Thank you, Puneet. Let me talk to both. I'll start by saying that, you know, the answer we gave around the 10% wasn't intended to be a guide for next year. It was intended to just talk about how we were thinking about some of the factors that are at play Q4 going into Q1, and we'll give a specific guide as we get into next year once we've done the bottoms-up budget. In terms of the flow cells, I think you're absolutely right in the sense that the, you know, the first flow cell we ship, the 10 billion read flow cell, is going to be very meaningful for customers that are looking to get familiar with the NovaSeq 6000 that are comparing it to the existing instrument they have. Because it's very similar in terms of footprint, in terms of output, and will probably take on some of the same workloads. Customers will feel, you know, a sense of familiarity as they move to the X with that flow cell. You'll see customers that start with that, and then the 25 billion read flow cell is really intended to unlock the next generation of studies, the very large programs that customers have been talking to us about and have been waiting for the price points of the X that are fundamentally enabling to those studies. You can think about it as, you know, they'll be the first flow cell that existing NovaSeq 6000 customers will view as very familiar to them in terms of output and the workloads that it does, and will start using as sort of their entry point into the X series. It's the bigger flow cell that unlocks, you know, the next wave of elasticity and demand. Dan, maybe Puneet to add, right? We expect the transition obviously to move forward on the consumable side much faster with research customers than clinical customers because their invalidated workflows will switch a little bit later into the cycle. Our next question will come from Julia Qin with JP Morgan. Hi, good afternoon. Thanks for taking the question. Francis, I remember you noted at the Analyst Day that, enabled by NovaSeq, you know, it could be a meaningful catalyst event for some of the PopSeq initiatives around the world. At the same time, I think you noted in Q4, there will be some, you know, research project delays, including, you know, recruitment challenges for some of the PopSeq programs. I guess in light of that, how should we think about, you know, how meaningful the PopSeq programs will be in terms of, revenue contribution next year? Let me address both parts of your question. One is around, you know, the effects we're seeing in Q4 around some of these PopSeq programs. Then two, about, you know, the X being enabling to future PopSeq programs and how important that'll be. In Q4, what we said is that there are some, a small number of very specific ongoing population sequencing programs that are experiencing some recruiting delays associated with those programs. It's a small handful, and they're experiencing delays, you know, in these existing projects. We have no doubt that these projects will continue on and complete, and they will get the recruiting they did, but a little bit slower in Q4 than they were expecting to go. Now, if we think about what X enables, that's sort of the next generation, if you like. What customers have been talking to us about for a while, and then in earnest over the last five weeks since we announced the X, is the very large projects that they want to do. You know, where the number of samples are measured sometimes in the millions. They're talking about very large exome projects, very large genome projects that frankly were just not economically viable until we brought out the X. One of the things we talked about on Investor Day that, you know, that's relevant here is that, you know, our team in some cases plays an important role in making those projects. Not only a technology enabler role by putting out a scalable instrument at the price points that make these projects viable, but in many cases, we are also helpful in bringing together the parties, whether it's pharma companies, or biobanks or national health systems. We are responsible for helping bring to convene those parties together to get those projects off the ground. I can tell you that over the last few weeks, Susan and our commercial team have been very busy and in high demand around health systems around the world that are interested in leveraging the power of the X to put together programs to create, for example, cohorts that are vastly more diverse than we have today, or much bigger than they are today. I think the X will be a very substantial needle mover on that front. Our next question will come from David Westenberg with Piper Sandler. Hi, thank you for taking the question. Sorry, on a continuation of the question I asked last quarter on consumable ordering behavior. I know there's usually an expiration date on some of these consumables. I know there was a little bit you mentioned, Joydeep, I think some of that continued dynamics around burndown, you know, lasting into the fourth quarter. You know, maybe it's a little bit, maybe it's right on your expectation, but it does look like compared to my model that is one of the culprits that continues to happen. You know, how are we not interpreting this as a slowdown for sequencing or the market in general in context of, you know, a lot of your customers have budgets, they have NIH budgets flowing in. They have tests that they have