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Investor Presentation ProPhaseLabs.com NASDAQ: PRPH Fall 2025
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2 Except for the historical information contained herein, this document contains forward looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding our strategy, plans, objectives and initiatives, including our expectations regarding the future revenue gr owth potential of each of our subsidiaries, our expected timeline for commercializing our BE - Smart Esophageal Cancer Test, our expectations regarding future liquidity events, the success of our efforts to collect accounts receivables and anticipated timeline for any payments relating thereto, and our ability to successfully transition into a consumer products company. Mana gem ent believes that these forward - looking statements are reasonable as and when made. However, such forward - looking statements involve known and unknown risks, uncertainties, and other factors that may cause actual results to differ materially from those projected in the forward - looking statements. These risks and uncertainties include but are not limited to our ability to obtain and maintain necessary regulatory approvals, general economic conditions, consumer demand for our products and services, challenges relating to entering into and growing new busi nes s lines, the competitive environment, and the risk factors listed from time to time in our Annual Reports on Form 10 - K, Quarterly Reports on Form 10 - Q and any other SEC filings. The Compa ny undertakes no obligation to update forward - looking statements except as required by applicable securities laws. Readers are cautioned that forward - looking statements are not guara ntees of future performance and are cautioned not to place undue reliance on any forward - looking statements. FORWARD LOOKING STATEMENTS This presentation includes market and industry data and forecasts that the Company has derived from independent consultant re por ts, publicly available information, various industry publications, other published industry sources, and its internal data and estimates. Independent consultant reports, industry pu blications and other published industry sources generally indicate that the information contained therein was obtained from sources believed to be reliable. Although the Company belie ves that these third - party sources are reliable, it does not guarantee the accuracy or completeness of this information, and the Company has not independently verified this information. The Company’s internal data and estimates are based upon information obtained from trade and business organizations and other contacts in the markets in which the Company operates an d m anagement’s understanding of industry conditions. Although the Company believes that such information is reliable, it has not had this information verified by any independent sou rces. MARKET AND INDUSTRY DATA
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BE - Smart PROPHASE LABS BUSINESS VERTICALS ProPhase has entered into an initiative with Crown Medical Collections targeting over $50 million in net near - term cash recovery form COVID - 19 receivables. Crown Medical appointed as Special Counsel to launch litigation against the insurance companies. The team is now entering “meet and confer” discussions, with the Company anticipating meaningful settlements within the next few months. ProPhase BioPharma includes BE - Smart , a potentially ground - breaking early detection esophageal cancer diagnostic test, with a target market of $7 - 14 billion 1 . The recent publication of its pivotal validation study in Clinical and Translational Gastroenterology confirms BE - Smart’s clinical utility, marking a key milestone toward commercialization. Collaborating with world - class consultants to initiate commercialization as a laboratory developed test (LDT) with an eye toward a potential strategic partnership with one of numerous, large cancer diagnostic companies. Nebula Genomics, co - founded by Dr. George Church, world renowned Professor of Genetics at Harvard Medical School and Massachusetts Institute of Technology. We believe that Nebula’s dataset is one of the largest and most diverse genomic datasets in the world, which includes world class proprietary bioinformatics. Nebula has a uniquely diverse 16 - petabyte DNA dataset (equivalent to roughly 150 million ancestry SNP - based tests), with samples spanning 130 countries. Includes DNA Complete, a world - class Whole Genome Sequencing and Bioinformatics DTC test offering. ProPhase Supplements, l everaging deep expertise in direct - to - consumer marketing and sales. Company is d eveloping Equivir as a potential lead product. 3 1Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2021 - Gastroenterology (gastrojournal.org) ProPhase Supplements & Crown Medical Collections $50 million net accounts receivable initiative Committed to executional excellence, smart diversification, and a synergistic, omni - channel approach
