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Jasper Therapeutics SPOTLIGHT Data Update June 16, 2025
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2BRIQUILIMAB IS AN INVESTIGATIVE DRUG AND IS NOT APPROVED FOR ANY INDICATION Safe Harbor Statements Forward-Looking Statements Certain statements in this Presentation include “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. All statements other than statements of historical fact contained in this Presentation, including statements regarding Jasper’s future opportunities and prospects, including milestones, potential regulatory filings and the anticipated timing thereof, patient enrollment, future timelines, business strategy , plans and objectives for future operations, Jasper’s ability to obtain additional funding for its operations in this or future offerings and its expectations related to the use of any net proceeds from this offering are forward-looking statements. Jasper has based these forward-looking statements on its estimates and assumptions and its current expectations and projections about future events. These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including those contained in the "Risk Factors" section of the Company's Annual Report on Form 10-K for the year ended December 31, 2024, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K that the Company has subsequently filed or may subsequently file with the SEC. In light of these risks, uncertainties and assumptions, the forward-looking events and circumstances discussed in this Presentation are inherently uncertain and may not occur, and actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements. Accordingly, you should not rely upon forward-looking statements as predictions of future events. Jasper undertakes no obligation to update publicly or revise any forward-looking statements for any reason after the date of this Presentation or to conform these statements to actual results or to changes in Jasper's expectations. Industry and Market Data Certain data in this Presentation was obtained from various external sources, and neither the Company nor its affiliates, advisers or representatives has verified such data with independent sources. Accordingly, neither the Company nor any of its affiliates, advisers or representatives makes any representations as to the accuracy or completeness of that data or undertakes any obligation to update such data after the date of this Presentation. Such data involves risks and uncertainties and is subject to change based on various factors. Trademarks The trademarks included herein are the property of the owners thereof and are used for reference purposes only. Such use should not be construed as an endorsement of the products or services of the Company.
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BRIQUILIMAB IS AN INVESTIGATIVE DRUG AND IS NOT APPROVED FOR ANY INDICATION3 Today’s Agenda • Opening Remarks • SPOTLIGHT 180mg Results Summary • Upcoming Milestones and Closing Remarks • Question & Answer Session
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SPOTLIGHT 180mg Results Summary
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5BRIQUILIMAB IS AN INVESTIGATIVE DRUG AND IS NOT APPROVED FOR ANY INDICATION CIndU can be a severe & debilitating disease with negative impacts on quality of life for patients • Chronic inducible urticaria (CIndU) is a debilitating inflammatory condition of the skin with a specific trigger such as heat, cold, sunlight, rubbing or scratching the skin or tight clothing • Mast cell degranulation, leading to the release of histamine and other inflammatory mediators, is the key driver of severe itching, hives and angioedema in CIndU patients • CIndU patients suffer both physically and psychologically. Severe disease has a similar negative impact on QoL as other dermatologic diseases like plaque psoriasis • Targeting the KIT receptor with briquilimab disrupts a critical survival pathway on mast cells leading to mast cell apoptosis and disease resolution 1. Munoz M, et al. Current Allergy and Asthma Reports June 20242. Ozdemir SO, et al. JEADV Mar 2024 3. Maurer M, et al. J Allergy Clin Immunol 20174. Nikolaev I, et al. EAACI Hybrid Congress, July 1-3, 2022 5. Mauer M, et al. EAACI Hybrid Congress, May 31- June 3 2024
