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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 Form 10 - K ( Mark One ) [ X ] Annual Report Pursuant to Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 For the fiscal year ended December 31 , 2020 or [ ] Transition Report Pursuant to Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 For the transition period from to Commission file number 001-38185 PRESSURE BIOSCIENCES , INC . ( Exact Name of Registrant as Specified in its Charter ) Massachusetts ( State or Other Jurisdiction of Incorporation or Organization ) 14 Norfolk Avenue South Easton , Massachusetts ( Address of Principal Executive Offices ) 04-2652826 ( I.R.S. Employer Identification No. ) 02375 ( Zip Code ) ( 508 ) 230-1828 ( Registrant's Telephone Number , Including Area Code ) Securities registered pursuant to Section 12 ( b ) of the Act : Title of Each Class None Name of Each Exchange on Which Registered None Securities registered pursuant to Section 12 ( g ) of the Act : ( Title of Class ) Common Stock , par value $ .01 per share Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . Yes [ ] No [ X ] Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15 ( d ) of the Act . Yes [ ] No [ X ] Indicate by check mark whether the registrant : ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . Yes [ X ] No [ ] Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T during the preceding 12 months ( or for such shorter period that registrant was required to submit and post such files . Yes [ X ] No [ ] Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , or a smaller reporting company or an “ emerging growth company ” . See the definitions of “ large accelerated filer , ” “ accelerated filer , ” “ smaller reporting company ” and “ emerging growth company ” in Rule 12b - 2 of the Exchange Act .