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2012 2017 2018 2020 2021 Ted Karkus, CEO, restructures and turns around the Company. Stock bottoms at $.65 per share. Sold the Cold-EEZE cold remedy brand for $50m to Mylan Pharmaceuticals. From 2018 to 2022, delivered shareholder value through special cash dividends of $2.40 per share in total. Commenced CLIA lab services for COVID-19 testing. Generated enormous revenues and earnings for the following two years. Cash flow used to diversify the company for long term growth. Acquisition of Nebula Genomics. Providing world class whole genome sequencing. 202420232022 Exclusively licensed a broad- based compound, Equivir (Dietary Supplement). Acquired worldwide exclusive rights to the BE-Smart Esophageal Pre-Cancer diagnostic screening test. Multi-billion-dollar potential. Nebula Genomics opened a world class whole genome sequencing (WGS) lab in Garden City, NY. This includes 4 leading platforms of WGS equipment. Capable of providing incredibly low prices which creates major opportunities. Initiates expansion plan for Pharmaloz Manufacturing. New, automated equipment installed, significantly increasing capacity. Number of customers growing. Revenues and earnings growing going into 2025.* Exploring strategic alternatives including a potential sale of PMI. OUR BEST IS YET TO COME! PERFORMANCE TRACK RECORD •Management’s analysis and guidance announced by ProPhase Labs on January 23, 2024: https://www.globenewswire.com/en/news -release/2024/01/23/2814037/0/en/Pharmaloz- Manufacturing-Accelerates-Expansion-Improves-Pricing-Boosts-Profitability-and-Secures-New-Contracts.html 4 Launched DNA Complete and DNA Expand on November 4, 2024. Plans to introduce Equivir dietary supplement to the marketplace early 2025. Q4 2024 – Q1 2025 Q1 2025 January: Sold Pharmaloz Manufacturing for $23.6 million February: Shut down the genomics laboratory, saving over $6 million per year. March: Significantly reduced lab IT services and employee headcount saving millions of dollars per year. Q3 2025 August: Announced full USPTO approval for issuance of U.S. patent protecting esophageal adenocarcinoma risk assessment. Moving forward aggressively with Crown Medical Collections $50 million initiative.
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ProPhase has entered into an initiative with Crown Medical Collections targeting over $50 million in net near - term cash recovery from COVID - 19 receivables. • Crown Medical appointed Special Counsel to launch litigation against insurance companies. The team is now entering “meet and confer” discussions that have been strategically prepared over recent months, with the Company anticipating meaningful settlements within the next few months. • Crown Medical is so confident in this initiative, their entire compensation for legal work is based on contingency fees; ther e i s no cost to ProPhase Labs for this initiative. • ProPhase has been collaborating with Crown Medical Collections to pursue over $150 million in uncollected COVID - 19 testing receivables from more than 1,100 insurance companies. • Crown’s legal strategy is unique and targets insurance companies and their unwillingness to reimburse valid COVID - 19 claims as defined in the Cares Act. • After closely reviewing these outstanding claims, Crown estimates that ProPhase could collect in excess of $50 million dollar s net of fees, potentially more than double the current amount of COVID - 19 receivables recorded on its financial statements. • Crown Medical’s specialization lies in recovering unpaid COVID - 19 reimbursements through a robust team of experienced attorneys who communicate directly with insurance companies’ legal departments. CROWN MEDICAL COLLECTIONS 5
