Greetings and welcome to Jaguar Health's May 15, 2025 investor webcast. Before I turn the call over to Management, I'd like to remind you that Management may make forward-looking statements relating to such matters as continued growth, prospects for the Company, uncertainties regarding market acceptance of products, the impact of competitive products and pricing, industry trends and product initiatives, including products in the development stage which may not achieve scientific objectives or meet stringent regulatory requirements. Forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially from those contemplated in such forward-looking statements. These statements are based on currently available information and Management's current assumptions and expectations and projections about future events. While Management believes its assumptions, expectations and projections are reasonable in view of currently available information, you are cautioned not to place undue reliance on these forward-looking statements. The Company's actual results may differ materially from those discussed during this webcast for a variety of reasons, including those described in the Forward-Looking Statements and Risk Factors sections of the Company's Form 10-K for the year 2024, which was filed March 31, 2025, and its other filings with the SEC, which are available on the Investor Relations section of Jaguar's website. Except as required by law, Jaguar undertakes no obligation to update or revise any forward-looking statements contained in this presentation to reflect new information, future events or otherwise. Additionally, please note that the Company supplements its condensed consolidated financial statements presented on a GAAP basis by providing non-GAAP EBITDA and non-GAAP recurring EBITDA. Jaguar believes that the disclosure items of these non-GAAP measures provide investors with additional information that reflects the basis upon which Company management assesses and operates the business. These non-GAAP financial measures should not be viewed in isolation or as substitutes for GAAP net sales and GAAP net loss and are not substitutes for or superior to measures of financial performance in conformity with GAAP. Today's conference is being recorded. At this time, it's my pleasure to turn the call over to your host, Lisa Conte, Jaguar Health's Founder, President and Chief Executive Officer. Lisa, the floor is yours. Thank you very much. Nicely done, Rob, and thank you for the introduction. Again, my name is Lisa Conte and as usual I may use the words Jaguar and Napo interchangeably to refer to our company. After I speak, our CFO, Carol Lizak, will provide a recap of the financial highlights for the First Quarter of 2025. While our net revenue decreased in Q1 2025 versus Q4 2024, this was mostly driven by increased sales and higher distribution chain inventory levels in the Fourth Quarter of 2024 which resulted in fewer purchases in Q1 of 2025. This is in contrast to dispensed prescriptions for Mytesi, which I am pleased to announce increased in the First Quarter of 2025 versus the First Quarter of 2024 by approximately 2%. This is an indication of increased demand and that more patients are receiving treatment for HIV-related diarrhea from Mytesi. To move though onto the bigger picture for Jaguar, this is the year of convergence of key catalysts for Jaguar, catalysts that we feel will be transformational in terms of the value they bring to all the stakeholders in the company and this includes paradigm shifting medicines and mechanisms of action to address patient supportive care, comfort, dignity as well as disease progression, modification, ability to stay on life saving medicines and standard of care and more. To recap both our recent and upcoming catalysts, on April 30th we released initial results from an independent proof of concept study in pediatric patients of a novel liquid formulation of crofelemer, a highly concentrated liquid formulation which is distributed, a distinct product from Mytesi, and crofelemer of course is our first-in-class plant-based prescription drug and this was for intestinal failure associated with MVID, microvillus inclusion disease. I'm going to refer to this as MVID. It's an ultra-rare disease and also results that we released on that same date, April 30, for intestinal failure associated with short bowel syndrome, which I'll refer to as SBSIF, another rare disease. What is intestinal failure? Intestinal failure is the condition where patients cannot adequately absorb the necessary nutrients of life—carbohydrates, protein, fats, vitamins, electrolytes, et cetera. The necessary absorption to sustain life. Patients with intestinal failure due to MVID and often short bowel syndrome, but with MVID, require total parenteral nutrition, TPN, up to seven days a week for more than 20 hours a day and also are suffering from devastating diarrhea. It's like a sieve. Everything that goes in goes right out. The dehydration associated with that, electrolyte imbalance, and more complications. TPN, total parenteral nutrition, to be graphic here. It's a medical feeding method where nutrients are delivered directly into a vein through an IV line, bypassing the digestive system. Chronic TPN has the risk of morbidity and mortality, infections from the lines, metabolic complications, liver and kidney disease problems, neurodevelopment delay. It's a catastrophic chronic situation and it impacts, in addition to all these medical issues, obviously quality of life of both patients and their caregiver community. These patients are in a highly fragile state and children in particular with intestinal failure are off normal growth curves, failing to thrive. MVID patients have a short life. They typically die at age 11 or 12. For MVID patients, again, TPN is necessary from the first day of birth to survive. If they are not initially diagnosed and not put on TPN, they do not survive. There are no approved drug treatments for MVID or anything that we're aware of in