Good morning, and welcome to Intellia Therapeutics' Second Quarter 2024 Financial Results Conference Call. My name is Drew, and I will be your conference operator today. Following formal remarks, we will open the call up for a question-and-answer session. This conference is being recorded at the company's request and will be available on the company's website following the end of the call. As a reminder, all participants are currently in listen-only mode. If anyone requires operator assistance during the conference, please press star zero on your telephone keypad. I will now turn the conference over to Ian Karp, Senior Vice President of Investor Relations and Corporate Communications at Intellia. Please proceed. Thank you, operator, and good morning, everyone. Welcome to Intellia Therapeutics' Second Quarter 2024 Earnings Call. Earlier this morning, Intellia issued a press release outlining the company's progress this quarter, as well as topics for discussion on today's call. This release can be found on the Investor and Media section of Intellia's website at intelliatx.com. This call is being broadcast live and a replay will be archived on the company's website. At this time, I'd like to take a minute to remind listeners that during the call, Intellia management may make certain forward-looking statements and ask that you refer to our SEC filings available at sec.gov for discussion of potential risks and uncertainties. All information presented on this call is current as of today, and Intellia undertakes no duty to update this information unless required by law. Joining me from Intellia are John Leonard, Chief Executive Officer, Laura Sepp-Lorenzino, Chief Scientific Officer, Ed Dulac, Chief Financial Officer. Also in the room and available for the Q&A is Liron Walsh, Head of Development for In Vivo Programs. Our Chief Medical Officer, David Lebwohl, is unable to join us today, but he will be participating in upcoming investor conferences. John will begin with updates on our clinical pipeline progress and recent business highlights. Laura will then provide R&D updates, and Ed will review our financials before we open the call for questions. With that, I'll now turn the call over to John, our Chief Executive Officer. Thank you, Ian. Good morning, everyone, and thank you all for joining us today. At Intellia, we're harnessing the power of CRISPR-based gene editing for developing potentially curative treatments. Now, with over 150 patients dosed with our investigational therapies and multiple programs in clinical development, we are undoubtedly at the forefront of the gene editing revolution. We're proud to report another quarter of substantial progress and continued innovation across our full spectrum, pipeline, and platform. I'll start with NTLA-2002 for the treatment of hereditary angioedema, also known as HAE. It is a debilitating and potentially fatal condition that manifests as recurrent episodes of unpredictable swelling. Despite existing treatments, we've heard loud and clear from patients and physicians, and through our market research, that HAE patients are seeking improved efficacy and convenience. Beyond that, patients tell us that what they want most is to live a life free from their disease and the many challenges that come with it, even while on chronic treatments available today. While current and other emerging therapies attempt to differentiate themselves with modest improvements in attack rate reduction or extending dosing intervals for prophylactic therapy, what we are pursuing is a total paradigm shift in the treatment of HAE. Our goal for NTLA-2002 is to provide a complete response, that is, a treatment outcome in which patients are both free from attacks and untethered from the requirements of chronic treatment after a single administration. This is the outcome patients and physicians seek, and with the revolutionary advancement of our gene editing technology, we believe we are making it a reality. In June, we reported positive long-term data from the phase I study of NTLA-2002. Of the 10 patients treated, eight continued to be completely attack-free for 18-26 months following a single administration of the drug. Across all patients, we observed a 98% reduction in attacks through the latest follow-up. Importantly, the data from these 10 patients continue to demonstrate a favorable safety profile. The most frequent adverse events were infusion-related reactions and fatigue, which were mostly grade 1. These unprecedented results reinforce the potential of NTLA-2002 to be a one-time functional cure for this life-threatening disease. Today, we are thrilled to announce that NTLA-2002 met its primary efficacy and all secondary endpoints in the 16-week primary observation period of the phase II study. As a reminder, the ongoing phase II was a randomized, placebo-controlled study to further evaluate the safety and efficacy of the 25 mg and 50 mg doses. The key objective of the phase II was to determine which of the two doses to move forward into the global pivotal phase III trial. The primary efficacy endpoint was the reduction in the number of angioedema attacks per month during the 16-week primary observation period. Key secondary endpoints included safety, the number of angioedema attacks per month during weeks 5- 16, the number of angioedema attacks per month requiring acute therapy, and the change from baseline in the total plasma kallikrein protein level. We plan to present the detailed results at a medical meeting in the fourth quarter of this year. As such, we will be limiting our discussion of the top-line results to what we disclosed in today's press release. A single 25 mg or 50 mg dose of NTLA-2002 led to deep reductions in attacks for patients with HAE. No new safety findings were observed. We have now selected the 50 mg dose to advance into the global phase III trial because we saw a greater kallikrein reduction