Hello, and welcome to the 2026 virtual annual meeting of Prime Medicine. Please note that today's meeting is being recorded. Stockholders may submit questions by following the instructions on the annual meeting interface. I would like to turn the meeting over to Allan Reine, the Chairperson of the Annual Meeting. Dr. Reine, you may begin. Good afternoon, everyone. My name is Allan Reine, Chief Executive Officer and Director of Prime Medicine. The meeting is now called to order. It is a pleasure to welcome our stockholders to the annual meeting of Prime Medicine. This meeting is being held in accordance with the company's bylaws and Delaware law. Our meeting will consist of the formal business at hand, which is described in our notices of Internet availability of proxy materials, a copy of which was mailed on or about April 23rd, 2026 to all our stockholders of record as of the close of business on April 9th, 2026, and the proxy statement filed with the SEC. During the meeting, all discussion will be limited to the official business at hand. Before proceeding to the formal business, I would like to welcome the directors of the company and the members of our executive team who are with us today, as well as the representatives from PricewaterhouseCoopers, Prime Medicine's audit firm. Thank you. Let's proceed to the formal business of the meeting, notice of which was sent to all stockholders of record as of the close of business on April 9th, 2026. Stockholders of record as of the close of business on that date are entitled to vote at this meeting. A record of stockholders as of the date has been on file at the principal place of business of the company for the last 10 days immediately prior to the date of this meeting and has been available for inspection by any stockholder during that period at any time during normal business hours. Rules of conduct for the meeting are available in the Files section on the right side of the screen. Please note that only stockholders who have logged in using their 16-digit control number will be able to vote and ask questions at the meeting. To allow us to answer questions from as many stockholders as possible, we will limit each stockholder to two questions related to the official business at hand. If you have any questions, I would encourage you to please submit them now so that they will be in the queue to be answered. If any stockholder wishes to address the Chairperson during the formal part of the meeting, please do so by submitting your question in writing through the Virtual Meeting platform via the link provided. The Board of Directors has appointed Richard L. Leza Jr. to act as Inspector of Election for this annual meeting, and he will tabulate results of the voting. The Inspector of Election has signed the oath at his office, which will be filed with the minutes of this meeting. Mr. Leza, do you have a quorum present? Yes, we do, Dr. Reine. Of the 180,615,889 shares of common stock entitled to vote at the meeting, 140,384,724 shares or 77.7%, are represented either in person or by proxy. Therefore, a quorum is present. I declare that a quorum is present. We may now proceed to transact the business for which this meeting has been called. Let me briefly describe the voting procedures. Voting will be by proxy and by using the voting link provided through the Virtual Meeting platform. If you have previously turned in your proxy and you do not intend to change your vote, it is not necessary that you complete another proxy or ballot. Your vote will be counted. If you are eligible to vote and have not submitted your proxy, or if you want to change your vote, you may do so by clicking on the link provided through the Virtual Meeting platform. In order to allow stockholders to vote through the Virtual Meeting platform at any time during this meeting, I now declare the polls open for voting. It is 2:04 P.M. on June 5th, 2026. Our first item of business is the election of directors. At this meeting, we will be voting on two nominees for Class I Directors to serve for a term of three years. All is set forth in the proxy statement. In accordance with the bylaws, your directors have nominated Michael Kelly and David Schenkein to be elected to serve as Class I Directors. The company's bylaws require that a stockholder provide advance notice to the company of a stockholder's intent to nominate persons or directors. No such notice was received. Accordingly, I declare the nominations for directors closed. The Board of Directors unanimously recommends that stockholders vote in favor of this proposal. Have we received any questions concerning the proposal? No questions. The second item of business is the ratification of the appointment of PricewaterhouseCoopers as our independent registered public accounting firm for the fiscal year ending December 31st, 2026. The audit committee of the Board of Directors, which consists entirely of independent directors, appointed PricewaterhouseCoopers as the company's independent registered public accounting firm to audit the company's financial statements for the fiscal year ending December 31st, 2026. The Board of Directors approved the selection of PricewaterhouseCoopers and has asked the stockholders to ratify the selection. Stockholder ratification is not required by the company's bylaws. However, the Board of Directors is submitting this to the stockholders for ratification as a matter of good corporate governance. If the stockholders do not approve the selection of PricewaterhouseCoopers as the company's independent registered public accounting firm, the Board of Directors and the audit committee will reconsider the appointment. Have we received any questions concerning the proposal? We have no questions. Anyone who has not yet voted and desires to do so, please do so now through the Virtual Meeting platform. It is now 2:07 P.M. on June 5th, 2026, and the polls for each matter to be voted on at this meeting are now closed. No additional ballots, proxies, or votes, and no changes or revocations will be accepted. Inspector of Election, please report on the results of the voting. Thank you, Dr. Reine. With regard to Proposal 1, a plurality of the votes properly cast has been voted in favor of the election of the persons nominated. With regard to Proposal 2, a majority of the votes properly cast have been voted in favor of the ratification of PricewaterhouseCoopers as the company's independent registered public accounting firm for the fiscal year ending December 31st, 2026. Thank you, Mr. Leza. I declare that all of the proposals presented at the meeting have been ratified or approved by the stockholders. The final results of voting, including any ballots and proxies recorded during this meeting, will be set forth in the report of the Inspector of Election and will be included in the minutes of the meeting. The final results will also be included in our reports filed with the SEC. There being no other matters for consideration at this meeting, I hereby adjourn this meeting. This concludes today's annual meeting. You may now disconnect.