Good day, everyone, and welcome to Pfizer's fourth quarter 2021 earnings conference call. Today's call is being recorded. At this time, I would like to turn the call over to Mr. Chris Stevo, Senior Vice President and Chief Investor Relations Officer. Please go ahead, sir. Thank you, Sylvia. Good morning, everyone. Welcome to Pfizer's fourth quarter earnings call. I'm joined today by Dr. Albert Bourla, our Chairman and CEO, Frank D'Amelio, our CFO, Mikael Dolsten, President of Worldwide Research and Development and Medical, Angela Hwang, Group President, Pfizer Biopharmaceuticals Group, Aamir Malik, our Chief Business and Innovation Officer, and Doug Lankler, our General Counsel. We expect this call to last 90 minutes. The materials for this call and other earnings-related materials are on the investor relations section of pfizer.com. Please see our forward-looking statements disclaimer on slide 3 and additional information regarding these statements and our Non-GAAP financial measures is available on our earnings release and in our SEC forms 10-K and 10-Q under Risk Factors. Forward-looking statements on the call are subject to substantial risks and uncertainties, speak only as of the call's original date, and we undertake no obligation to update or revise any of these statements. With that, I will turn the call over to Albert. Thank you, Chris. Hello, everyone. 2021 was a watershed year for Pfizer, a year in which we set all-time highs in all major areas of focus for Pfizer. We reached an estimated 1.4 billion patients with our medicines and vaccines. That's more than one out of every six people on Earth. Never before has Pfizer's patient impact been so wide-reaching. We improved our ranking from fourth to second among large biopharma companies in the PatientView Global Survey. According to Morning Consult, 61% of Americans have a favorable view of Pfizer, which is up 33 points since January 2020. Just last week, Fortune ranked us fourth on its annual World's Most Admired Companies list, the highest ranking we have ever achieved. 95% of our colleagues said in an internal survey that they are proud to work for Pfizer, which ranks among the best in corporate America. We increased our investments in research and development from $8.9 billion in 2020 to $10.5 billion in 2021, and we initiated 13 pivotal clinical studies, the highest number ever for Pfizer. Last but not least, we grew revenues by 92% operationally to $81.3 billion and adjusted diluted EPS by 92% operationally to 4.42. Our success in leading the fight against COVID-19 have not only made a positive difference in the world, I believe that have fundamentally changed our company and our culture forever. Colleagues across Pfizer are inspired by what we have achieved and more determined than ever to be part of the next potentially game-changing breakthrough. To that end, we are applying the Lightspeed principles developed for our COVID-19 work to our other therapeutic areas to make sure we continue to move at the speed of science for the benefits of all patients. As a result, we believe we can do even better with each of these metrics in 2022. Each one of them. Our full year 2022 financial guidance, for example, includes for the first time ever a forecasted revenue midpoint that it is triple-digit, $100 billion, and an adjusted diluted EPS midpoint of $6.45. While Comirnaty is having a significant positive impact on Pfizer's financial performance, it is the tremendous impact that COVID-19 vaccines have had on society that it is most important. In the U.S. alone, the COVID-19 vaccination program is estimated to have saved more than 1 million lives and prevented more than 10 million hospitalizations according to a December 2021 Commonwealth Fund report. The economic impact is equally astonishing. Astounding. According to a December 2021 Heartland Forward report, the rapid deployment and wide availability of COVID-19 vaccines in the U.S. created an estimated economic savings of $438 billion in 2021 alone, which amounted to U.S. GDP being 2.3% higher than it otherwise would have been, 2.3 points. I'm proud to say that Pfizer contributed significantly to these benefits, given that approximately six doses out of 10 doses administered in the U.S. as of February 6th, 2022 were Comirnaty. This is the value of our science, what our culture has enabled, and what drives our people. Now I would like to speak to three factors that will help drive our growth going forward. The first is the long-term outlook for COVID-19 and why we believe we are well-positioned to continue to lead the battle against this disease. Second, our thoughtful capital allocation strategy and why we believe it can help drive our growth in the second part of the decade. Third, how our commitment to ESG principles is designed to create sustainable growth for Pfizer to deliver meaningful value to patients and society. Let me start with the COVID-19 pandemic. Our scientists continue to monitor the SARS-CoV-2 virus and believe it is unlikely that it will be fully eradicated in the foreseeable future. They believe this for several reasons. The global distribution of the virus makes it difficult to contain. The virus has shown an ability to mutate often, making it difficult to stay ahead of it. The data appear to show that natural infections do not lead to the type of durable protection needed to prevent all transmissions and viral mutations. As a result, people can become reinfected by the same or different strains over time. That said, we now have the tools in the form of vaccines and treatments that we believe will help enable us to not only better manage the pandemic, but also help countries move into an endemic phase. In other words, we believe these tools will help allow us to go back to normality and spend time with family and friends, travel, attend indoor dining and concerts, and enjoy many other activities while lowering the risk of overburdening hospitals and healthcare systems around the world. All of us at Pfizer are extremely proud of the role we have continued to play in bringing these tools to the world. Throughout 2021, we continued our efforts to bring our COVID-19 vaccine to more populations and to further ramp up our manufacturing and distribution capabilities. As a result, the market share of our Comirnaty vaccine has continued to grow, representing 70% of all doses distributed across the U.S. and EU as of February 5th. When it comes to Paxlovid, we expect to produce 6 million treatment courses during the first quarter of 2022. Overall, we expect to produce 30 million courses in the first half of 2022 and 120 million courses for the full year. Of course, depending on the global need. Having recently received a conditional marketing authorization from the European Medicines Agency, Paxlovid has now received emergency or conditional authorization for use with certain populations in approximately 40 countries so far. We are in discussions with governments around the world and expect that as the number of authorizations increase, so will the number of contracts for this treatment, which could truly be a game changer. At Pfizer, we are keenly aware of our responsibility to continue to invest in R&D, to maintain our leadership in providing these tools and other meaningful solutions to the world. That's why we continue to develop and test different versions of our vaccine to potentially address variants of concern as they emerge, and why we are currently working on a new Omicron-based vaccine candidate and on a bivalent COVID-19 vaccine candidate. It is also why, just two months after receiving emergency use authorization from the U.S. Food and Drug Administration for Paxlovid, we are already working on a potential next-generation oral COVID-19 treatment. Going forward, we are confident in our ability to maintain this leadership position because of our significant investments in R&D, combined with our ability to move at the speed of science without compromising quality or safety, the strong credibility we have earned with governments, healthcare providers, and consumers, combined with our extensive global field presence and our unparalleled capabilities for high-quality manufacturing at scale. Now, the second thing I wanted to touch on is how we think about our capital allocation and to repeat once more our strategy. We feel that the entirety of our business continues to demonstrate a robust top-line growth trajectory through 2025. Consensus estimates are beginning to slowly recognize this momentum. However, consensus estimates currently show our top line shrinking from 2025- 2030. I want to repeat that this is inconsistent with our own plans. Our goal is to continue to be a growth company from 2025- 2030, despite the impact of LOIs expected during that period. Our confidence in our ability to achieve that is underpinned by the momentum of our business, the durability of our COVID-19 offerings, which as I just described, the underestimated strength of our internal pipeline, and of course, by our ability to deploy capital into growth-focused business development to access external science. A few words about that. We leverage business development opportunities to advance our business strategies and objectives. The strength of our balance sheet and cash flows allow us to pursue new business development opportunities going forward that could add at least $25 billion of risk-adjusted revenues to our 2030 top line expectations. We expect to do this while still maintaining our growing dividend, as well as flexibility for other uses of our cash. The focus of our business development efforts will continue to be on compelling external science in the form of both later-stage assets as well as earlier medical innovations that have the potential to be breakthroughs for patients. Our focus will largely be in the therapeutic areas and platforms where we have the scientific skills and acumen to add substantial value and select the most successful targets. In addition, we feel that we have distinctive attributes, such as world-class excellence in clinical development and a surpassed manufacturing and commercial capabilities at scale that makes us a very attractive partner across a variety of deal arrangements. We believe the opportunities to deliver on this approach exist, and I will be personally focusing on this execution. I want to emphasize that despite our significant capital flexibility, we will never lower the scientific and financial standards we apply in our business development. As we pursue these opportunities, we will continue to be highly disciplined in our evaluation and prioritization processes. Since 2019, we have already invested almost $25 billion in business development transactions, adding more than $13 billion in consensus. I repeat, in consensus 2030 revenue. I would point out that the $13 billion of consensus currently includes nothing for the Trillium assets, the Biohaven collaboration, or the recently announced mRNA deals, all of which have substantial potential. I see this pace of business development accelerating going forward, and I'm confident it will be an important driver in ensuring Pfizer as a growth company in the back half of this decade. One highly visible example of our approach to business development is the recent investments we are making in mRNA technology and collaborations. mRNA has emerged as a versatile technology with potential application across many infectious diseases, cancer, rare genetic disorders, and even autoimmune diseases. Although mRNA is not the holy grail, we believe the technology has the potential to have a game-changing impact on global health, which is why we have developed a robust mRNA strategy and are aggressively building our platform. While the pandemic has demonstrated that it is not that easy to deliver mRNA vaccines at scale, Pfizer has emerged as a leader in this space. With