Good day, ladies and gentlemen, and welcome to The Third Quarter 2024 Illumina Earnings Conference Call. At this time, all participants are in listen-only mode. After the speaker's presentation, there will be a question-and-answer session. Please be advised that today's conference is being recorded. I would now like to hand the conference over to Salli Schwartz, Vice President of Investor Relations. Hello, everyone, and welcome to our earnings call for the third quarter of 2024. During the call today, we will review the financial results we released after the close of market and offer commentary on our commercial activity, after which we will host a question-and-answer session. Our earnings release can be found in the Investor Relations section of our website at illumina.com. Providing prepared remarks for Illumina today will be Jacob Thaysen, Chief Executive Officer, and Ankur Dhingra, Chief Financial Officer. Jacob will provide an update on the state of Illumina's business, and Ankur will review our financial results for Core Illumina. As a reminder, we divested GRAIL in June of this year. For a review of historical financial results for GRAIL and consolidated Illumina, please see our earnings release and our SEC filings. We will be discussing non-GAAP results, which include stock-based compensation. We encourage you to review the GAAP reconciliation of these non-GAAP measures, which can be found in today's release and in the supplementary data available on our website. As we go through the results, please note that year-over-year is as compared against the third quarter of fiscal 2023, while sequential is as compared against the second quarter of fiscal 2024. This call is being recorded, and the audio portion will be archived in the Investor section of our website. It is our intent that all forward-looking statements regarding our financial results and commercial activity made during today's call will be protected under the Private Securities Litigation Reform Act of 1995. Forward-looking statements are subject to risks and uncertainties. Actual events or results may differ materially from those projected or discussed. All forward-looking statements are based upon current available information, and Illumina assumes no obligation to update these statements. To better understand the risks and uncertainties that could cause actual results to differ, we refer you to the documents that Illumina files with the Securities and Exchange Commission, including Illumina's most recent Forms 10-Q and 10-K. With that, I will now turn the call over to Jacob. Thank you, Salli. Good afternoon, and thank you, everyone, for joining our call today. Illumina delivered another quarter of strong financial performance. We are making significant progress in expanding margins and driving earnings, growing the utilization of the NovaSeq X platform, and bringing the next phase of sequencing innovation to our customers. In Q3, revenue was $1.1 billion, in line with our expectations. Across our regions, Americas revenue was down 6% year-over-year. Europe revenue was up 12%. EMEA revenue was up 7%, and Greater China was down 23%. In the quarter, we placed an additional 58 NovaSeq X Plus instruments, bringing our total installed base to 527. Approximately 40% of this installed base has been shipped to clinical customers, highlighting the diversity of our user base. The X Series surpassed $1 billion in cumulative revenue, a major milestone. Our non-GAAP operating margin of 22.6% and diluted earnings per share of $1.14 exceeded our expectations, and we began executing on the capital allocation strategy we laid out at our August strategy update. Looking ahead through year-end, while the funds remain healthy, the near-term macroeconomic environment has been persistently constrained. We now expect our 2024 revenue growth to be slightly lower than our prior guidance range. However, we are raising our guidance for both 2024 operating margin and earnings per share, reflecting the significant progress we have made so far this year in our transformative journey, driving operational excellence and strengthening our culture of performance. Ankur will provide additional details during his remarks. During our August strategy update, we laid out a plan to drive high single-digit revenue growth and 500 basis points of operating margin expansion by 2027, while achieving annual EPS growth in the double digits to teens over the next three years. To achieve this, I've set key priorities to guide execution against our strategy: deeper customer collaboration, continuous innovation, and commitment to operational excellence and margin expansion. Our first priority, deeper customer collaboration, is centered on providing a range of targeted solutions to serve the increasingly diverse needs of our customer base. Over the past several months, I've continued connecting with our customers worldwide. Most recently, this included a group of academic core lab directors that have a long legacy of collaboration with Illumina and are some of our most experienced users. I'm grateful to them for their ongoing partnership and support. As we evolve the way we engage with customers, we have focused on two key initiatives. One, shifting how we interact and collaborate with customers to support their ambitions. My observation was that we needed to do better in this area. And now I'm beginning to hear from customers that they are seeing Illumina present itself in a new way. And two, giving customers a clear line of sight to the significant innovations we have in the pipeline. Their early input is invaluable, allowing us to develop the most impactful products and solutions in the industry. I'm pleased to see this partner mindset become increasingly embedded into our company's culture. It will serve as a cornerstone of our success going forward. Our second priority is continuous innovation, which follows naturally from our first priority as it is driven and shaped by what customers are telling us they need. For example, we recently announced the launch of the groundbreaking MiSeq i100. We are addressing demand for flexible solutions for smaller-scale projects with faster turnaround time. Early feedback is validating our approach of bringing customers into the fold as advisors throughout the product development process. Customers are excited about room temperature shipping and storage of reagents, allowing for sequencing on demand without the need to thaw reagents. The shorter runtimes, paired with our-proven end-to-end workflows, are what our customers have been asking for, and they have expressed that