Good day, and thank you for standing by. Welcome to Labcorp's Fourth Quarter 2024 Conference Call. At this time, all participants are in a listen-only mode. After the speaker's presentation, there'll be a question-and-answer session. To ask a question during the session, you need to press star one one on your telephone. You will then hear an automated message advising your hand is raised. To withdraw your question, please press star one one again. Please be advised today's conference is being recorded. I would now like to hand the conference over to your speaker today, Christin O'Donnell. Please go ahead. Thank you, Operator. Good morning, and welcome to Labcorp's Fourth Quarter 2024 Conference Call. As detailed in today's press release, there will be a replay of this conference call available. With me today are Adam Schechter, Chairman and Chief Executive Officer, and Julia Wang, Executive Vice President and Chief Financial Officer. This morning, in the Investor Relations section of our website at www.labcorp.com, we posted both our press release and an Investor Relations presentation with additional information on our business and operations, which include a reconciliation of the non-GAAP financial measures to the most comparable GAAP financial measures, both of which are discussed during today's call. Please see the use of adjusted measures section in our press release and Investor Relations presentation for more information regarding our use of non-GAAP financial measures. Additionally, we are making forward-looking statements. These forward-looking statements include, but are not limited to, statements with respect to the estimated 2025 guidance and the related assumptions, the spinoff of Fortrea Holdings Inc, the projected impact of various factors on the company's businesses, operating and financial results, cash flows and/or financial condition, including global economic and market conditions, future business strategies, expected savings, benefits, and synergies from the LaunchPad Initiative and from acquisitions and from other strategic transactions and partnerships, the completed holding company reorganization, and opportunities for future growth. Each of the forward-looking statements is subject to change based upon various factors, many of which are beyond our control. More information is included in our most recent annual report on Form 10-K and subsequent quarterly reports on Form 10-Q, and in the company's other filings with the SEC. We have no obligation to provide any updates to these forward-looking statements, even if our expectations change. Now I'll turn the call over to Adam Schechter. Thank you, Christin. Good morning, everyone. We appreciate you joining us as we review our 2024 performance and share our outlook for 2025. Today, I'm also joined by Julia Wang. Julia joined us as Executive Vice President and CFO this past December. As you know, Julia succeeded Glenn Eisenberg following his retirement announcement. Julia and I have hit the ground running, and Julia's experience in both diagnostics and pharmaceuticals, combined with her strong financial expertise, has already been very valuable to Labcorp. In 2024, our market-leading diagnostics and biopharma laboratory services businesses made meaningful advances in our strategy through organic growth, transformative acquisitions, and through continued commitment to science, innovation, and technology. Looking back on 2024, we executed well on our strategic priorities. We furthered our role as a trusted partner to hospitals and health systems and to regional local laboratories by closing or signing 10 transactions. We advanced our position in key high-growth markets, including oncology, women's health, neurology, and autoimmune disease, and we introduced new important diagnostic tests to meet significant unmet medical needs. We expanded our leadership in genetic testing solutions through our acquisition of select assets of Invitae. Our clients now have access to Invitae's cutting-edge science and genetic testing solutions to guide personalized treatment recommendations for oncology and rare disease patients. We advanced the development of Plasma Detect, an assay that uses whole genome sequencing and a proprietary machine learning analysis to detect MRD. Plasma Detect is in 12 global trials across several tumor types. We expect to move into clinical use in 2025 in the U.S., with an early experience program for academic medical centers beginning with colorectal cancer. We launched Labcorp Global Trial Connect, a suite of central laboratory solutions aimed at increasing the speed of clinical trials at investigator sites. Turning now to our fourth quarter financial results, we performed very well across diagnostic laboratories and biopharma laboratory services, driven by strong underlying demand and advancements in science and technology solutions to better serve the needs of our customers. Revenue in the quarter was $3.3 billion, an increase of 10% compared to the fourth quarter of 2023. Diagnostics and biopharma revenue each grew by approximately 10% in the quarter. Enterprise margins were down 40 basis points due to the expected impact of Invitae, which we referenced in our previous earnings call. Adjusted EPS of $3.45 was up 5% year- over- year. Free cash flow from continuing operations was $665 million. As we look ahead to 2025, we expect enterprise revenue growth of 6.7%- 8% and improving margins across both diagnostics and biopharma. We also expect an adjusted EPS range of $15.60-$16.40, which represents an implied midpoint growth rate of 10%. Additionally, we expect free cash flow to grow in line with our earnings. In just a moment, Julia will provide more details on our results and our 2025 guidance. Turning to highlights of our enterprise strategy in the quarter. First, we advanced our leadership position as a partner of choice for hospitals and health systems and regional local laboratories. In November, we completed the acquisition of the select assets and molecular testing location of Lab Works, enabling broader access to comprehensive