development. The biggest impact we could have on a patient with intestinal failure is an achievement of reduction in the quality and the time on TPN. The initial proof of concept results that we issued on April 30th showed that crofelemer reduced TPN in the first MVID patient to participate in the study by up to 27% and for the first pediatric SBS patient by up to 12.5%. I should say so far these patients will continue on an open label basis on crofelemer for some time. These results are groundbreaking and they have the opportunity to modify disease progression for this catastrophic patient condition, intestinal failure. These initial results are potentially transformative for the patients and their caregiving community and it's not possible to overstate the significance of reduction in TPN. The results were presented April 26, 2025 at the annual Elite PGI Conference which was hosted by Dr. Mohamed Migdady. He also presented the results and he is a recognized leader in pediatric gastroenterology. This conference is his brainchild that he established over 12 years ago. I think this was the 12th, 13th, 14th, 15th annual and he serves as the Chief of Pediatric Gastroenterology, Hepatology and Nutrition at the Sheikh Khalifa Medical City in Abu Dhabi. He is the principal investigator for this ongoing exploratory single arm, open label, non randomized study for MVID and pediatric SBS patients and he's a member of our Scientific Advisory Board. This conference was a major international event. There were over 150 healthcare professionals participating. Right after his presentation on April 26, Dr. Migdady and his colleague Dr. Christos Savinikos took part in an extemporaneous Fireside Chat to discuss the initial findings of this study and in a few minutes we're going to replay the recording for you of that Fireside Chat in case anyone participating today did not take part or did not get a chance to hear this Fireside Chat in our April 30th investor webcast. The Fireside Chat was moderated by my longtime colleague and Jaguar's long term colleague, Dr. Praveen Chettavelli, the Chief Scientific Officer of Jaguar and Napo and the Chair of our scientific advisory board. Dr. Savinikos is the founder of the Pediatric Gastrointestinal Department at Al Jalila Children's Specialty Hospital in Dubai and an Adjunct Clinical Assistant Professor at the Mohammed Bin Rashid University of Medicine and Health in Dubai. He is also an investigator and key opinion leader in another trial of ours and as I said, you're going to see the real time medical reaction to these extraordinary results. This fireside chat was just moments after those results were presented. Our rare disease programs have been in the works at Jaguar for close to eight years. We have been developing close working relationships with KOLs, principal investigators around the world, conducting regulatory interactions, developing protocols and endpoint definition, formulation development. These first proof of concept results are also catalysts to enhance potential business development plans for partnering with a goal of achieving funding through access and license fees for the extraordinary risk based development and success Jaguar has achieved over the years. These important results put us in a position to close collaborations, potentially closed collaborations with receipt of non dilutive dollars. As I mentioned, access fees and license fees and there are many large deal precedents in the orphan drug space and several with much less clinical data, even preclinical opportunities at the time of deal closing. While short bowel syndrome affects approximately 10,000-20,000 people in Europe and roughly the same in the United States, MVID, and that is an orphan designation and we do have orphan designation for short bowel syndrome and MVID for which we also have orphan designation, is an ultra rare condition with an estimated prevalence of just a couple hundred patients globally. Given this situation, initial results in a very small number of MVID patients showing benefit with crofelemer may allow us to explore pathways for expedited regulatory approval for this indication, including the FDA of Europe, European Medicines Agency's PRIME Program for expedited and assisted regulatory approval, full approval in the 27 countries of the EU, and FDA's Breakthrough Therapy Program for expedited regulatory approval in the United States. We have already had preliminary interactions with PRIME officials at the EMA, and Jaguar, in collaboration with Napo Therapeutics in Italy, is currently supporting two ongoing proof of concept investigator-initiated trials in addition to the one that we've mentioned with Dr. Migdady, and also conducting two placebo-controlled phase 2 trials with crofelemer, one for MVID and one for adult short bowel syndrome intestinal failure. These trials are global in the U.S., Europe, and MENA regions as you typically do with orphan designated indications. In addition to Dr. Migdady's study, there's an investigator-initiated trial in adult patients with short bowel syndrome intestinal failure at Cleveland Clinic, and between these two studies we expect to have proof of concept results from these investigator-initiated trials throughout 2025 and potentially even into 2026. At the same time, simultaneously running are the placebo-controlled phase 2 trials for MVID and SBSIF, which are expected to conclude and have results in the first half of 2026. A lot of news is associated with our rare disease program and again a convergence of results and important news based on almost eight years of planning and development work on the part of the company. Moving on to our other core profile MER development program which also has a convergence of catalysts happening right now. On Target was a global phase 3 prophylactic clinical trial conducted by Jaguar, again prophylaxis for diarrhea in adult patients with solid tumors receiving targeted therapy with or without standard chemotherapy. It was a big bold study, a big hug around