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iRhythm Technologies Second Quarter 2025 Results July 31, 2025
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© 2025 iRhythm Technologies, Inc. 2 Cautionary statement re forward-looking statements, non-GAAP measures and other matters Certain data in this presentation was obtained from various external sources, and neither “iRhythm Technologies, Inc. (“iRhythm” or the “Company”) nor its affiliates, advisers or representatives has verified such data with independent sources. Accordingly, neither the Company nor any of its affiliates, advisers or representatives makes any representations as to the accuracy of that third-party data or undertakes to update such data after the date of this presentation. Such data involves risks and uncertainties and is subject to change based on various factors. The trademarks included herein are the property of the owners and are used for reference purposes only. Such use should not be construed as an endorsement of the products or services of the Company. This presentation and the accompanying oral presentation include forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. Forward-looking statements give the Company’s current expectations or forecasts of future events. An investor can identify these statements by the fact that they do not relate strictly to historical or current facts. They use words such as ‘anticipate’, ‘estimate’, ‘expect’, ‘intend’, ‘will’, ‘project’, ‘plan’, ‘believe’, ‘target’ and other words and terms of similar meaning in connection with any discussion of future operating or financial performance. In particular, these include statements relating to future actions, prospective products or product approvals, future performance or results of current and anticipated products, sales efforts, expenses, strategy and plans, market size and opportunity, competitive position, industry environment, potential growth opportunities, business model, reimbursement rates and coverage, the outcome of contingencies such as legal proceedings and our expectations for future operations and results. These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including, but not limited to, those described herein and in “Risk Factors” in our most recent 10-K and 10-Q filed with the SEC. Moreover, we operate in a very competitive and rapidly changing environment. New risks emerge from time to time. It is not possible for our management to predict all risks, nor can we assess the impact of all factors on our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements we may make. In light of these risks, uncertainties and assumptions, the forward-looking events and circumstances discussed in this presentation may not occur and actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements. You should not rely upon forward-looking statements as predictions of future events. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee that the future results, levels of activity, performance or events and circumstances reflected in the forward-looking statements will be achieved or occur. Moreover, except as required by law, neither we nor any other person assumes responsibility for the accuracy and completeness of the forward-looking statements. We undertake no obligation to update publicly any forward-looking statements for any reason after the date of this presentation to conform these statements to actual results or to changes in our expectations. This presentation regarding the Company and the accompanying oral presentation shall not constitute an offer to sell or the solicitation of an offer to buy any securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. Sales and offers to sell iRhythm securities will only be made in accordance with the Securities Act of 1933, as amended, and applicable SEC regulations, including prospectus requirements. This presentation and the accompanying oral presentation contain non-GAAP financial measures. The appendix to this presentation reconciles the non-GAAP financial measures to the most directly comparable financial measure prepared in accordance with Generally Accepted Accounting Principles (GAAP). These non-GAAP financial measure include adjusted operating expenses, adjusted net income (loss), adjusted net income (loss) per share, adjusted EBITDA, and adjusted EBITDA margin. iRhythm reports non-GAAP financial measures in addition to, and not as a substitute for, or superior to, measures of financial performance prepared in accordance with GAAP. We believe that non-GAAP financial measures should only be used to evaluate our results of operations in conjunction with the corresponding GAAP financial measures. Other companies, including other companies in our industry, may not use this measure or may calculate this measures differently than as presented. We encourage investors to carefully consider our results under GAAP as well as our supplemental non-GAAP information and reconciliations between these presentations to more fully understand our business.
