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Inspire Sleep Apnea Innovation Inspire Medical Systems , Inc. Announces Second Quarter 2021 Financial Results and Updates 2021 Outlook ● MINNEAPOLIS , Minnesota - August 3 , 2021 - Inspire Medical Systems , Inc. ( NYSE : INSP ) ( " Inspire " ) , a medical technology company focused on the development and commercialization of innovative and minimally invasive solutions for patients with obstructive sleep apnea , today reported financial results for the quarter ended June 30 , 2021 . Exhibit 99.1 Recent Business Highlights Generated revenue of $ 53.0 million in the second quarter of 2021 , a 335 % increase over the same quarter last year Reported gross margin of 85.8 % in the second quarter of 2021 , an increase over the 84.0 % reported in the same quarter last year Activated 63 new centers in the U.S. in the second quarter of 2021 , bringing the total to 535 U.S. medical centers implanting Inspire therapy Created 13 new U.S. sales territories in the second quarter of 2021 , bringing the total to 130 U.S. sales territories Announced positive coverage policy issued by Anthem for Inspire therapy " Our significant commercial momentum continued throughout the second quarter , " said Tim Herbert , President and Chief Executive Officer of Inspire Medical Systems . " We remain focused on our commercial execution driven by increasing our capacity at existing implanting centers , opening new centers and improving the education process with patients . Based on our strong performance in the second quarter and the anticipated continuation of positive implant growth trends in 2021 , we are raising our full year 2021 revenue guidance to between $ 210 million to $ 213 million , an increase from our prior guidance of $ 192 million to $ 196 million . We continue to closely track the on - going challenges presented by COVID - 19 and the latest resurgence and , despite the associated uncertainty , we intend to continue our robust investment in the further growth in adoption of Inspire therapy . " Second Quarter 2021 Financial Results " The 63 new U.S. implanting centers we added in the second quarter was well above our guidance of 36 to 40 new centers per quarter in 2021 , and represents the significant demand by physicians and centers for access to Inspire therapy . To further support this demand , we created 13 new sales territories in the second quarter in the U.S. , also well above our guidance of eight to nine new territories , " continued Mr. Herbert . " We are dedicated to scaling our sales management and training teams to optimize our on - going expansion and focus on positive patient outcomes and center productivity . On the commercial reimbursement front , we are pleased that Anthem , which , through its affiliated companies , serves 42 million individuals within its family of health plans , is now providing coverage of Inspire therapy . Finally , we are pleased with the proposed national average physician payment , which is in - line with the results of the RUC physician survey and provides physicians with strong reimbursement for performing the Inspire procedure ; as well as the increase in proposed Medicare reimbursement in hospitals , and we will continue to work with CMS with the goal of assuring that the final reimbursement levels for Inspire therapy procedures in Ambulatory Surgical Centers is appropriately established . " Revenue was $ 53.0 million for the three months ended June 30 , 2021 , a 335 % increase from $ 12.2 million in the corresponding period in the prior year . U.S. revenue for the quarter was $ 49.4 million , an increase of 349 % as compared to the prior year quarter . Second quarter European revenue was $ 3.6 million , an increase of 201 % as compared to the second quarter of 2020 .