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BE - Smart ESOPHAGEAL CANCER DIAGNOSTIC IN FINAL STAGES OF PREPARATION FOR COMMERCIALIZATION Barrett’s Esophagus Esophageal Cancer GERD 7 ESOPHAGEAL ADENOCARCINOMA (EAC) – ONE OF THE DEADLIEST CANCERS • 16,000+ Estimated Deaths in 2023 in the U.S. 1 • 78.3% - 5 - Year Mortality Rate (2013 - 2019) 1 • 21,000+ Estimated New Cases in 2023 1 • The change in the annual incidence of EAC was 766.67% higher in 2017 compared to 1973 ² • Journal of American Medical Association once again reported that GI cancers for the 2nd straight decade are the fastest growing cancer type in America ³ Gastroesophageal Reflux Disease (GERD) occurs when stomach acid repeatedly flows back into the esophagus. Backwash (acid reflux) can irritate the lining of esophagus. Many experience acid reflux from time to time; for some, GERD may trigger a change in the cells lining the lower esophagus causing Barrett's Esophagus . Barrett's Esophagus - Esophagus becomes damaged by acid reflux; causes the lining to thicken and become red. Associated with increased risk of developing Esophageal Adenocarcinoma . Discovering pre - cancerous tissue in early and treatable stages may increase disease survival and decrease cost of care. As high as 40% of esophageal carcinoma is missed or found late leading to more unfavorable diagnosis. 1 - - https://bit.ly/40ONuqt - Cancer Stat Facts: Esophageal Cancer 2 - . https://bit.ly/3KGWGr9 - Epidemiology of early esophageal adenocarcinoma 3 - . https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2808381
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OPPORTUNITY TO PREVENT ESOPHAGEAL CANCER WITH EARLY AND ACCURATE DIAGNOSIS 1- https://www.ncbi.nlm.nih.gov/books/NBK441938/ 2 - https://www.census.gov/popclock/ 3- https://www.aafp.org/pubs/afp/issues/2022/1000/barrett- esophagus.html#:~:text=Barrett%20esophagus%20is%20estimated%20to,Barrett%20esophagus%20or%20esophageal%20adenocarcinoma. 4-https://pmc.ncbi.nlm.nih.gov/articles/PMC10007944/#:~:text=Carcinoma%20of%20esophagus%20is%20the,for%2016%2C410%20deaths%20(2 5-https://linkinghub.elsevier.com/retrieve/pii/S0016508521036556 Target Market Endoscopies: Estimated average cost per test: Total Potential Addressable Market: ~7mm $1k - $2k ~$7b - $14b 8 Prevalence of GERD in the U.S of 20% 1 (Census 337 million 2 ) ~ 67 million Prevalence of Barrett’s Esophagus in the U.S. is 5.6% of the population 3 (Census 337 million 2 ) ~ 18 million New Cases of Esophageal Adenocarcinoma in U.S. per year ~ 20K Endoscopy (upper) related to GERD and Barrett's Esophagus average 5 ~ 7 million 4
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ADVANTAGES OF THE BE - Smart ESOPHAGEAL CANCER DIAGNOSTIC COMPARED TO LIQUID BIOPSIES 9 ✓ BE - Smart is designed to take EXISTING biopsy blocks from routine endoscopies, which is the standard of care for diagnosis of GER D, Barrett’s Esophagus and esophageal adenocarcinoma. No additional samples are needed from patients after the endoscopy. With liq uid biopsies, the patient would have to return to the physician’s office to draw the blood. ✓ BE - Smart is highly sensitive and specific in distinguishing early - stage esophageal adenocarcinoma in studies to date. On the oth er hand, liquid biopsies require the cancer to spread to neighboring tissue and blood vessels in order to produce detectable markers i n t he blood. ✓ Our BE - Smart test examines the suspicious tissue DIRECTLY, not a bi - product somewhere in the blood. In liquid biopsies, there ar e factors that can create many false positives and false negatives as the tested markers are at very low concentrations. These fac tors can be other pathological and non - pathological conditions, including exercise, trauma, and surgery. 1 ✓ We are testing the affected tissue directly on a clinically proven instrument (mass spectrometer), which is highly sensitive. ✓ By directly analyzing the affected tissue, the BE - Smart test is designed to detect early stages of cancer before markers have en tered the blood. ✓ While we are still studying the test's safety and effectiveness, we believe that the BE - Smart test may have the ability to deter mine early carcinogenesis. FDA Approved liquid biopsy tests on the market are used to monitor a disease or to determine treatment path o f a disease. They are still required to be used in combination with standard tests such as endoscopies. Conclusion: The utility of BE - Smart is potentially quite significant. The BE - Smart test is designed to determine early carcinogenesis of biopsies in which a pathologist might be on the fence and/or mistakenly classify as non - cancerous. This can literally mean the d ifference between life and death for the patient. An accurate and early diagnosis can lead to more effective and earlier treatments which can lead to significantly better outcomes for the patient. 1. :Braig D., Becherer C., Bickert C., Braig M., Claus R., Eisenhardt A.E., Heinz J., Scholber J., Herget G.W., Bronsert P., et al. Genotyping of circulating cell - free DNA enables noninvasive tumor detection in myxoid liposarcomas. Int. J. Cancer. 2019;145:1148 – 1161. doi: 10.1002/ijc.32216.
