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( Mark One ) UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 FORM 10 - K ☑ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31 , 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM Delaware ΤΟ Commission File Number 001-39503 Athira Pharma , Inc. ( Exact name of registrant as specified in its charter ) ( State or other jurisdiction of incorporation or organization ) Title of each class 18706 North Creek Parkway , Suite 104 Bothell , Washington 98011 ( Address of principal executive officer ) ( 206 ) 221-8115 ( Registrant's telephone number , including area code ) Securities registered pursuant to Section 12 ( b ) of the Act : Common Stock , $ 0.0001 par value per share Securities registered pursuant to Section 12 ( g ) of the Act : None Trading Symbol ( s ) ATHA 45-3368487 ( I.R.S. Employer Identification No. ) Name of each exchange on which registered The Nasdaq Stock Market LLC ( The Nasdaq Global Select Market ) Indicate by check mark if the Registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . YES NO Indicate by check mark if the Registrant is not required to file reports pursuant to Section 13 or 15 ( d ) of the Act . YES □ NO Indicate by check mark whether the Registrant : ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the Registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . YES NO □ Indicate by check mark whether the Registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( §232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the Registrant was required to submit such files ) . YES NO □ Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , smaller reporting company , or an emerging growth company . See the definitions of “ large accelerated filer , " " accelerated filer , " " smaller reporting company , " and " emerging growth company " in Rule 12b - 2 of the Exchange Act . Large accelerated filer Non - accelerated filer ☐ 冈 Emerging growth company 冈 Accelerated filer Smaller reporting company ㅁ If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 ( a ) of the Exchange Act . ☐ Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404 ( b ) of the Sarbanes - Oxley Act ( 15 U.S.C. 7262 ( b ) ) by the registered public accounting firm that prepared or issued its audit report . Indicate by check mark whether the Registrant is a shell company ( as defined in Rule 12b - 2 of the Exchange Act ) . YES NO The aggregate market value of the common stock held by non - affiliates of the registrant , based on the closing price of the shares of common stock on September 22 , 2020 as reported by The Nasdaq Stock Market LLC on such date was approximately $ 460.5 million . The registrant has elected to use September 22 , 2020 , which was the closing date of its initial public offering of common stock , as the calculation date because on June 30 , 2020 ( the last business day of the registrant's most recently completed second fiscal quarter ) , the registrant was a privately held company . Shares of the registrant's common stock held by each executive officer and director and by each other person who may be deemed to be an affiliate of the registrant have been excluded from this computation . This calculation does not reflect a determination that certain persons are affiliates of the registrant for any other purpose . The number of shares of Registrant's Common Stock outstanding as of March 22 , 2021 was 37,120,363 . None . DOCUMENTS INCORPORATED BY REFERENCE