this is a game changer. Over time, we intend to leverage these new technologies in future releases across our portfolio. MiSeq i100 instruments for early access customers will begin shipping in late Q4, driven by the strong demand we saw in the days following the announcements. At our strategy update, we shared a number of additional innovations, including comprehensive whole genome sequencing and our five-base genome that will launch over the next 12 - 18 months. Collectively, these technologies will reinvent genome while making NGS workflow easier. Comprehensive whole genome solution leverages a novel constellation mapped read technology to add additional layers of genomic data, redefining the extent of information created by the SBS chemistry. Standard library prep is eliminated as it is performed directly on the flow cell, going from multiple hours of hands-on time to just a few minutes. Another customer-driven innovation is the five-base genome, which will provide variant and epigenetic information from a single library prep. Customers will have access to methylation information in every one, which is important to understand diseases, including cancer, obesity, and infectious diseases. Both the five-base genome and constellation mapped read technology solutions are currently in development, with customers providing feedback that will influence our product advancements. We will be providing further details on these two innovations, including results from early access customers at upcoming industry events like ASHG later this week. In the near term, Illumina continues to deliver innovations for the NovaSeq X Series. We remain on track to begin shipping the single flow cell NovaSeq X by the end of this year. This instrument will be upgradable to the NovaSeq X Plus. In Q4, we will introduce 100-cycle and 200-cycle 25B flow cells designed for high-output counting applications such as single-cell and proteomics. Our third priority is operational excellence. Our focus here is to build a foundation that powers our long-term success, regardless of the top line. By enhancing productivity, optimizing our investment spend, and driving smart capital allocation, we are positioning Illumina to directly benefit not only our customers and the patients they serve, but also our employees and our shareholders. Indeed, we have made great progress in building a culture where every employee is driving efficiencies to contribute to operational excellence. Now, I will ask Ankur to share more detail on our third-quarter results and outlook. Thank you, Jacob, and good afternoon, everyone. I'll give you an overview of our financial results, provide more color about revenue, expenses, earnings, and developments on our balance sheet, and then speak about our outlook going forward. All financial information, including guidance that we shared on this call, is for Core Illumina only and excludes GRAIL. During the third quarter, Illumina's revenue of $1.08 billion was in line with our expectations, and the team delivered a very strong margin and earnings expansion through ongoing cost discipline and operational excellence. Cash generation remained strong, and we also put cash to use across all dimensions of our capital allocation strategy. Now, I will add color to each of these items. Third-quarter revenue was down 2% year-over-year on both a reported and constant currency basis, with strong growth in our consumables business offset by the instruments business declining against launch year compares. Sequencing consumables revenue was $741 million, up 7% year-over-year, driven by continued strong uptake in X consumables. The NovaSeq X transition progressed faster than we forecasted. As of end of Q3, more than 55% of high-throughput gigabases sequenced and more than 35% of high-throughput consumables revenue was on the NovaSeq X Series. We saw some acceleration of the transition from 6K to X this quarter, including in clinical, as approximately 40% of high-throughput clinical gigabases sequenced were on the NovaSeq X Series. As legacy assays transition to the X Series, we have seen increased clinical volumes and increasing adoption of the 25B flow cell from clinical customers. While there will be some quarterly variations in the pace of transition based on choices our customers make, we still believe almost half of high-throughput consumables revenue could transition to the X Series by middle of 2025. Moving to sequencing activity, total sequencing Gb output on our connected high- and mid-throughput instruments continued to grow at a rate more than 40% year-over-year, with robust growth from both clinical and research customers. Sequencing instruments revenue was $104 million for Q3, a 42% year-over-year decline, slightly behind our expectations. The year-over-year decline was driven by two factors. One, lower NovaSeq X placements as compared to significant pre-order launch-related shipments in the third quarter of 2023, and two, a decline in mid-throughput shipments as capital and cash flow constraints continue to impact purchasing behavior and moderate instrument placements globally. Sequencing service and other revenue was $150 million, up 6% year-over-year, driven by an increase in revenue from strategic partnerships as well as high instrument service contract revenue on a growing install base. Moving to the rest of the P&L, Non-GAAP gross margin of 70.5% for the quarter increased 450 basis points year-over-year. This strong gross margin performance was driven primarily by the execution of our operational excellence initiatives that continue to improve productivity and deliver cost savings. Year-over-year improvement in gross margin was also supported by a more favorable revenue mix of sequencing consumables, making approximately half of that improvement. While the business mix will change on quarter-to-quarter basis, the productivity improvements we have achieved are sustainable and will support our margin expansion going forward. Non-GAAP operating expenses of $517 million were roughly flat to last quarter. This includes the additional headcount and expenses resulting from our acquisition of Fluent BioSciences. The Illumina team continues to manage expenses effectively. As I mentioned during our strategy update, we have several actions in play to reprioritize and reduce our expenses. As a result, non-GAAP operating margin for the quarter was 22.6% compared to the 22.5% in the prior year period. This came in well above our guidance of approximately 20%, driven by strong operational performance across gross margin and discipline and expenses. Below the