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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 Form 10 - K ( Mark One ) ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31 , 2020 OR TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from ☐ to NUVASIVE , INC . ( Exact name of registrant as specified in its charter ) Delaware ( State or other jurisdiction of incorporation or organization ) 7475 Lusk Boulevard San Diego , California ( Address of principal executive offices ) Commission file number : 000-50744 ( 858 ) 909-1800 ( Registrant's telephone number , including area code ) Securities registered pursuant to Section 12 ( b ) of the Act : Title of each class Common Stock , par value $ 0.001 per share Trading Symbol ( s ) NUVA 33-0768598 ( I.R.S. Employer Identification No. ) 92121 ( Zip Code ) Name of each exchange on which registered The Nasdaq Stock Market LLC ( Nasdaq Global Select Market ) Securities registered pursuant to Section 12 ( g ) of the Act : None Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . YES Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Act . YES Indicate by check mark whether the registrant ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period than the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . YES NO □ NO NO Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( Section 232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) . YES NO Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , smaller reporting company , or an emerging growth company . See the definitions of " large accelerated filer , " " accelerated filer , " a " smaller reporting company , " and " emerging growth company " in Rule 12b - 2 of the Exchange Act . Large accelerated filer ✓ Accelerated filer Non - accelerated filer Smaller reporting company Emerging growth company If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 ( a ) of the Exchange Act . Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404 ( b ) of the Sarbanes Oxley Act ( 15 U.S.C. 7262 ( b ) ) by the registered public accounting firm that prepared or issued its audit report . Indicate by check mark whether the registrant is a shell company ( as defined in Rule 12b - 2 of the Act ) . YES NO The aggregate market value of the voting and non - voting common equity held by non - affiliates of the registrant was approximately $ 2.8 billion as of the last business day of the registrant's most recently completed second fiscal quarter ( June 30 , 2020 ) , based upon the closing sale price for the registrant's common stock on that day as reported by the Nasdaq Global Select Market . Shares of common stock held by each officer and director on June 30 , 2020 have been excluded in that such persons may be deemed to be affiliates . As of February 23 , 2021 , there were 51,379,052 shares of the registrant's common stock issued and outstanding . DOCUMENTS INCORPORATED BY REFERENCE Part III of this Form 10 - K incorporates information by reference to portions of the definitive Proxy Statement for the registrant's 2021 Annual Meeting of Stockholders , which will be filed with the U.S. Securities and Exchange Commission not- later than 120 days after December 31 , 2020 .