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Table of Contents ( Mark One ) UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , DC 20549 Form 10 - K ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31 , 2020 TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from COMMISSION FILE NO . 001-36714 JAGUAR HEALTH , INC . ( Exact name of registrant as specified in its charter ) Delaware ( State or other jurisdiction of incorporation or organization ) SECURITIES REGISTERED PURSUANT TO SECTION 12 ( b ) OF THE ACT : Title of each class Common Stock , Par Value $ 0.0001 Per Share 200 Pine Street , Suite 400 San Francisco , California 94104 ( Address of principal executive offices ) Registrant's telephone number , including area code : ( 415 ) 371-8300 to Trading Symbol ( s ) JAGX 46-2956775 ( I.R.S. Employer Identification No. ) Name of each exchange on which registered The Nasdaq Capital Market SECURITIES REGISTERED PURSUANT TO SECTION 12 ( g ) OF THE ACT : None Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . Yes No Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15 ( d ) of the Act . Yes No Indicate by check mark whether the registrant : ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . Yes 0 Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) . Yes No Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S - K is not contained herein , and will not be contained , to the best of registrant's knowledge , in definitive proxy or information statements incorporated by reference in Part III of this Form 10 - K or any amendment to this Form 10 - K . Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , a smaller reporting company , or an emerging growth company . See the definitions of " large accelerated filer , " " accelerated filer , " " smaller reporting company , " and " emerging growth company " in Rule 12b - 2 of the Exchange Act . Large accelerated filer Accelerated filer Non - accelerated filer Smaller reporting company Emerging growth company If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 ( a ) of the Exchange Act . Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404 ( b ) of the Sarbanes - Oxley Act ( 15 U.S.C. 7262 ( b ) ) by the registered public accounting firm that prepared or issued its audit report . Indicate by check mark whether the registrant is a shell company ( as defined in Rule 12b - 2 of the Exchange Act ) . Yes No As of June 30 , 2020 , the aggregate market value of the registrant's common stock held by non - affiliates was approximately $ 14,755,325 based upon the closing sales price of the registrant's common stock on The Nasdaq Capital Market on such date . The number of shares of the registrant's common stock outstanding as of March 19 , 2021 was 127,906,558 shares of voting common stock and 2,120,785 shares of non - voting common stock , par value $ 0.0001 per share , outstanding ( convertible into 2,020 shares of voting common stock ) . DOCUMENTS INCORPORATED BY REFERENCE Portions of the proxy statement for the registrant's 2021 Annual Meeting of Stockholders , or Proxy Statement , to be filed within 120 days of the end of the fiscal year ended December 31 , 2020 are incorporated by reference in Part III hereof . Except with respect to information specifically incorporated by reference in this Form 10 - K , the Proxy Statement is not deemed to be filed as a part hereof .