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Table of Contents ( Mark One ) ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31 , 2020 OR TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from Commission file number : 001-37478 ☐ UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON , D.C. 20549 FORM 10 - K Delaware State or Other Jurisdiction of Incorporation or Organization 13011 McCallen Pass Building A Suite 100 Austin , TX ( Address of Principal Executive Offices ) Large accelerated filer Non - accelerated filer Title of each class Common Stock , par value $ 0.0001 per share NATERA , INC . ( Exact Name of Registrant as Specified in its Charter ) to ( 650 ) 249-9090 Registrant's Telephone Number , Including Area Code X Trading Symbol Securities registered pursuant to Section 12 ( b ) of the Act : 01-0894487 ( I.R.S. Employer Identification No. ) 78753 ( Zip Code ) NTRA Securities registered pursuant to Section 12 ( g ) of the Act : None Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . Yes > No Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Securities Act . Yes No Indicate by check mark whether the registrant : ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . Yes No □ Name of each exchange on which registered The Nasdaq Stock Market LLC ( NASDAQ Global Select Market ) Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( §232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) . Yes No Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , a smaller reporting company or an emerging growth company . See the definitions of " large accelerated filer , " " accelerated filer , " " smaller reporting company " and " emerging growth company " in Rule 12b - 2 of the Exchange Act .: Accelerated filer Smaller reporting company Emerging growth company 0 0 ☐ If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 ( a ) of the Exchange Act . Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404 ( b ) of the Sarbanes - Oxley Act ( 15 U.S.C. 7262 ( b ) ) by the registered public accounting firm that prepared or issued its audit report . Indicate by check mark whether the registrant is a shell company ( as defined in Rule 12b - 2 of the Exchange Act ) . Yes No 区 The aggregate market value of the voting and non - voting common equity held by non - affiliates of the registrant was approximately $ 3.51 billion based on the last reported sale price of $ 47.55 per share as reported on the Nasdaq Global Select Market on June 30 , 2020 , the last trading day of the most recently completed second fiscal quarter . As of February 19 , 2021 , the number of outstanding shares of the registrant's common stock , par value $ 0.0001 per share , was 86,574,688 . DOCUMENTS INCORPORATED BY REFERENCE Information required in response to Part III of this annual report on Form 10 - K is hereby incorporated by reference to portions of the Registrant's proxy statement for its Annual Meeting of Stockholders to be held in 2021. The proxy statement will be filed by the registrant with the Securities and Exchange Commission within 120 days after the end of the registrant's fiscal year ended December 31 , 2020 .