decades of experience on our side, we have developed what is arguably the most efficient clinical development and vaccine manufacturing capabilities the world has ever seen. We also have rapidly scaled and built our new capabilities in record time by hiring nearly 2,400 new colleagues in these functions in a nine-month time frame. Going forward, we plan to continue to invest to capitalize on the leadership we have built in terms of both mRNA R&D and manufacturing. In addition, of course, to these internal investments and improvements, we are also making external investments to build out our capabilities in this space. For example, Pfizer recently has entered into four important business development deals to help advance our mRNA strategies. We are expanding our collaboration with BioNTech to use the existing platform to co-develop an mRNA vaccine candidate for herpes zoster virus to protect against shingles. Our agreement with Beam Therapeutics expands our mRNA efforts to another core therapeutic area for Pfizer, a rare disease, with a four year research collaboration for three targets for rare genetic diseases of the liver, muscle, and central nervous system. We believe this will give us the potential to use mRNA to treat diseases, not just prevent them, treat them. Our agreement with Acuitas gives us the ability to collaborate with and license their proprietary lipid nanoparticle technology for up to 10 targets for mRNA vaccines and therapy. We believe this will give us greater independence in this space. We have signed a strategic collaboration and licensing agreement with Codex DNA, a leader in the development of automated solutions for on-demand synthesis of genes and mRNA, potentially allowing enzymatic assembly of DNA at the front end of the mRNA production process. This could possibly reduce the time to produce a new vaccine from three months down to two months. If successful, this would be an important differentiator when developing a vaccine for the flu, for example, as it would allow us to select a strain much closer to the start of any flu season. These deals represent only four pieces of a much bigger strategic puzzle. As we continue executing on our mRNA strategy, you should expect to see more targeted activity in this area. Of course, our business development activity in the last quarter went beyond executing on our mRNA strategy. This is an update of the slide I showed you last quarter, and I would like to highlight a few of the other recent deals. You can see them with the new indications. The acquisition of Trillium builds on our strong track record of leadership in oncology, enhancing our hematology portfolio as we strive to improve outcomes for people living with blood cancers around the globe. Our strategic collaboration with Biohaven leverages our leading commercial capabilities in pain and women's health with Biohaven's groundbreaking oral CGRP receptor antagonist, the only one approved in the U.S. for both acute and preventative treatment of migraine, so that we can potentially bring a valuable new treatment option to patients living with this debilitating neurological disease outside the U.S. Through our proposed acquisition of Arena, we plan to leverage Pfizer's leading research and global development capabilities to accelerate the clinical development of etrasimod for patients with immuno-inflammatory diseases. Now, I would like to share some details about Pfizer's enhanced ESG strategy. The strategy is focused on six areas where we see opportunities to create a meaningful and measurable impact over the next decade. Product innovation, equitable access and pricing, product quality and safety, diversity, equity and inclusion, climate change, and business ethics. Each quarter going forward, I will provide examples of how we are embedding ESG into all core areas of our business. This quarter, I would highlight our efforts to improve clinical trial diversity, to improve diversity within our colleague base, and help ensure equitable access to our COVID-19 vaccine and treatment. Last year, Pfizer published an industry-first retrospective analysis of demographic data of U.S. participants in 213 of our interventional clinical trials that initiated enrollment from 2011 through 2020. The analysis demonstrated that overall trial participation of Black or African American individuals was at the U.S. Census level, 14.3% versus 13.4%. Participation of Hispanic or Latino individuals was below U.S. Census, 15.9% versus 18.5%. Female participation was at U.S. Census, 51.1% versus 50.8%. We published this analysis to be transparent and for it to serve as the baseline as we measure progress in this area. We believe that diversity in trials is a matter of equity and good science and are taking decisive steps designed to improve diversity in our trials. Our goal is to achieve racially and ethnically diverse participation at or above U.S. Census or disease prevalence levels as appropriate in all our trials. The second item I want to highlight is the significant progress we are making in diversifying our colleague base, particularly at more senior level positions. In the last 3 years, for example, we have increased the percentage of women at the vice president level and above globally from 32%- 42%. Over the same time frame, we have increased the percentage of minorities at the vice president level and above in the U.S. from 19%- 25%. The third item I wanted to highlight is the progress we are making to help ensure our COVID-19 vaccine and oral treatment are accessible by everyone everywhere. I am thrilled to say that we remain on track to meet or exceed our goal of delivering at least 2 billion doses of our vaccine to low- and middle-income countries by the end of 2022, having just met our goal of delivering the first 1 billion by the end of 2021. I also want to highlight two data points about our 2 billion-dose commitment. 1 billion of these doses are being provided to the poorest countries completely free of charge. Thanks to our agreement with the U.S. government, Pfizer is providing these doses to the U.S. government at a not-for-profit price, and the government is then providing them to the poorest countries for free. Also, the 1 billion doses we delivered in 2021 represented 37% of all doses we delivered this last year. In terms of our oral COVID-19 treatment, we have signed a voluntary license agreement with a Medicines Patent Pool, which we hope will lead to expanded access pending country regulatory authorization or approval in 95 low- and middle-income countries that account for approximately 53% of the world's population. Lastly, I'm pleased to announce that the compensation committee of our board of directors has been reviewing methods to linking executive compensation with ESG performance, which we expect to begin this year. For details regarding the impact of our ESG strategy had on our business in 2021, please keep an eye out for Pfizer's 2021 ESG report, which will be published online in mid-March. In summary, 2021 was an outstanding year for Pfizer and we look forward to continuing to apply the lessons learned from COVID-19 to deliver breakthroughs for patients across all our therapeutic areas. We remain focused on being nimble, investing in our R&D organization, and exploring dynamic partnerships that will enable us to fully realize the power of our science. None of this is possible without the contributions of our amazingly purpose-driven colleagues who continue to rise to the challenge of addressing the world's most devastating diseases. In 2021, our colleagues exceeded expectations. Therefore, we will once again use part of the bonus pool that the board approved for bonus eligible colleagues and executives to provide a one-time special COVID-19 circumstances bonus to our non-bonus eligible colleagues across the board to reward them for their hard work and to help them cover personal, family, and living expenses incurred because of the COVID-19 pandemic. With that, I will turn it over to Mikael to update you on our R&D efforts. After Mikael, Frank will provide financial details on the fourth quarter and our outlook for 2022. Mikael. Thank you, Albert. I'm delighted to share updates from this quarter as we continue to deliver first in class science. Today, I will share updates from our COVID-19 programs and select other assets in our pipeline. Let's start with Paxlovid. As the COVID-19 pandemic continues to burden public health, we have advanced the science on our novel oral antiviral therapeutic. Importantly, we see consistent potent antiviral activity in vitro against all current variants of concern, including both Delta and Omicron. This would be expected from how the compound was designed. On the left, you can see a crystal structure showing how tightly nirmatrelvir binds to the active site of the Omicron variant. History has told us from the HIV protease field that the closer the therapeutic is designed to mimic the substrate, the harder it is for resistance to emerge. That combined with the essential nature of the protease, the short duration of treatment, and the co-dosing with ritonavir to drug exposures that are over 5 to 6 times the amount of compound needed to kill the virus in an in vitro assay, suggests this reduced risk for resistance. External data support our findings. In this slide, the lower values, the stronger potency illustrated by nirmatrelvir being on the lower end of the y-axis on the left, having the most potent activity. Nirmatrelvir maintains in vitro potency in the low nanomolar range. As you can see in these graphs that include other authorized or approved therapeutics. On the left is in vitro data from a study done with the Icahn School of Medicine at Mount Sinai and Pfizer. nirmatrelvir demonstrated potent antiviral activity as measured by IC50, a measure of drug efficacy indicating the concentration needed to inhibit infection by half. This is consistent with findings from the Rega Institute at KU Leuven in Belgium, shown on the right. We anticipate a new drug application decision by the FDA in the high-risk population in second half of 2022. Pivotal readouts of our household contact and standard risk studies in the second quarter and second half of 2022 respectively, and a study start in children six to 18 years old in the first quarter of 2022. In the standard risk study, we're expanding enrollment by 750 non-hospitalized patients with symptomatic COVID-19 and vaccinated standard risk patients may also be eligible, provided their last SARS-CoV-2 vaccine dose was received at least 12 months prior to screening. This expansion will allow us to further evaluate the secondary endpoint seen in the interim analysis, which showed a 70% reduction in hospitalization and no death in the treated compared to placebo. We also are advancing work on a potential next generation SARS-CoV antiviral with the aim of achieving similar high clinical efficacy in pan-coronavirus design properties that maintain activity with a favorable safety profile and counter potential viral resistance, but without the need for ritonavir boosting. A first-in-human study is expected in the second half of 2022. Now, we also continue to advance vaccine development and have achieved emergency use authorization for use in children as young as age five. Effectiveness data for three doses of the vaccine for people 12 years and older, and early laboratory data observed with Delta and other variants of concern, including Omicron, suggest that people vaccinated with three doses of Comirnaty may have a higher degree of protection against both symptomatic and severe outcome compared to two primary doses. Informed by this data, in addition to the immunobridging data, we are evaluating a third 3-microgram dose in our study of children 6 months through four years of age, with the belief that the third dose may be optimal for this age group. However, as