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© 2025 iRhythm Technologies, Inc. 3 $186.7 million Second quarter 2025 revenue, a 26.1% increase compared to second quarter 2024 5+ million tests Target market opportunity across prioritized EU and APAC countries* Data on file. iRhythm Technologies, July 2025. *See sources in appendix for ‘Multiple levers for long -term growth and sustainable value creation’ and ‘International opportunity represents $1+ billion TAM with 5+ million tests in prioritized countries ac ross EMEA and Asia Pacific’ 27+ million Potential patients in the United States who could benefit from ambulatory cardiac monitoring* 2.5+ billion Hours of curated ECG data since company inception thru 2024 125+ Original scientific research manuscripts Over 30% penetration in core U.S. ambulatory cardiac monitoring market as of December 31, 2024 10+ million Patient reports posted since company inception through March 31, 2025 2+ million Patient reports posted annually
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© 2025 iRhythm Technologies, Inc. 4 Multiple levers for long-term growth and sustainable value creation 6.5M ACM tests in the US today 5M+ ACM tests in prioritized countries across EMEA and Asia Pacific 27M+ Patients presenting in primary care who may be symptomatic or at- risk for arrhythmias CURRENT U.S. MARKET Over 70% market share in LTCM with Zio monitor (of 3.0M annual tests)1 Over 10% market share in MCT with Zio AT (of 950k annual tests)1 INTERNATIONAL TAM U.K. registrations primarily through private hospital contracts Early commercial launch in Switzerland, Austria, Netherlands, Spain, and Japan UNDIAGNOSED TAM Record number of contracts with innovative primary care channels Addressing population health management through targeted patient inclusion criteria at large, national customer accounts LTCM = long-term continuous monitoring; MCT = mobile cardiac telemetry. 1. Estimates based off combination of Internal Data, Me dicare Public-Use Files, IQVIA data, Definitive Healthcare data, Komodo Health data, and other publicly-available information.
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© 2025 iRhythm Technologies, Inc. 5 iRhythm uniquely positioned to win with clinically accurate, trusted services and the ability to scale in expanded channels, international markets, and additional vitals Clinical evidence: Clinical evidence translated rapidly to product feature set demonstrating excellent outcomes and costs for continued traction with clinicians, health systems, payers AI: FDA cleared AI, expansive data set for future signal development, and world-class clinical oversight deliver comprehensive, curated clinical reports to support clinicians and physicians Provider preference: Long-term continuous monitoring market dominance, first mover advantage into primary care physician channels, and positioned to own additional specialties IDTF: Largest IDTF in the ACM space with physician and clinician trust to deliver accurate monitoring with ability to expand well beyond arrythmias at scale, effectively and efficiently Ability to scale: Continuous operational excellence delivering clinically accurate product at efficient scale and cost profile maximizing commercial opportunities Superior workflows: Proven seamless staff and provider workflow with bidirectional, EHR-agnostic integrations, including a new collaboration with Epic Competitive Advantage
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© 2025 iRhythm Technologies, Inc. 6 15M+ Primary care patients with palpitations and cardiac disease suspected 16M+ ≥65 individuals in the U.S. with undiagnosed arrhythmias per mSToPs criteria Underpenetrated ambulatory cardiac monitoring market in the United States TOTAL MARKET OPPORTUNITY BENEFITS OF BRINGING DIAGNOSIS EARLIER IN CARE PATHWAY 4M 20% potential overlap due to symptoms 27M+ Nearly half (46.3%) of all counties in the U.S. – including 86.2% of rural counties - do not have any cardiologists Many patients are referred for cardiology specialty care due to concerns of symptoms without any diagnostic testing performed Average wait time to see a cardiologist in the U.S. is around 26.6 days for non-urgent appointments, representing significant increase compared to prior years See appendix for sources