operating income line, non-GAAP other expense was $14 million in Q3. During the quarter, we issued $500 million in debt at a 4.65% coupon that was used, along with cash on hand, to redeem in full the high-cost $750 million delayed draw term loan, effectively delivering and also reducing our interest rate. Non-GAAP tax rate was 21% for the quarter. In Q3, we received the benefit of a few one-time credits as we filed our return for last year. Putting it all together, non-GAAP net income for Q3 was $181 million for diluted earnings per share for $1.14 per diluted share. Our non-GAAP weighted average diluted share count for the quarter was approximately 160 million shares. Moving to cash flow and balance sheet items for the quarter. Cash flow provided by operations was healthy at $316 million. Capital expenditures were $32 million, and free cash flow was $284 million. During the quarter, we put cash to work in line with our stated capital allocation strategy. We acquired Fluent BioSciences, adding innovative instrument-free single-cell technology to Illumina's portfolio. We're excited about the potential for very large single-cell experiments this technology can enable. In addition, following authorization from our board earlier this quarter, we put a share repurchase program in place and repurchased 770,000 shares of Illumina stock for $98 million at an average price of $127.71 per share, and as noted, we delivered. Taken together, these capital actions show the strength of our operational execution in the quarter. We ended the quarter with approximately $939 million in cash, cash equivalents, and short-term investments. In summary, revenue was in line with expectations. The transition of high-throughput sequencing to the NovaSeq X is going quite well. We announced breakthrough new products in low throughput. We made significant progress towards our stated goal of margin expansion, and we have been deploying our strong cash flow towards revenue growth, improved earnings, and shareholder-friendly capital actions. Moving now to 2024 guidance. Although our overall Q3 revenue results met our expectations, we are tempering our revenue expectations for year-end business and now expect full-year revenue to be down approximately 3%. For Q4, we expect revenue to be approximately $1.07 billion. We continue to see strong utilization levels and pull through on our instruments, but the near-term macroeconomic environment remains constrained and does not support any uptake in purchasing behavior through the end of the year. From an instruments versus consumables perspective, the projected mix is unchanged, and we're still forecasting instrument revenue to decline in the mid-30s% range relative to 2023. Although we are very excited about MiSeq i100, it is in early access, and we will receive minimal revenue contribution in Q4. As we had planned for, our low-throughput instrument business will likely decline in Q4, with customers waiting for the new instrument. For high throughput, we still expect second-half NovaSeq X shipments to be above what we delivered in the first half of 2024. We also still forecast sequencing consumables revenue to grow towards the upper end of the low single-digit% range versus 2023. We saw strong uptake and Gb usage in the third quarter, setting the stage for exiting the year with solid year-over-year consumables growth. While we are disappointed in our lower revenue guidance, we are increasing our guidance for operating margin and diluted EPS, reflecting both the outperformance in Q3 and carrying forward the impact of our operational excellence initiatives into Q4. We are raising our non-GAAP operating margin guidance to a range of 21%-21.5% for 2024. We are reducing our projected tax rate for the year to approximately 24%. And lastly, we're raising our guidance range for non-GAAP diluted earnings per share to $4.05-$4.15 range for full year 2024. With that, I will now turn it back over to Jacob for his closing remarks. Thank you. Thanks, Ankur. As I reflect on my first year, I'm excited for the early progress Illumina has made and the momentum we have created to drive the industry forward. We refocused the company on our strong core business and launched our new strategy. We reset the leadership team and made the necessary structural changes to support our customer-first orientation. We've been increasingly embedding operational excellence in our culture, and the results are beginning to show in our financials. This is a good start to our multi-year transformation journey. For 2025, we are looking forward to returning to growth, although I would like to finish Q4 before providing specific guidance. Ultimately, I'm encouraged and feel confident in bringing Illumina back to high single-digit revenue growth by 2027, as stated during our strategy update. Thank you for joining today. I will now invite the operator to open the line for Q&A. Thank you. If you would like to ask a question, please signal by pressing star one on your telephone keypad. If you're using a speakerphone, please make sure your mute function is turned off to allow your signal to reach our equipment. As a reminder, please limit yourself to one question so that we can accommodate as many analysts as possible. You are welcome to reenter the queue if you have additional questions. Once again, that was star one to ask a question. We'll move first to Doug Schenkel with Wolfe Research. Good afternoon. On guidance, just specifically, keeping in mind you are guiding revenue down a slight bit sequentially, what do you expect to drop? And specifically, do you expect sequencing consumable revenue to grow sequentially? And kind of building off of this, from a clinical standpoint, you're making really good progress in terms of placements with clinical customers. When you place a box, how much visibility do you have on that customer's plan? Specifically, do you know when existing assays are going to be moved from a legacy instrument to the X? I'm just looking for some help addressing concerns about a clinical cliff for consumable revenue as we look ahead to 2025. Thank you. Yeah, thanks for that. And I've heard this clinical cliff a few times, and I don't think that's the way we look at the business right now. I think first and foremost, we are, of course, excited to see that there continues to be strong momentum moving towards the X. As Ankur was mentioning here earlier, that we are seeing the strong momentum. We are seeing a lot of volume moving towards the X. So everything is pointing into the direction that we were also presenting at the strategy day. As you also