testing and laboratory services in Alabama. In December, we completed the acquisition of select outreach laboratory services for Valley Health in the Appalachian region. In January, subsequent to quarter end, we announced a strategic collaboration with New Jersey-based Inspira Health to manage the operations of the health system's hospital laboratories and to serve as the primary lab for Inspira's physician network. As we look ahead to 2025, our pipeline remains strong, and we look forward to supporting more health systems and to expanding access to Labcorp's world-class diagnostic solutions. We also made several advancements in science, innovation, and technology in the quarter. As part of our focus on autoimmune disease, we launched a multiple sclerosis monitoring profile used to monitor neurofilament light chain serum and GFAP values in multiple sclerosis patients. Working with the CDC, we announced the commercial availability of an H5 bird flu molecular test, and we announced the availability of the first companion diagnostic assay to identify gastric cancer patients eligible for targeted treatment for people with advanced cancer of the stomach. In addition, we continue to help consumers manage their health and well-being through Labcorp OnDemand. We launched several consumer-initiated tests in the quarter, including homocysteine for heart health, vitamin A, vitamin C, and vitamin E. We announced several enhancements to Global Trial Connect, including sample tracking with earlier visibility into samples' chain of custody and electronic requisition, a fully digital solution that improves workflows, efficiency, and document management. We also experienced continued adoption of Labcorp Diagnostic Assistant by health system clients and their physicians. Labcorp Diagnostic Assistant brings together lab result data, clinical guidelines, and EHR data to inform clinical decisions at the point of care. New capabilities like smart trends combine information from the client's EHR with all of the patient's lab results available through Labcorp, regardless of ordering provider, and it brings it into a single integrated view. Labcorp Diagnostic Assistant and Global Trial Connect are just two examples of how we're harnessing our innovative testing capabilities, our vast data assets, and technology to support clinical trials and patient care. In closing, 2024 was a strong year for Labcorp as we continued to execute against our enterprise strategy, and we are well-positioned for continued growth in 2025. I want to thank our 70,000 employees for the hard work and dedication as we pursue our mission to improve health and improve lives. In fact, we were just named to Fortune Magazine's World's Most Admired Companies list for 2025, a testament to the efforts of our team and their dedication to our mission. Finally, I want to personally thank Glenn for his contributions to the company during his 10-year successful run as CFO. Glenn and I have worked side by side since I joined as CEO, and I've truly enjoyed having him serve as a key member of our executive committee. Glenn is a remarkable CFO and a remarkable executive. He remains as a special advisor to me through the end of April to ensure a smooth, collaborative transition that positions Labcorp to further accelerate our strategy in 2025. Please join me in wishing Glenn and his family all of the best in his retirement. With that, I'll turn the call over to Julia. Thank you, Adam. Hello, everyone. I want to start by sharing that I'm really excited to be with you all today. My experience across broader healthcare, including diagnostics and drug development, has been very helpful as I jump-started my new role. I have been truly inspired by the strength of our business fundamentals, our passionate employees, and the tremendous impact that Labcorp has on the patients that we serve each and every day. Now, I'm going to focus my comments on our financials, starting with a review of our fourth quarter results, followed by a discussion of our performance in each segment, and conclude with an update on our full-year guidance. For reference, we have also included additional business information that can be found in our supplemental deck on our Investor Relations website. Revenue for the quarter was $3.3 billion, an increase of 9.8% compared to last year, driven by organic growth of 5.4%, the impact from net acquisitions of 4%, and foreign currency translation of 0.3%. Operating income for the quarter was $217 million, or 6.5% of revenue, which is 12.7% on an adjusted basis. During the quarter, we had $120 million of restructuring charges and special items, primarily related to acquisitions and LaunchPad initiatives. In addition, we had $16 million of expense for the transition service agreements related to the spin-off for Fortrea, with the corresponding income recorded in other income. Excluding these items and amortization of $17 million, adjusted operating income in the quarter was $423 million, or 12.7% of revenue, compared to $395 million, or 13% of revenue last year. The increase in adjusted operating income was primarily due to organic demand and LaunchPad savings, partially offset by higher personnel costs. The 40 basis points decline in adjusted operating margin was due to Invitae. Our LaunchPad initiative delivered savings for the full year in line with our long-term target of $100 million-$125 million per year. The adjusted tax rate for the quarter was 22.4%, compared to 19.5% last year. The higher adjusted tax rate was primarily due to the geographic mix of earnings. We expect our adjusted tax rate for 2025 to be approximately 23%. Net earnings from continuing operations for the quarter were $144 million, or $1.70 per diluted share. Adjusted EPS was $3.45 in the quarter, up 5% from last year. Operating cash flow from continuing operations was $777 million in the quarter, compared to $580 million a year ago. The increase in cash flow was primarily due to higher cash earnings. Capital expenditures totaled $112 million in the quarter. For the full year, capital expenditures were 3.8% of