and importantly, a higher number of patients who achieved complete elimination of attacks compared to the 25 mg dose cohort, which is consistent with the prior phase I results. In addition to the positive results, we recently completed a successful end of phase II meeting with the FDA. We believe we have completed addressing their questions and have a clear understanding of the path forward. We are on track to begin the phase III trial in the second half of this year, and if positive, plan to submit the BLA for NTLA-2002 in 2026. We anticipate that NTLA-2002 will be the first in vivo gene editing therapy to come to market, and most importantly, we strongly believe it will reset the standard of care for HAE. Switching now to NTLA-2001 for the treatment of ATTR amyloidosis. The drug now has a new name, nexiguran ziclumeran, or nex-z for short. Recent competitor data confirmed our long-standing hypothesis that TTR reduction leads to a clinically meaningful improvement in patients with cardiomyopathy. This is an important advancement in the field's understanding of the disease, and this result further increases our confidence that nex-z could lead to even better clinical outcomes for patients. Our belief is based on the consistently deep and durable TTR reductions observed in the phase I study. Further, the competitor clinical data recently reported reaffirmed that the ongoing magnitude trial is well designed. As appropriate, we will incorporate additional learnings into our trial as they become available. The rapid enrollment of the magnitude trial continues to track well ahead of our internal projections. In addition to the significant physician and patient interest in the trial, we're also progressing well with global regulatory approvals for the study. In total, we've now received regulatory clearance in over a dozen countries and are actively enrolling at over 35 sites around the world. Building on our significant progress in cardiomyopathy, we are on track to initiate the pivotal trial for polyneuropathy by year-end. As previously announced, the study is expected to be a small, placebo-controlled trial of approximately 50 patients conducted in ex-U.S. regions with limited or no access to TTR silencers. Finally, we look forward to presenting data from the ongoing phase I study in the second half of 2024. We plan to include safety and TTR reduction data from both the CM and PN arms, as well as other clinical endpoints such as NT-proBNP, 6-minute walk test, and mNIS+7. We anticipate these data will build upon insights recently reported in other TTR silencer clinical trials. With three pivotal phase III trials and our first gene insertion study, all expected to be active by year-end, Intellia is closer than ever to transforming the future of medicine with our 1-time in vivo gene editing therapies. In parallel to our clinical execution, we're making strategic investments for our exciting evolution from late-stage clinical development to a commercial organization. This is exemplified by the recent appointment of Brian Goff to our board of directors and Ed Dulac as Chief Financial Officer and Treasurer. Brian's extensive global commercialization experience, coupled with his track record of success leading rare disease product launches, will be invaluable. Similarly, Ed's deep financial and business development experience at clinical and commercial stage biotech companies will be critical as we enter the next chapter in our evolution. I'll now hand the call over to Laura, our Chief Scientific Officer, who will provide updates on the NTLA-3001 program and our R&D efforts. Thank you, John. Good morning, everyone. At Intellia, we're deploying the industry's broadest toolbox of novel gene editing and delivery technologies for in vivo and ex vivo therapeutic applications. Let me begin with NTLA-3001. As we announced last week, we received regulatory approval from the United Kingdom's Medicine and Healthcare Products Regulatory Agency to initiate the first-in-human study in patients with alpha-1 antitrypsin deficiency associated lung disease. Following the IND clearance of Regeneron's Factor IX program, this marks the second program leveraging our modular gene insertion platform set to enter the clinic, another accomplishment from our industry-leading research engine. Unlike traditional gene therapy, we expect our approach will permanently restore a missing or defective protein without a waning effect over time. As a reminder, NTLA-3001 is designed to precisely insert the wild type SERPINA1 gene to permanently restore production and secretion of fully functional alpha-1 protein. Our goal is to replicate what we demonstrated in non-human primates, to restore patients to normal alpha-1 levels after a single dose. The phase I/II study will be a two-part, open-label, multicenter study to evaluate the safety, tolerability, PK, and PD of NTLA-3001. Up to 30 patients will enroll. Phase I will be a single ascending dose design with up to three cohorts. Patients will receive a single infusion of NTLA-3001, which consists of a sequential dose of AAV and LNP. The AAV delivers a certain A1 DNA template, and the LNP delivers the CRISPR machinery. Based on our learnings from NTLA-2001 and NTLA-2002, we will be evaluating a fixed LNP dose of 50 mg. The only variable component from cohort to cohort in the dose escalation will be the dose of AAV. We will begin with doses of AAV that we expect will show some level of activity even in the first cohort. Once we've identified the optimal dose, we plan to move into the phase II, which will be a single dose expansion cohort to further characterize the activity of NTLA-3001. We are on track to dose the first patient in the second half of this year. Assuming success, NTLA-3001 could redefine how alpha-1 is treated and unlock a whole new category of diseases we can pursue with our in vivo gene insertion platform. Turning to another