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6BRIQUILIMAB IS AN INVESTIGATIVE DRUG AND IS NOT APPROVED FOR ANY INDICATION Screening/Eligibility • Diagnosis of Cold Urticaria ( ColdU) or Symptomatic Dermographism (SD) for ≥ 3 mos • H1-antihistamine-failed • 18+ years • 18-65 years of age Study Operations • EU Lead: Martin Metz, MD • ~5 sites in the EU • N = ~27 Key Assessments • Provocation Test: TempTest® (ColdU), FricTest® (SD) • Disease Scores: UCT • Mast Cell Depletion & Recovery: Serum Tryptase, Skin Biopsies • Safety: TEAEs, SAEsProvocation Test Measured at 12 Weeks (Primary Endpoint) Provocation Tests Used for Clinical Evaluation 40 mg 120 mg 180 mg n=3 n=12 n=12 Symptomatic Dermographism FricTest® CR – No response at Fric Level 4 PR – ≥ 2 pin improvement Cold Induced Urticaria TempTest® CR – Negative test at ≤ 4ºC PR – Improvement by ≥ 4ºC Single Dose PatientsDose Schedule Key Assessments & Follow -up 12 Week Efficacy Observation Period (6 Week Preliminary Analysis) + 24 Week Additional Safety Observation Phase 1b/2a SPOTLIGHT Study in Chronic Inducible Urticaria Open-label, single ascending dose study Open-Label Extension Patients may roll over to open-label extension study evaluating briquilimab at 180mg Q8W
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7BRIQUILIMAB IS AN INVESTIGATIVE DRUG AND IS NOT APPROVED FOR ANY INDICATION Rapid Onset of Deep and Durable Efficacy Observed at 180mg Dose Depth of Response • 12 of 12 patients (100%) at 180mg achieved clinical response following single-dose of briquilimab • 11 of 12 patients (92%) at 180mg achieved complete response (CR) • 10 of 12 patients (83%) at 180mg had tryptase measurements below lower limit of quantification Rapid Onset of Effect • 67% of 180mg patients with CR or partial response (PR) at week 2 assessment Durability of Effect • 5 CRs and 2 PRs maintained at week 8 (58%, 7/12), durability assessment ongoing
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8BRIQUILIMAB IS AN INVESTIGATIVE DRUG AND IS NOT APPROVED FOR ANY INDICATION SPOTLIGHT Baseline Demographics Briquilimab 40mg (n=3) Briquilimab 120mg (n=12) Briquilimab 180mg (n=12) Age (years), mean (SD) 35.3 (8.0) 46.4 (13.8) 39.9 (16.0) Female, n (%) 1 (33%) 8 (67%) 7 (58%) Weight (kg), median (range) 86.0 (69-94) 99.0 (57-115) 86.5 (54-104) Cold Urticaria, n 1 4 3 Symptomatic Dermographism, n 2 8 9 Baseline Provocation Threshold TempTestTM (°C), mean (range) 16.0 (16-16) 20.8 (15-27) 18.7 (10-26) FricTestTM (Pin Count), mean (range) 3.5 (3-4) 3.9 (3-4) 3.7 (3-4) Urticaria Control Test (UCT) score, mean (SD) 3.7 (2.5) 6.3 (3.3) 6.5 (2.7) Tryptase (ng/ml), mean (range) 4.7 (4.1-5.3) 7.6 (3.6-25.7) 5.1 (3.2-11.2)
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9BRIQUILIMAB IS AN INVESTIGATIVE DRUG AND IS NOT APPROVED FOR ANY INDICATION * All values below LLOQ (1.0 µg/L) are represented as 0 µg/L SPOTLIGHT: Dose dependent reductions in serum tryptase Reduction to below Lower Limit of Quantification (LLOQ) (1 µg/L) seen in 83.3% (10/12) participants at 180mg
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10BRIQUILIMAB IS AN INVESTIGATIVE DRUG AND IS NOT APPROVED FOR ANY INDICATION SPOTLIGHT Efficacy Evaluation Briquilimab 180mg single dose achieved 92% (11 of 12) CR by week 8 Briquilimab 40mg (n=3) Briquilimab 120mg (n=12) Briquilimab 180mg (n=12) Briquilimab All doses (n=27) Complete Response, n (%) 1 (33%) 10 (83.3%) 11 (92%) 22 (82%) ColdU, n 0 3 3 6 Symptomatic Dermographism, n 1 7 8 16 Partial Response, n (%) 2 (67%) 1 (8%) 1 (8%) 4 (15%) ColdU, n 1 0 0 1 Symptomatic Dermographism, n 1 1 1 3 Complete or Partial Response at any time, n (%) 3 (100%) 11 (92%) 12 (100%) 26 (96%)
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11BRIQUILIMAB IS AN INVESTIGATIVE DRUG AND IS NOT APPROVED FOR ANY INDICATION SPOTLIGHT: Clinical response through 8 weeks with briquilimab 180mg (n=12) AD_T0003, AD_T0004, AD_L0001, AD_L0002 • 12 of 12 patients (100%) achieved either CR or PR by week 8 • 8 of 12 patients (67%) achieved clinical response by the week 2 assessment • 11 of 12 participants (92%) reported either CR or PR at week 6 • 9 of 12 patients (75%) achieved complete response at week 6 • 5 CRs and 2 PRs (58%) maintained through week 8, durability assessment ongoing Complete Response Partial Response