revenue, in line with the prior year, and we expect this to be consistent in 2025. Free cash flow from continuing operations for the quarter was $665 million. During the quarter, the company invested $88 million in acquisitions, paid out $16 million in dividends, and repurchased $75 million of stock. For the full year, free cash flow from continuing operations was $1.1 billion. The company invested $839 million in acquisitions, paid out $243 million in dividends, and repurchased $250 million of stock. We continue to have a robust pipeline of potential acquisition opportunities that meet our financial criteria and will supplement our organic growth. In addition, we continue to believe that our share repurchase program is an important part of our capital allocation strategy. The company currently has approximately $1.3 billion of share repurchase authorization. At year-end 2024, we had $1.5 billion in cash, while total debt was $6.3 billion. These higher balances are due to the pre-funding of maturing debt. The company paid down $1 billion of debt that matured on February 1, 2025. Our debt leverage as of year-end is 2.2x net debt to trailing 12-month adjusted EBITDA. Now, I will review our segment performance, beginning with diagnostics laboratories. Revenue for the quarter was $2.6 billion, an increase of 10.2% compared to last year, with organic growth of 5.1% and net acquisitions of 5.2%. The business was up 11.4% compared to the business last year, driven primarily by organic growth of 6.2%. Total volume increased 6.8% compared to last year. Business volume grew 7.5% compared to the business last year, as organic volume increased 4.7%, while acquisitions contributed 2.9%. Price mix increased 3.4% versus last year due to organic business growth and acquisitions, partially offset by lower COVID testing. Business organic price mix was up 1.5% compared to the business last year due to mix, as we benefited from an increase in test per session and lab management agreements. Diagnostics adjusted operating income for the quarter was $360 million, or 13.9% of revenue, compared to $354 million, or 15.1% of revenue last year. Adjusted operating margin was down 120 basis points due to Invitae and the unfavorable impacts of days and weather. Excluding these items, adjusted operating margin would have been up approximately 50 basis points, as the benefit of organic demand and LaunchPad savings was partially offset by higher personnel costs. As we look to 2025, we anticipate Invitae will perform in line with our expectations. That is, we expect Invitae revenue growth to be approximately 10% annually and to be slightly accretive for full year 2025. Now, I will review the segment performance of Biopharma Laboratory Services. Revenue for the quarter was $767 million, an increase of 10.4% compared to last year due to an increase in organic revenue of 8.9% and foreign currency translation of 1.5%. Central Labs continued its strong performance with revenue growth of 10%. Early development also demonstrated strong year-over-year revenue growth in the quarter, up 12%, albeit the prior year was a soft comparison. Biopharma adjusted operating income for the quarter was $131 million, or 17% of revenue, compared to $109 million, or 15.7% of revenue last year. Adjusted operating income and margin increased due to organic demand and LaunchPad savings, partially offset by higher personnel costs. We ended the quarter with a backlog of $8 billion. We expect approximately $2.5 billion of this backlog to convert into revenue over the next 12 months. Book to bill for the quarter was 1.17, with the trailing 12-month book to bill of 1.00. Now, I will discuss our 2025 full-year guidance, which assumes foreign exchange rates effective as of December 31st, 2024, for the full year. The enterprise guidance also includes the impact from currently anticipated capital allocation, utilizing free cash flow for acquisitions, share repurchases, and dividends. We expect enterprise revenue to grow 6.7%-8% compared to 2024. This includes a headwind from foreign currency translation of approximately 50 basis points. We expect diagnostics revenue to be up 6.5%-7.7% compared to 2024. This guidance assumes roughly half of the revenue growth comes from organic growth, and half comes from the annualization of acquisitions completed in 2024. We expect biopharma revenue to grow 3%-5% compared to 2024. This guidance includes a headwind from foreign currency translation of 140 basis points. We expect both Central Labs and Early Development to grow at a mid-single-digit constant currency growth rate for the year. We expect enterprise margins to be up, with margins improving in both diagnostics and biopharma in 2025 versus 2024, driven by top-line growth and Launchpad savings. Our guidance range for adjusted EPS is $15.60-$16.40, with an implied growth rate at the midpoint of 10%. Our free cash flow guidance range is $1.1 billion-$1.25 billion, and due to normal seasonality, we expect it to be weighted towards the second half of the year. In summary, we are encouraged by the underlying strength of our business. As we move into 2025, we expect to drive continued profitable growth and strong free cash flow generation that will be used for acquisitions that support our strategy and supplement our organic growth, while also returning capital to shareholders through our share repurchase program and dividends. Lastly, I want to thank Glenn, as he has been a tremendous resource during this transition. I have been really impressed by the passion and the quality of our team, and I look forward to advancing the market-leading position of the company in an extremely impactful industry. Operator, we will now take questions. Thank you, ladies and gentlemen. If you have a question or a comment at this time, please press star one one on your telephone. If your question has been answered and you wish to move yourself from the queue, please press star one one again. We'll pause for a moment while we compile our Q&A roster. Our first question comes from Michael Cherny with Leerink Partners. Your