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BE - Smart - ESOPHAGEAL CANCER DIAGNOSTIC 10 Announced full USPTO approval for issuance of U.S. patent protecting esophageal a denocarcinoma risk assessment.* I ssued U.S. Patent No. 12379378 - B2 for the Company’s biomarker - based systems and methods to assess progression risk in Barrett’s esophagus and esophageal adenocarcinoma. Continued refining the BE - Smart test algorithm with new data analysis, enhancing its accuracy in predicting Barrett’s Esophagus risk. Collaborating with Mayo Clinic and other experts to further validate the test through additional samples, studies and peer - reviewed publications, including the recent publication of a pivotal validation study in Clinical and Translational Gastroenterology , which confirms BE - Smart’s clinical utility as a risk stratification tool. ProPhase announced the successful completion of a key validation study evaluating the performance of the BE - Smart molecular diagnostic test compatibility with samples obtained from esophageal brush cytology .** The study demonstrated BE - Smart achieved greater than a 95% technical success rate, confirming the BE - Smart’s ability to reliably and accurately detect our panel of biomarkers, designed to assess progression risk in Barrett’s esophagus and other distal esophageal conditions. The dual capability of BE - Smart now validated to analyze both “pinch” and “brush” standard of care biopsies enables a powerful tool for comprehensive esophageal disease surveillance and clinical management. ProPhase is thrilled to appoint Dr. Joe Abdo , former CEO of Stella Diagnostics, to drive the commercialization of its BE - Smart diagnostic asset. With deep expertise in biomarker discovery and gastrointestinal disease management, Dr. Abdo has a proven track record, having launched a prostate cancer blood test and an immunotherapy response assay — both now thriving in the U.S. market. ProPhase also announced the formation of its Clinical Science Advisory Board to support the clinical adoption and commercialization of the BE - Smart molecular test for esophageal disease. The advisory board includes Dr. Joe Abdo , the inventor of the BE - Smart test and a nationally recognized leader in molecular oncology. Dr. Abdo looks to leverage his deep relationships with academia, the Mayo Clinic GI Path department, KUMC gastroenterology and KOLs in the esophageal cancer space. Also joining the advisory board is Mr. James McCullough , founder and CEO of Renalytix and former Chief Executive Officer of Exosome Diagnostics Inc., a pioneer in liquid biopsy diagnostics. Additional key opinion leaders and experts in the field will be added to the advisory board in the near future as the Company plans for its initial commercial launch. *Source: Company Press Release, August 12, 2025 https://ir.prophaselabs.com/news - events/press - releases/detail/244/prophase - labs - announces - full - uspto - approval - for - issuance - of ** Source: Company Press Release, June 17, 2025 https://ir.prophaselabs.com/news - events/press - releases/detail/238/prophase - labs - ann ounces - successful - study - demonstrating
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0.0 500.0 1000.0 1500.0 2000.0 2500.0 3000.0 3500.0 4000.0 4500.0 5000.0 5500.0 6000.0 6500.0 7000.0 7500.0 8000.0 8500.0 9000.0 9500.0 10000.0 AXL CBLB CDK4 EGFR HER2 HER3 Marker 1 Marker 2 Marker 3 Marker 4 Marker 5 Marker 6 Marker 7 Marker 8 IDO-1 IGF-1R MET MSLN Ki67 PD-L1 PD-L2 STLA101 EAC Expression Compared to Routine Targeted Therapy Markers Mean expression (amol/ug) 53/55 2/55 29/55 4/55 51/55 34/55 3/55 8/55 0/55 0/55 0/5529/55 26/55 46/55 XX/55 = number of EAC tumors expressing these markers out of 55 samples 55/55 55/55 53/55 55/55 55/55 55/55 51/55 30286.7 amol/ug BE - Smart - OVEREXPRESSION IN EAC COMPARED TO ROUTINE MARKERS FOR PROGNOSTICATION AND THERAPY 11
