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O UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 FORM 20 - F REGISTRATION STATEMENT PURSUANT TO SECTION 12 ( b ) OR ( g ) OF THE SECURITIES EXCHANGE ACT OF 1934 OR X ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 ° о For fiscal year ended December 31 , 2020 OR TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to OR SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of event requiring this shell company report : Commission file number : 001-38512 ONCOLYTICS BIOTECH INC . ( Exact name of Registrant as specified in its charter ) Province of Alberta , Canada ( Jurisdiction of incorporation or organization ) Suite 210 , 1167 Kensington Crescent , N.W. Calgary , Alberta , T2N 1X7 ( Address of principal executive offices ) Kirk Look Suite 210 , 1167 Kensington Crescent , N.W. Calgary , Alberta , T2N 1X7 Tel : ( 403 ) 670-7377 E - mail : info@oncolytics.ca ( Name , Telephone , E - mail and / or Facsimile number and Address of Company Contact Person ) Securities registered pursuant to Section 12 ( b ) of the Act : Title of each class Common Shares , no par value Trading Symbol ONCY Name of each exchange on which registered Nasdaq Capital Market Securities registered pursuant to Section 12 ( g ) of the Act : None Securities for which there is a reporting obligation pursuant to Section 15 ( d ) of the Act : None Indicate the number of outstanding shares of each of the Registrant's classes of capital or common stock as of the close of the period covered by the annual report : 46,166,980 common shares as at December 31 , 2020 Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . Yes o No ý If this report is an annual or transition report , indicate by check mark if the Registrant is not required to file reports pursuant to Section 13 or 15 ( d ) of the Securities Exchange Act of 1934. Yes o No ý Indicate by check mark whether the Registrant ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . Yes ý No o