to get ordered. You know, what I'm getting into is if it's not this, why still a 10% in 2023, given the fact that I would think there would then be catch-up from all these consumables missed in Q3 and Q4? Sorry if that was a really long question. Yeah, let me try to address it. Again, you know, as Francis said, we are still in the process of budgets. You know, the 10% wasn't meant as a guide. It's more of a, you know, from the macroeconomic conditions we see. I think that maybe two parts, David. First, in terms of your question about, you know, are we seeing inventory deleveraging, has it accelerated or decelerated, right? We were actually quite on point with what we had expected in terms of inventory deleveraging, with maybe a very small part of the additional guidance we provided on Q4 actually coming from incremental inventory deleveraging. That's part one, right? Now, in terms of whether things have slowed down rather from what we had communicated at the end of Q2, we did see two specific things that we mentioned which had been slower than we had expected, right, in terms of demand or activity. One of them were the few key customers or a handful of customers that Francis mentioned that had these large research and PopGen projects that had some issues with recruitment, right? Those are things that we, you know, expect will recover over time. This is not a budget issue. This is not a, you know, mostly an inflation-related issue. The other thing that we did see was inflation and FX related and specifically related to research customers in Europe, right? There we did see a slowdown happening. We expect that some of this will continue into next year, as some of these headwinds persist. Again, it's not a structural change, it's a temporary change that are caused by very specific macroeconomic factors. Our next question will come from Michael Ryskin with Bank of America. Great. Thanks for taking the question, guys. I wanna try to squeeze in a couple, but they're all on the same topic. One, for the Grail write-down, the $3.91 billion, could you talk through the, you know, the rationale, the underlying reason for taking that this quarter? Does that have any impact on divestment discussions or sort of the puts and takes and what goes into that decision? Especially if you sort of think back to a year ago, I've, you know, I think the deal closed right around a year ago for $8 billion. And then also, could you clarify why Grail was down sequentially, $12 million in the second quarter, $10 million in the third, but the midpoint of the fiscal year guidance the same? Is it just some, you know, lumpy orders coming through? Just what's going on there? Thanks. Yeah. Let me, Mike, take the first part of your question. The reassessment of Grail's book value was really more of an accounting requirement triggered by some of the regulatory decisions coming out of Europe. Again, the primary driver of the valuation change was the higher discount rate used really as a result of the current capital and equity market conditions, right? The underlying, you know, the performance of Grail in terms of how it's progressing on its clinical results and signing up customers really has not changed, in fact has improved a little bit over the last few quarters. You know, impairment again is an accounting change. It has no impact on our, you know, on our pursuance of various options on the Grail front, and those are continuing as we had described earlier on our investor day. I'll turn it over to Francis. Yeah. Then in terms of the Grail number, so the way the quarter played out, you know, the first month of the quarter, July, was slow in terms of test ordering. Then the pace really picked up in September, partially driven by the ramp-up in the sales force that Grail has brought on board, you know, and we talked about that on the Q2 call. That's paid off in the last month of last quarter and in the first few weeks of this quarter. So that's what's driving the shape of the curve. In terms of the expectations for the year, you know, they're off to a strong start for Q4, and the midpoint of sort of our guide remains the same. The other factor that's playing out in Q4 is the revenue they're getting from their pharma partnerships associated with their MRD development. Our next question will come from Kyle Mikson with Canaccord. Hey, thanks for the question. Just a quick multi-part question from me. On NovaSeq X, was wondering what your expectations are for trade-ins and bundles in the near term, just given the X is basically like, you know, the equivalent of multiple six thousand. So maybe you could talk about that in the context of the 2023 shipment numbers that you provided earlier, maybe kind of spoke to earlier. Kind of separately, Francis, just wondering if you can share your thoughts on the complete offering in the long read space, just given the updates from PacBio and others recently. Thanks. Yeah. Let me take the first part first, which was around our expectation of trade-ins. Our customers, based on their experience with us, know that we, you know, have always helped keep customers whole when we launch a new platform. As we've always done when we've launched a new platform, we have trade-in programs for customers that have recently purchased a six thousand. We actually have programs even now that if you want to buy a six thousand now to get going, you can