Page 1

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 FORM 10 - K ( Mark One ) ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended November 30 , 2020 OR TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Delaware ( State or other jurisdiction of incorporation or organization ) 1700 Owens Street , Suite 205 San Francisco , CA ( Address of principal executive offices ) NURIX THERAPEUTICS , INC . ( Exact name of Registrant as specified in its Charter ) Commission File Number 001-39398 Title of each class Common Stock , par value $ 0.001 per share 0 27-0838048 ( I.R.S. Employer Identification No. ) 94158 ( Zip Code ) Registrant's telephone number , including area code : ( 415 ) 660-5320 Securities registered pursuant to Section 12 ( b ) of the Act : Trading Symbol ( s ) NRIX Name of each exchange on which registered Nasdaq Global Market Securities registered pursuant to Section 12 ( g ) of the Act : None Indicate by check mark if the Registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . YES NO Indicate by check mark if the Registrant is not required to file reports pursuant to Section 13 or 15 ( d ) of the Act . YES NO Indicate by check mark whether the Registrant : ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the Registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . YES > NO Indicate by check mark whether the Registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( §232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the Registrant was required to submit such files ) . YES NO Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , smaller reporting company , or an emerging growth company . See the definitions of " large accelerated filer , " " accelerated filer , " " smaller reporting company , " and " emerging growth company " in Rule 12b - 2 of the Exchange Act . Large accelerated filer Non - accelerated filer Emerging growth company Accelerated filer Smaller reporting company | If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 ( a ) of the Exchange Act . Indicate by check mark whether the Registrant is a shell company ( as defined in Rule 12b - 2 of the Exchange Act ) . YESNO Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404 ( b ) of the Sarbanes - Oxley Act ( 15 U.S.C. 7262 ( b ) ) by the registered public accounting firm that prepared or issued its audit report . The aggregate market value of the common stock held by non - affiliates of the Registrant , based on the closing price of the shares of common stock on July 28 , 2020 as reported by the Nasdaq Global Market on such date was approximately $ 452 million . The Registrant has elected to use July 28 , 2020 , which was the closing date of its initial public offering of common stock , as the calculation date because on May 29 , 2020 ( the last business day of the Registrant's most recently completed second fiscal quarter ) the Registrant was a privately held company . This calculation does not reflect a determination that certain persons are affiliates of the Registrant for any other purpose . As of February 11 , 2021 , the Registrant had 38,907,223 shares of common stock , $ 0.001 par value per share , outstanding . DOCUMENTS INCORPORATED BY REFERENCE Certain sections of the Registrant's definitive Proxy Statement to be filed in connection with the Registrant's 2021 Annual Meeting of Stockholders are incorporated by reference into Part III of this Annual Report on Form 10 - K where indicated . Such definitive Proxy Statement will be filed with the Securities and Exchange Commission pursuant to Regulation 14A within 120 days of the Registrant's fiscal year ended November 30 , 2020 .