exciting development with our in vivo platform, in June, Intellia achieved yet another landmark milestone for the field of gene editing. We presented the first-ever clinical data demonstrating that redosing with CRISPR when utilizing Intellia's LNP-based delivery platform, enable an additive pharmacodynamic effect. Critically, the follow-on dose was generally well tolerated. Overall, the safety and pharmacodynamics of redosing with NTLA-2001 were consistent with dose observed after a single dose. The ability to successfully redose these patients is a testament to our high standard in developing our proprietary LNP formulation to ensure both safety and activity. Going forward, while not planned for our current clinical programs, the option to redose could be an important advantage for Intellia as we continue to push the boundaries of what we can do and expand where we can go outside the liver with CRISPR-based technology. We look forward to updating you on our progress across our R&D platform more broadly this year. I'll now hand over the call to Ed, our Chief Financial Officer, who will provide an update on our financial results as of second quarter 2024. Thank you, Laura. Good morning, everyone. Intellia continues to maintain a strong balance sheet that allows us to execute on our pipeline and platform. Our cash, cash equivalents, and marketable securities were approximately $939.9 million as of June 30, 2024, compared to $1 billion as of December 31, 2023. The decrease was driven by cash used to fund operations of approximately $234.4 million. The decrease was offset in part by $96.4 million of net equity proceeds from the company's at-the-market program, $35.9 million of collaborator reimbursements, including a one-time $30 million payment received in April related to the company's technology collaboration with Regeneron, $25.1 million of interest income, and $4.8 million in proceeds from employee-based stock plans. Our collaboration revenue was $7 million during the second quarter of 2024, compared to $13.6 million during the second quarter of 2023. The $6.6 million decrease was mainly driven by a reduction in revenue related to the AvenCell license and collaboration agreement. R&D expenses were $114.2 million during the second quarter of 2024, compared to $115.3 million during the second quarter of 2023. The $1.1 million decrease was primarily driven by a decrease in employee-related expenses. Stock-based compensation, including an R&D expense, was $25.4 million for the second quarter of 2024. G&A expenses were $31.8 million during the second quarter of 2024, compared to $30.7 million during the second quarter of 2023. The $1.1 million increase was primarily related to stock-based compensation. Stock-based compensation included in G&A expense was $15.4 million for the second quarter of 2024. Finally, we expect our cash balance to fund our operating plans into late 2026. Thanks, Ed. In conclusion, Intellia continues to deliver on the promise of gene editing, and we are looking forward to several important clinical milestones in the second half of this year. With that, we'll now open the call for your questions. To do our best to address as many questions as possible, we will only be able to take one question per caller. Operator, you may now open the call for Q&A. We will now begin the question-and-answer session. To ask a question, you may press star then one on your touchtone phone. If you are using a speakerphone, please pick up your handset before pressing the keys. To withdraw your question, please press star then two. Please limit yourself to one question. At this time, we will pause momentarily to assemble our roster. The first question comes from Terence Flynn with Morgan Stanley. Please go ahead. Hi, thank you for taking our questions. This is Chris on for Terence, and congratulations on the progress. Regarding the HAE phase II data, can you talk about how competitive it is against Ionis drug? Thank you. Thanks, Chris. As we said in our earlier comments, we're very excited about the profile of NTLA-2002. The way we're approaching the disease is we're trying to reset what is the current therapeutic regimen that's available to patients. And that starts with having a deep understanding what patients are actually looking for. They're not looking for minor improvements in prophylactic therapy. They're not looking for primarily extensions in dosing intervals. What they're looking for is to be as normal as possible, and that means not having to take any medicines. So as we look at HAE and its development, that is the profile we're looking for, a single dose that leads to a complete elimination of attacks, and patients no longer to take any medication at all. That is the profile we're shooting for. That's what we've seen in our early phase I program, and as information becomes available for our phase II program, you'll be able to see for yourself in terms of our ability to achieve that profile. We think we're resetting the bar, and with that, in an entirely new category of responses for patients, we think the drug will be without equal. Great. Thank you. The next question comes from Mary Kate Davis with Bank of America. Please go ahead. Good morning. Thank you for taking our question. Looking at the AATD program here, could you comment on how impactful the whole insertional program could be for the current market, given unmet need in the space? Thank you. Well, our assessment of alpha-1 antitrypsin deficiency therapies, as they currently exist, is that it's almost a complete absence of effective therapy. So our view is that it's essentially wide open in terms of resetting the bar. Remember what we're trying to do. We're trying to have the production of a fully normal protein that is the wild type alpha-1 antitrypsin deficiency, or sorry, alpha-1 antitrypsin protein that has normal activity. That doesn't exist yet today. And so we view