pediatric cases and hospitalization are at an all-time high, FDA urged us to start the rolling EUA authorization submission with the 2-dose efficacy, immunogenicity, and safety data we have accumulated thus far while we continue to collect data, including on third dose administration. We plan to submit third dose data once available. In the meantime, FDA has scheduled an advisory committee meeting for February 15th to consider the two-dose pediatric data collected to date. If emergency use authorization of two doses is granted and the CDC recommends usage, parents will have the opportunity to begin a COVID-19 vaccination series for the children between 6 months and 4 years of age while awaiting potential authorization of a third dose. Turning to the adult population. In the wake of surging Omicron cases, in January, we completed a lab analysis of the effect of a third dose boost of Comirnaty on live virus neutralization. Encouragingly, there was a more than 25-fold increase in Omicron live virus neutralization titers observed between day of dose three and 1 month post dose three. We observed a moderate four months post dose three antibody decay for wild type and the Omicron variant. Between one month and four months post dose three, neutralizing titers were 1.6 and twofold lower for wild type and the Omicron variant respectively. We're now starting to see effects of a third dose boost in maintaining a high level of protection against Omicron in the real world. These data from Kaiser Permanente Southern California show Omicron-related emergency department visits with outpatient hospitalization on top and hospitalization on the bottom. three doses of Comirnaty provided better vaccine effectiveness against Omicron than two doses, and there was high vaccine effectiveness of three doses against Omicron-related hospitalization, similar to Delta-related hospitalization. We did see some waning of effectiveness against emergency department admissions due to Omicron three months or more after the third dose, which suggests the potential need for another boost of the current vaccine or an Omicron-based vaccine. We have started an Omicron-based vaccine candidate trial in adults 18 years-55 years of age. This study will evaluate more than 1,400 participants across three cohorts. Those who have already received two doses of the current vaccine 90 days-180 days prior to enrollment will receive one dose or two doses of the Omicron-based vaccine. Those who have already received three doses of the current vaccine 90 days-180 days prior to enrollment will receive 1 dose of the current vaccine or the Omicron-based vaccine. Those who are vaccine naive will receive three doses of the Omicron-based vaccine. This study is part of our science-based approach to develop a variant-based vaccine that will help achieve a similar level of protection against Omicron as the current vaccine has with both wild type and earlier variants, but with potentially longer duration of protection. Now, let's turn to our next-generation CDK inhibitors for cancer. Most patients with advanced or metastatic breast cancer eventually develop resistance to both endocrine and CDK4/6 inhibitor therapy despite their transformative efficacy. Inhibition of CDK2 delivered with a CDK selective active drug or a triple-active CDK2/4/6 agent may prevent, delay, or reverse resistance and prolong survival. These are data from a subset in the CDK2/4/6 inhibitor phase I dose escalation and antitumor activity study of heavily pretreated patients with hormone receptor-positive metastatic breast cancer. The most improvement in terms of tumor size reduction was seen in patients treated with monotherapy or in combination with fulvestrant. We observed three confirmed partial responses and three patients with stable disease for more than 12 months. One patient has been receiving ongoing treatment for more than 28 months. There's been an acceptable safety profile at the recommended phase II dose, which is 25 mg twice daily. We plan to conduct the phase I dose expansion, expect to complete it in the fourth quarter of this year. Selective CDK2 inhibition with a CDK2 only inhibitor may allow dose titration and has the potential to be used in combination with approved CDK inhibitors such as palbociclib or other next generation CDK selective inhibitors. There were two confirmed partial responses in the phase I study of our selective CDK2 inhibitor in patients with advanced and metastatic hormone receptor, HER2-negative breast cancer, who had progressed on prior CDK4/6 inhibition and endocrine therapy. One patient had a maximum tumor shrinkage of 54% following CDK2 inhibitor treatment for approximately 8 months, and the second had 100% shrinkage of all target lesions following treatment for approximately nine months. We are showing scans of the first patient at baseline and eight weeks. There was an acceptable safety profile as a monotherapy, and we're currently exploring combination. We expect the phase I/II study to be completed in the second quarter of 2023. Now, let's turn to our six-valent Lyme disease vaccine candidate, which we are developing in partnership with Valneva. We have received further positive data from our phase II proof-of-concept study and expect to start phase III in the third quarter of this year with a dosing regimen of zero, two months, and six months to prime, followed by routine boosters before the start of a Lyme season. Our phase II study is continuing and includes a pediatric population ages 5-years- 17- years. Since Lyme disease is seasonal, our goal is to establish a regimen that results in high antibodies at the beginning of each season. We therefore looked at the boost one year after the primary series. We saw substantial boost antibody response in phase II to all six serotypes present in North America and Europe following the three-dose primary series vaccination schedule with a 14- to 31-fold rise in season one and a 51- to 69-fold rise in season two. The vaccine candidate was generally well-tolerated at all dose levels tested, and we are excited about further development and the potential to help prevent this debilitating disease. Last quarter, we told you that we saw robust dystrophin expression out to one year in our Duchenne muscular dystrophy gene therapy phase I-B study. I will show you encouraging functional motor data in a moment. We recently shared some very sad news that the DMD patient with advanced disease in the non-ambulatory cohort of the phase I-B trial passed away after presenting with hypovolemia and cardiac shock. The patient was 16 years old and the first in the non-ambulatory cohort treated with rapamycin along with steroids as part of the immunosuppressive regimen. Rapamycin is not used in the phase III ambulatory study. Like most non-ambulatory DMD patients, he had more advanced disease with underlying cardiac dysfunction. There is evidence of an active viral infection, and we're investigating how this may have contributed to the outcome. Additional assessment will be required to define next steps to restart the phase I-B study non-ambulatory patients who are more progressed in the disease. I will now share data from this study. Ambulatory cohort. Sorry, I had one more sentence to say here. 19 patients were enrolled in this study, 16 of whom received the dose selected for our phase III program, and three of whom received a previously studied lower dose. At one year post-treatment, there was a 5.6-point improvement in ambulatory function as measured by North Star Ambulatory Assessment compared to an external control matched for age and baseline function. This is particularly encouraging given that patients at this age and stage of disease typically experience a considerable decline in ambulatory function as illustrated by the external control. On the right, we show long-term study with six participants nearing or more than three years in treatment. The ambulatory cohort in phase I B is similar but slightly older on average to the population in the phase III CIFFREO trial. Considering the favorable benefit-to-risk profile in this study and observed in the ambulatory patient population and in consultation with the Data Monitoring Committee, we believe the safety profile of our DMD gene therapy is manageable in this patient group. Additional mitigation are being added to our study in consultation with DMC and other medical experts. Pending regulatory feedback, we anticipate phase III study sites to begin to reopen in the next few months with the potential to report top-line results and, subject to clinical trial success, submit the BLA by the end of 2023. Turning now to Internal Medicine and ponsegromab, our candidate for cancer cachexia. It targets GDF-15. GDF-15 is frequently elevated in cancer patients, drives reduction of appetite and body weight loss, and is associated with poor outcomes. There may also be potential to treat cachexia associated with other chronic diseases such as heart failure and COPD. We have encouraging phase IB data which I will show next. Ponsegromab was evaluated in 10 cancer patients who were undergoing antitumor treatment and had more than 5% body weight loss in the last six months, or more than 2% body weight loss with a body mass index of less than 20 kg per meter squared or diagnosed sarcopenia. Ponsegromab administration was found to suppress circulating GDF-15 levels in cancer cachexia patients below the level observed in healthy subjects. Preliminary data from the phase IB trial show ponsegromab treatment resulted in significant body weight gain compared to historical placebo. You can see the nice trend in body weight increase remained even after the dosing was stopped at week 12. The gray dotted line indicates the historical cutoff associated with improved survival. We are co-developing a companion diagnostic with Roche Diagnostics designed to enable precision medicine, and we expect to start a phase II study in cancer cachexia in the fourth quarter of this year. Injectable GLP-1 receptor agonists offer potent lowering of glucose and weight in diabetic and obese patients with proven cardiovascular benefit. This drug class is underutilized due to its injectable administration route. Our small molecule oral GLP-1 receptor agonist, danuglipron, could potentially offer a convenient oral alternative to injectables and is being evaluated for the treatment of type 2 diabetes, obesity, and NASH. It has been developed in our internal medicine research group with a vision to expand the use of this potent, easily administered GLP-1 drug class to a primary care setting. Here are data from the phase II study in type 2 diabetes. We have recorded strong dose-dependent reduction in both HbA1c, a measure of long-term blood sugar levels, and body weight compared to the marginal effect noted with placebo. After 12 weeks of treatment with a 200mg twice daily dose, HbA1c decreased by almost 1.6% and body weight decreased by 5.4 kg. The safety and tolerability profile is consistent with the GLP-1 class, and the most frequent adverse event rates were GI related. We expect to start a phase IIb titration optimization study mid-2022 with doses up to 200 mg twice a day and complete the phase IIb study in non-diabetic subjects with obesity in the first quarter of next year. Finally, here are select recent and upcoming milestones from across the pipeline. The solid blue dots represent milestones achieved and the open blue dots represent anticipated milestones. Programs in bold are major anticipated events. Some of the programs on the right have already been designated as Lightspeed, meaning they have accelerated development timelines or are being considered for Lightspeed designation. Finally, I would like to take a moment to thank Morris Birnbaum, our outgoing Chief Scientific Officer of the Internal Medicine Research Unit, for his immense contribution over