mentioned, we did take down, and we were tweaking the guidance here for coming out of Q3 into Q4, as we did not see, even though we see a very healthy instrument funnel, we're not seeing the normal end-of-year activity that we would normally see. But as you're also mentioning, is that we actually saw very nice uptake in our revenue for the consumables. And I think that's also what we mentioned before is a strong indicator for that we are seeing the trajectory of moving towards the X. With the specifics on clinical and on how we have transparency into our customers, we do spend actually quite a lot of time, especially with our larger customers. As I mentioned before, we are spending a lot of time actually to work closely with them to understand where they're going to actually go deeper into where we are with our funnel and what we have in our R&D pipeline so they can get prepared to transition when we come out with new technologies. That goes both for our academic customers, but certainly also our clinical customers. And we also have a quite good understanding on what the different projects they're looking into and when they're transitioning over to the X. Now, I would say that if I just look at it from a high-level perspective, we don't see a lot of customers that is going from completely 6K and over to X in a few months. This is normally assay by assay, and it takes time. It usually takes a year, if not 18 months, to transition over to the X. But what Ankur was also saying, we're seeing more than 40% of the volume now for the clinical accounts. This is Ankur. Doug, so on the other part, specifically to your question about the guidance for Q4 consumables, our guide right now assumes a typical seasonal decline from Q3 to Q4 in consumables. As you know, there are lots of holidays during Q4 relative to the other quarters. I looked back and looked at the trends for the last few years as well, and seasonally, the consumables purchases do kind of follow that seasonal pattern down in Q4, and that's what I'm assuming in the guide right now. Nothing underlying from a transition perspective or a clinical transition, etc., perspective there, simple seasonality. We'll move next to Puneet Souda with Leerink Partners. Yeah, hi, Jacob, Ankur. Thanks for taking my question. So I just wanted to clarify on the mid-throughput side, was that decline in mid-throughput came mostly from China, or was the decline in the quarter US and Europe seeing more competition from a US-based mid-throughput competitor? And then just briefly asking about 2025, I understand it's hard for you to provide a number there, but just can you walk us through the considerations that you have there for 2025? One of the biggest is obviously the clinical transition here for the customers. As they switch over, obviously, they'll purchase new instruments. That's a revenue, but at the same time, they will also be taking a lower cost, which will reduce revenue to you. So just can you walk us through the considerations as you think about 2025? Thank you so much. Okay, thanks for that, and I think, Puneet, let me start with the first one is that I think we continue to see a lot of competition across the world. I'm actually quite encouraged with China. As you might recall, we have a new leader coming in almost six months ago in China, and Jenny has done a fantastic job to reset the organization, reconfigure the organization, also reset our relationship with many of our partners, and including also looking at different types of pricing strategy. And I think we're starting to see that actually working now, meaning that we are starting to see that sequentially we are seeing flat revenue there, so at least we are starting to see a change in pattern in China. It's too early to call it up. Competition in the rest of the world, you're absolutely right that we are seeing most competition in the mid-throughput. I will say that we take that very seriously. I've said that before, but I actually think it's something that keeps us on the toes here, and it's something that I truly believe is important as a company to have competition. It makes us more agile. It makes us better in front of our customers. So I enjoy that. I will say that if you look into the performance of the mid-throughput itself, I had a conversation the other day, as also mentioned, with the academic collab directors, and during those conversations, we were also looking to where they're getting their business from. And we see more and more of, or they see a lot of customers, the small biotech companies, all the small companies that previously would likely buy a mid-throughput instrument and do sequencing themselves. Due to their financial constraints right now, many of them are outsourcing. And we still see, and thereby those lab directors see more of that business. And for us, as we mentioned before, the macroeconomic is still the majority of the pressure we see in the mid-throughput. So if you look into 2025, I think we would still like to see the end of this year before we go deeper into our considerations into 2025. But that said, as I mentioned, in the Strategy Day, we are expecting. We're still very committed to that we will end at high single-digit growth by 2027. As we were also mentioning, we were stepping ourselves into that, and we expect to go from 2024 where we had negative growth here and then step into positive growth regime in 2025. We'll move next to Vijay Kumar with Evercore ISI. Hey, guys. Thanks for taking my question. And Jacob or Ankur, maybe both of you can chime in on a lot of details here. The activity levels were about 40%, but I didn't hear a price for Gb commentary. Was that in line with the -20 to - 25 that you expected at the Analyst Day? And given the mixed impacts here on margins, sorry, I think at the Analyst Day, you said 500 basis points of margin expansion. Is that off of the updated margin base of 21 - 21 1/2, or should we readjust the expansion given the guidance increase for fiscal 2024? First, thanks for that, Vijay. I'll have Ankur to talk a little bit about the specifics in the guidance here. I will say that I'm very encouraged to see us delivering on our GAAP gross margin, but also our operating margin and EPS. I think it speaks volumes to the Illumina team and the company we want to be that in tough times, we're also able to deliver significant progress in our margin expansion. I'm excited about that, and I think it should give certain very strong proof points that we are highly committed to deliver on the 500 basis points that we set out to do at the strategy day. Ankur, do you want to