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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 FORM 20 - F ( Mark One ) [ ] REGISTRATION STATEMENT PURSUANT TO SECTION 12 ( b ) or ( g ) OF THE SECURITIES EXCHANGE ACT OF 1934 OR [ X ] ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31 , 2020 OR [ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 OR [ ] SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 001-37611 PYXIS TANKERS INC . ( Exact name of Registrant as specified in its charter and translation of Registrant's name into English ) Marshall Islands ( Jurisdiction of incorporation or organization ) 59 K. Karamanli Street , Maroussi 15125 Greece ( Address of principal executive office ) Mr. Henry Williams , Chief Financial Officer 59 K. Karamanli Street , Maroussi 15125 Greece Tel : +30 210 638 0200 Fax : +30 210 653 7715 ( Name , Telephone , E - mail and / or Facsimile number and Address of Company Contact Person ) Securities registered or to be registered pursuant to Section 12 ( b ) of the Act . Title of each class Common Stock , par value $ 0.001 per share Series A Cumulative Convertible Preferred Shares , par value $ 0.001 per share of $ 0.001 per share Warrants to purchase Common Stock , par value Trading Symbol ( s ) PXS PXSAP PXSAW Name of each exchange on which registered Nasdaq Capital Market Nasdaq Capital Market Nasdaq Capital Market Securities registered or to be registered pursuant to Section 12 ( g ) of the Act . None Securities for which there is a reporting obligation pursuant to Section 15 ( d ) of the Act . None Indicate the number of outstanding shares of each of the issuer's classes of capital or common stock as of the close of the period covered by the Annual Report .