the last seven years, and welcome William C. Sessa, who joins us from Yale School of Medicine following a decades-long career in academia, including service as Vice Chair of Pharmacology, Professor of Medicine, and Director of the Vascular Biology Therapeutics program at Yale. William C. Sessa is an eminent lead in the field, a groundbreaking scientist, and a celebrated innovator. I know he will bring his tremendous vision and insights to our investigation of cardiovascular and metabolic diseases. Thank you for your attention. I look forward to your questions. Now let me turn it over to Frank. Thanks. Thanks, Mikael. I know you've seen our release, so let me provide a few highlights regarding the financials. The COVID-19 vaccine once again had a significant positive impact on our quarterly results, and Albert and Mikael have already addressed the key points on the COVID-19 landscape. Turning to the income statement, revenue increased 106% operationally in the fourth quarter of 2021, driven by COVID-19 vaccines, vaccine sales, and strong performance from a number of our other key growth drivers. Looking at the revenue excluding the COVID-19 vaccine direct sales and alliance revenues and Paxlovid contribution, fourth quarter was slower than the first nine months of the year, declining by 2% operationally. As we discussed during our third quarter call, there was a 4% negative impact or approximately $500 million from fewer selling days in the U.S. and international. Excluding that impact, operational growth would have been 2%, which is still lower than the mid- to high single-digit growth we had experienced during the rest of the year. This was factored into our forecast for the year, but let me briefly walk you through this. In our biopharma business, you will remember that the fourth quarter of 2021 faced a tough comp from the fourth quarter of 2020 for Prevnar, as pneumococcal vaccinations were strong ahead of COVID-19 vaccine availability. Excluding vaccines from the current and comparable period would add five percentage points to the growth. Adjusting for the unusual comp period differences related to vaccines and selling days, our revenue growth would have been approximately 7%, which is similar to what we've been delivering lately. For the year, operational revenue growth was 92%. Excluding Comirnaty, direct sales, and alliance revenues in Paxlovid, 2021 operational revenue growth was 6%. This is consistent with our projected revenue CAGR of at least 6% from 2020 through the end of 2025. Of course, there will be some variability in quarterly and annual growth rates due to a variety of factors, but we continue to expect at least a 6% CAGR through 2025. The adjusted cost of sales increase shown here reduced this quarter's gross margin by approximately 16 percentage points compared to the fourth quarter of 2020, which is almost entirely driven by the impact of the COVID-19 vaccine. Adjusted S&A expenses in the fourth quarter increased primarily due to increased product level spending, including Comirnaty and higher healthcare reform sales-based fees. The increase in adjusted R&D expense this quarter was primarily driven by increased investments in late-stage pipeline projects, including additional spending related to our oral COVID-19 treatment. We've again provided total company guidance, which includes the business with the COVID-19 vaccine. We will continue to provide insight into our expected revenues for Comirnaty, and now for the first time, we'll also provide some color on our expected revenues for Paxlovid. However, note that we'll no longer be providing EPS guidance for the business excluding Comirnaty. Similarly, we won't provide EPS guidance for Paxlovid. Our revenue guidance represents a record for Pfizer, and we expect total company revenue to be in a range of $98 billion-$102 billion, representing an operational growth rate of 24% midpoint. Please consider that this revenue range reflects approximately $1.1 billion of anticipated negative impact from changes in foreign currencies, and also the impact of the loss of Meridian sales of approximately $300 million, both of which your models may not take into account. Regarding our COVID-related revenues, we now expect the COVID-19 vaccine revenue for the year to be approximately $32 billion, an increase of approximately $1 billion compared to our prior guidance provided on December 17th. For Paxlovid, we expect sales of approximately $22 billion. This means that excluding the COVID-related revenues, we expect sales to be $46 billion at the midpoint, representing operational growth of 5%. While this is slightly below the 6% CAGR that we continue to expect between 2020 and 2025, I would remind you that there will be volatility along the way. Let me give you some detail on our cost and expense guidance. For adjusted cost of sales, we are expecting a range of 32.2%-34.2%. Given that we are now more than 12 months past the launch of Comirnaty, we expect its negative impact on our cost of sales margins to be less than it was in 2021, assuming a similar level of revenues. Further, Paxlovid is expected to have a very positive impact on cost of sales as a percentage of revenues in 2022. On adjusted SI&A, we expect $12.5 billion-$13.5 billion, an increase of $900 million at the midpoint. We expect our adjusted R&D guidance range to be $10.5 billion-$11.5 billion at the midpoint, that is about $500 million higher than last year. We expect an adjusted effective tax rate for the year somewhat higher than 2021 at approximately 16%. These assumptions yield an adjusted diluted EPS range of $6.35-$6.55 or 47% operational growth at the midpoint compared to 2021, excluding an expected $0.06 negative impact from foreign exchange. I'd like to point out some additional information which may be helpful for your models. You will note that our guidance assumes a weighted average share count of approximately 5.8 billion, which represents an increase of approximately 100 million shares over 2021. This accounts for the number of shares that we normally issue for employee compensation annually. The increase of 100 million shares over 2021 decreases our EPS by about $0.10 at the midpoint. I noticed that most of your models instead assume a flat share count for 2022 as compared to 2021. From the first quarter of 2022 and going forward, we've made a decision to modify our adjusted financials treatment of amortization of intangibles. Previously, we only included amortization related to large mergers and acquisitions. Now we exclude all intangible asset amortization expense. This is anticipated to contribute $0.06 to our 2022 adjusted diluted earnings per share and helps improve comparability with our peers. 2022 guidance once again assumes no share repurchases. We will note that Pfizer did not repurchase shares in either 2020 or 2021. While we continue to have outstanding unused authorization to repurchase another $5.3 billion of stock, we can be opportunistic. Given the potentially value-enhancing business development opportunities which are available to us, we do not expect to repurchase shares in 2022. Now a word on our 32% stake in the consumer joint venture with GSK. You know, GSK has announced its intention to engage in a demerger transaction for at least 80% of its 68% stake in the JV in the summer of 2022. We talked about our stake as a non-core asset whose value we will seek to realize over time. While we have determined neither the manner nor timing of how we will do so, there are a number of possible alternatives, and we will attempt to monetize this asset in the manner which will create the most value for our shareholders. We receive approximately $600 million in pre-tax income from the JV annually, and this will not change as a result of the demerger transaction, and our guidance assumes that this will continue throughout 2022 with no change to our 32% stake. Let me quickly remind you of some assumptions and context on the projected COVID-19 vaccine contribution and our collaboration agreement. The Pfizer-BioNTech COVID-19 vaccine collaboration construct is a 50/50 gross profit split. Pfizer books the vast majority of the global collaboration revenue, except for Germany and Turkey, where we receive a profit share for BioNTech, and we do not participate in the China region. We continue to expect that we can manufacture 4 billion doses in total by the end of 2022. The $1 billion increase in expected COVID vaccine revenues to approximately $32 billion in 2022 primarily represents the impact of contracts signed since mid-December, which is the cutoff for our prior guidance. While we cannot predict what may be needed due to Omicron or other variants, I would also caution you that there is less potential upside to this guidance to the year compared to the situation we faced in 2021 when the vaccine was newly available and few people had received any doses of the vaccine. As you will remember, our cost of sales for the COVID-19 vaccine revenue includes manufacturing and distribution costs, applicable royalty expenses, and a payment to BioNTech representing 50% gross profit and split. We expect that the adjusted income before tax margin for the COVID-19 vaccine contribution to be slightly higher than the high 20s% of revenue that we had in 2021. Unlike the situation for Comirnaty, demand for Paxlovid should have upside from these levels, depending on the outcomes of discussions with certain governments and potential purchases for stockpiling against future coronavirus pandemics. If we remove the projected COVID-19 vaccine and Paxlovid contribution from both periods, you will see that we expect the 2022 revenue range to be $45 billion-$47 billion, representing approximately 5% operational revenue growth at the midpoint. Please remember our guidance excludes the former revenue contribution of approximately $300 million for Meridian, and all 2021 quarters have been recast to exclude Meridian as discontinued operations accounting for its divestiture. Going forward, we will not give earnings guidance excluding the estimated income from our COVID direct sales and alliance revenues and Paxlovid. However, to help you with your forecasting, a couple of minutes ago, I gave you my view on 2022 Comirnaty pretax margins. For Paxlovid, I would think about its margins as being typical for a small molecule drug, and unlike Comirnaty, it is expected not to be dilute to pretax earnings. To help you further, several years ago, before COVID-19 existed, I spoke about our business being on a path to a 40%+ pretax margin level in 2022, the business excluding Comirnaty and Paxlovid. Going forward, we will continue to be prudent in our capital allocation activities with the opportunities for deployment shown here on this slide. In summary, exceptionally strong quarter and year based on continued strong performance for our growth drivers. During the year, we raised guidance, and for the year, we met or exceeded our guidance in all key metrics. Our pipeline continues to advance, and we have invested record amounts to support that advance. Last week, Arena shareholders voted to approve Pfizer's acquisition of the company. We look forward to a targeted closing of the Arena acquisition as soon as the first half of 2022, subject to the satisfaction of the closing conditions, including antitrust approvals. We continue to expect to be active in regards to business development throughout 2022 as we continue to get access to the best external science and bring breakthroughs to patients in 2025 and beyond. With that, let me turn it over to Chris to start the Q&A session. Thank you, Frank. Apologies, everyone, for those technical difficulties. Just want to remind you, we do have the prepared remarks posted to the website, so if there's anything you missed because of difficulties, please refer to the prepared remarks. Given the technical difficulties, we're