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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 FORM 10 - K Annual Report Pursuant to Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 For the fiscal year ended December 31 , 2020 OR Transition Report Pursuant to Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 For the transition period from to Commission file number : 001-38241 optinose OPTINOSE , INC . ( Exact name of registrant as specified in its charter ) Delaware ( State of other jurisdiction of incorporation or organization ) Title of Each Class Common Stock , $ 0.001 par value 1020 Stony Hill Road , Suite 300 Yardley , Pennsylvania 19067 ( Address of principal executive offices , including zip code ) ( 267 ) 364-3500 ( Registrant's telephone number , including area code ) Securities registered pursuant to Section 12 ( b ) of the Act : 42-1771610 ( I.R.S. Employer Identification Number ) Trading Symbol ( s ) OPTN Name of each exchange on which registered The Nasdaq Global Select Market Securities registered pursuant to Section 12 ( g ) of the Act : None Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . Yes No > Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Act . Yes No > Indicate by check mark whether the registrant : ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . Yes > No