line is open. Good morning, Michael. Good morning. Thanks so much for the question, and Julia, welcome to the call. Maybe if I can just ask a simple one, straightforward. You talked about margins stepping up over the year, year- over- year. Obviously, we still have Invitae ramping over the course of the year. Can you give us a sense of what underlying margins are in terms of embedded into guidance and how you're thinking about the push and pull on what would lead you to either the upside or the downside of the guidance range, the EPS guidance range? Sure, Michael. I'll start. I'll start by focusing on diagnostics, right? If you looked at diagnostics business, it was very strong. The revenue grew 10.2%, and it was really driven by strong organic growth of 5% and acquisitions of 5%. If you look at the margins, the margins were about 39% of revenue when you look at AOI as a% of revenue. That's compared to 15.1% last year. The margin was down due to three things. It was down to Invitae, weather, and days. The impact of Invitae was more than double each of the other two. As we look at this year, the reason we feel confident about margin expansion in both businesses, not just diagnostics but also in biopharma, is because, number one, we expect Invitae to be slightly accretive. It'll be diluted to margins in the first half of the year, but then when we overlap the acquisition, it'll be slightly accretive for the full year, meaning it'll be accretive in the second half. The second thing is we've built in $0.10 due to weather in the first quarter, and that's built into the guidance that we've provided. But if there's no additional other weather things, that could help us potentially with margin. And then the last thing is the number of days. So we have some real tailwinds that will help us with the margins as we come into 2025, making us feel confident. Got it. And then just one other question, I guess, on the implications of guidance. You're ending the year on a strong mix of both organic volumes and price mix on the diagnostic side. What do you see as the environment going forward? Is there anything kind of, I won't call it one-timey in nature, but elevated versus what you would have expected on a run rate and how that factors into how you're thinking about the 2025 growth in diagnostics? Yeah. So if you look at the 2025 growth that we put for diagnostics, the range is 6.5%-7.7%. So it's a midpoint of 7.1% growth. Now, if you look at 2024 in the fourth quarter, the 10% growth, volume was up 6.8%, and price mix was up 3.4%. And of our volume growth, organic was up 4%, and acquisitions were about 2.8%. At the end of the day, the volume continues to be higher than what we've seen historically. Historically, you see volume growing at 1%-2%. You would add a little bit on for that because I do think we're gaining some market share. So over time, I would expect that the volume would come back to more in line with what we've seen historically. Hi, Michael. Got it. Yeah. The only thing I would add is when you look at the growth for our diagnostic business in 2025, our guidance is assuming half of the growth, about 3.5%, will be coming from our organic business, and the other half will be coming from acquisitions that we've already completed in 2024. So it's a fairly balanced profile in terms of the sources of growth for 2025. Great. Thank you. One moment for our next question. Our next question comes from Jack Meehan with Nephron Research. Your line is open. Good morning, Jack. Good morning. Adam, just wanted to start. A big story of the last year has been M&A in the lab industry. Your cash flow here is pretty strong. Leverage is just over two times. Can you give us an update on how your pipeline of deals look and just how active you expect to be even as you integrate everything you consummated last year? Yeah, sure, Jack. What I first off saying, if you look at this year, we had 10 acquisitions, and it was very strong from acquisition year, particularly with the hospital, regional, local laboratories, but we also had the acquisition of Invitae, which was kind of one of those opportunistic acquisitions that became available to us. As I look at the pipeline, it's strong, and it's impossible to know the exact number because sometimes they take three months, sometimes they take two years, but overall, as I look at the potential before us, I feel very good about the acquisition pipeline. But more broadly speaking, the way I think about our capital allocation is we first and foremost are committed to the dividend. We then look for as many of these hospital, local, regional laboratory deals as we can do, assuming that they meet our financial criteria of being accretive in the first year, return on cost of capital in two-to-three years, and that they're good partners that we can integrate the business well. And then we'll look into the specialty areas to see if there's anything strategic there or if there's anything strategic in the biopharma area. Then we have the authority to do additional buybacks, and we have the wherewithal to add buybacks where we think appropriate. So I think we have a very balanced mix. I think we have a good pipeline of deals. And when you look at our longer-term guidance, we've actually increased the amount of revenue that we expect to come from deals. Historically, I would have said 1%-2% of revenue. Now it's 1.5%-2.5%, and I feel good a bout that. Great. Yes. Hi, Jack. The only other comment I would add is our 2025 guidance does include the impact from currently anticipated capital allocation, essentially utilizing our free cash flow generation for acquisitions, share repurchases, and dividends. The other point is, as you already commented, we ended last year with a leverage ratio of about 2.2x in terms of our net debt to trailing 12-month EBITDA, which clearly demonstrates that we have additional balance sheet flexibility to pursue share repurchase or M&A opportunities should attractive opportunities do emerge throughout the year. Great. And then, Julia, one for you. Just be great to hear your initial impressions