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© 2025 iRhythm Technologies, Inc. 7 SLEEP APNEA: US prevalence of 40.1 million, with up to 80% of AFib patients having sleep apnea2 Addressing population health management through the power of artificial intelligence1 to enable targeted monitoring for undiagnosed arrhythmias COPD 11.7 million TAM 2.0M3 CAD 20.5 Million TAM 8.4M3 CKD 35.5 Million TAM 12.7M3 Diabetes 32.2 Million TAM 10.3M3 1. The predictive-AI solution does not represent the functionality of any Zio branded medical device. 2. See appendix for source s. 3. TAMs are not mutuality exclusive as there is likely significant overlap in patient populations. 3. Real World Evidence on Health C are Resource Utilization and Economic Burden of Arrhythmias in Patients with Diabetes and COPD. Abstract presented at: 2024 AHA Scientific Sessions; November 16 to 18, 2024; Chicago, IL. ARRHYTHMIA PATIENTS USE THE HEALTHCARE SYSTEM AT A MUCH HIGHER RATE COMPARED TO NON -ARRHYTHMIA PATIENTS 3 Arrhythmia patients were hospitalized more than 2x per 1,000 cohort patients per year than non-arrhythmia patients Of those hospitalized, patient length of stay increased by 2-5 days for arrhythmia patients with a combined cohort The rate of emergency room visits were more than 2x for arrhythmia cohort relative to non-arrhythmia cohorts HEART FAILURE : US prevalence of 8.4 million, with 25% of heart failure patients having AFib2
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© 2025 iRhythm Technologies, Inc. 8 Approaching the primary care channel through two-pronged strategy within both symptomatic and undiagnosed patient populations 1. Data on file. iRhythm Technologies, June 2024. 2. Data on file. iRhythm Technologies, January 2025. Q1 Q2 Q3 Q4 Q5 Q6 Q7 Q8 Q9 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Zio XT registrations Card/EP Zio XT registrations PCP Zio XT registrations PCP onboarding LAND -AND -EXPAND WITHIN INTEGRATED DELIVERY NETWORKS 1 TOP -DOWN INTEGRATION AT LARGE NATIONAL ACCOUNTS Over 80% of patients in representative customer programs had at least one arrhythmia identified2
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© 2025 iRhythm Technologies, Inc. 9 Collaboration with Epic Aura enables bidirectional data flow, enhances clinician workflow efficiency, and supports rapid system-wide implementation Hospital EHR system Cloud Interface Engine Proprietary AI Clinical Curation Staff/Ordering Physician places order in EHR MA updates order on EHR and patches patient Order (ORM) Results/Report ORU/MDM w/ embedded PDF/discrete values Report published in EHR or CVIS Physician interprets Zio report in EHR System requirements: HL7 version 2.3 or higher; secure communication interface (e.g. VPN, HTTPs, SFTP). Integration Service a re also available with the option for physicians to interpret Zio Patient Reports in ZioSuite.com. Physician interpreted reports can then be posted to the EHR/CVIS system.
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© 2025 iRhythm Technologies, Inc. 10 International opportunity represents $1+ billion TAM with 5+ million tests in prioritized countries across EMEA and Asia Pacific 1,600,000 Ambulatory cardiac monitoring tests annually JAPAN Early commercialization GOALS Commercially launched in 2025 500,000 Ambulatory cardiac monitoring tests annually UNITED KINGDOM Early commercialization GOALS Pursue growth in private market Pursue long-term reimbursement 2,100,000+ Ambulatory cardiac monitoring tests annually in target countries PRIORITIZED EU COUNTRIES Switzerland, Spain, Austria, the Netherlands, Germany and France Early commercialization GOALS Continue to build commercial presence in Switzerland, Spain, Austria, and the Netherlands See appendix for sources