going to try to let the Q&A session run a little longer to answer people's questions. Sylvia, first question, please. Thank you. Your first question comes from the line of Geoff Meacham from Bank of America Securities. Hey, guys. Thanks for taking the questions. Just have two. The first one on Paxlovid guidance. You know, I know you guys are factoring in only signed agreements, but could you give us a general sense as to agreements or doses perhaps that are under discussion, and is that dependent on supply ramping? The second question, you know, on external BD, Albert. I understand the strategy. I think the uncertainty is really the ability to scale some of the products that you brought in. So if COVID is less of a long-term contributor than you assume, what's the appetite, you know, to do higher impact, larger deals? You clearly have the capacity. Thank you. Thank you. Angela, you want to take a little bit the Paxlovid? Sure. Currently we are in active discussions with over 100 countries and governments around the world. I'd say that, you know, the discussions are going really well. In terms of where we are with the contracting, as you say, you know, we've included some of the contracts that we have. Of course, you know, this number changes every day and contracts are being secured and distribution agreements being secured, you know, literally on a day-to-day basis. I think that this is a number to watch out for, and we do continue to expect movement. I think that there is a tremendous amount of interest for our product, and certainly as the clinical program, you know, continues to develop and emerge. As you know, we only have the high-risk study right now. We still have the standard risk and the prophylaxis that's coming up. I think that the full clinical program will also be another point of emphasis for contracting and ordering. I think it's going just really well and more to come on this front. Thank you. Aamir, maybe some comments on the BD. Sure. Thanks for the question, Geoff. I think in terms of the top line, we're gonna be incredibly flexible. We have said repeatedly that we are most interested in compounds that have potential to be real breakthroughs, and this can take the form of later stage clinical development as well as earlier stage medical innovation. We're gonna bias to the TAs, oncology, I&I, rare vaccines, internal medicine and hospital, where we've got the scientific chops to make good choices and add real value. We're gonna be flexible on the deal types. Acquisitions are obviously very much in the cards, but strategic partnerships and alliances as well, and in fact, some of our best successes have come from some capital light collaborations. If we see a larger opportunity that's strategic and creates value and meets the criteria that I just described, we've obviously got the balance sheet to utilize to do that. We certainly will look at those. We're gonna talk about and focus on the priorities that I described more so than synergy-driven deals per se. Thank you, Aamir. Geoff, just to add to both points, because I'm sure that both will be asked a lot. On Paxlovid, clearly, numbers could become way bigger than what we have right now. This is not something that we have done in the past, and we don't plan to do right now to give based on what could be the potential as a guidance. We are giving guidance based on what it is more or less secure, either signed deals or already agreed but not signed yet, deals but agreed prices and volumes, I mean. Clearly, if you remember, when we started with the vaccine in the beginning, we had a guidance of, I think, $15 billion in the first quarter, something like that. Eventually we made $36 billion. Here, we start even stronger on our first projections with Paxlovid. That's why we manufacture it to move ahead with our plans. We are at 120 million treatments, and we have the ability to go higher if the discussions that we're having materialize at all. In terms of also the business development, I just want to emphasize that because I'm getting a lot of this question on the size. We are agnostic to size. We are biased to deals, but in order to justify the premium, we will have to do significant cost synergies. These could be very profitable deals for other, let's say, periods in the history of the company, not now. Right now, the company is having a manufacturing machine, but it is performing at its best, an R&D machine, but it's performing at its best, a commercial machine that keeps being the leader in the industry in terms of their ability to execute and deliver. The last thing I want to do is to do a deal, but in order to justify the premium to the shareholders of the other company, we will have to shut down manufacturing sites and to consolidate research sites and consolidate field forces so we can generate the cost synergies. This is not the time to disrupt the momentum of the company. This is the time to bring into this manufacturing machine, the research machine, the commercial machine, more substrate in addition to what we produce organically ourselves. This is why the business development is aiming in these areas. Let's go to the next one. Your next question comes from Mohit Bansal from Wells Fargo. Great. Thanks. Thanks for taking my question. Maybe one on Paxlovid. There have been some news reports talking about logisticals and access issues for Paxlovid, and I understand that supply is tight for now, but would love to get your thoughts on how you're working on improving the logistics when the supply is no longer an issue, especially in a world where home testing will become a norm and one needs to take this drug within five days of diagnosis. Thank you. Yeah. I wouldn't say that we have logistical issues of supply, but Angela, would you like to take that, please? Sure. So first of all, you know, again, our deliveries and our allocations for the doses have gone extremely well here in the U.S. Just to give you some context, 265,000 doses have been allocated by the U.S. government since the EUA was approved. And of that 265,000, 85% of all the doses have been ordered. So, and, you know, we see a range of ordering patterns from the states. Some states are ordering 100% of the allocation, others are at 80%, 70%, so on and so forth. So there's really only a handful that haven't really ordered up to their allocation. But I would say for the most part, the weekly orders are going up and increasing week by week, and there is a very strong placement of orders. I would say that the drawdown, right, of the doses and the utilization is going really well. Again, it differs by state, what the allocations are and how that's going. As Albert said, I don't know that we have logistical issues. I think initially, what was difficult was that it was not clear where the doses were being located because every state had a different system for where to actually distribute Paxlovid from. But there are a number of tools now that have gone up online, both at the state level as well as on Pfizer's website. We've taken the state government tools and also loaded it on our website so that both HCPs and patients can see where it's available and where the orders as well as prescriptions can be placed. I think in that regard, you know, that's all been ironed out. I think looking forward into the future, I mean, clearly, having a seamless sort of end-to-end from diagnosis, you know, positive results to then being able to prescribe quickly and having the patient be able to acquire the drug quickly is our goal. I think on all of those fronts, we're working, you know, with a number of partners, both from a testing and a diagnostics perspective, but also from a telemedicine perspective and from a pharmacy perspective to ensure that we have as fast and as efficient a patient journey, I can say, you know, right? From diagnosis right until treatment. All of that is in place and you'll hear more. You know, you'll continue to hear more about that as the launch and utilization increases. Again, to punctuate and give a little bit of context to what Angela said, the 85% that it has already been ordered from the quantities that we are making available to U.S. government is a very, very high number. For example, the same number in the first month for vaccines, if you remember from that time, was dramatically lower than that because takes time for the states to get their act together. It is really variable, state by state. There are states right now that once the quantities are made to them available, they are ordering immediately, and there are states that take their time until they get their act together for the distribution. In general, way more efficient than what used to be in the first month of the vaccine. What is extremely important it is that every week there is constant replenishment, which although we do not have right now data for scripts because it's too early, what we do have it is that, the quantities that the states are accumulating, they're disappearing, and then immediately they are placing orders. I would say, we have, let's say, we are pretty happy with the way that the first month the collaboration with the U.S. government went in terms of allocating doses. There is dramatically also improvement in the tools, as Angela described. The bigger improvement will come from the fact that the second month we'll make available way more quantities, and the third month, way more quantities. Because the issues right now for people trying to find it is that, it is in few places in the state because you can't expand the network of places that it is available when you have smaller quantities. That will be very, very different in this month and, basically all over the place, I think in the third month, where significant quantities will be delivered. Okay. I think, let's go to the next question. Your next question is from Evan Seigerman from BMO Capital Markets. Hi, guys. Thank you so much for taking my question. I was wondering if you could provide an update on the FTC review process for the Arena deal. If I'm not mistaken, there was a recent procedural move where you and Arena withdrew and refiled the HSR Act filing, essentially to allow the FTC an additional 30 days for review. Then I'd also love for you to walk me through your assumptions on how you forecast $13 billion in revenue from BD transactions. That would imply that you have specific targets and a combination of targets in mind. Any color here that you could provide would be very helpful. Thank you. Yeah. Thank you very much. On the last one, just to make sure, but this is not our assumption. Our assumption is way higher over $13 billion. What I just gave you it is what is the consensus of the deals that we have signed so far. But on the FTC review, I would like to ask Doug to provide us maybe a review on that. Doug Lankler, our General Counsel. Yes. As you pointed out, we did request to refile, which is not unusual. It is, of course, subject to customary closing conditions and typical antitrust clearance and shareholder approval, which as you know, we've received. We don't expect a significant break in time from our proposed sense that the deal will close in the first half of this year. We still expect it to close in the first half of this year. Thank you. Aamir, although I did explain that this is consensus numbers, not our numbers, you want to make any other comment on the $13 billion of 2030 revenues that consensus forecasts for the deals that we have signed? Yeah. The only thing I would add is we feel very good about the progression of all of the substrate in the deal since 2019 that Albert outlined. We've seen a significant number of approvals and EUAs in that group, submissions, as well as, quite a few phase III starts. We think that substrate is progressing well, and the $13 billion is the consensus number. Our expectations of what's there are materially