this very large market as one that, one that we can be very, very successful in, and we're very excited about beginning a clinical program with NTLA-3001. The next question comes from Dae Gon Ha with Stifel. Please go ahead. Hey, good morning, guys. Thanks for taking our question as well. I'll also stick with AAT. Maybe a question for Laura. As we think about the 3001, specifically on the AAV component, I guess, can you speak to what your learnings are or what your derivations are from the Astellas, Audentes' experience when it comes to AAV8 and how that gets factored into your dose? And specifically, can you also talk about sort of the biology behind wild type AAT and still having ZAAT production, whether the ZAAT lingering might have some pro-inflammatory effects on the lung pathology? Thanks so much. So, Laura, do you want to take that and start with some of the dosing differences with this dose? Yeah, sure Yes. So Dae Gon, thank you for the question. So, you know, here we're using the AAV to deliver the template for insertion. So it's, you know, quite a different approach when we're using traditional gene therapy, where you need to load the cells with episomes to ensure that you have, you know, long duration of effect. So, you know, given that, our doses are much, much lower, not only than what Audentes, you know, has used, but what, you know, others have used, including for, you know, liver-directed diseases, you know, using AAV8. So again, you know, the thing is we need to have enough template to have insertion in a few percentage of hepatocytes that's going to drive the levels of alpha-1 that we believe are going to be fully therapeutic. Based on our, you know, data and, you know, not all the patients who have alpha-1 antitrypsin deficiency have liver disease, right? That's a minority of the patients. So we don't expect any issue by, you know, having expressing the wild type protein in patients who have, you know, the Z allele. John, anything you would like to add? No, I think that speaks to it. Thank you, Laura. The next question comes from Joseph Thome with TD Cowen. Please go ahead. Hi there. Good morning, and thank you for taking my question. Maybe one quickly on the 2001 PN proposed study. I think you indicated that it would be ex-U.S., which obviously makes sense given the availability of silencers. But do you think the FDA would like to see dosing of any U.S. patients prior to an approval in this setting? Or do you think ex-U.S. patients for the entire program would be sufficient? Would you do, like, an open label extension or anything like that? Thank you. Thanks for the question, Joe. We've reviewed this extensively with the FDA. We have a very good understanding, excuse me, of what they're looking for. We have agreement and alignment on how we're conducting the study outside the United States. They're not requiring patients to be dosed in that particular indication inside the United States. Remember that they're gonna see many other patients that will come from our cardiomyopathy study, where already we're enrolling patients in the United States, so they'll see a very extensive prior exposure to the drug. Perfect. Thank you. The next question comes from Luca Issi with RBC. Please go ahead. Oh, great. Thanks so much for taking my question. Congrats on the progress. Maybe, Laura, one more here on alpha-1. Obviously, the competitive landscape continues to evolve. Obviously, Vertex giving up on their approach, but we are seeing a lot of other innovations coming down the pipe, including, I think we're gonna see clinical data for the first time for ADAR and RNA editing toward the end of the year. Wondering if you can just kind of compare and contrast that approach versus your approach and why you think your approach is better. Any thoughts there are much appreciated. Thanks so much. Thank you for the question. Look, based on the preclinical data that we have seen, right? We believe that with SERPINA1, we have demonstrated, you know, in non-human primates, the ability to Intellia Therapeutics, not just 11 micromolar, right? But, you know, the full normal dose. And I think that that's, if we can translate that to humans, that's going to be differentiated. And because of the mechanism of action, right, this is going to be potentially one and done, right? So you're looking for a single solution that will achieve normal levels. Of course, there is other modalities that are being advanced. At the end of the day, the proof of the pudding will be in the clinic, so I'll await the clinical data. Thanks so much. The next question comes from Gena Wang with Barclays. Please go ahead. Thank you. I will ask one question regarding the HAE program. What is the status of the partial clinical hold in HAE for the women of reproductive age and also for the phase II HAE full data? I assume you will be presenting at the medical conference, you know, is the ACAAI in Boston a good venue for the full data? Thanks, Gena. As soon as we're in a position to share where we're presenting the data, we will, of course, do that as we've always done, and we look forward to seeing you in the audience as we go through what we think is very exciting data. With respect to the women of childbearing potential, I just want to clear up one thing. There was no partial clinical hold. That's, that's not correct. As we said, we've addressed all of the issues with the FDA. We have complete alignment with respect to the phase III study, and we will be including women of childbearing potential, not only in the United States, but around the world, as we've been doing up until now, with the exception of the United States. So we look very, very much forward to beginning that trial and collecting results in the full population. I would add that beyond just women of childbearing potential, the goal of that trial is to be very expansive and to include the largest set of patients with