since joining Labcorp. On this topic of M&A, Invitae was a headliner last year. Just how you feel like the integration is going with that? Yes, of course, Jack. As Adam commented earlier, I joined Labcorp in December of last year, so this is month number three for me. Let me just say that I am so happy to be here. In terms of my early observations, first of all, I'm really excited about our growth profile. When you look at our long-term guidance, you are looking at a top-line growth of mid- to high-single-digit. I have to say that this growth rate is meaningfully higher than what I would have thought the last time I worked in the industry prior to COVID. Then if you take that strong top-line growth coupled with margin expansion, along with the expectation to drive adjusted EPS growth and free cash flow generation in the range of high single digit to low double digit, to me, this is truly compelling. I believe that we have a tremendous platform and opportunity to potentially create outsized returns for our shareholder. I also like our people and our culture. What we do is grounded in science, innovation, and technology, and our people are truly passionate, dedicated, and focused. From a personal perspective, it is a delight coming back to this part of the country, which was essentially where I started when first coming to the U.S. years ago to study at Duke University. So in many ways, life has come full circle for me. So I'm really excited to be here working across both internally and externally to continue to advance our leadership position in an industry that is extremely impactful to the patients that we serve. And Jack, with regard to the Invitae integration, it's going very well. I actually had a chance to spend time with the team in California in January. And the science, the people, the technology, the patient experience that they have is really remarkable. I was excited about the deal when we first announced it. I'm actually even more excited about it, as I sit here today. We remain on track financially. We expect the revenue to grow by more than 10%, and we also expect it to be slightly accretive as we look at full year 2025, second half of the year being accretive, first half still diluted. So as I look at that business, if I look at the integration, it's going as well as I would have expected. Awesome. Thank you, guys. One moment for our next question. Our next question comes from Lisa Gill, JP Morgan Chase. Your line is open. Good morning, Lisa. Good morning, Adam and Julia. Just really wanted to follow up on your thoughts around the organic growth rate for diagnostics. Adam, when we were together in January, you talked about esoteric testing being three times the typical growth rate of what we see. And then you also talked and you highlighted again today that you expect kind of normal utilization to go back to 1%-2%. So how do I think about the makeup of the 3.5% that Julia talked about as far as organic? How much of that is coming from esoteric? Is your underlying assumption that we go back to 1%-2% historical utilization in that number? And then as we think about esoteric and your relationship with Medicare, and anything changing there as far as shifting more volume to you, etc., as w e think about 2025? Yeah. Thank you for the question, Lisa. And when I talk about esoteric business, I then kind of subset it a little bit to look at oncology, women's health, neurology, and autoimmune disease. It's in those four areas that I see the growth at three times the historical rate of diagnostics. So it's not the entire set of esoteric tests. It's that kind of subset, which is still a big portion of esoteric testing. And we continue to see those growth rates faster than others. And then when I think about the underlying market, historically at 1%-2%, a big part of it is still that the market is so big. And if you look at the CAGR, it's from 2019, the volume has been in a 1%-2% range. And I think that's just like a historical rate. With that said, I do believe that we are gaining some market share. And I think with these hospital deals, with the geography surrounding the hospitals, I think it is enabling us to grow faster than the market. And therefore, I would expect us to continue to do that even if the market growth goes back to historical levels. In terms of esoteric testing, we continue to work with our managed care payers. I think because we have such a broad pipeline, we have 6,500 different tests available to them. It actually gives us a good mix that we can talk to them about when we speak about reimbursement. So I think having the breadth of the test profile that we have helps us. And just one follow-up on the guidance. Lab-developed tests, there's supposed to be something obviously coming into play. Your trade organization currently has a lawsuit. Is that cost meaningful? And could there be a meaningful shift if you're able to win the lawsuit in May? Yeah. So with regard to lab-developed tests, the vast majority of what's being required to do, we actually were already doing because we submit our tests to New York State for approval. And that's a lot of where the cost was. So we were incurring that. There might be some other costs in terms of systems to track safety and other things, but those are kind of within the ranges that we provided, nothing that I would call out specifically, Lisa. I still think it's the wrong thing for the industry. I think it could slow down the ability to get new important tests to market for people that need them. I think it caused some healthcare disparities where if you live around an academic medical center, you might have access to an LDT before the rest of the population. For those reasons, I don't think it's the right answer. I think the trade organization needs to work to find a better way with the administration to move forward. At the same time, it's not a significant financial impact to us. Okay. Great. Thanks for the comments. One moment for our next question. Our next question comes from Erin Wright with Morgan Stanley. Your line is open. Good morning, Erin. Good