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© 2025 iRhythm Technologies, Inc. 11 Artificial intelligence underpins core capabilities and enables future service innovation Curated heartbeat data and other data linkages opens opportunities for additional expansion Evolving from detection towards prediction and insights generation Artificial intelligence continues to add significant clinical value to Zio® and further differentiates Zio® versus competition Prediction of Atrial Fibrillation, Heart Failure Sleep, Activity Adjacent Market Opportunities Efficient Delivery of Service at Scale Insight Generation Alternative Business Model OpportunitiesCommercial Published evidence In development Artificial Intelligence
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© 2025 iRhythm Technologies, Inc. 12 $125.2 $143.8 * $116.7 * $140.4 * $145.2 * $- $20.0 $40.0 $60.0 $80.0 $100.0 $120.0 $140.0 $160.0 2Q2024 3Q2024 4Q2024 1Q2025 2Q2025 R&D SG&A 3.4% -13.5%* 11.7%* -1.7%* 8.4%* 2Q2024 3Q2024 4Q2024 1Q2025 2Q2025 $148.0 $147.5 $164.3 $158.7 $186.7 2Q2024 3Q2024 4Q2024 1Q2025 2Q2025 69.9% 68.8% 70.0% 68.8% 71.2% 2Q2024 3Q2024 4Q2024 1Q2025 2Q2025 Second quarter 2025 financial performance GLOBAL NET REVENUE (USD, MILLIONS) GROSS PROFIT MARGIN ADJUSTED OPERATING EXPENSES * (USD, MILLIONS) ADJUSTED EBITDA MARGIN * *Adjusted operating expenses and adjusted EBITDA margin for 3Q24, 4Q24, 1Q25, and 2Q25 include $32.1 million, $0.3 million, $ 0.3 million, and $1.7 million respectively, of acquired in-process research and development expense. Adjusted operating expenses exclude impacts from business transformation, certain intellectual property litigation expenses, and impairment and restructuring cha rges. Adjusted EBITDA excludes non-cash operating charges for stock-based compensation expense, changes in fair value of strategic investments, impairment and restructuring charges, business transformation costs, certain intellectual property litigation expenses, and l oss on extinguishment of debt. Business transformation costs include costs associated with professional services, employee termin ation and relocation, third-party merger and acquisition, integration, and other costs to augment and restructure the organization, inclusive of both outsourced and offshore resources.
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© 2025 iRhythm Technologies, Inc. 13 2025 annual revenue and profitability guidance *Adjusted EBITDA excludes non-cash operating charges for stock-based compensation expense, changes in fair value of strategic investments, impairment and restructuring charges, business transformation costs, certain intellectual property litigation expe nses and settlements, and loss on extinguishment of debt. Business transformation costs include costs associated with professional services, employee termin ation and relocation, third-party merger and acquisition, integration, and other costs to augment and restructure the organization, inclusive of both outsourced and offshore resources. Net revenue $720 - $730 million Adjusted EBITDA margin 8.0% - 8.5% of revenue* UPDATED GUIDANCE PRIOR GUIDANCE Net revenue $690 - $700 million Adjusted EBITDA margin 7.5% - 8.5% of revenue*
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© 2025 iRhythm Technologies, Inc. 14 MARKET EXPANSION OPPORTUNITIES INNOVATION OPERATIONAL EFFICIENCY FOCUS IMPROVING FINANCIAL PROFILE Core US market penetration Greenfield specialist growth Primary care physician growth Channel expansion International expansion Adjacent market development Relentless patient focus Insight generation AI and prediction capabilities Connected care Commitment to quality, safety and regulatory compliance Supply chain resilience Unit cost economics Digital transformation Continuous process improvement Focus on profitable growth Disciplined opportunity prioritization Balanced reinvestments Strategic portfolio management Investments for opening adjacent markets Compelling investment thesis for long-term shareholder value creation