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BE - Smart - ESOPHAGEAL CANCER DIAGNOSTIC NEAR TERM PATH TO COMMERCIALIZATION Filed US patent application on May 19, 2021 Initiated 1,000 patients on STLA101 assay with Mayo Clinic Completed first ~200 tests Submitted and presented interim results to ACG/ASCO - GI/SAGES/AACR/DDW in 2022 Filed all patent applications for all significant international jurisdictions Initiated testing of additional specimens, including brush - acquired ones Published first validation specific to BE - Smar t, finding that its “proteomic panel is comprised of predictive biomarkers that are both statistically significant and mechanistically meaningful ” Expanded support from key opinion leaders at conferences (including USCAP) and in focus groups Collaborated with brush - technology company to develop brush - capture technique to replace the need for endoscopy Completion of BE-Smart Dossier Integrate finalized biomarker panel and algorithm into a pipeline for GI-friendly result generation Initiate discussions with p ayers for coverage in medical policy Go - to - market strategy: • Commercialize with a large pharma or cancer - testing company • Work on global commercialization initiatives in parallel • Work with insurance companies to cover BE - Smart and contract for reimbursement Launch BE-Smart as a cash-based test in the near future US Patent 11,874,277 granted protecting BE - Smart 12 Submit manuscript with BE-Smart’s performance metrics in Q2 Publication of a clinical validation study, bolstering the test’s credibility Expanding research with more specimens and complying with new FDA lab test guidelines
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Prof. George Church , co - founder of Nebula Genomics; Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard University and the Massachusetts Institute of Technology (MIT). Contributed to the development of multiple DNA sequencing methods. In particular, molecular multiplexing approaches that enabled next - generation DNA sequencing as well as long - read nanopore sequencing. Initiated the Personal Genome Project whose pioneering work contributed to the development of DNA sequencing and genome engineering technologies for which he received multiple awards including the 2011 Bower Award and Prize for Achievement in Science from the Franklin Institute and election to the National Academy of Sciences and Engineering. Co - authored over 550 publications; more than 150 patents; authored the book, “Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves”; started over 20 companies. "Genome sequencing is like the internet back in the late 1980s." George M. Church Professor - Harvard and MIT Co - founder - Nebula Genomics MEET GEORGE CHURCH, FOUNDER OF NEBULA GENOMICS AND SCIENTIFIC ADVISOR Mission: To usher in the era of personal genomics by providing access to affordable and secure Whole Genome Sequencing. Nebula Genomics turns these breakthrough technologies into B2C and B2B products available around the globe. 14
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• The Company believes that Nebula is a compelling acquisition candidate, offering a uniquely diverse 16 - petabyte DNA dataset (equivalent to roughly 150 million ancestry SNP - based tests), with samples spanning 130 countries. We believe that Nebula’s dataset is one of the largest and most diverse genomic datasets in the world. • Nebula delivers full WGS coverage and proprietary bioinformatics, generating over 350 personalized health, wellness and advanced ancestry reports. • Its scalable, subscription - based revenue model, with strong margins on renewals, further enhances its commercial appeal. • Recent transactions in the genomics sector, such as the recently announced sale of substantially all of 23andMe’s assets to Regeneron for $256 million (source: Bloomberg, May 5, 2025), highlight the value of large genomic datasets. NEBULA GENOMICS 15