morning. Could you characterize, I guess, the backdrop right now across biopharma? What are your expectations in terms of the underlying market into 2025? And if you could provide an update on the NHP business as well, just the supply given some of the news on that front more recently, and just how we think about also from a margin perspective for that business in the quarterly progression, anything to think about into 2025. Thanks. Yeah. Thank you, Erin. I'll tell you, it's nice to see the growth that we had anticipated in both of the biopharma segments, so if you look at biopharma, we had 10% revenue growth for essential labs, and as expected, we did see growth in early development. Early development actually grew 12% year- over- year. As I look at the guidance that we're providing for 2025, we're giving a range of 3%-5% with a midpoint of 4%, realizing that there's a significant impact in that from foreign exchange levels. As I look at that business, it remains healthy. We are a leader in both of those segments. When I start with essential labs, I mean, about 85% of the forecast comes from the backlog. So I feel good about the forecast that we have, and I feel good about the backlog that we have. As I look at early development, I look at three things. I look at the number of RFPs in dollars as well as numbers. I look at our win rate, and then I look at the cancellations. If you look at the RFPs, they remain strong both in dollars and numbers. If you look at our win rate, it remains consistent. And if you look at cancellations, although it's not back to exactly normal levels, it's at the high end of normal now. So it's come down much better than where it had been historically. So I feel good coming into the year with both of those businesses. As I think about margins, we expect margins to expand in the biopharma laboratory services business as well as in diagnostics. And I think the expansion comes from increased volume as well as increased utilization, particularly in early development. As far as NHPs, we have the supply that we need for the forecast that we've provided. I feel good about our supplies. Maybe I could add a little bit more color as it relates to the margins for the BLS segment in 2025 versus 2024. So first of all, we did share in the opening remark that we are anticipating this currency impact to the top line, which will translate to about a 140 basis points of a negative impact to the BLS revenue growth versus prior year. Therefore, when you look at the margin expansion drop-through in 2025, the pace of that growth will not be as much as you saw in 2024. The other factor is the sources of our growth from a revenue standpoint from the two business lines within BLS is not going to be as heavily weighted towards central labs as it did in 2024. The other point that is worth noting is Q1 typically is the margin quarter of the year. So you might want to take that into consideration as you think about the quarterly phasing within the year. Okay. That's helpful. And just a quick one on regulatory. You mentioned LDTs, but what about PAMA, SALSA, and just the broader regulatory environment where we stand today with the new administration? Thanks. Yeah. So with PAMA, we continue to work with our trade organization to find ways to get better legislation in place that we think is more applicable to what they were trying to achieve and a better way to actually move it forward. We've been trying that for many years now, to be frank. And if that doesn't happen, we'll try for a delay as has happened in the last several years. And then at the same time, we continue to just push it out a year. So in my base case, I assume PAMA's coming in 2026. We build a plan that looks good, assuming PAMA does happen. And then if it doesn't happen, it looks even better. But at this point in time, we continue to work to try to find a better legislative option. Thank you. One m oment for our next question. Our next question comes from Elizabeth Anderson with Evercore ISI. Your line is open. Elizabeth, good morning. Elizabeth, you there? This is Joanna for Elizabeth. Can you hear me? Yep. We can't hear you. Hi. Hi. This is Joanna for Elizabeth. Ok ay. Go ahead, Joanna. Sorry. Yeah. Maybe go back to the one-time items. I think you said you have 10% weather impact impacting 2025 guide. So maybe what's the total weather impact for 2024? And is revenue day and payroll day going to be tailwind or headwind for fiscal 2025? Thanks. Yeah. If you look at 2025, in January, we had about 10% impact from weather. And we built that into the guidance that we've already provided to you. As we also look at 2025, payroll will actually be a tailwind for us, and let's see what happens with the rest of the quarter with weather before we comment any further, but a this point, we've built in $0.10. Hi, Joanna. The only thing I would add, I definitely agree with Adam, so clearly, if you look at 2025 full year, calendar is largely not a factor. However, Q1, it will be slightly unfavorable because we expect to have one less revenue day, partially offset by one less payroll day, so you might want to take that into consideration as you work through the quarters within the year. That makes sense. Thank you. One moment for our next question. Our next question comes from Andrew Brackmann with William Blair. Your line is open. Good morning, Andrew. Hi. Good morning. Good morning, Adam. Hi, Julia. Looking forward to working with you and glad if you're listening. Congrats and best of luck in retirement. Maybe just two on the macro front I'll ask upfront. So sort of first here, can you maybe sort of talk about underlying inflation assumptions and how those might impact margins this year, any sort of spending categories that should get either better or worse in 2025? And then secondly, a lot of noise on the tariff front right now. Are you sort of thinking about any impacts to your supply costs, if any, for this year? Thanks. Yeah. Thank you, Andrew. So two thoughts. First of all, underlying inflation, a big part of our inflation is cost of people. And we've assumed 