higher. There are a number of transactions. We spoke to Trillium, Biohaven, and even some of the recent things that we've done in mRNA that are not yet factored in the consensus forecast on those transactions. Thank you. Next question, please. Your next question comes from Umer Raffat from Evercore ISI. Hi, guys. Thanks so much for taking my questions. Perhaps two on vaccines today, if I may. First, on the flu vaccine, I know you've had a trial ongoing on your modRNA since September. I noticed you just initiated a new trial of a self-amplifying mRNA for flu. I wonder if the decision to progress a second mRNA program in flu was triggered by any emerging data from your first gen flu phase I that's been ongoing. Then secondly, on Omicron-specific booster, perhaps in light of some of the emerging data on immunogenicity differences or lack thereof, versus regular COVID vaccine, I guess my question is, what's your confidence on ability to show superiority of an Omicron-specific booster versus regular, and what would be the regulatory criteria? Thank you. Thank you. Thank you very much. I think Mikael can take the question. On the flu vaccine, just to make sure that I clarify, the plan was always to initiate an SA mRNA for flu and to run the two programs in parallel. It's not that we saw data that forced us to do SA/NA. It was always the plan. We are advancing new forms of mRNA technology, and SA, it is one of the most promising next generation of RNA technologies. Mikael, any comments on that and on the Omicron-specific, our confidence for superiority? Thank you. Yes, we are accumulating, first of all, from our mod mRNA data trial, data on various regimens, and on multivalent constructs. We remain of the view that we aspire to develop a flu vaccine. Currently, the most aggressive timelines are focused on the mod mRNA. Our plans is to develop something that have differentiation versus the current tetravalent standard of care. I know other companies have spoken about being similar, while at this moment we still see opportunities to possibly differentiate with an mRNA based on mod mRNA. As Albert alluded to, we are actually filing the IND for the self amplified. I think the protocol may have gone up already on ClinicalTrials.gov, but dosing is going to be within the next couple of months or so, and it's entirely based on us aiming to develop that platform, which has particular relevance for combination vaccine, given that possibly we expect to have much lower mRNA burden and can over time build vaccine combination of several different pathogens. We'll keep you updated on progress with the modRNA flu, and we certainly see data that suggests that this is a feasible path, and we are working to refine our approach to aim for a differentiated vaccine. What about Omicron? How confident are we about the superiority? Yeah. The regulatory path is that we expect to have... If successful, an Omicron boost would show higher neutralizing antibodies for Omicron versus a similar boost by the wild type vaccine and acceptable titers to the other previously available strains to provide preserved broad protection, but possibly with higher Omicron. I really think we should let the science play out here. We are talking about, you know, a number of weeks before we get data. As alluded to, it has three different arms on top of three doses, Omicron versus a wild type. That was on top of three previous doses, on top of two previous vaccine doses, one or two Omicron. That will be very interesting data set, and then Omicron or naive. I think it's a really interesting trial, and we'll extract a lot of data, and we'll report whether we can get that superiority. In any case, I would just want to punctuate that our current vaccine is active after three doses and raise relevant neutralizing antibodies. The T cell responses that we see are likely the one that contribute in real world evidence to provide effective protection of the current vaccine against hospitalization and death. Omicron vaccine is an interesting opportunity that we'll learn more about, but our science is progressing against several dimensions on how to further improve over time mRNA vaccines, although they're all pretty good ones. You should expect Pfizer continue to be a leader in this field through multiple approaches together with BioNTech. Thank you, Mikael. Next question, please. Your next question comes from Louise Chen from Cantor. Hi. Thanks for taking my questions. My first question for you is, what are the key pushes and pulls to your underlying business excluding COVID? What gives you confidence that you can still meet that top line sales guidance that you gave through 2025, despite some of the volatility that we're seeing right now? Then just wanted to ask you on your TL1A antibody and where you are with development of that product and the reporting of data. Have you changed any of the timelines for when you report data? Thank you. Thank you very much. On the 6%, what gives us confidence is that we keep meeting the goal. As I said that, we set the goal in 2019 for a 6% all the way CAGR, and then we had year to date, we are at 6% right now. The year particularly it is at 5% for the underlying business. There is a little bit of a volatility. We always knew that this would be a year that we are losing some of the revenues of Chantix and compared to previous year, which affects quite significantly this year, which then as we are launching new products, they are coming up. Maybe I will ask Angela to give a little bit more details on the inputs and how this is progressing, and also Mikael on the antibody question. Angela? You know, thank you, Louise. You know, I think the 6% confidence is really driven by two things. First of all, the launches, right? That will take place between now and 2025, which will continue to drive growth for us. Also importantly, in our in-line portfolio, Louise, every single one of our products still have opportunities to grow. They can grow from, you know, a number of different ways, right? There's still underdiagnosed patients. From new diagnosis, you can continue to drive a tremendous amount of growth in Eliquis and in VYNDAQEL. In many of our products, we still have class growth. I mean, think about, you know, the CDK4/6s, think about XTANDI, think about Braftovi. These are all therapies that are still, I think, underutilized from a class perspective, so there's growth there. Then finally, for all of them, there's the opportunity to grow in terms of market share, just given, you know, just the strong clinical profile and strong lifecycle support that we have for all of our products. I think, you know, we see tremendous amount of growth still. We just have not tapped out of growth in our core inline brands. You add on top of that the launch brands, you know, this is where we're gonna get our growth from. Mikael? Thank you, Angela. On the TL1A, as you remember at the previous earnings call, we showed some really strong data in the range of 34% endoscopic improvement and with a biomarker of 48%, in patients way above expected standard of care. That trial has enrolled very fast. It's fully enrolled. Full trial readout will be Q4. We are obviously considering based on the encouraging data in the previous trial, opportunity for interim analysis that pending data could allow us to accelerate development of the program towards potential pivotal studies. All in, it's moving very well and very fast. Thank you. Next question, please. Your next question comes from Steve Scala from Cowen. Thank you very much. Just to be absolutely clear, I understand that Pfizer wants to be conservative on Paxlovid, but it seems that Pfizer has merely scratched the surface on its 2022 potential, and that scratching of the surface is what's in 2022 Paxlovid guidance. Please just tell me if you disagree with that statement. Secondly, and just to be clear once again, do you not see growth for Pfizer overall in 25 through 30 without business development? Then lastly, on danuglipron, slide 39 shows some very good data. I'm curious what was the discontinuation rate in the study? Can the dose be increased further? And does Pfizer expect additional weight loss beyond 12 weeks? Thank you very much. Yes. Let me take the two first questions, and then Mikael can take the research one. Look, it's not that we are giving a conservative guidance. What we do, we have principles that we follow, because otherwise you can be lost. The principles that we are following, it is that we are only giving guidance for contracts that have been signed, or they are very close to be signed because we have agreed critical terms predominant, right? This is what you have heard about Paxlovid. Clearly, this is only a very small fraction of the 120 million treatments that we are right now preparing to manufacture. It is a small fraction of things that we are discussing right now with different governments. We are not taking, for example, an approach that we take all the discussions that we're having with the different governments. We risk adjust them to see how many we think can go forward, and then we give a guidance. This is not what we do. We only give, and this is the same with the vaccines, things that have been signed or are really agreed by the time in a specific deadline. I think Frank said it was last week, I think this deadline. Clearly there is a lot of potential, but it is not that we are putting a little bit of our own conservatism in the numbers. We are following a principle so that we can always be clear with what we say and why we say it. That's the thing. What about the study dose and the 12-week delay, Mikael? Yeah. On the danuglipron, I'm pleased that you were happy and impressed with our data. Indeed, I would say the glucose lowering through HbA1c and the body weight reduction are probably among the best in such a short treatment period. Tolerability and discontinuation rates improved versus previous study because we extended the dose titration from week to 2 weeks. Overall safety adverse events, I think, are very much in line with what you see comparable titration approaches with injectables. Given that we see that we can improve solubility and discontinuations with this medium titration rate, we have the next study coming up with the further slow dose titration, maybe up to a month or so. We think that may even bring readouts of efficacy further above this. We're very pleased with the profile, and I think the next study will nail down for us dose regimen and will help us to move with a strong profile into a potential pivotal study. All right. Next question, please. Your next question comes from Tim Anderson from Wolfe Research. Thank you. A few questions. The RSV vaccine data previously said early 2022, now you're saying first half 2022. Does that imply there's been some slippage? Because early to me, I always felt that meant, you know, January, February, something like that. mRNA flu, second question, what's a realistic timeframe for a potential regulatory filing of a product like that, assuming you find success in your trials? Then last question, IBRANCE sales soft, you say it's due to patient assistance programs. We haven't seen that impact other CDK4/6s, and I haven't generally heard about those programs impacting other brands, either at Pfizer or other companies. So I'm wondering what else may be putting pressure on IBRANCE. Are you having to cut price to maintain access? Yes. What was your question on Flutime? a realistic timeframe for filing for approval of an mRNA flu vaccine? Thank you. Why don't we go, Mikael, what about RSV? You can speak about both. We have both now, adult and maternal, and then the mRNA. Angela, you speak about IBRANCE. Yeah. On the RSV, we have enrolled very well maternal and adult and are basically, I would say, fully enrolled. It's entirely to ensure we have the number of events that we were looking for. We