different degrees of the illness to begin with, so we can have a very expansive label when we're done. Thank you. The next question comes from Maury Raycroft with Jefferies. Please go ahead. Hi, congrats on the update, and thanks for taking my question. I'm wondering if there's more you can say on feedback from the HAE and the phase II meeting and your latest thoughts on the pivotal trials design. And in particular, I'm wondering how big this study would need to be and if there's anything more you could say about effect size or placebo response expectations. Thanks, Maury. I guess I would characterize the FDA meeting as profoundly successful. We presented, as they've seen earlier, preclinical data. We've shared our manufacturing approach, and they've seen the clinical data from not only the phase I but the phase II program. The key decision there was to decide on which dose to take into phase III. We've done that, and as we shared here, that will be the 50 mg dose, and as per the prior question from Gena, we will expose the full population with, of people with the disease, to the drug. So we're very, very excited about that. We now know the size of the trial, and we expect that this will be fewer than 70 patients. It will be a placebo-controlled trial, as is the standard. We'll look for a variety of different outcomes, not only attack rate reduction, but of course, the number of patients who achieve that complete response that we think is so fundamental to the profile of the drug. And these things will be measured over a six-month interval as opposed to the 16 weeks that we've done in phase I and phase II. Again, just to make the point, we're on track to begin this before the end of the year, and we're very, very excited about advancing this program because we believe it will be the very first in vivo approved agent for any CRISPR program. Got it. Thank you. Sure. The next question comes from Mani Foroohar with Leerink. Please go ahead. Hey, thanks for taking the question. I know you have been more reticent than others to use the phrase functional cure, which is realistically what we're talking about for HAE, if you're gonna take patients off all therapy. The competitor program from Ionis, which is a chronic therapy, so not pursuing a curative and functional cure, has a number of studies. They had to do a switch study, et cetera. They chose to do a switch study. When you think about the path to commercialization for what's meant to be a one-time functionally curative therapy for at least some, if not the majority of patients, how do you think about providing data for patients to switch, for patients moving off of prophylactic therapy, discontinuing, you know, the practice of keeping on-demand therapy on them, et cetera? Will there be a couple of other more broadly, will there be a couple of other studies as part of your larger strategy to inform physicians on how to roll patients off therapy? Or do you think you can take advantage of data sets produced by others in terms of providing the operational input of how physicians move off, move patients off of current polypharmacy to your therapy and eventually nothing on top of it? That may have been six questions, Mani, and I don't know if I can speak to all of them, but let me try to give some perspective on what I think you're getting at. First of all, you know, we're being very judicious with the words that we use to describe the outcomes for these patients. You know, you yourself are calling it a functional cure. We think that that's something that we're achieving with these patients. What we'll be able to say from a regulatory point of view remains to be determined as we work with the Food and Drug Administration, but the evidence will speak for itself. Again, the goal is to have patients following a single application of drug no longer take therapy, and you can decide what you want to call that. With respect to moving forward with the agent into the marketplace, we expect that there will be a set of patients immediately who want to have access to the drug, and these are patients who are not responding well to existing therapy of whatever form. Doctors tell us and patients tell us that they look very much forward to having the drug available to them. Then there's a set of patients who have responses that are incomplete, have a propensity to switch, and the mechanism by which that plays out is something that we'll learn with the investigators and our key opinion leaders as we work with them. We may be in a position to do a switch study that's not currently laid out, but as we complete our thinking and get more information, as we work with leaders in the field, we'll get back to you and the larger community and talk about the way forward there. Either way, we believe that the drug will be extremely successful in the marketplace, given a profile that is unmatched. The next question comes from Joon Lee with Truist Securities. Please go ahead. Hi. Good morning, everyone. This is Mehdi on for June. Congrats on the progress, and thanks for taking our question. So on NTLA-2001, given acoramidis now has a PDUFA date of November 19th and shows 50% CVH reduction with 81% survival. So what do you expect to be, you know, the outcome of 2001 in this regard? Basically, what do you think is the bar now for phase III magnitude study? Well, we, based on the TTR results that we presented in multiple forums, which are the deepest that have been reported and the most prolonged that have been reported, we expect that we'll be able to meet or achieve any profile that's been put forward by any of the other competitive agents, whether a stabilizer or a silencer. We've designed a phase III trial that is designed to demonstrate that, and we have looked at patients with, you know, a range of different degrees of stability from their cardiomyopathy. And we think that that patient population, whether on existing therapy