trade it in. You can buy now and trade it in once we launch the X next year. Certainly, there have been customers that appreciated that very much and have taken us up on that, and we expect some more to take us up on that, you know, through this quarter and going into next year. That's a standard, you know, part of our launching a new product. In terms of our Complete Long Reads, you know, we've seen a really enthusiastic response from our customers around being able to use their existing installed base across the throughput sizes. Whether you're a MiSeq all the way to NovaSeq 6000 or the NovaSeq X to do both long read and short read workloads. And to do that in a way that allows them to take advantage of low sample inputs, lower than they can perhaps on other platforms. We expect that to be fundamentally enabling to that space. Especially if you combine the existing platforms you have with the Complete Long Reads of enrichment, you end up with the ability to do long reads much, much more cost effectively than you could do on other platforms without compromising accuracy in any way. You still get the gold standard of accuracy, and you can do it, you know, much more cost effectively. That's really exciting. What it does is it opens up that last bit of the genome, that last, you know, few percent of the genome that historically was hard to read with short read technology. Our next question will come from Tejas Savant with Morgan Stanley. Hey guys, good evening. Francis, a two parter for you here. First I wanna talk about, you know, the metered ramp down for the NovaSeq 6000 consumables you alluded to at the analyst day because of a higher proportion of clinical users. But then today, you know, you guys called out a higher clinical mix for the X. I'm just trying to juxtapose those two dynamics as we think about how the NovaSeq 6000 consumables tail off over the next couple of years here. My second question is really around, you know, some of the pop gen recruitment delays that you called out over here. If I remember right, you know, in the last product cycle, essentially, PopSeq had to be removed from the guide because it became so unpredictable in terms of timing. Can you just call out sort of what you see is different this time around that drives your confidence that at least as far as PopSeq goes, you will continue to get that sort of, you know, elasticity of demand? Yeah, a great question. Let me take the first one first. You're absolutely right in the sense that if you are running production clinical workloads today, you are going to continue to run them on the NovaSeq 6000 for a while, and then it'll be a, you know, there'll be a metered, you know, transition that'll be measured in quarters and years before you move that entire production workload onto the X. That continues to be what we believe, that continues to be the feedback we're getting from our customers. What's really exciting, though, is that clinical customers are talking to us about, and their purchases are really about new workloads. You know, it's areas that they want to expand into, that they're saying, instead of starting on the six thousand, they'd like to start that development on the X with an idea then, of course, to ramp it up into production on the X. That has been more substantial than we expected. That means that there are a bunch of our large clinical customers that are expanding into new clinical areas. You know, it's an exciting development for the field. It's also an exciting development for as well. In terms of PopSeq, what we have talked about is that when we are bringing on new PopSeq deals, new big PopSeq deals, we'll tend to binary them out of our guide if they're big and you know, we're still trying to figure out when they land. As you know, that's a learning we had in terms of how these deals develop. Once they're in production, they are in the guide, right? There, the variability isn't quite as big as whether a big deal will come on or not. You know, it may ramp up or down in a quarter, and then certainly we'll call it out, you know, for you if that happens or if we see that starting to happen, which is what we're doing for Q4. That's less variability rather than an entirely new deal coming on, which again, will tend to be more conservative in terms of building that into our guide. Francis, I'll just add, I think this is a great question about clinical side, right? I think we are seeing some of these newer tests that Francis called out going, you know, more towards NovaSeq X, because these are also the higher intensity tests which have, you know, much higher throughput requirements, which is consistent with what we mentioned regarding elasticity of demand continuing to go up with the introduction of new technologies. Moving on to Dan Leonard with Credit Suisse. Hi, thank you. I just wanna make sure I understand the change in the 2022 guidance for Core Illumina. It seems like you attributed half of the guidance reduction to delays associated with the X, if I'm doing the math right, 70% of the two-thirds. You knew you were launching the X, so what evolved differently from your expectations? Yeah, you're absolutely right. You know, we knew we were launching the X, and we sort of modeled the customer interest based on the previous launches we've done. Frankly, we've been really surprised in a positive way around how much interest there has