expect both trials to read out, you know, whether it's somewhere between Q1, Q2 or at a later part of Q2. We'll just see and as events accumulate, but it's going very well. I feel very optimistic with RSV study to conclude, and we're looking forward to that data. mRNA flu, we are right now accumulating immunogenicity from several different type of dose regimens. If we are able to conclude with optimal dose regimen using the Moderna mRNA, a potential phase II, phase III study could certainly be initiated this year. Of course, it's a little bit early to speculate before you have identified the right phase II/III dose regimen. If we would embark on such a study this year, we expect it can conclude very fast, given our experience to run very large trials in this sector and this population of adults. We're talking about, you know, possible conclusion then within next year. It's, I would say, one step at a time. We'll keep you informed. We are encouraged so far, and we'll go from there. Thank you, Mikael. What about Angela on the Ibrance? Sure. I can confirm that the patient assistance program is indeed the primary reason for the decline in volume that you're seeing on IBRANCE. Just to give you some perspective, in Q4 of 2021, our PAP prescriptions were up 32% compared to where it was in Q4 of 2020. All of this is 53% more than what it was pre-COVID. This is really what has cost us, you know, a tremendous amount of paid prescriptions. That's really the primary reason. We also saw, throughout the year, this is something that we've been watching quarter-over-quarter, just some slowdown in new patient starts. But we've seen this sort of phenomenon across, you know, multiple products in our portfolio. There's a small contribution from that, but the largest contribution by far is truly this phenomenon we're seeing here in terms of PAP. Thank you, Angela. Before we move to the next question, I realized that I didn't answer one of the questions that Steve made, Steve Scala, about if we believe that we need business development to grow in the period 2025 to 2030. Clearly, this is not the belief right now. We think that we have a clear LOI number. We estimate around $17 billion, and we have a pipeline that delivers more than the LOIs. Only organically with what we have right now in our calculations, we are a positive growth trajectory. The $25 billion I just mentioned needs to be on top of everything, the balance between LOIs and internal R&D, everything new that will be invented in the meantime, and of course, the COVID trajectory through 2030. We don't need right now business development at all to grow. What we need business development is to maintain high level of 6% growth top line, all the way to 2030, for example. Let's go now to the next question, please. Your next question comes from Andrew Baum from Citi. Thank you. Couple of questions. First, what are your expectations that you'll need- Two shots of Omicron as opposed to one. The reason I ask is, recently published animal models suggest that one Omicron mRNA vaccine actually generates lower levels of neutralizing antibody against Omicron than the ancestral spike variant, presumably due to antigenic sin. It obviously has implications for both, revenues in terms of two shots, but also compliance. Then second, perhaps you could comment on the outlook for CD47 and talk to the differences between, your molecule and Gilead's, which obviously has run into some safety issues with the trial suspension. Many thanks. Yes. I will take the first one very quickly so that I can give time to Mikael to speak about the second one. Look, we have to wait to see the results, but I don't think it is all mRNA vaccines are the same, so I don't think we should extrapolate preclinical data for one effort to what will be the clinical, let's say results of the other effort. We are testing both one shot, we are testing two shots. We are testing pretty soon hybrid vaccines, but everything what we have seen so far give us confident that we will have a very strong reaction and immunogenicity of an Omicron against Omicron. But of course, that's based on preclinical. We need to wait to see the first clinical data so that this assumption can be validated. With that, Mikael, what about the Gilead? Yeah. By the way, also, Andrew, you said, what about your expectations? Our expectations are not based on one shot or two shots or five shots. Our expectations, as I said, it is contract signed as for last week with Comirnaty. What we'll sign further on will be in addition to whatever we have given so far. Mikael on the Gilead. Yeah. The interest in our product from Trillium was triggered by its unique design. It is what we call a receptor fusion blocker protein, in contrast to Magrolimab that you refer to, that's on hold, the Gilead antibody. It binds with a lower affinity to the target, and that was by purpose to allow it particularly to accumulate on high expressing cancer cells and less accumulate on red blood cells not to cause anemia or hemolytic anemia. Indeed, in our studies that have generated proof of concept, we have seen single agent activity in blood cancers with basically negligible effect on red blood cells. This is playing well out. We do not know why Magrolimab is on clinical hold, but of course, this differentiation that we have in our molecule may be one example of why our molecule has been doing so well this far. While we initially focus on lymphoid malignancies of the B cell type, we think we also may become increasingly interested in to go to the myeloid space where Magrolimab has been AML and MDS, particularly if our profile now may be superior and we're waiting readout from such studies also. For us, the Trillium deal is delivering on all what we expected and may actually have upside due to its more unique profile. Thank you, Mikael. Next question please. Your next question comes from Chris Schott from J.P. Morgan. Great. Thanks so much for the questions. Maybe just two to start with on just some clarifications around guidance. I know you're not giving a lot of details around core versus COVID related earnings this year, but I guess a lot of questions on that front. If I just take the low end of your sales range at $45 billion, apply a 40% margin, tax adjust that, I think I'm getting a number somewhere around $2.60 per share at the low end. Is there any issues with that math I'm doing, or am I in the right ballpark there if I just wanna think about a low end of core guidance for this year? My second question was on Paxlovid, and you're referencing here typical small molecule, I guess, gross margins for this one. Just help us frame that a bit more. I guess, is something in the mid-80s% a reasonable level to think about for gross margins for this product, or is it substantially higher or lower? I'm just trying to better understand profitability as we maybe think about some of these contracts coming forward this year and maybe that Paxlovid number moving. Then just a final one just to wrap up. I'm still trying to get my hands around the BD side of the business and kind of the approach. I guess should we be thinking about a significantly different approach to business development for Pfizer today versus what the company was doing two or three years ago prior to the COVID upside? Is this more just a continuation of, I guess, the focus and what you were looking at if we're thinking back to like 2019, as an example? Thanks so much. Yes. I'll take very quickly the third one, and then, Frank can take the first two questions. I would say it is a continuation but with a way more accelerated pace. I don't think we are changing what we're saying since 2019. We are going into the science, as Amir said. We are going into areas that we think will make fewer mistakes in selecting the right targets. We will be more successful, so we will be able to meet at least the success rates of the industry. Our aim is to exceed them as we're selecting assets. We prefer to go to areas that we can add value, and there are significant areas that we can add value by becoming the preferred partner of several biotechs. We have seen, as Aamir said, that some of the best deals we have done were not the most capital-intensive deals, right? There are. All of that we are learning. We are not going to relax the discipline that we are having in selecting, but we are going to intensify a lot our activity in that area because of course we think that now is the time, science is at the stage that we can find enough targets to be able to add value and create volume. That's on the BD side. Now, Frank, a lot of financial questions for margins, guidance, et cetera. Sure. Chris, on the walkthrough you did on the business excluding Comirnaty and Paxlovid, I would use the midpoint on the revenue. You used, I think, a 40% income before tax margin, and then you got to tax affect that. I didn't hear you say tax affected. If you do the math, you do the walkthrough, and then you tax affect it, you know, obviously you're dividing that by shares outstanding. That'll give you, I think, you know, a number that's in the ballpark. On Paxlovid gross margin, let me answer the question this way. One, 'cause you know we don't give margin information by individual product, right? It's something that, you know, for many reasons we don't do. The way to think about it is, one, that the income before tax margin on that, the margin profile is similar to our other solid oral dose products. Remember, when you look at the gross margin, there's gonna be SI&A investment in Paxlovid this year because we're launching that product. There's additional R&D investment in that product that year because we're continuing, obviously, to evolve that product. All of that obviously is captured in the income before tax margin on that business, which is similar to our other solid oral dose products. That's all factored in our guidance. The one place where you can really see the impact, and hopefully this is helpful, you look at our cost of sales as a percentage of revenue last year for the full year, 37.7%. You look at our guidance this year, 32.2%-34.2%, the midpoint is 33.2%. That's down, at the midpoint, 4.5%, most of which is being driven by the Paxlovid revenue this year. Maybe that's a way to help you in terms of just how to work the numbers. Thank you, Frank. Next question, please. Your next question comes from Chris Shibutani from Goldman Sachs. Thank you very much. Two questions. One, again, just to make sure I understand clearly the thinking about what underpins the intermediate of growth expectation through 2025. I believe when that was originally issued back in 2019, that did not assume contribution from business development to achieve that CAGR of 6% to 2025. Is that still the case? That would be the first question. And then the second question relates to Paxlovid. We have the standard risk study that you've modified expanding. Can you talk about what kind of result we would need to see in order to influence the kinds of decisions and discussions that Angela is having with governments? In particular, the primary endpoint, which just missed statistical significance on the alleviation of symptoms. Do you need to hit that or are the discussions being guided around the ability to meet the secondary endpoint, which was the decreased risk of hospitalizations and severe disease from that standard risk study? Thank you. Yes. Maybe I can take both in the interest of time. I can confirm that our guidance for 6% was excluding BD. That was from 2019 all the way to 2025, 6% CAGR from the things that we had at that time. As regards the standard risk primary endpoint, I think most of the governments, if not all, are focusing right now all their purchases and the discussions that they're having on the ability to reduce hospitalizations. By the way, most of the, I mean, FDA, for example, has already approved vaccinated