or on monotherapy with 2001, will have outcomes that are superior to what's been reported to any of the other agents. So stay tuned. The pro. As we said in our comments earlier, there's a lot of enthusiasm in the marketplace with investigators and patients now essentially around the world coming into the study very, very quickly, well above our own expected accrual rate. So we're excited, and as we get that information down the road, obviously we'll share it, and I'm sure it will be much watched. So we'll proceed as quickly as we can. Thank you. The next question comes from Kostas Biliouris with BMO Capital Markets. Please go ahead. Hi, this is Theo for Kostas. Thank you for taking our question. Just one question from us: So on the Intellia 3001 program, how do you think about the competition for patient enrollment, given that Beam and also other RNA editing companies are also recruiting in the United Kingdom? Thank you. Thanks for the question. We work with investigators who know the patients they have, and we're quite confident that certainly in a phase one setting, not only in the U.K., but other countries where we will have sites, including New Zealand and Ireland, that we'll be in a position to recruit the study expeditiously and look for the results that tell us how the drug is performing. We don't see this being a competitive situation. The next question comes from Rick Bienkowski with Cantor Fitzgerald. Please go ahead. Hey, good morning, and congrats on the update in HAE. So one of the observations from the phase I data was there was a small number of breakthrough attacks during the primary observation period and then complete suppression of attacks afterwards. So for the full phase II presentation later this year, will we see any follow-up for patients that's longer than the primary observation period? And could you just discuss if there are any plans to follow these patients for longer term and maybe present those data at a later date? We'll present data through the 16-week observation period. Remember that there's a couple differences in the phase II from the phase I. In the case of the phase II study, there are two different doses, but a placebo arm as well. And what we offered all patients in the study was a switch, so we're not gonna be in a position to look at, you know, ongoing placebo patients over time. We will follow all of these patients as we've done with every single one of the patients that we've dosed, irrespective of the program, and I would expect that down the road, at the appropriate times, we'll present follow-up information on every single one of the patients that we've treated thus far. The next question comes from Jay Olson with Oppenheimer. Please go ahead. Oh, hey, congrats on all the progress, and thanks for taking the question. For 2001, can you talk about the number of study sites you plan to activate for the magnitude study? And how could that be impacted by other competing trials that are wrapping up? And then what you'll be looking for in the Helios-B results when they're reported at ESC. Thank you. Sure. Thank you for the question. We anticipate around 100 or so sites, spread around the world with a variety of different company or countries participating. As we said in our comments, there's about 12 so far that have given the regulatory approval to begin enrolling, and that number will increase in the coming weeks. About 35 of the overall 100+ sites are now active, and so we expect to see enrollment actually even accelerating beyond our strong start already. As we put the study together and thought about where and how we were doing the study, we were cognizant of what was going on around the world, and we were very thoughtful about which sites to participate and which countries to carry out the work in. And thus far, you know, with the accumulated experience over the last few months, we don't see that we're really in a different competitive situation from the one that we surmised. In fact, as I said, we're ahead of our expectations, and we continue. We expect that to continue to be the case as time goes on. The next question comes from Brian Cheng with JP Morgan. Please go ahead. Hey, guys. Thanks for taking our questions this morning. Just on the back of your recently reported redosing data, is there any plan to build in redosing for those patients that didn't achieve, perhaps a certain biomarker reduction threshold, if it happens, in the next set of studies for TTR polyneuropathy, HAE, or AATD? Thanks for taking our questions. Thanks for the question, Brian. One of the things that I think is really noteworthy of all of the patients that we've treated thus far, certainly those that have been treated at the doses that we deem to be therapeutic, is that almost without exception, every single patient has achieved the level of reductions that we're looking for. Which is a remarkable outcome that I think is sometimes lost, when, particularly when you look across other drugs and the variability that you see with not only the pharmacokinetic outcome, but pharmacodynamic outcome. I mean, what we're seeing here is quite unique. The way I would think about redosing is that it doesn't apply to the amyloidosis program. It doesn't apply, we don't think, to the alpha-1 program or HAE. But there may be instances where, in certain situations, if the level of editing is lower than what we're shooting for, you may want to walk up to a particular effect. And I can think of instances outside the liver where that might be the case, but that doesn't apply to any program that we're currently doing. And, for all practical purposes, we think every one of the patients participating in the ongoing studies will be a one-and-done case. The next question comes from Steve Seedhouse with Raymond James. Please go ahead. Hi, this is Timur Ivannikov for Steve. For AATD lung disease, historically, it's been difficult to show improvements