3%-3.5% inflation. As we look at our labor, it's actually gotten better in 2024 than it was prior, particularly at turnover rate. So I feel like we're in a pretty good place with 3%-3.5%. In terms of tariffs, it's hard to know exactly what would happen, the timing of what would happen. But we've taken a look at a lot of different scenarios, and we think that it would be very manageable for us. Hi, Andrew. Very nice to meet you. To just build on what Adam has already shared, as you know, we have this Launchpad initiative that every year we drive about $100 million-$125 million of savings through really process and technology improvement that really drops through to the bottom line. So that actually helps us to really absorb, for the most part, the increase in labor cost. Great. Thanks so much. One moment for our next question. Our next question comes from Pito Chickering with Deutsche Bank. Your line is open. Good Morning, Pito. Hey. Good morning, guys. So a quick follow-up question on ED. I think you said that would grow sort of mid-single digits. I guess, what's the components there between pricing and volume for 2025? Yeah. Thank you, Pito. So ED, we didn't give specific guidance for ED. We just said that biopharma services is expected to grow range 3%-5%, 4%. Both segments will grow within that. ED does tend to grow slightly faster than what central laboratory business grows. Price is basically pretty flat. I mean, there's a little bit of pressure, but nothing more significant than what we would expect. So it comes from volume. Okay. Got it. So pricing flat for ED and growth coming from the volume side. Looking at the free cash flow conversion for 2025, can you walk us through the delta between sort of EPS growth on 2025 versus your free cash flow growth that looks to be sort of some working capital or some pressure on your free cash flow growth versus your earnings growth? Thanks. Yes. Maybe I can get started on that question. So to help us understand the 2025, let me start with re-grounding ourselves about how we landed 2024, particularly in Q4. So as you may be aware already, in terms of the free cash flow generation, we typically generate the majority of our free cash flow in the second half of the year, with the fourth quarter being the strongest. And that was exactly what we saw in the fourth quarter last year. Specifically, the Q4 free cash flow from continuing operations was $665 million, which was up over 60% versus the year before. And the increase was primarily driven by higher cash earnings, lower capital expenditures, as well as favorable working capital due to timing. Now, when you transition to 2025, you might have already seen coming out of the strong cash flow in 2024 of $1.1 billion. Our guidance for 2025 for the free cash flow is between $1.1 billion- $1.25 billion, with a midpoint of $1.175 billion. And that growth, once again, is really driven by the higher cash earnings and, to a certain degree, some variability as it relates to working capital. But what I would say is, from a cash conversion perspective, we are targeting around mid-80s% to higher, which was what you have seen historically, which is also what we built in the guidance for 2025. And overall, I would say we are really pleased with the strong cash flow that we have been generating, which has been serving and will continue to serve as a key funding source for our capital deployment strategy and execution. Thank you. One moment for our next question. Our next question comes from Patrick Donnelly with Citi. Your line is open. Mor ning, Patrick. Hey. Good morning, Adam. Thanks for taking the questions. Maybe I'll just kind of package a couple together here. When you think about the lab business, the core diagnostics business here, can you just talk about the pricing side, what those conversations have been with payers, the expectations for 2025 on that front? And then in a similar vein, just the utilization, obviously, it's been elevated. It feels like it's going to continue. How much conservatism did you guys put in the utilization side, and how are you seeing that play out as we work our way through 2025? Thank you. Yep. Thank you, Patrick, so as I look at 2024, I mean, we ended the year and the quarter very strong, and it gives us momentum as we come into 2025, and if you look at the guidance that we provided for 2025 for diagnostics, it's midpoint of 7%, so once again, showing very strong underlying demand, of which we believe 3.5% will come organically. The other 3.5% will come from deals that we already completed in 2024. Our discussions with the payers go very well. We continue to show them the value that we add. They see the benefit of us acquiring some of the hospital business because that actually helps them as well as helps the patient, helps the hospital, and helps Labcorp. So those deals are very helpful to, I think, the entire healthcare system. I think the payers see that. They also see that we are a very high-quality lab. We now have so many specialty tests in almost every one of the specialty areas that they're focused on. They see that we are a lower-cost provider. We give very high quality. Because of our scale, we're able to give it at a lower cost, which works in our favor in those discussions. I feel good about the environment. I feel good about where we are in 2025 and as we move forward. Great. Appreciate it. One moment for our next question. Our next question comes from Kevin Caliendo with UBS. Your line is open. Hi, Kevin. Good morning. Good morning. Thanks for taking my question. In the quarter, in the fourth quarter, you mentioned ex weather, ex days, ex Invitae, core margins and diagnostics that have grown 50 basis points. Is there any dynamic that's different when you think about 2025 such that core margins would continue to grow? And I guess, as you mentioned, labor turnover is better versus LaunchPad. I'm just wondering, when you think about the business, ex the one-timers, weather, and everything else, would you still expect core margins to expand by roughly what you saw third quarter, fourth quarter, the 