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Anticipated revenue growth from large underpenetrated markets on a global scale Expect to deliver meaningful improvements in financial profile Addressing the future focus of healthcare Expanding existing markets while extending into adjacent markets
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Appendix
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© 2025 iRhythm Technologies, Inc. 17 Reconciliation of net loss to adjusted EBITDA (USD, THOUSANDS) THREE MONTHS ENDED JUNE 30, SIX MONTHS ENDED JUNE 30, ADJUSTED EBITDA RECONCILIATION* 2025 2024 2025 2024 Net loss1 $ (14,218) $ (20,107) $ (44,918) $ (65,774) Interest expense 3,278 3,312 6,551 6,172 Interest income (5,321) (6,685) (10,240) (9,742) Changes in fair value of strategic investments (2,152) — (2,995) — Income tax (benefit) provision (183) 194 482 226 Depreciation and amortization 5,105 5,160 10,315 10,291 Stock-based compensation 22,827 21,821 46,171 42,812 Impairment charges 2,479 — 2,479 — Business transformation costs 925 1,296 1,428 1,296 Intellectual property litigation costs2 2,956 — 3,788 — Loss on extinguishment of debt — — — 7,589 Adjusted EBITDA $ 15,696 $ 4,991 $ 13,061 $ (7,130) *Certain numbers expressed may not sum due to rounding. 1 Net loss for the three and six months ended June 30, 2025, include $1.7 million and $2.0 million of acquired in-process research and development expense, respectively. 2 Excludes third-party attorneys' fees and expenses associated with patent litigation brought against the Company by Welch Allyn, Inc. and Bardy Diagnostics, Inc., subsidiaries of Baxter International, Inc. Adjusted EBITDA is a non-GAAP financial measure and is presented for supplemental informational purposes only and should not be considered as an alternative or substitute to financial information presented in accordance with GAAP. Adjusted EBITDA excludes non-cash operating charges for stock-based compensation expense, changes in fair value of strategic investments, impairment and restructuring charges, business transformation costs, certain intellectual property litigation expenses and settlements, and loss on extinguishment of debt. Business transformation costs include costs associated with professional services, employee termination and relocation, third-party merger and acquisition, integration, and other costs to augment and restructure the organization, inclusive of both outsourced and offshore resources.
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© 2025 iRhythm Technologies, Inc. 18 THREE MONTHS ENDED (USD, THOUSANDS) JUNE 30, 2025 MARCH 31, 2025 DECEMBER 31, 2024 SEPTEMBER 30, 2024 JUNE 30, 2024 Net loss1 $ (14,218) $ (30,700) $ (1,333) $ (46,182) $ (20,107) Interest expense 3,278 3,273 3,320 3,329 3,312 Interest income (5,321) (4,919) (5,740) (6,456) (6,685) Changes in fair value of strategic investments (2,152) (843) (843) (1,059) — Income tax (benefit) provision (183) 665 151 188 194 Depreciation and amortization 5,105 5,210 5,289 5,135 5,160 Stock-based compensation 22,827 23,344 16,008 17,158 21,821 Impairment and restructuring charges 2,479 — — 641 — Business transformation costs 925 503 2,416 7,360 1,296 Intellectual property litigation costs2 2,956 832 — — — Adjusted EBITDA $ 15,696 $ (2,635) $ 19,268 $ (19,886) $ 4,991 Revenue $ 186,687 $ 158,677 $ 164,325 $ 147,538 $ 148,047 Adjusted EBITDA margin 8.4% -1.7% 11.7% -13.5% 3.4% Adjusted EBITDA is a non-GAAP financial measure and is presented for supplemental informational purposes only and should not be considered as an alternative or substitute to financial information presented in accordance with