been from our customers in getting to the X. Again, as I said, we fully expected our clinical customers to be a little bit slower in terms of coming on board for the X. What we're finding is that they're not for the reasons we talked about, that while they're keeping production workflows on the six thousand, they are excited about using the X for their new applications, which as Joydeep said, tend to be more sequencing intensive applications. that has been an upside surprise in terms of the enthusiasm for the X, but has a knock-on effect then that people are saying, "Look, I'm gonna hold on to 6,000 in Q4 and wait for the X as it starts to ship in Q1. Thank you. Our next question will come from Patrick Donnelly with Citi. Hey, guys. Thanks for taking the questions. Francis, maybe one just on the customer base, more on the kind of clinical diagnostic side. I know the past quarter you kinda called out there being a little more conservative with cash, you know, particularly kind of speaking to the inventory question. Are you still seeing that piece? What are the conversations like and then kind of the outlook for that market in 2023? Yeah. Thanks, Patrick. We're definitely seeing that continue to play out. We're seeing two things play out. One, activity levels in terms of runs on the instruments that they have continue to be robust and generally in line with the commentary we shared in Q2. At the same time, we are seeing concern around, you know, their cash position and a desire to want to manage their inventory levels more conservatively, perhaps, than they have historically. That's also enabled by the fact that they've seen that our supply has been very consistent and robust and stable even through the pandemic. Their confidence around saying, "Look, we can run at a lower inventory level for a while and still maintain the integrity of their operations capability." We're definitely seeing that dynamic continue to play. Our next question will come from Luke Sergott with Barclays. Awesome. Thanks for the question, guys. Can you give us a sense of the margin profile, what XLEAP is going to come through? I think it's important to think about as you ramp on the NovaSeq X next year, and as that continues to come up and you're, you know, having the higher pull-through, we need to kind of figure out where the operating margin is gonna come through. Yeah, sure, Luke. The expectation and the design point is to maintain similar margins with the instruments that use the new XLEAP chemistry as the instruments that they're replacing. If you look at the X, for example, you should think about it over time as it scales to have a similar margin profile to the NovaSeq 6000, both in the, you know, generally on the instrument side and certainly on the consumable side. That's the design, you know, criteria we use. The idea is to invest in technology that fundamentally lowers the cost to make the product and then pass on those savings to our customers. Maintain the same margins and pass on the savings, you know, to our customers associated with the innovations that we're bringing, like X, like the new optics, like the new flow cells and so on. Our next question will come from Jack Meehan with Nephron Research. Thank you. Good afternoon. Wanted to talk a little bit about the guide here for the fourth quarter. I think for the year, the new consumables guide is flat, by my math, and you can check me on this, a lot of earnings tonight. I think that implies down 16% in the fourth quarter. Can you just talk us through what's going on there, maybe between price and volume? It just seems like, you know, given you're talking about it's kind of concentrated in one part of the customer base, it just feels like a big move. Yeah. Overall, Jack, you know, for the full year, you're right, it's sequencing consumables tends to be is tending to be flat. Pricing actually is not impacted, right? This is mostly volume. We track the price piece pretty carefully, and it is in line with what we have seen in previous quarters. I think the reasons for the volume, you know, reduction is what we have stated earlier, right? There is a component of it, by the way, as you look at the revenues, there's a component of FX that has come through. In terms of the volumes, there are two components, right? Primarily, there's an inventory de-leveraging part which we had some of, most of it, which called out earlier, and then there's some additional piece. Then the two specific pieces around large research customers and the recruitment delays and some slowdown inflation related and FX related that we have seen in Europe. Those continue to be the largest sources of, you know, a slowdown. Then, you know, one of the things that Francis had mentioned as well is on the NovaSeq X side, right? The increased interest in NovaSeq has delayed some of the consumables purchases on NovaSeq X as well, right? That is a component there. Thank you. That does conclude our question and answer session. I will now hand the call back over to Salli Schwartz. Thank you for joining us today. As a reminder, a replay of this call will be available in the investor section of our website. This concludes our call, and we look forward to our next update with you at the JP Morgan Healthcare Conference in January. Thank you. That does conclude today's conference. We do thank you for your participation. Have an excellent day.