remind where we are? Yeah, absolutely. So Vijay, I think I answered the first question in between around that price thing. Yes, it was in that 25%-ish range. You've said that if the transition from 6K to X, since it accelerated, this quarter, we did see the price impact towards the higher end of that range, closer towards 25% rather than 20%, but it was still within that model range. Now, around the margins, I can tell you I'm very pleased with the results as I think about the 500 basis points. And I'm thinking of 21% as the base to work off that 500 basis point expansion. It's premised on two things, right? Our ability to expand our gross margins and be in that high 60s-70% range. And what the team has been able to do here is crank up that model and start giving us a view of what the model could be as we keep driving it higher. We still have lots of opportunity to take cost out within COGS to structurally get closer to that 70%. For now, this quarter higher mix was certainly beneficial. And then on the OpEx side, again, several levers still, but I think working off of that 21% and where we land this quarter and how we're looking at Q4 2024 to end, I feel very good about the progress that we're making. We'll move next to Dan Brennan with TD Cowen. Great. Thanks for your questions. Maybe first one, sorry I joined late, but maybe could you break out, I know a little you gave some color on data growth, I believe, but could you break out a little bit how we think about NGS consumable revenue growth from the perspective of the research customer base versus the clinical customer base in Q3 and kind of how did that progress versus expectations? Yeah, I think I can. I don't know if you're breaking that out very clearly, but overall, our consumables growth was up 6% for the quarter. And then both research and clinical grew nicely. There wasn't a dramatic shift between the two. Okay. Maybe stepping back just on kind of the outlook for kind of instruments that you discussed, could you give some color what's now contemplated in the full year guide from a mid-throughput basis? I don't think you guys gave any kind of breakdown in the quarter what the mid-throughput placements were, but I know they were light. So any kind of math or any color you can provide for us about the mid-throughput number and kind of what's assumed now for the full year? Yeah. So at this point, we're not providing actual placement for mid-throughput. We will give you an update for the full year at the JPMorgan as we usually do. And I think, Ankur, maybe you're a little, you want to go back on. Margins, yeah. Yeah. I misspoke. The consumables growth for the quarter is 7%, not 6%. And yeah, the research and clinical are both grew nicely. Maybe, can I sneak one other one in just on the X? I mean, is it fair to think while you're not commenting on 2025 at this point, I know we're in a difficult CapEx environment, but is it fair to contemplate X placements in 2025? Is it likely to start down year- over- year versus 2024, or is it too early to say just given kind of the environment we're in? Yeah, we would like, as I mentioned, we would like to do the guidance when we report that by the beginning of the year. We'll move next to Tycho Peterson with Jefferies. Hey, thanks. Just thinking a little bit about the clinical X transition seems to be happening, maybe some momentum picking up here. How are you thinking about the pricing headwind to that as we think about going forward? Obviously, cost per gig is lower. And then you have the dynamic of some of those oncology customers locked into multi-year contracts around GRAIL that they were able to sign. Do those break, I guess, with the transition to X? How do we think about those dynamics? Overall, we are quite pleased with that we continue to see our customers move towards X. We believe that the X platform is providing substantial benefit from our customers, both from a lower price point, but also the workflows that is able to combine with the DRAGEN compute power that we have and the interpretation power that we have. So there's a lot, and there's a lot of reasons why our customers want to move on to the X. But as you also know, in the clinical space, you need to do a lot of work upfront, validation, and so on to make sure that you are ready to move all your assets over. There's the other considerations also. If you see that you're working on a new type of asset, you might not want to move your current asset over because the cost of the validation might be outpacing what it costs or the cost reduction you get by moving it over to the other. So that's encouraging for us because we are seeing that many of the assets that the customers are moving over actually are either bigger panels or deeper sequencing, and thereby the elasticity is still working out. And now we are expecting our customers to do that. I mean, that's under our expectations that we are seeing, as we say, more than 40% of our placements are with clinical, and we expect that to continue to grow over the next period of time. So I know there is a concern out there that we certainly see a cliff. That's not how we see it. That's not how we speak to our customers. We are seeing this to be a transition that is happening, and it will be staged over time and thereby follow the trajectory we have seen over the past quarters of transition. And, Tycho, so far during the transition, and, granted, I've been here six months. I've seen two quarters, but every time customers are transitioning, the elasticity and the higher throughput that's going through the instrumentation is kind of playing out. The thesis I laid out during the strategy day, we just saw a little bit of acceleration of that during the quarter. We still saw very solid Gb shipped growth. And given the higher transition, we did see a higher price impact. But all in all, despite that, we were able to grow our consumables at a high single-digit rate this quarter because a larger portion of the business has now transitioned into X, right? I'm talking more than 55, so over half of the volume's already transitioned. So that puts us in a good position that a larger part of the Gb growth starts translating into revenue. Yeah. And by the way, Tycho, also on your question about what you call the multi-year contracts, I think you are referring to what we call the open offer letter. And this is not instrument-specific, so those contracts are also in place or will continue with the X. We'll move next to David Westenberg with Piper Sandler. Hi. Thank you for taking the question. So I'm going to build on both of Doug's question. I