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12BRIQUILIMAB IS AN INVESTIGATIVE DRUG AND IS NOT APPROVED FOR ANY INDICATION Clear Dose Response Demonstrated at 6 Weeks Post-Dose 75% CRs at 180mg dose improved on 50% CRs observed at 120mg Briquilimab 40mg (n=3) Briquilimab 120mg (n=12) Briquilimab 180mg (n=12) Complete Response, n (%) 0 (0%) 6 (50%) 9 (75%) ColdU, n 0 1 3 Symptomatic Dermographism, n 0 5 6 Partial Response, n (%) 0 (0%) 1 (8%) 2 (17%) ColdU, n 0 0 0 Symptomatic Dermographism, n 0 1 2 Complete or Partial Response at week 6, n (%) 0 (0%) 7 (58%) 11 (92%)
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13BRIQUILIMAB IS AN INVESTIGATIVE DRUG AND IS NOT APPROVED FOR ANY INDICATION SPOTLIGHT Safety and Tolerability Briquilimab 40mg (n=3) Briquilimab 120mg (n=12) Briquilimab 180mg (n=12) Any adverse event 2 12 10 Any serious adverse event 0 2* 0 Any adverse event leading to discontinuation 0 0 0 Adverse event leading to death 0 0 0 Adverse event ≥ grade 3 0 1* 0 *SAE: Biliary colic leading to cholecystectomy, Grade 3 Fracture of the right shoulder (both unrelated to treatment) AEs occurring in ≥3 participants: Nasopharyngitis, neutrophil count decrease, fatigue, headache, abdominal pain, COVID- 19, diarrhea, dizziness, nausea
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14BRIQUILIMAB IS AN INVESTIGATIVE DRUG AND IS NOT APPROVED FOR ANY INDICATION SPOTLIGHT Safety/Tolerability Observations Possibly Related to KIT Blockade Were Generally Limited to Low Grade Events All events were grade 1 or 2 and none resulted in discontinuations Adverse Event as reported term Briquilimab 40mg (n=3) n (%) Briquilimab 120mg (n=12) n (%) Briquilimab 180mg (n=12) n (%) Briquilimab All doses (n=27) n (%) Hair color changes 0 (0) 0 (0) 0 (0) 0 (0) Skin discoloration 0 (0) 0 (0) 0 (0) 0 (0) Taste change/Hypogeusia 0 (0) 1 (8.3) 2 (16.7) 3 (11.1) Neutrophil count decreased 1 (33.3) 1 (8.3) 6* (50) 8 (29.6) * Four participants with Grade 1, two with Grade 2 ; median time to resolution 16d; four of six observations occurred proximal to a common cold diagnosis, one of six observations occurred proximal to COVID 19 diagnosis Grade 1 neutrophil count decrease defined as ANC between1,500 – 1,700/mm3 Grade 2 neutrophil count decrease defined as ANC between1,000 – 1,500/mm3
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15BRIQUILIMAB IS AN INVESTIGATIVE DRUG AND IS NOT APPROVED FOR ANY INDICATION SPOTLIGHT Absolute Neutrophil Count Neutrophil counts generally remained stable, with predictable reductions which subsequently resolved
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Upcoming Milestones and Closing Remarks
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17BRIQUILIMAB IS AN INVESTIGATIVE DRUG AND IS NOT APPROVED FOR ANY INDICATION Takeaways • Single 180mg dose of briquilimab demonstrated 100% clinical response in participants with CIndU • Deep reduction of tryptase observed with 83% of participants below LLOQ in 180 mg cohort • Rapid onset of symptom control with 67% achieving clinical response by week 2 • 91.6% of participants in 180 mg cohort achieved CR vs 83% in 120 mg cohort • Durability of 180mg dose shown with 58% clinical response maintained at 8 wks (5 CRs and 2 PRs) • Briquilimab was well tolerated in participants with CIndU • All possibly KIT related adverse events observed were low -grade and transient in nature • Briquilimab’s robust efficacy and safety, supports continued evaluation in chronic urticaria • Full SPOTLIGHT study results expected at medical conference in 2nd half of 2025
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18BRIQUILIMAB IS AN INVESTIGATIVE DRUG AND IS NOT APPROVED FOR ANY INDICATION Key milestones = Completed = Future events/milestones 2 02 4 CSU CIndU Asthma Conferences P H A S E 1 B / 2 A 2 02 5 2 02 6 Registrational Phase 1b/2a a. Initial clinical data OLE Study Phase 1b/2a Phase 1b/2aa. OLE Study Clinical data all patients Next Mast Cell Indication Initial clinical data Phase 1b/2a ase 1b/2aa. First patient dosed Initial clinical data Phase 2b Phase 1b/2a EADV ACAAI AAAAI EAACI EADV GA2LEN ATS ACAAI AAD AAAAI EAACI ATS AADERS EADV GA2LEN ACAAI ERS Clinical data all cohorts
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Jasper Therapeutics SPOTLIGHT Data Update June 16, 2025