in FEV1 and pulmonary exacerbations. So do you think the FDA will require showing improvements on those endpoints, besides just showing the reduction in neutrophil elastase activity? It's an evolving space, and, as far as we can determine in our interactions, as well as talking to, experts in the space, is that the FDA is likely to approach this as a function of the degree of normality that's achieved. If patients achieve normal levels of the protein, the requirements we expect for functional aspects of that may be different from those instances in which either an abnormal protein or less than a complete normalization of effect is achieved, because in those cases, you're going to need supplementary information to indicate that, that less than a complete response is actually beneficial to the patient. That's why we want to normalize patients. We think that the best we can do is put them in a position as if they never had the disease in the first place, and that's the objective for the program. Thank you. The next question comes from Silvan Türkcan with Citizens JMP. Please go ahead. Hey, good morning, and thanks so much for taking my question, and congrats on the data update. Just about the open label trial, the phase I in HAE, the long-term attack rate post the most recent presentation. I don't know if you can comment on it, but do you still have eight out of 10 patients with no attacks post the observation period? Thank you for the question, Silvan. I would say watch for updates as they come. As we said to one of the earlier questions, we'll follow all of these patients, and as we collect the information, we'll share it. We continue to be very, very excited about what we see and how these patients are performing after their single dose of 2002. Great. Thank you so much. Looking forward to the data. Thank you. The next question comes from William Pickering with Bernstein. Please go ahead. Hi, good morning. Congrats on all the progress, and thank you for taking my question. Now that it looks increasingly likely that a silencer will become available during your magnitude trial and potentially even before enrollment completes, can you speak to your assumptions on silencer drop-in rate? Is there a cap, and can you just confirm that patients who are already on a silencer would not be eligible to enroll? Thank you. We will look at the data as it becomes available from Helios-B, which we're very interested in confirming some of the assumptions that we have in terms of the design of our trial. And as that study becomes available and our own study evolves, we'll address what we think may be appropriate, if at all, for any drop-ins for patients on silencers. So, stay tuned. But as it stands now, those drugs are not available, and we've made provisions for tafamidis use, which is integral to the study as well as monotherapy. So, the story will evolve, and as it changes, we will adapt as necessary. Thank you. The next question comes from Salveen Richter with Goldman Sachs. Please go ahead. Hi, this is Lydia on for Salveen. Thanks so much for taking our question. Just a quick one from us on ATTR cardiomyopathy, just with regard to the enrollment progression for the MAGNITUDE trial. I think that last quarter you said that there were 30 patients enrolled. Could you just provide an updated figure here, and then when you expect to complete enrollment? Thanks so much. Thank you for the question. What we won't be doing is giving updates on a quarterly basis. We shared that information because it was the first time we had reported after we began the study, and we wanted people to see the very strong start in enrollment, which, as I said, continues to be above our expectations. Again, we have more than 35 sites up and running in 12 countries. That will continue to expand in the weeks that lie ahead. In terms of the complete enrollment, I would encourage you to look at proxies for the work that we've done, and the Helios study would be, I think, a good place to look in terms of overall rate of enrollment, but of course, our objective is to improve upon that. The next question comes from Myles Minter with William Blair. Please go ahead. Hey, thanks for taking the question. Just on Alpha -1, just curious what your definition of normal AAT levels are, 'cause there's a wide range, I think 20-53 micromolar, and if that range will be achievable with your initial 50 mg dose that you're going with. And final question is just on the risk of albumin reduction, just with the fact that you're inserting into the albumin locus and if that's gonna be material or not. Thanks very much. We'll turn to Laura, who can speak to what we're shooting for in terms of normal. But just one thing you said, you referred to the 50 mg dose. We will be holding the LNP dose constant in our phase I study in varying the AAV dose, which again, is at levels that are significantly below what's typical for gene therapy, at least in recent examples. Maybe Laura, you can speak to? Yeah. Right. So, so normal levels, right, and what you quoted is right. Right? So they vary from 20- 50, and that's the goal that we want to achieve, right? In the monkeys, we were in the, you know, 20s to, so that's what we, you know, expect we're going to be able to achieve in humans. With regards to albumin, that was obviously extensively evaluated in our GLP toxicology studies, and, you know, we do not see a decrease in albumin expression that in any way could put patients in danger. So we believe that, again, the doses that we're going to be investigating, even the first dose, we expect we designed the trial for even the first dose to have lead to alpha one levels that will be therapeutically relevant. Then, we expect that the safety of the approach 31 will be, you know, pristine. Thank you. The next question comes from Liisa Bayko with Evercore ISI. Please go ahead. Hi, this is June for Liisa. Thanks so much for taking