guess that was Doug and Tycho's question just here on the elasticity of demand. I'm sorry to belabor this point, but that cliff is a big topic we're getting from investors. So can you maybe give us some sort of conceptualization in terms of new assays to market or anything like that that would help us flavor the fact that this whole Gb is actually getting, that these whole flow cells are actually playing out to a net positive revenue there? I know you've already given a lot of color, but it still is a little bit of a build I want to make on that. And then just on the fourth quarter seasonality here, to build on that part of the question, I think there's only been one year where Q4 was lower than Q3. Can you just talk about maybe some of the budget flush dynamics that have not been or that are not happening in the quarter? I know there's obviously a low throughput weight on that one. However, low throughput as a% of capital sales, I mean, is fairly tiny on the overall P&L. So thank you very much. Yeah, Dave, let me go into that. I think there are two things to think about if you see those assays. I think I've definitely spoken to customers that have decided to make bigger assays. So if they have an oncology assay, they have decided to add more markers on, but also maybe methylation markers on, all the things that require substantially deeper sequencing. So we see that happening right now. And on top of that, what should really be encouraging is that we are, as Ankur was also saying, we continue to see the strong volume uptake for both clinical and for academic customer segments. So it really speaks to that while the X is offering, and most of that volume is obviously coming from the X. So even though that the X is offering lower price, we see the elasticity actually works for both of the clinical and the research market. We are not seeing a lot of customers right now that are just shifting over and stay with the same volume. Most of them are transitioning to the X and also creating more volume. Ankur, do you want to? Nope, that's great. In terms of your seasonality questions there, in our guide, if you're thinking sequentially, I think our instruments, given that we're holding at - 30% decline, sequentially, the instruments would still be up relative to Q3. And my seasonality comment around a decline Q3 to Q4 was more for consumables with lesser number of working days, driving potentially lower testing and inventory, etc. One of the other things I would remind everyone, I think we've said this before, our X consumables have a relatively shorter shelf life still relative to what was for 6K. So some of those inventory dynamics might play out for the end of the year. If there are lesser number of tests to be performed or there's lesser number of working days, our customers may choose to manage their inventory accordingly. We'll go next to Conor McNamara with RBC Capital Markets. Hey, guys, thanks for taking my question. I'm just following up on just the overall revenue guidance change. It works out to $20 million-$25 million, I think, for the year. And I'm assuming most of that's in Q4. Is it safe to assume that's all in instruments? And if so, can you kind of give a breakdown of where you're seeing? Is that all in the low and mid throughput, or where else are the pockets that you're taking revenue out of guide? Yeah. Yeah, good question. And you're right, it is in the range that you're talking about overall if you think of it from a relative to midpoint perspective. And just to bubble back up, we're effectively, when we looked at our business in Q3 and the pace at which we'd close, very, very pleased with how the consumables panned out. But when we look at the instrumentation side and the pace at which deals were closing, the pace at which we look at the funnel, we look at the closures, our sales team comes back and gives us the inputs. And that pace has been more variable off late. And that is the fundamental reason behind us going back and saying if the same environment, if the same variability continues, it's hard to kind of put a pin on saying how much the year-end business is going to be. But that was the fundamental thought process behind the guidance change. And we kind of pointed, as we worked through it, we figured there's a better way to think about this landing closer to the lower end of our previous guidance rather than the midpoint. And that's how we landed closer to that 1070-ish mark approximately. Now, as we look at our different components, I would, for modeling purposes, kind of take them out roughly equally from instruments, consumables, and our services businesses. That's probably a good way to do it because we're thinking from a deal closure velocity perspective rather than pointing to weakness in a certain area overall. So you could take it out a third out of all three. And the reason I'm also specifically saying out of services is because we do have certain CDx deals. As you know, our TSO Comp assay was recently approved by FDA. We have a few CDx agreements that are tied to that. Milestones related to those CDx agreements are getting pushed into next year. So I would probably figure about a third equally across the three lines. We'll move next to Dan Arias with Stifel. Yeah, hi guys. Thanks for the questions here. Jacob, you guys have pretty consistently called out the macro environment as a headwind to placements throughout the year. It doesn't feel like there's a big change coming when the calendar flips and we're now in 2025. So how are you getting comfortable with the headwind actually abating? What should we look for as a shift that can impact the placement rate positively? Yeah, you're definitely right, Dan. I can't wait for the day that none of us have to talk about macro headwinds in these calls here. And I do think that, as we mentioned before, we do think that, at least from an Illumina perspective, the consumables growth is the early indicator that things are starting to turn around. That said, I mean, if I look, as we mentioned strategy day, it's at this point easier to look a few years out because we can see that in our models while we transition the business over to the X, but it's still very difficult to call quarter by quarter at this point or beyond a quarter at this point. But that said, we are seeing improvements, green shoots in different parts, as you say. The consumables are looking better. We believe that the MiSeq i100 is giving us some momentum. But tomorrow's going to change everything again with the election coming up. So let's see, and we're taking quarter by quarter right now. The