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DNA Complete is a world - class Whole Genome Sequencing and Bioinformatics direct to consumer test offering. Whole Genome Sequencing (“WGS”) Technology Our WGS DNA technology analyzes virtually 100% of your DNA compared to typical DNA Ancestry tests that analyze less than 1% o f y our DNA, at a competitive price. This provides more accurate and in - depth health and ancestry reports. Proprietary Bioinformatics Platform 340+ personalized health pre - disposition reports covering Longevity, Mental Health, Cancer & more. New Advanced Ancestry platform Comprehensive ancestry analysis that provides personalized ancestry reports, such as Regional ancestry, Ancestry timeline, Co mpa rison with ancient populations & more. Data Security No Third - Party Access to Genomic Data: DNA Complete ensures that no third parties have access to back - end raw genomic data. All genomic information is securely stored within our infrastructure and is not shared with external entities. Data Storage and Encryption: All genomic data is securely stored on AWS (Amazon Web Services) and is encrypted both at rest and in transit, using industry - le ading encryption protocols to ensure the highest level of security and privacy. No Data Sharing for Research or Monetization: DNA Complete does not share raw genomic data with third parties research companies, for studies or any other purpose. We main tai n full control of the data, ensuring it is used solely for the benefit of our users, with no external monetization or unauthorized access. DNA COMPLETE® - LAUNCHED NOVEMBER 4, 2024 16
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DNA COMPLETE® Direct To Consumer Launch of DNA Complete Shape The Future of Your Health and Explore Your Ancestry with DNA Complete • Built a comprehensive marketing campaign featuring top influencers, managed by an experienced marketing leader with a proven track record in building global brands. Launched Q4 2024. • The new offering is designed to deliver a robust genetic user platform, industry - leading pricing and faster turnaround times. • This new product harnesses our cutting - edge bioinformatics platform and the launch of our proprietary advanced Ancestry platform, offering customers deep analysis of their genomic data. • Offering genetic counseling services, enhancing the value proposition for customers. Essential DNA Test $195 Pro DNA Test $495 Elite DNA Test $1,495 Amount of DNA Analyzed 1X WGS 30X WGS 100X WGS Accuracy High accuracy Higher accuracy Maximum accuracy First year of membership included New Reports + Existing Report Updates Essential Ancestry Reports Advanced Ancestry Reports New Reports Per Month Up to 3 Up to 5 Up to 10 Total Personalized Health Reports Provided 175+ and counting 250+ and counting Up to 350+ and counting
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DNA Upload, Expansion and Analysis • Consumers effortlessly upload their DNA data from other DNA Ancestr y tests to unlock our proprietary reports and advanced features. • Low cost offering for consumers, makes it a highly attractive offer. • Significant gross profit margins presents enormous profit opportunity . • Expands your DNA data: user’s file is boosted with 50x more data after upload, to provide them with significantly more in - depth health and wellness reports compared to typical DNA ancestry tests. • No need to be tested again. Millions of consumers can easily upload their DNA Ancestry test data from their previous testing. No additional lab sequencing is required. Therefore, DNA Expand can offer low prices while still achieving highly attractive margins. DNA EXPAND 18 Most Other DNA Data Upload Services DNA data expansion. Expands raw DNA data more than 50 times to over 35 million genetic variants. No DNA data expansion. Superior trait reports. More comprehensive trait reports enabled by DNA data expansion. Limited trait reports. New Dynamic Reports. Receive frequent new reports that are based on the latest scientific discoveries. Reports are updated very rarely. Privacy First DNA Testing. Technology that enables users to have full ownership and control over their genomic data. Sell customer genomic data. Diverse, Extensive Database. Built over the last 6 years from whole genome sequencing tests spanning more than 130 countries, and equivalent to roughly 150 million ancestry SNP- based tests. Not nearly as extensive.
