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( Mark One ) 0 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 FORM 10 - K ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Fiscal Year Ended December 31 , 2020 TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Transition Period from to Commission File Number : 000-30111 Lexicon Pharmaceuticals , Inc. ( Exact Name of Registrant as Specified in its Charter ) Delaware ( State or Other Jurisdiction of Incorporation or Organization ) or 8800 Technology Forest Place The Woodlands Texas 77381 ( Address of Principal Executive Offices and Zip Code ) Title of Each Class Common Stock , par value $ 0.001 per share Trading Symbol ( s ) LXRX 76-0474169 ( I.R.S. Employer Identification Number ) ( 281 ) 863-3000 Securities registered pursuant to Section 12 ( b ) of the Act : ( Registrant's Telephone Number , Including Area Code ) Name of Each Exchange on which Registered Nasdaq Global Select Market Securities registered pursuant to Section 12 ( g ) of the Act : None Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act of 1933. Yes No Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Securities Exchange Act of 1934. Yes No Indicate by check mark whether the registrant ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) and ( 2 ) has been subject to such filing requirements for the past 90 days . Yes No Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T during the preceding 12 months ( or for such shorter period that the registrant was required to submit and post such files ) . Yes No Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , a smaller reporting company or an emerging growth company . See definitions of “ large accelerated filer , ” “ accelerated filer , ” “ smaller reporting company ” and “ emerging growth company " in Rule 12b - 2 of the Securities Exchange Act of 1934. ( check one ) : Large accelerated filer Accelerated filer Non - accelerated filer Smaller reporting company Emerging growth company If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 ( a ) of the Securities Exchange Act of 1934 . Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404 ( b ) of the Sarbanes - Oxley Act ( 15 U.S.C. 7262 ( b ) ) by the registered public accounting firm that prepared or issued its audit report . Indicate by check mark whether the registrant is a shell company ( as defined in Rule 12b - 2 of the Securities Exchange Act of 1934 ) . Yes No The aggregate market value of voting stock held by non - affiliates of the registrant as of the last day of the registrant's most recently completed second quarter was approximately $ 82.0 million , based on the closing price of the common stock on the Nasdaq Global Select Market on June 30 , 2020 of $ 2.00 per share . For purposes of the preceding sentence only , our directors , executive officers and controlling stockholders are assumed to be affiliates . As of March 6 , 2021 , 144,354,161 shares of common stock were outstanding . Documents Incorporated by Reference Certain sections of the registrant's definitive proxy statement relating to the registrant's 2021 annual meeting of stockholders , which proxy statement will be filed under the Securities Exchange Act of 1934 within 120 days of the end of the registrant's fiscal year ended December 31 , 2020 , are incorporated by reference into Part III of this annual report on Form 10 - K .