and unvaccinated, which is included, that means that includes also people that were in the standard risk population because the high-risk population were all unvaccinated. If we go the standard risk, I think will contribute, but I think everybody is moving with the assumption that we give it to all people to prevent hospitalization. That's the main and deaths. That's the main thing that everybody's looking. Now, the in-house contact it is a very different, and that can change very much the landscape. There are no discussions around that right now. If it comes positive, clearly that could be used also in preventing infections in high-risk populations when someone in the household or in the senior house or in other, let's say, business, in other, let's say, settings that people are living together, one is getting infected. This is something that will come on top of any discussions that we're having right now if it is positive. Let's go to the next question, please. Your next question comes from Vamil Divan from Mizuho Securities. Hi, great. Thanks for taking the questions. I guess I'll stick with the same theme around Paxlovid and business development. First on Paxlovid, just to make sure we're all starting on the same page, I guess, can you comment on exactly how many doses are included in the guidance that you're giving right now? You mentioned the release of 20 million to the U.S., I think 2.75 to the U.K. There's obviously been some other contracts that have been signed. I don't know if you can give us a number or a range just so we have a sense of kind of what's included right now. On business development, I just thought one thing was sort of interesting, when you were talking about slide 13, Albert, you mentioned the strength of your balance sheet and cash flows allow you to pursue new BD opportunities going forward that could add at least $25 billion of risk-adjusted revenues to 2030. I'm just curious, that $25 billion sort of a specific number. I'm wondering sort of and obviously, this is in your prepared remarks, so I'm sure it's well thought out. I'm just curious what sort of drove that, because obviously that number could be much smaller or probably a lot bigger, depending on what you do over the next few years. Maybe you can just provide some clarity on why you worded that the way you did. Thank you. Why we selected 25 to speak about 25, you mean? Yeah, saying at least $25 billion in adjusted revenue. Yes. I got it. Yep. Frank, would you like to take the Paxlovid and the doses? Of course. Vamil, on the Paxlovid guidance, you already, Angela mentioned before, we're you know very active right now, 100+ negotiations with different governments. We don't wanna put any information out there that could, I'll call it, lead to misleading assumptions, and those assumptions being detrimental to those contract negotiations. But now you mentioned a couple of contracts that have been announced publicly and where the dose information was included. You mentioned the U.S., 20 million, the U.K., 2.75 million. If you look at everything we've announced publicly, give or take, it's around 30, about 30 million treatments. That 30 million treatments is clearly included in the guidance that we provided in the $22 billion of revenue. Thank you. Aamir, why you selected $25 billion? Sure. Vamil, a couple of thoughts. One, we obviously, between the strength of our balance sheet and the cash flows, we have the ability to deploy significant capital. Going beyond our growing dividend, we think that those cash flows deployed into business development are gonna give us an attractive return. That's one piece of it. The second is, we think that this is frankly a great time for scientific advancement in our industry. As we look across academia, venture, biotech, big, small, there is no shortage of external substrate that we think can complement what we're doing internally. We're gonna be thoughtful and disciplined about the science that we wanna pursue. The combination of those two things, combined with the capabilities that we have, we think that there is significant growth that we can add to our business through business development going forward. Yeah. Also it is very important also to understand, Vamil, that we believe that once you put a target, you better execute way better when you have a target in front of you. I actually believe that the target needs to be public because it's a public company, and we don't have a problem to do it. Also we went in to analyze the substrate and the opportunity. As always, we are providing at least 25%, because as always, we like to have targets that we are putting out there and we are beating them. We believe that with the current all our analytics that we have done, this is a very reasonable target to achieve without, let's say, utilizing all of our cash or of our firepower right now. That will allow us to do dividend and other uses of capital and still do that. We are confident to put it out there so that people can start measuring against it. Thank you very much. The next question. Your next question comes from Kerry Holford from Berenberg. Thank you. Firstly, just on the oral GLP-1, I wonder if you can confirm the number of pills per day that you'll be using in your phase IIb study up to that maximum dose of 200 mg twice a day. What's that pill burden for the highest dose? And also on obesity, you've not discussed that today, but do you have the phase IIa data in-house? I know too that you've moved another oral GLP-1 molecule into the clinic, and I'm just interested to know how that asset maybe differ from the initial danuglipron. And then lastly, just on the guidance. If I'm thinking about the $4 billion range on your sales guidance, given you've given us the point estimates, there or thereabout, for the vaccine and the antiviral, should I assume the majority of the flex remaining relates to the base business? If so, can you help me understand the key moving parts within that element of the business? Which drugs may be the driver of that flex? Thank you. No, thank you very much. Let me take very quickly in the interest of time, the last one. No, the flex is spread around everything. You should assume, for example, in the $31 billion, in the $32 billion that we gave for 2023, right, on the vaccines, the $500 million up, $500 million down, that's $1 billion. On the Paxlovid, $500 million up, $500 million, that's another $1 billion. Then on the business, as always, we gave $1 billion up and down. Whatever you think is the midpoint, $1 billion up, $1 billion up, which is consistent with what we were doing all of these years for that level of business. Mikael, on the oral? Yeah. The GLP-1. danuglipron is a BID drug, and pill burden will be relatively low. You also asked for the additional GLP-1 drug we have in clinical development. That's a once a day drug. As we have now, I think, really defined what will be soon optimal titration for an oral GLP-1, and we were, you know, of course, pioneering that there isn't really data on it, we may actually consider to take the once daily in the same study as danuglipron, given that we have now this unique opportunity to look through what seems to be two great drugs. Currently, I believe danuglipron has all what it takes to go forward to a potential pivotal study based on this study that we shared with you. It's of course, a unique situation to have more than one molecule. It gives us the very best option for going into phase III quite rapidly after concluding that phase IIb pending, of course, expected outcome. Thank you, Mikael. The last question, please. Your final question comes from the line of Carter Gould from Barclays. Great. Good morning. Thanks for taking the question. I'll keep it to one since we're at the end. At the risk of not getting an answer on OUS pricing for Paxlovid, I understand the underlying aspects driving sort of your pricing strategy between GDP and volume-based discounts. But in practice, how consistent has the pricing been across geographies? Any color at a high level would be helpful. As we think about potentially the standard risk data, the prophylaxis data kind of playing out over the course of the year, should we anticipate that pricing will be relatively consistent per course in the second half relative to the first half? Any color there would be helpful. Thank you. Yes. Our pricing for Paxlovid is a tier pricing. There is a tier for high-income countries, and that is more or less in line with what you have seen published for Merck's, for example, product, and we have seen published ourselves. Only exception was the U.S. that they got a very special price because of higher orders, but the rest are more or less consistent. Then there's of course a second tier for middle-income countries. For the low-income countries, we are going to provide it at cost. Also for the low-income countries, in addition to our own providing at cost, of course, we have also initiated a process that a very big number of generic companies will start manufacturing for the low-income countries, which will be 53% of the global population. Now, if the price will remain consistent, clear, this is nothing to comment here. We will not, let's say, commenting on how prices may or may not evolve in the future. Thank you very much. Now, some closing comments very quickly. We have generated strong results, of course, for both patient impact and financial performance, and we look forward to continue that in 2022. I want to speak a little bit about a few changes in people that we are doing. Speaking about that, we continue to attract visionary, purpose-driven leaders with a track record of delivering breakthrough results for patients. Case in point, last week, we announced that Dr. William Pao will join Pfizer as Executive Vice President and Chief Development Officer, effective March 21st of this year. Dr. Pao brings more than 25 years of experience as an oncologist and scientist. He joins us from Roche, where he most recently served as the Head of Pharma Research and Early Development. He oversaw the discovery and early development of a portfolio of new molecular entities to treat diseases related to cancer, neuroscience, ophthalmology, rare diseases, and can go on and on and on. Of course, cancer is a very big part of his portfolio. Clearly, I want to mention that Dr. Pao succeeds Rod MacKenzie, a legendary leader in Pfizer, who recently announced his intent to retire after 35 years of Pfizer. I want to thank Rod, his incredible contributions to Pfizer, including the outstanding leadership in helping bring Comirnaty and Paxlovid to the world so quick. Of course, also, I want to touch base on something that everybody has in mind. I want to take a moment to recognize my trusted colleague and friend, Frank D'Amelio, who also has announced his intention to retire from Pfizer after an incredibly impactful decade and a half with the company as CFO. Frank is one of the smartest, more respected, and most effective leaders I have ever had the good fortune to work with, and the positive impact he has had on Pfizer and on all our stakeholders is immeasurable. Frank isn't going anywhere yet, just to clarify, as he has agreed to stay on board and as we search for his successor, and also to serve in a consulting role through the transition. That said, I wanted to take the opportunity to thank him publicly for all he has meant to Pfizer and to me personally. Frank, on behalf of our 80,000 colleagues around the world, I wish you good health, every happiness as you begin a new chapter when this time comes, because it's not yet. Wherever life's journey takes you, I'm sure it will be directionally correct. That will bring an end to our call. Thank you for joining us. Have a great rest of your day. Ladies and gentlemen, this does conclude Pfizer's fourth quarter 2021 earnings conference call. You may now all disconnect.