only one thing I would add then is, as Jacob was saying, consumables is the right leading indicator for us. Some of our thesis around consumables returning to growth and then providing the foundation going forward, it's kind of playing out in the back half here. The instrumentation, yeah, as Jacob said, we have to kind of see it play out. We'll move next to Patrick Donnelly with Citi. Hey, guys. Thank you for taking the questions. Ankur, it's probably one for you on the margin side. Nice to see the gross margins back above 70% this quarter. Can you just talk about the cost savings programs? Obviously, you have the $100 million this year, how that's progressing, and then that incremental $200 million as we look forward. Just the pacing of it. Obviously, we have that longer-term up margin guidance of the 500 basis points or so over the next three years. But can you just talk about, I guess, the impact next year on the cost savings side and then any offsets that we should think about on margins as we just think of that high-level framework for 2025? Any headwinds that we should be aware of would be helpful. Thank you, guys. Yeah. So before Ankur goes into the details of the specifics here, I just want to mention again that the result we're seeing today is a very intentional focus on the whole company, Illumina, since I came in here, of really putting an effort saying, "Look, there might be still a period ahead where we will be challenged on the top line." But in the meantime, we really want to set up the culture for the right focus on operational excellence and make sure we make the right priorities to both drive efficiencies in the company, but also drive a much better way to run the company. And that goes way beyond just looking into operations. It goes from the commercial organization all the way through R&D operations and everything we do. And I truly believe, as I said before, this is what good companies do. And that won't change the day that we see substantially top-line improvements. I truly believe this is what a good company will look like also in the future and how we drive the culture. So, Ankur, you want to go into the details? No, thanks, Jacob. And that is playing out right now in the last six months has come in really in the same message across the organization, laying out plans for where some of the savings could come from. But also culturally, what we're also seeing is that the teams are the ones now, from a bottom-up perspective, starting to come up with initiatives, starting to come up with ideas around where the potential productivity gains could be, which is exactly where we want to drive this culture. So very pleased with how this is heading. Now, to your question, feel good about the $100 million savings this year. If you simply look at the guidance overall, even at that 10.70 and our operating margin, we're talking about a 3% revenue decline year- over- year and a pretty substantial margin expansion. Now, more heavily focused towards gross margin during this year. We've been able to substantially offset all of our inflationary or a good part of our inflationary pressures during 2024. So feel good about that $100 million during this year. For the $200 million going forward or the 500 basis points margin expansion, as I said, during the strategy day, our focus will continue to take costs out of both COGS as well as operating expenses. We have a series of strategies, some already in execution and some in the early stages of execution around setting up global capability centers. We've moved our shipping line changes. We're consolidating some parts of our manufacturing lines into specific sites. We're looking at our R&D programs, etc. So across the board that we're looking at. And in terms of where are we reinvesting, we'll likely reinvest in our sales and marketing a little bit more than where we are today. In terms of headwinds going forward, I don't see anything beyond the usual inflationary pressure. Every year, there will be a merit and an inflation that will come in, and we'll find ways to offset that as part of taking out our expenses. But all in all, going back to our strategy of expanding 500 basis points over the next three years, I feel good about that. We'll go next to Subbu Nambi with Guggenheim. Hey, guys. Thank you for taking my question. You generated almost $300 million in free cash flow. Anything abnormal in the quarter? Where does this go from here? And are there enough levers to drive robust FCF from these levels? And building off of that, would you consider a more aggressive buyback at current levels? Yeah, Subbu, thanks for that. And first of all, I'm, of course, very pleased where we are now with our cash generation, and especially here after we focused the company back into our core business. I think you can start to see that the model is starting to work. We're creating a good amount, excellent cash generation. As we also mentioned at our strategy day, we will start to execute on our capital allocation strategy. You will see us in this quarter. We have started to do so. Our focus will be both, of course, on stock repurchases, but also, of course, on M&A. We did both in this quarter with the acquisition of Fluent, which we finalized in this quarter here, but also, of course, started to buy back shares. So, Ankur? Yep. Thanks, Jacob, and thanks for the question. Subbu, very happy with the cash generation profile of the business. Nothing material unusual. So in terms of if you're thinking about net income to FCF conversion, I anticipate to remain well above that 100%, but even closer to 150%, I think, is what it is this quarter in that kind of territory here in the near term. So very, very healthy cash generation just from a business perspective. Over a period of time, when you think about the next 3-4 year timeframe, I do expect the FCF conversion to narrow a little bit, and part of it is going to be, as we take different expense controls, as we manage our capital expenses, some of our depreciation and our stock-based compensation, etc., will also come down. And those two are some of the components that lead to the higher FCF conversion. Now, I still expect it to remain well above 100% overall. So strong cash generation position. And as you saw, we've started, as Jacob was saying, started putting that cash to use. And that's our intent. We do intend to start deploying this cash back to the core business towards growing revenue as well as buying back shares. So on the share buybacks and the overall strategy, what we laid out during the strategy day was that our focus is heavily towards