GAAP. Adjusted EBITDA excludes non-cash operating charges for stock-based compensation expense, changes in fair value of strategic investments, impairment and restructuring charges, business transformation costs, certain intellectual property litigation expenses and settlements, and loss on extinguishment of debt. Business transformation costs include costs associated with professional services, employee termination and relocation, third-party merger and acquisition, integration, and other costs to augment and restructure the organization, inclusive of both outsourced and offshore resources. *Certain numbers expressed may not sum due to rounding. 1 Net loss for the three months ended September 30, 2024, December 31, 2024, March 31, 2025, and June 30, 2025, include $32.1 million, $0.3 million, $0.3 million, and $1.7 million, respectively, of acquired in- process research and development expense. 2 Excludes third-party attorneys' fees and expenses associated with patent litigation brought against the Company by Welch Allyn, Inc. and Bardy Diagnostics, Inc., subsidiaries of Baxter International, Inc. Reconciliation of GAAP to non-GAAP financial information*
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© 2025 iRhythm Technologies, Inc. 19 Reconciliation of GAAP to non-GAAP financial information (USD, THOUSANDS) THREE MONTHS ENDED JUNE 30, SIX MONTHS ENDED JUNE 30, ADJUSTED NET LOSS RECONCILIATION* 2025 2024 2025 2024 Net loss, as reported1 $ (14,218) $ (20,107) $ (44,918) $ (65,774) Impairment charges 2,479 — 2,479 — Business transformation costs 925 1,296 1,428 1,296 Intellectual property litigation costs2 2,956 — 3,788 — Changes in fair value of strategic investments (2,152) — (2,995) — Loss on extinguishment of debt — — — 7,589 Tax effect of adjustments3 (214) — (305) — Adjusted net loss $ (10,224) $ (18,811) $ (40,523) $ (56,889) THREE MONTHS ENDED JUNE 30, SIX MONTHS ENDED JUNE 30, ADJUSTED NET LOSS PER SHARE RECONCILIATION* 2025 2024 2025 2024 Net loss per share, as reported1 $ (0.44) $ (0.65) $ (1.41) $ (2.12) Impairment charges per share 0.08 — 0.08 — Business transformation costs per share 0.03 0.04 0.04 0.04 Intellectual property litigation costs per share2 0.09 — 0.12 — Changes in fair value of strategic investments per share (0.07) — (0.09) — Loss on extinguishment of debt per share — — — 0.24 Tax effect of adjustments per share3 (0.01) — (0.01) — Adjusted net loss per share $ (0.32) $ (0.61) $ (1.27) $ (1.84) Weighted-average shares, basic and diluted 31,990 31,145 31,791 31,089 THREE MONTHS ENDED JUNE 30, SIX MONTHS ENDED JUNE 30, ADJUSTED OPERATING EXPENSES RECONCILIATION* 2025 2024 2025 2024 Operating expenses, as reported $ 151,565 $ 126,452 $ 293,337 $ 252,106 Impairment charges (2,479) — (2,479) — Business transformation costs (925) (1,296) (1,428) (1,296) Intellectual property litigation costs2 (2,956) — (3,788) — Adjusted operating expenses $ 145,205 $ 125,156 $ 285,642 $ 250,810 *Certain numbers expressed may not sum due to rounding. 1 Net loss for the three and six months ended June 30, 2025, include $1.7 million and $2.0 million of acquired in-process research and development expense, respectively. 2 Excludes third-party attorneys' fees and expenses associated with patent litigation brought against the Company by Welch Allyn, Inc. and Bardy Diagnostics, Inc., subsidiaries of Baxter International, Inc. 3. Income tax impact of Non-GAAP adjustments listed.
