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X UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON , D.C. 20549 Annual Report Pursuant to Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 For the fiscal year ended December 31 , 2020 FORM 10 - K Transition Report Pursuant to Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 For the transition period from to Nevada ( State or other jurisdiction of incorporation or organization ) or INVO BIOSCIENCE , INC . ( Exact name of registrant as specified in Charter ) Title of each class Common Stock , $ 0.0001 par value per share 001-39701 ( Commission File No. ) 5582 Broadcast Court Sarasota , Florida , 34240 ( Address of Principal Executive Offices ) Registrant's telephone number , including area code : ( 978 ) 878-9505 Securities registered pursuant to Section 12 ( b ) of the Act : Trading symbol ( s ) INVO 20-4036208 ( IRS Employee Identification No. ) Name of each exchange on which registered The Nasdaq Stock Market LLC Securities registered pursuant to Section 12 ( g ) of the Act : Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . YES □ NO É Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Act . YES NO Indicate by check mark whether the registrant ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . YES NO Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( §232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) . YES 冈 NO O