50 basis points or so? Okay. So as I think about 2025, we expect to see margin expansion. And we expect to see it in both businesses, in our diagnostic business, but also in the biopharma laboratory businesses. Some of the things that you mentioned, in particular, it works in our favor. And it's actually a tailwind. It'll be dilutive for the margins in the first half of the year, but it'll be slightly accretive for the full year, saying that the second half of the year there'll be accretive for it. So overall, I feel very good and confident that we've got some tailwinds on the margin improvement that will help us as we expect in 2025. I agree with Adam. And maybe one more color. As you look at 2024 and Q4 in particular, from a diagnostic margin perspective, once you neutralize the impact from the strategic acquisition of Invitae as well as some unusual operational items like weather and days, the leverage for our diagnostic business was actually in the mid to high 20s, which was in line with our past performance. And as we move into 2025, we expect to continue to build upon that foundation and continue to expand the margin, particularly as we also overlap the dilution to margin from Invitae in 2024. Got it. Okay. That's helpful. And just one follow-up. You've made some comments about 1Q and weather and the timing of Invitae. But just when we think about cadence, is there any other color you can give us around cadence for the year as we think about EPS growth or however you'd want to clarify that as we think about 1 Q versus 2Q versus 3Q versus 4 Q? Because there's obviously some one-timers this year that might throw off normal seasonality. Yeah. So we're not going to give quarterly guidance. But as I did say, in the first quarter, we have a $0.10 impact through the month of January due to weather. We'll see if there's anything else that happens with weather. We haven't built in anything above the $0.10. But we're not going to give quarter-by-quarter guidance at the moment. And earlier I shared, right, in the first quarter, there will be a day impact. But I think that's included in our supplemental information on the website as well. Thank you. One moment for our next question. Our next question comes from David Westenberg with Piper Sandler. Your line is open. Good morning, David. Hey. Good morning, everyone. So I'll just have one question here on the Invitae acquisition integration plus some of the growth here. So it did have an MRD assay that you talked about bringing both the first to biopharma and then eventually commercialization. Can you talk about reimbursement or expectations on timelines and reimbursement? I know Invitae had reimbursement, but it also had some IP fights. I'm not really sure where that actually wound up shaking out. So if you can give us an update there. And then just in terms of the back half of the year, accretion on Invitae, how much of this is growth-dependent versus maybe cost synergies that you've already identified and really already have them in place? And thank you. I'll just ask one upfront because that was a little longer. Yep. Yep. So two points. One is, and they both come together. As I look at the accretion for Invitae, I mean, we are taking costs out, but we're doing it in a very thoughtful manner. And we're doing best of best. So we have MRD assets. They have MRD assets. We were looking at the ones that were scientifically most advanced from a timeline. We're furthest along, and we're taking the best of best. So we continue to have a significant number of assets as we look at liquid biopsy, including MRD. With regard to the timing of accretion dilution, I would say part of it is just it's a year later. So we've overlapped the year. And then the second part of it is that we've taken out significant costs where it made sense. Thank you. One moment for our next question. Our next question comes from Tycho Peterson with Jefferies. Your line is open. Morning, Tycho. Hey. Thanks. I wanted to ask on Geneoscopy on the partnership there. I know there have been, I think, some developments. There was a hearing at the end of last month on the injunction. And just how are you thinking about resources you need to put behind that ahead of the launch later this year? And then any thoughts on USPSTF and the Braidwood case and whether that may impact timing of the launch? Yeah. I think it's best to actually talk to them about the specifics of any type of cases and where they are with litigations and those types of things. With regard to us, we'll be prepared to launch, and when it's appropriate, we'll be ready. Okay. And then, follow-up is just, I know you had the question earlier on PAMA. Going back to your comments at JPMorgan on SALSA you had commented it makes sense and it's logical, but there might be kind of pieces you can pull out of if you can't get it all approved. Can you maybe just talk a little bit more about what you're implying there and what parts you might pull out of? Yeah, so we're trying again, I didn't want to say we're pulling apart bills or legislation. Our trade group is working to figure out what's the best path forward to try to get approval of legislation that addresses the needs. And with any legislation, you talk with Democrats, Republicans, and Congress, and the Senate, and you try to find things that are appropriate for all involved. So I feel like we've got a path forward that we continue to work on. We've had Democrats and Republicans very supportive that the current PAMA, the way it had been implemented, doesn't make sense. Now we just have to find the most logical way to move forward where it does make sense. Okay. Thank you. We ll, ladies and gentlemen, so that's concluded the question and answer portion of today's call. I'd like to turn the call back to Adam for any closing remarks. All right. Thank you, everybody, for joining us today. We appreciate your time, and we look forward to updating you on the first quarter of 2025 in April. Thank you, ladies and gentlemen. So that's concluded today's presentation. You may now disconnect and have a wonderful day.