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© 2025 iRhythm Technologies, Inc. 20 SLI DE(S) SOURCES Multiple levers for long-term growth and sustainable value creation / International opportunity represents $1+ billion TAM with 5+ million tests in prioritized countries across EMEA and Asia Pacific UK: iRhythm estimate. • UK Office for National Statistics; Hospital Episode Statistics, NHS Digital, 2019-2020 • UK Healthcare Market Review 33ed, LaingBuisson, 2021. Accessed 5 January 2022. • The UK private health market, Kings Fund, 2014. Accessed 5 January 2022. • NHS England and the Health and Social Care Information Centre, NHS Hospital Data and Datasets: A Consultation. Published July 22, 2013. • The Health and Social Care Information Centre, Hospital Episode Statistics (HES): Improving the quality and value of hospital data. Published 2011. Prioritized EU countries: iRhythm estimate. • Ohlrogge etc. Burden of Atrial Fibrillation and Flutter by National Income: Results From the Global Burden of Disease 2019 Database. J Am Heart Assoc. 2023;12:e030438; supplemental data tables https://www.ahajournals.org/doi/suppl/10.1161/JAHA.123.030438. • Global population and healthcare spend per capita, World Bank, 2019 and 2020. Accessed February 29, 2024. https://data.worldbank.org • The Burden of Cardiovascular Disease and Diabetes, OECD, 2011. Accessed 5 January 2022. • Federal Statistical Office of Germany and Gesundheitsberichterstattung; Dutch Healthcare Authority; Swedish ICD & Pacemaker Registry and Swedish Society for Clinical Physiology. Japan: • Irie, Shoichi and Hiroshi Tada. The Relationship between Holter Electrocardiography and Atrial Fibrillation Diagnosis Using Real-World Data in Japan: A Claims-Based Retrospective Study. Int Heart J, 2023; 64: 178-187. • Japan Ministry of Health Labor and Welfare. Underpenetrated ambulatory cardiac monitoring market in the United States US Core ACM Market Sizing • iRhythm estimates based off combination of Internal Data, Medicare Public-Use Files, IQVIA data, Definitive Healthcare data, Komodo Health data, and other publicly-available information. Expansion opportunity in symptomatic market • U.S. Census Bureau. “U.S. Census Bureau Profile.” https://data.census.gov/profile/United_States?g=010XX00US. Accessed January 12, 2025. • CDC ambulatory care use and physician office visits. CDC, published October 26, 2024. Accessed January 12, 2025. https://www.cdc.gov/nchs/fastats/physician-visits.htm. • Wexler RK, Pleister A, Raman SV. Palpitations: Evaluation in the Primary Care Setting. Am Fam Physician. 2017 Dec 15;96(12):784-789. • Weber BE, Kapoor WN. Evaluation and outcomes of patients with palpitations. The American Journal of Medicine. 1996;14(6):138-148. Expansion opportunity in at-risk population • Steinhubl at al. Effect of a Home-Based Wearable Continuous ECG Monitoring Patch on Detection of Undiagnosed Atrial Fibrillation: The mSToPS Randomized Clinical Trial. JAMA. 2018 Jul 10;320(2):146-155. • U.S. Census Bureau. "Age and Sex." American Community Survey, ACS 1-Year Estimates Subject Tables, Table S0101, 2022, https://data.census.gov/table/ACSST1Y2022.S0101?q=Age and Sex. Accessed on February 29, 2024. • 4 out of 5 Medicare Advantage survey respondents indicated they would be more satisfied and likely to stay with their current plan if an early AFib detection program were offered to them at no cost. Market survey of 200 respondents currently enrolled in a Medicare Advantage plan. Data on file. iRhythm Technologies, 2022. • Nancy Ochieng, Jeannie Fuglesten Biniek, Meredith Freed, Anthony Damico, and Tricia Neuman. 2023. “Medicare Advantage in 2023: Enrollment Update and Key Trends.” Published August 09, 2023. Accessed February 29, 2024. https://www.kff.org/medicare/issue-brief/medicare-advantage-in-2023-enrollment-update-and-key-trends/#
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© 2025 iRhythm Technologies, Inc. 21 SLI DE(S) SOURCES Underpenetrated ambulatory cardiac monitoring market in the United States (cont’d) • American College of Cardiology. (2024, July 8). Almost Half of US Counties Have No Cardiologists Despite Higher Prevalence of CV Risk Factors, Mortality [Press Release]. https://www.acc.org/About-ACC/Press-Releases/2024/07/08/18/25/Almost-Half-of-US-Counties-Have-No-Cardiologists-Despite-Higher-Prevalence-of-CV-Risk-Factors-Mortality • Pallikadavath SP, et. al. High number of unnecessary referrals to cardiology clinics for benign palpitations due to poor adherence to local referral guidelines. European Journal of Arrhythmia & Electrophysiology. 