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COMPETENT AND PROVEN EXECUTIVE MANAGEMENT TEAM Jason Karkus President Nebula Genomics & DNA Complete Jason was instrumental in the strong revenue growth at ProPhase Diagnostics, leading sales, business development, logistics operations, and account management. He oversaw the development of two CLIA-certified labs, generating approximately $200 million in revenues since 2021. Jason developed and now oversees DNA Complete and DNA Expand. Jason is a graduate of the University of Maryland. Ted Karkus Chairman & CEO ProPhase Labs, Inc. . Ted Karkus, CEO and Chairman of ProPhase Labs, drives the company's diverse and synergistic businesses with his successful track record in biomedical and health companies. He transformed ID Biomedical's strategy and valuation from $25 million to $1.4 billion sale to GlaxoSmithKline. As CEO of ProPhase Labs, he restructured the go-to-market strategy for the flagship product Cold-EEZE, turned around and significantly grew revenues, ultimately selling it for $50 million to Mylan. ProPhase Labs is a biotech, genomics and diagnostics company with a commitment of growth, innovation, and execution excellence outlined in Ted’s high growth roadmap. He pivoted into industry leading CLIA labs, and then further diversified by acquiring genomics leader Nebula Genomics. Constantly innovating, Ted then created ProPhase BioPharma to deliver antivirals, cancer tests and therapeutic cancer compounds. The new acquisitions and legacy businesses work to drive synergistic growth with multi-billion-dollar potential. He holds a BS in Psychology from Tufts University with Magna Cum Laude Honors and an MBA in Finance from Columbia University School of Business with Beta Gamma Sigma Honors. Lance is an accomplished finance leader experienced in all areas of finance and accounting. Lance has over 17 years of experience in working with large brands, both public and private, of varying industries and sizes. Prior to ProPhase Labs, Lance served in finance leadership roles at multiple large brand companies including Colgate- Palmolive, Casper Sleep, Newmark and Forest Laboratories, where he was responsible for all accounting matters including financial reporting, general accounting, and related internal controls functions. He began his career with five years in public accounting with Marcum LLP. Lance earned a BBA in accounting from Hofstra University. He is a certified public accountant and is a member of the American Institute of Certified Public Accountants. Lance Bisesar Corporate Controller ProPhase Labs, Inc. Steven M. Plumb Fractional CFO ProPhase Labs, Inc. Steven M. Plumb is an experienced CPA with over 30 years of experience with a wide range of companies: start up, early stage, mature, in a wide range of industries, both public and private, with a primary focus of helping these clients with their financial reporting responsibilities. Mr. Plumb has extensive experience advising on capital structure, capital raising strategies and SEC reporting. Mr. Plumb is a former KPMG auditor who is an expert in preparing workpapers for auditors and interfacing with them on behalf of his clients. 19
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INVESTMENT HIGHLIGHTS Completed restructuring and transition to significantly leaner company for H2 2025 • Sold Pharmaloz Manufacturing • Shut down Nebula Genomics laboratory • Dramatically reduced headcount • Significantly reduced IT and related overhead ProPhase Labs is in current discussions for a strategic initiative to realize significant underlying value in the Company. Crown Medical Collections initiative targeting over $50 million in net near - term cash recovery from COVID - 19 receivables. Crown Medical appointed Special Counsel to launch litigation against insurance companies. The Company anticipates meaningful settlements wi thi n the next few months. BE - Smart Esophageal Cancer Test: announced full USPTO approval for issuance of U.S. patent protecting esophageal adenocarcinoma risk assessment. Also announced the successful completion of a key validation study evaluating the performance of the BE - Smart molecular diagnostic test compatibility with samples obtained from esophageal brush cytology . The study demonstrated BE - Smart achieved greater than a 95% technical success rate, confirming the BE - Smart’s ability to reliably and accurately detect our panel of biomarkers. The recent publication in Clinical and Translational Gastroenterology further validates BE - Smart’s clinical utility as a highly sensitive risk stratification tool, advancing its path to commercialization. DNA Complete/Nebula Genomics is Well Positioned to Capitalize on the Future Growth of Genomics and Personalized Medicine. Equivir (OTC): Clinically studied dietary supplement with significant potential. Commercialization is to be determined. Competent and Proven Executive Management Team for more than a decade. 20
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INSTITUTIONAL INVESTOR RELATIONS investorrelations@prophaselabs . com RETAIL INVESTOR RELATIONS John Boidman Renmark Financial Communications 514 - 939 - 3989 jboidman@renmarkfinancial . com TED KARKUS Chairman & CEO 626 RXR Plaza 6 th Floor Uniondale, NY 11556 ProPhaseLabs . com Thank You