revenue growth. We do want to buy back shares, at least to the extent of our anti-dilution, to keep the share count at least constant and then be opportunistic thereafter. On the M&A side, we intend to remain focused on tuck-in type of M&A, things that can be revenue-accretive for our businesses and bring in those technologies, and then continue to manage our balance sheet tightly. We delivered a little bit this quarter. Now, we don't have any other bonds coming due here in the short term, but we'll continue to manage the balance sheet quite conservatively from there on. We'll go next to Sung Ji Nam with Scotiabank. Hi, thanks for taking the question. Just wondering if you might be able to elaborate a bit more on the end market dynamics, specifically Europe relative to the Americas. If you look at Europe, your growth this year has been pretty steady, both year- over- year and sequentially, and just kind of curious what the drivers might be there, if they're any different from what you're seeing in the Americas from a macro perspective. Thank you. Yeah, you're absolutely right. We were certainly pleased with our European performance. It's great to see that even under some tough challenges, conditions also in Europe, that we have seen very consistent results, and we anticipate that that will continue over the next period of time. If you look into Americas, to U.S., that's also where we have higher pressure in the mid-throughput from a competitive situation, but also where we placed substantially more of the X instrument last year, and thereby, the compare has been a little more tough in U.S. than it was in Europe, so we anticipate that we will continue to look strong in Europe going forward, and the compares will be a little bit easier for U.S. going forward. We'll move next to Mason Carrico with Stephens. Hi, this is Ben on for Mason. Thanks for taking the question. I was just hoping you'd be able to maybe dive into the opportunity in single-cell, and if you could just talk through how you see your ownership of Fluent, either growing the overall served addressable market or sort of taking share from some other players out in the space. Just if you could talk through those balancing forces there, that'd be great. Thank you. Yeah, thanks for that, and we're certainly excited with the Fluent acquisition and truly believe that we'll be able to build a very, very strong workflow that will help many of our customers. As you know, since you don't need to have a capital outlay in the beginning, you can actually get very easy into doing single-cell experiments. And also, the cost per cell experiment for a very high volume is also allowing for a really huge amount of single-cell experiments. So I actually think that the Fluent acquisition is helping to expand the market opportunity for all of us, and at the same time, even though we now, Illumina, we have our own sample prep for single-cell, we are very committed to support our current partners to make them very successful on our platforms. Our fundamental focus is to help our customers to be successful in single-cell. I truly believe single-cell is going to be a huge cornerstone, first and foremost, in research over the next period of time. And there's a tremendous insight that you get through single-cell. So I'm actually very bullish on the single-cell opportunity. And I truly believe by focusing on our customers and what they need and make sure we can serve them, whether they choose the Fluent or some of our partners, we will make sure they're successful, and that will make all of us successful going forward. We'll go next to Dan Leonard with UBS. Thank you. I could use some help trying to better frame the impact of the MiSeq i100 launch. What's been the growth trend in that low-throughput sales category? And that might be helpful as I think about what would be the impact if that changes. And then a follow-up on the XLEAP launch next week. What's been the impact of that launch? Has that impacted the sales trajectory of consumables on that mid-throughput line at all? Yeah. So let me start with the MiSeq. I mean, we certainly MiSeq i100. We're certainly very excited about bringing a new instrument solution out to the low-throughput end of the market. As you know, it is more than 10 years ago since we came out with the MiSeq. And now the MiSeq i100 is going to be absolutely the best solution in that part of the market. We are really focusing on making it easy to use, to make it easy to operate from. You don't have to store reagents or ship reagents or consumables in the freezer anymore. And that actually makes it much easier since you can take them directly, unwrap, open the package, and use the consumables immediately instead of having to prepare for that. So we expect this to be very well received from our customers. We actually think that some of the customers that potentially would have gone after a mid-throughput instrument might actually decide to go with the MiSeq i100 because it creates such a benefit for them. As you could imagine, also, since our portfolio in the low-throughput was in, it was time for an update. We have seen some weakening performance in that space. Thereby, we do believe that over the next 12 to 18 months, we will see a pickup in that space. As we also said before, we are not really seeing that to be meaningfully impacting Q4, but we expect that to start to have impact in 2025. Just to dimensionalize it for you, Dan, the low-throughput instruments business on dollar terms is less than 1% or close to 1% of our revenue. So it's an exciting technology that MiSeq has been around for over 10+ years now. And the kind of interest that we're getting is substantial. We're also getting additional call points with customers to talk about our entire portfolio as well. But in terms of moving the overall revenue number for Illumina, just to help you dimensionalize that. Yeah. And then on the XLEAP chemistry, we have seen a lot of interest in that. We have more than 60% of our NextSeq 1000, 2000 users that have downloaded the software and thereby also starting to use the chemistry. So that has been very well received. We will continue to stay and be very committed to be competitive in the mid-throughput market. And I'm very excited about the future in that market also. That will conclude our Q&A session. I will now hand the call back over to Salli Schwartz. Thank you for joining us today. As a reminder, a replay of this call will be available in the Investor section of our website. This concludes our call, and we look forward to seeing you at upcoming conferences and other events.