2024;10(1):1-2 • Pallikadavath S, et. al. Palpitation referrals from primary care to a secondary care cardiology outpatient clinic: assessing adherence to guidelines, Family Practice, 2021;38(2):127–131. • Abbott AV. Diagnostic Approach to Palpitations. Am Fam Physician. 2005;71(4):743-750 • Weber BE, Kapoor WN. Evaluation and outcomes of patients with palpitations. Am J Med. 1996;100:138-48. • American College of Cardiology. (February 23, 2023). Five Things Physicians and Patients Should Question. https://www.acc.org/-/media/Non-Clinical/Files-PDFs-Excel-MS-Word- etc/2023/04/ACC-5-Things-List-2023.pdf • 2022 Survey of Physician Appointment Wait Times. Merritt Hawkins. https://www.merritthawkins.com/trends-and-insights/article/surveys/2022-physician-wait-times-survey/, Accessed January 12, 2025. Addressing population health management through the power of artificial intelligence to enable targeted monitoring for undiagnosed arrhythmias Sleep Apnea Market Sizing • Franklin, K. A., & Lindberg, E. (2015). Obstructive sleep apnea is a common disorder in the population—a review on the epidemiology of sleep apnea. Journal of thoracic disease, 7(8), 1311. doi: 10.3978/j.issn.2072-1439.2015.06.11 • Lyons, M. M., Bhatt, N. Y., Pack, A. I., & Magalang, U. J. (2020). Global burden of sleep‐disordered breathing and its implications. Respirology, 25(7), 690- 702. https://doi.org/10.1111/resp.13838 • Marshall, N. S., Wong, K. K., Liu, P. Y., Cullen, S. R., Knuiman, M. W., & Grunstein, R. R. (2008). Sleep apnea as an independent risk factor for all-cause mortality: the Busselton Health Study. Sleep, 31(8), 1079-1085. https://doi.org/10.5665/sleep/31.8.1079 • Sleep apnea information for clinicians. (2022, May 10). www.sleepapnea.org. https://www.sleepapnea.org/learn/sleep-apnea-information-clinicians Heart Failure Market Sizing • Atrial Fibrillation Fact Sheet. CDC, published May 15, 2024. Accessed January 12, 2025. https://www.cdc.gov/heart-disease/about/atrial-fibrillation.html • Dumitru, I. (2021, October 17). What is the mortality rate for heart failure? Latest Medical News, Clinical Trials, Guidelines - Today on Medscape. https://www.medscape.com/answers/163062-86190/what-is-the-mortality-rate-for-heart-failure • Gidding, S. S., Lloyd-Jones, D., Lima, J., Ambale-Venkatesh, B., Shah, S. J., Shah, R., Lewis, C. E., Jacobs, D. R., & Allen, N. B. Prevalence of American Heart Association heart failure stages in black and white young and middle-aged adults. Circulation: Heart Failure, 2019; 12(9). • Heart failure Fact Sheet. CDC, published May 15, 2024. Accessed January 12, 2025. https://www.cdc.gov/heart-disease/about/heart-failure.html • Ritchey, M. D., Wall, H. K., George, M. G., & Wright, J. S. US trends in premature heart disease mortality over the past 50 years: Where do we go from here? Trends in Cardiovascular Medicine. 2020; 30(6), 364-374. • Gianluigi Savarese, Lars H Lund, Global Public Health Burden of Heart Failure, Cardiac Failure Review 2017;3(1):7–11. Additional Disease State Market Sizing • Hilas O. COPD Prevalence, Risks, and Mortality. US Pharm. 2024;49(7):14. • Cardiovascular Disease Fact Sheet. CDC, published June 3, 2024. Accessed January 12, 2025. https://www.cdc.gov/cdi/indicator-definitions/cardiovascular-disease.html • Chronic Kidney Disease in the United States, 2023. CDC, published May 15, 2024. Accessed January 12, 2025. https://www.cdc.gov/kidney-disease/php/data-research/index.html • National Diabetes Statistics Report. CDC, published May 15, 2024. Accessed January 12, 2025. https://www.cdc.gov/diabetes/php/data-research/index.html • Real World Evidence on Health Care Resource Utilization and Economic Burden of Arrhythmias in Patients with Diabetes and COPD. Abstract presented at: 2024 AHA Scientific Sessions; November 16 to 18, 2024; Chicago, IL.