the cancer community including all solid tumor types, 24 different targeted agents, again with or without cytotoxic chemotherapy. What are targeted agents? Those are those agents that target CDK4/6s, epidermal growth factor receptor antibodies, tyrosine kinase inhibitors taken chronically by metastatic patients and often nine to 18 months in a curative situation to keep the cancer at bay. We did not achieve statistical significance in this big bold study. However, the analysis in adult breast cancer patients indicates that crofelemer achieved significant results. Statistically significant results in this pre specified subgroup and the patients with breast cancer accounted for approximately 65% or 183 of the 287 participants in this study. The results in breast cancer patients were the subject of an accepted poster presentation in December 2024 at the acclaimed San Antonio Breast Cancer Symposium and additional significant results in adult breast cancer patients from this on target study have been accepted for presentation at the Multinational Association of Supportive Care in Cancer Annual Meeting next month in Seattle. The FDA has granted Jaguar, Jaguar, Napo—again, use those word names interchangeably—a type C meeting now the second quarter of 2025 to discuss the responder analysis. The statistical analysis in this pre specified subgroup of patients with breast cancer for prophylaxis with crofelemer for diarrhea targeted therapy in the on target trial. Our goal for the meeting is to discuss the most efficient pathway to make crofelemer available to this patient population for cancer therapy related diarrhea in the United States. This is for the formulation currently known as Mytesi and I want to contrast this with what we were talking about in the Rare Disease Program, which is a new formulation, a new product into a different business model. This is literally the same formulation of crofelemer as Mytesi currently on the market. Diarrhea is unfortunately a very common side effect of targeted cancer therapies. There's about 21 unmet needs in supportive care area for cancer treatment and addressing this supportive care need is important not only for patient comfort and dignity, as important as those are, but also diarrhea can lead to dose changes, treatment delays or often even cancellation cessation of treatment altogether, which now is having an impact on the outcome of the patient's cancer treatment. I will now hand the discussion over to Carol Lizak, our Chief Financial Officer, for her recap of the financial highlights for the first quarter of 2024. Carol, take it away. Good afternoon Lisa, and thank you to all of you who have joined our webcast. Today I'll begin my review of our financials for the First Quarter of 2025. The total net revenue for the company's prescription products, Mytesi, Gelclair, and Canalevia-CA1, non-prescription products, and license revenue was approximately $2.2 million in the First Quarter of 2025, a decrease of approximately 6% versus the First Quarter of 2024. Revenue of $2.4 million and 37% versus net Fourth Quarter 2024 revenue of $3.5 million. Mytesi prescription volume increased by approximately 1.8% in the First Quarter of 2025 over the First Quarter of 2024 and decreased by approximately 13.5% in the First Quarter of 2025 over the Fourth Quarter of 2024. Prescription volume differs from invoice sales volume, which reflects, among other factors, varying buying patterns among specialty pharmacies in the closed network as they manage their inventory levels. Loss from operations increased by $1.2 million from $8.2 million in the Quarter Ended March 31, 2024 to $9.4 million during the same period in 2025. Non-GAAP recurring EBITDA for the first quarters of 2025 and 2024 were a net loss of $9.7 million and $8.8 million, respectively. Net loss attributable to common shareholders increased by approximately $1.2 million from $9.2 million in the Quarter Ended March 31, 2024 to $10.4 million in the same period in 2025. That concludes my recap of high-level financials for the first quarter of 2025. I will now hand the discussion back to Lisa Conte. Thanks Carol. All members of Jaguar, Napo Pharmaceuticals, Napo Therapeutics in Italy, all of us in this family are energized and excited about the multiple expected near-term and recently completed catalysts throughout 2025 and the beginning of 2026, all of which we view as important, value-enhancing, and potentially transformative for all our stakeholders, including first and foremost our patients. These catalysts, as I said, represent the convergence of key potential inflection points in our two major programs that have been in development for years and we expect these catalysts to lead to important collaborations, business development and licensing deals and the opportunity to bring in non-dilutive dollars to support these late stage products and programs and get them to regulatory approval and reimbursed patient access. There is also another potential business development opportunity that I do want to mention. Our crofelemer product approved for chemotherapy-induced diarrhea in doggies, Canalevia-CA1, conditionally approved for chemotherapy-induced diarrhea in dogs, is the subject of business development conversations as well to support bringing the approval to include all non-infectious acute diarrhea in doggies. It is really a very interesting situation at this time. If you are a patient in the United States with cancer and diarrhea and you have four legs, we can educate and promote crofelemer to you as a dog, but not to a human. Not yet. We are committed to make that happen. We will now play the recording for you of the fireside chat from the Elite PGI Conference, which was the first of the really important catalysts for this year. It is about 12 minutes long. After the replay finishes, it will be the end of today's webcast. I will say my goodbyes and my thank you and my gratitude for your participation at this time. Peter, I will let you take it away and play the webcast.