our questions, and congrats on the progress. So, we just have a question for phase III MAGNITUDE study. What method do you plan to use for analysis of the composite endpoint? Something like Finkelstein or Anderson Gill, like, in Helios-B. Thank you. Thanks for the question. Those are details that lie ahead, and we'll disclose at the appropriate time, but we appreciate your interest. All right, thank you. The next question comes from Ry Forseth with Guggenheim. Please go ahead. Hey, this is Rai from the Debjit team. Across HAE, ATTR-PN, and CM, what's your contemporary internal market research suggesting for uptake or enthusiasm to switch for gene editing? Is there any notable interindication differences that you've seen? Those are very different diseases, cardiomyopathy and hereditary angioedema. In the case of cardiomyopathy and polyneuropathy, those are progressive diseases. HAE is episodic in nature, and any one episode can be a fatal event. What our market research tells us is that, as we said in earlier comments, patients with HAE want to be normal. They're otherwise, in most cases, between attacks, normal, and they want to have that in all every day of their life, as much as possible. So, ranging from patients who have poorly controlled disease to patients who want to improve how they live their lives, which is most of the patients taking the drug, what our market research tells us is that 2002 will be very, very attractive to the preponderance of patients suffering for HAE. In the case of amyloidosis, whether polyneuropathy or cardiomyopathy, these are progressive diseases with patients getting worse and worse and ultimately succumbing to their disease. The objective here is for us to demonstrate not only stopping the progression of the disease, but we believe that in several instances, perhaps many of the cases will actually have some degree of reversal. As the year goes on, I would encourage you to look at the phase one results that we'll be presenting, in which patients have been followed now for a couple of years. And we think that that may be indicative of what lies ahead. So, in the end, patients want the best drugs available for whatever disease they suffer from, and it's our goal at Intellia to meet that need. Thank you. The next question comes from David Lebowitz with Citi. Please go ahead. Thank you very much for taking my question. Certainly understanding that you can't speak directly to anything with the MAGNITUDE trial and the potential adaptations. But could you indicate what specific items are most interesting to you in the upcoming Helios-B detailed readout at the ESC? What things you're focusing on and how, I guess, that might inform further aspects of design of the magnitude trial? Sure, David, it's an important question, and we and many others, I think, will be very interested in learning more details about what we think are exciting and initial results. What's of great interest to us and the field in general is some relationship between the level of TTR reduction and overall event rates and how that plays out in particular patient populations. That's a function of the stage of their disease. Patients who are early in the disease have a slower rate of events taking place, and how that plays out in patients with more severe disease will be of great interest to us. Remember that when we constructed our trial, we included patients who have been excluded in many of the other studies that have been done. We're allowing, in fact, requiring higher levels of proBNP at baseline, as well as allowing patients with Class III heart disease. We will be very interested in understanding the nature and the extent of the effect in patients receiving drug on top of tafamidis, and that will be something that we consider with our own study as it proceeds. Remember that we designed the study in a way that if we need to adapt it based on what we learn, we can adapt it, and because we're early in enrollment here, we think that we're in a really strong position to come up with what we think will be the strongest study in the space. Thank you for taking my question. Our last question will come from Andy Chen with Wolfe Research. Please go ahead. Hi, this is Brandon on for Andy. Congrats on the phase II success and move to phase III. Based on our understanding, the HAE market is somewhat saturated. Although there's still a chunk of patients who have not signed up for prophylactic treatments, your competitors don't seem to be activating those patients. So all of your competitors are competing for the same pie right now. Do you think gene editing could expand the pie of prophylactic treatment? In a word, yes. And with respect to saturation, I would be careful in terms of how I think what that means. The presence of therapy does not mean that the therapy is ideal. And again, as we look to our market research, and this involves extensive discussions with leading investigators in the space, multiple patient interviews, if you ask patients, most of them want to be normal, and that means never having to take any of those drugs that currently saturate the market that you referred to. It is our objective to meet that need, and we think that we'll be able to normalize the vast preponderance of patients with this disease. This concludes our question and answer session. I would like to turn the conference back over to Ian Karp for any closing remarks. Great. Thanks so much, Drew, and thank you everyone for joining us and for your continued interest in Intellia. I'd also like to give a special thanks for everyone's discipline in asking one question today, because I think it's, this may be the first time in a while that we've gotten through everyone's questions. So, we look forward to continued updates as the year continues. And with that, we wish everyone a great rest of the summer. The conference has ended. You may now disconnect your line. Thank you.