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Table of Contents ( Mark One ) ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31 , 2020 TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transaction period from Commission file number : 001-36860 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON , D.C. 20549 Form 10 - K Delaware ( State or Other Jurisdiction of Incorporation or Organization ) Title of Each Class Common Stock , $ 0.000041666 Par Value per Share 999 Skyway Road , Suite 150 , San Carlos , California ( Address of Principal Executive Offices ) IOVANCE BIOTHERAPEUTICS , INC . ( Exact Name of Registrant as Specified in Its Charter ) to ( 650 ) 260-7120 ( Registrant's Telephone Number , Including Area Code ) Securities registered pursuant to Section 12 ( b ) of the Act : Trading Symbol ( s ) IOVA Securities registered pursuant to Section 12 ( g ) of the Act : None Title of each class Common stock , par value $ 0.000041666 per value 75-3254381 ( I.R.S. Employer Identification No. ) 94070 ( Zip Code ) Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . Yes Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Act . Yes Indicate by check mark whether the registrant ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . Yes No No No Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S - T during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) . Yes No Name Of Each Exchange On Which Registered The Nasdaq Global Market Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , a smaller reporting company , or an emerging growth company . See the definitions of " large accelerated filer , " " accelerated filer , " " smaller reporting company , " and " emerging growth company " in Rule 12b - 2 of the Exchange Act . Large accelerated filer b Accelerated filer Non - accelerated filer 0 Smaller reporting company Emerging growth company Trading Symbol ( s ) IOVA If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 ( a ) of the Exchange Act . Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404 ( b ) of the Sarbanes - Oxley Act ( 15 U.S.C. 7262 ( b ) ) by the registered public accounting firm that prepared or issued its audit report . Indicate by check mark whether the registrant is a shell company ( as defined in Rule 12b - 2 of the Exchange Act ) . Yes No > Securities registered pursuant to Section 12 ( b ) of the Act : Name of each exchange on which registered The Nasdaq Stock Market , LLC The aggregate market value of the registrant's common stock held by non - affiliates on June 30 , 2020 , the last business day of the registrant's most recently completed second fiscal quarter , was approximately $ 3.7 billion . Shares of common stock held by directors and executive officers and any ten percent or greater stockholders and their respective affiliates have been excluded from this calculation , because such stockholders may be deemed to be " affiliates " of the Registrant . This is not necessarily determinative of affiliate status of other purposes . As of February 17 , 2021 , there were 146,979,253 shares of the registrant's common stock outstanding . Documents Incorporated By Reference Portions of registrant's proxy statement relating to registrant's 2021 Annual Meeting of Stockholders ( the " Proxy Statement " ) to be filed with the Securities and Exchange Commission pursuant to Regulation 14A , not later than 120 days after the close of the registrant's fiscal year , are incorporated by reference in Part III of this Annual Report on Form 10 - K . Except with respect to information specifically incorporated by reference in this Annual Report on Form 10 - K , the Proxy Statement is not deemed to be filed as part of this Annual Report on Form 10 - K .