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Table of Contents ( Mark One ) UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON , DC 20549 ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 FORM 10 - K TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 " For the fiscal year ended December 31 , 2020 . OR For the transition period from Delaware ( State or Other Jurisdiction of Incorporation or Organization ) Title of Each Class Common Stock , $ .01 par value per share OPKO Health , Inc. ( Exact Name of Registrant as Specified in Its Charter ) Commission file number 001-33528 4400 Biscayne Blvd. Miami , FL 33137 to ( Address of Principal Executive Offices ) ( Zip Code ) ( 305 ) 575-4100 ( Registrant's Telephone Number , Including Area Code ) Securities registered pursuant to section 12 ( b ) of the Act : Trading Symbol OPK 75-2402409 ( I.R.S. Employer Identification No. ) None Name of Each Exchange on Which Registered NASDAQ Global Select Market Securities registered pursuant to section 12 ( g ) of the Act : Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . Yes y No Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Act . Yes No ý